Putative cyclosporin 16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9J6_LEIBR

TriTrypDb:

LbrM.18.0940 , LBRM2903_180015100

Length:

1054

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H9J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9J6

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0018193	peptidyl-amino acid modification	5	8
GO:0018208	peptidyl-proline modification	6	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	8
GO:0003824	catalytic activity	1	8
GO:0016853	isomerase activity	2	8
GO:0016859	cis-trans isomerase activity	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.629
CLV_C14_Caspase3-7	4	8	PF00656	0.445
CLV_NRD_NRD_1	180	182	PF00675	0.590
CLV_NRD_NRD_1	204	206	PF00675	0.619
CLV_NRD_NRD_1	354	356	PF00675	0.486
CLV_NRD_NRD_1	442	444	PF00675	0.653
CLV_NRD_NRD_1	57	59	PF00675	0.482
CLV_NRD_NRD_1	572	574	PF00675	0.600
CLV_NRD_NRD_1	586	588	PF00675	0.744
CLV_NRD_NRD_1	669	671	PF00675	0.679
CLV_NRD_NRD_1	695	697	PF00675	0.573
CLV_NRD_NRD_1	772	774	PF00675	0.544
CLV_NRD_NRD_1	858	860	PF00675	0.795
CLV_NRD_NRD_1	870	872	PF00675	0.470
CLV_NRD_NRD_1	88	90	PF00675	0.656
CLV_NRD_NRD_1	920	922	PF00675	0.382
CLV_PCSK_KEX2_1	180	182	PF00082	0.590
CLV_PCSK_KEX2_1	204	206	PF00082	0.611
CLV_PCSK_KEX2_1	354	356	PF00082	0.486
CLV_PCSK_KEX2_1	378	380	PF00082	0.459
CLV_PCSK_KEX2_1	442	444	PF00082	0.653
CLV_PCSK_KEX2_1	572	574	PF00082	0.600
CLV_PCSK_KEX2_1	586	588	PF00082	0.744
CLV_PCSK_KEX2_1	669	671	PF00082	0.642
CLV_PCSK_KEX2_1	772	774	PF00082	0.682
CLV_PCSK_KEX2_1	858	860	PF00082	0.792
CLV_PCSK_KEX2_1	88	90	PF00082	0.656
CLV_PCSK_KEX2_1	920	922	PF00082	0.322
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.459
CLV_PCSK_SKI1_1	205	209	PF00082	0.540
CLV_PCSK_SKI1_1	379	383	PF00082	0.598
CLV_PCSK_SKI1_1	409	413	PF00082	0.610
CLV_PCSK_SKI1_1	62	66	PF00082	0.471
CLV_PCSK_SKI1_1	670	674	PF00082	0.638
CLV_PCSK_SKI1_1	697	701	PF00082	0.562
CLV_PCSK_SKI1_1	853	857	PF00082	0.578
CLV_PCSK_SKI1_1	858	862	PF00082	0.603
CLV_PCSK_SKI1_1	871	875	PF00082	0.509
DEG_APCC_DBOX_1	661	669	PF00400	0.623
DEG_APCC_DBOX_1	870	878	PF00400	0.545
DEG_ODPH_VHL_1	907	918	PF01847	0.376
DEG_SCF_FBW7_1	123	130	PF00400	0.479
DEG_SPOP_SBC_1	20	24	PF00917	0.516
DEG_SPOP_SBC_1	472	476	PF00917	0.457
DEG_SPOP_SBC_1	671	675	PF00917	0.466
DEG_SPOP_SBC_1	829	833	PF00917	0.727
DOC_CDC14_PxL_1	514	522	PF14671	0.573
DOC_CYCLIN_RxL_1	492	503	PF00134	0.466
DOC_CYCLIN_RxL_1	58	69	PF00134	0.422
DOC_CYCLIN_RxL_1	868	876	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	877	880	PF00134	0.613
DOC_MAPK_DCC_7	1036	1046	PF00069	0.219
DOC_MAPK_gen_1	344	352	PF00069	0.500
DOC_MAPK_gen_1	442	448	PF00069	0.588
DOC_MAPK_gen_1	493	501	PF00069	0.597
DOC_MAPK_gen_1	58	67	PF00069	0.506
DOC_MAPK_HePTP_8	133	145	PF00069	0.624
DOC_MAPK_HePTP_8	891	903	PF00069	0.300
DOC_MAPK_MEF2A_6	136	145	PF00069	0.624
DOC_MAPK_MEF2A_6	493	501	PF00069	0.606
DOC_MAPK_MEF2A_6	894	903	PF00069	0.300
DOC_PP1_RVXF_1	60	67	PF00149	0.422
DOC_PP1_RVXF_1	924	930	PF00149	0.395
DOC_PP2B_LxvP_1	877	880	PF13499	0.613
DOC_PP4_FxxP_1	153	156	PF00568	0.621
DOC_PP4_FxxP_1	700	703	PF00568	0.643
DOC_PP4_FxxP_1	884	887	PF00568	0.374
DOC_PP4_FxxP_1	998	1001	PF00568	0.369
DOC_USP7_MATH_1	163	167	PF00917	0.598
DOC_USP7_MATH_1	182	186	PF00917	0.577
DOC_USP7_MATH_1	196	200	PF00917	0.606
DOC_USP7_MATH_1	427	431	PF00917	0.639
DOC_USP7_MATH_1	557	561	PF00917	0.603
DOC_USP7_MATH_1	564	568	PF00917	0.649
DOC_USP7_MATH_1	593	597	PF00917	0.560
DOC_USP7_MATH_1	739	743	PF00917	0.644
DOC_USP7_MATH_1	76	80	PF00917	0.648
DOC_USP7_MATH_1	829	833	PF00917	0.773
DOC_USP7_MATH_1	848	852	PF00917	0.685
DOC_WW_Pin1_4	1039	1044	PF00397	0.360
DOC_WW_Pin1_4	123	128	PF00397	0.532
DOC_WW_Pin1_4	13	18	PF00397	0.604
DOC_WW_Pin1_4	192	197	PF00397	0.675
DOC_WW_Pin1_4	226	231	PF00397	0.665
DOC_WW_Pin1_4	421	426	PF00397	0.662
DOC_WW_Pin1_4	558	563	PF00397	0.668
DOC_WW_Pin1_4	623	628	PF00397	0.671
DOC_WW_Pin1_4	682	687	PF00397	0.525
DOC_WW_Pin1_4	818	823	PF00397	0.683
DOC_WW_Pin1_4	858	863	PF00397	0.623
DOC_WW_Pin1_4	882	887	PF00397	0.505
LIG_14-3-3_CanoR_1	1027	1032	PF00244	0.329
LIG_14-3-3_CanoR_1	21	26	PF00244	0.488
LIG_14-3-3_CanoR_1	254	262	PF00244	0.711
LIG_14-3-3_CanoR_1	269	273	PF00244	0.586
LIG_14-3-3_CanoR_1	288	297	PF00244	0.577
LIG_14-3-3_CanoR_1	379	386	PF00244	0.476
LIG_14-3-3_CanoR_1	436	446	PF00244	0.762
LIG_14-3-3_CanoR_1	465	469	PF00244	0.659
LIG_14-3-3_CanoR_1	482	490	PF00244	0.647
LIG_14-3-3_CanoR_1	529	538	PF00244	0.476
LIG_14-3-3_CanoR_1	572	581	PF00244	0.597
LIG_14-3-3_CanoR_1	669	678	PF00244	0.625
LIG_14-3-3_CanoR_1	747	755	PF00244	0.666
LIG_14-3-3_CanoR_1	853	862	PF00244	0.629
LIG_14-3-3_CanoR_1	88	94	PF00244	0.600
LIG_14-3-3_CanoR_1	926	930	PF00244	0.360
LIG_Actin_WH2_2	57	73	PF00022	0.426
LIG_APCC_ABBA_1	34	39	PF00400	0.569
LIG_APCC_ABBA_1	499	504	PF00400	0.618
LIG_BIR_III_4	49	53	PF00653	0.520
LIG_BRCT_BRCA1_1	149	153	PF00533	0.612
LIG_BRCT_BRCA1_1	993	997	PF00533	0.300
LIG_DLG_GKlike_1	21	29	PF00625	0.486
LIG_FHA_1	128	134	PF00498	0.613
LIG_FHA_1	140	146	PF00498	0.602
LIG_FHA_1	20	26	PF00498	0.487
LIG_FHA_1	324	330	PF00498	0.593
LIG_FHA_1	385	391	PF00498	0.588
LIG_FHA_1	399	405	PF00498	0.408
LIG_FHA_1	465	471	PF00498	0.560
LIG_FHA_1	538	544	PF00498	0.537
LIG_FHA_1	792	798	PF00498	0.631
LIG_FHA_2	142	148	PF00498	0.624
LIG_FHA_2	337	343	PF00498	0.579
LIG_FHA_2	472	478	PF00498	0.613
LIG_FHA_2	631	637	PF00498	0.678
LIG_FHA_2	638	644	PF00498	0.613
LIG_FHA_2	672	678	PF00498	0.453
LIG_FHA_2	862	868	PF00498	0.607
LIG_FHA_2	946	952	PF00498	0.360
LIG_HP1_1	664	668	PF01393	0.491
LIG_Integrin_RGD_1	944	946	PF01839	0.360
LIG_LIR_Apic_2	150	156	PF02991	0.616
LIG_LIR_Apic_2	698	703	PF02991	0.477
LIG_LIR_Apic_2	882	887	PF02991	0.403
LIG_LIR_Gen_1	304	313	PF02991	0.509
LIG_LIR_Gen_1	358	367	PF02991	0.512
LIG_LIR_Gen_1	488	497	PF02991	0.596
LIG_LIR_Gen_1	580	589	PF02991	0.656
LIG_LIR_Gen_1	617	627	PF02991	0.494
LIG_LIR_Gen_1	912	923	PF02991	0.304
LIG_LIR_Gen_1	928	937	PF02991	0.283
LIG_LIR_Nem_3	304	308	PF02991	0.477
LIG_LIR_Nem_3	358	364	PF02991	0.514
LIG_LIR_Nem_3	415	419	PF02991	0.541
LIG_LIR_Nem_3	484	489	PF02991	0.591
LIG_LIR_Nem_3	580	584	PF02991	0.632
LIG_LIR_Nem_3	606	612	PF02991	0.657
LIG_LIR_Nem_3	617	622	PF02991	0.535
LIG_LIR_Nem_3	912	918	PF02991	0.304
LIG_LIR_Nem_3	928	932	PF02991	0.283
LIG_LIR_Nem_3	994	1000	PF02991	0.300
LIG_MLH1_MIPbox_1	993	997	PF16413	0.300
LIG_PCNA_yPIPBox_3	148	161	PF02747	0.562
LIG_Pex14_1	94	98	PF04695	0.612
LIG_SH2_CRK	896	900	PF00017	0.360
LIG_SH2_CRK	924	928	PF00017	0.300
LIG_SH2_CRK	98	102	PF00017	0.594
LIG_SH2_PTP2	489	492	PF00017	0.575
LIG_SH2_PTP2	514	517	PF00017	0.553
LIG_SH2_SRC	213	216	PF00017	0.543
LIG_SH2_STAP1	551	555	PF00017	0.538
LIG_SH2_STAT5	202	205	PF00017	0.609
LIG_SH2_STAT5	305	308	PF00017	0.543
LIG_SH2_STAT5	489	492	PF00017	0.575
LIG_SH2_STAT5	514	517	PF00017	0.553
LIG_SH2_STAT5	98	101	PF00017	0.586
LIG_SH3_3	1037	1043	PF00018	0.300
LIG_SH3_3	218	224	PF00018	0.615
LIG_SH3_3	237	243	PF00018	0.539
LIG_SH3_3	332	338	PF00018	0.444
LIG_SH3_3	512	518	PF00018	0.522
LIG_SH3_3	70	76	PF00018	0.556
LIG_SH3_3	700	706	PF00018	0.677
LIG_SUMO_SIM_anti_2	1021	1027	PF11976	0.360
LIG_SUMO_SIM_anti_2	1047	1054	PF11976	0.478
LIG_SUMO_SIM_anti_2	326	331	PF11976	0.453
LIG_SUMO_SIM_anti_2	716	723	PF11976	0.631
LIG_SUMO_SIM_par_1	140	147	PF11976	0.613
LIG_SUMO_SIM_par_1	716	723	PF11976	0.631
LIG_TRAF2_1	144	147	PF00917	0.627
LIG_TRAF2_1	280	283	PF00917	0.485
LIG_TRAF2_1	838	841	PF00917	0.627
LIG_TRAF2_1	864	867	PF00917	0.614
LIG_TYR_ITIM	303	308	PF00017	0.539
LIG_UBA3_1	64	72	PF00899	0.583
LIG_WRC_WIRS_1	413	418	PF05994	0.534
LIG_WRC_WIRS_1	881	886	PF05994	0.545
MOD_CDK_SPxK_1	123	129	PF00069	0.479
MOD_CDK_SPxxK_3	226	233	PF00069	0.493
MOD_CK1_1	13	19	PF00069	0.522
MOD_CK1_1	226	232	PF00069	0.598
MOD_CK1_1	234	240	PF00069	0.496
MOD_CK1_1	24	30	PF00069	0.485
MOD_CK1_1	247	253	PF00069	0.668
MOD_CK1_1	255	261	PF00069	0.624
MOD_CK1_1	319	325	PF00069	0.630
MOD_CK1_1	560	566	PF00069	0.665
MOD_CK1_1	567	573	PF00069	0.676
MOD_CK1_1	607	613	PF00069	0.661
MOD_CK1_1	656	662	PF00069	0.503
MOD_CK1_1	882	888	PF00069	0.567
MOD_CK2_1	141	147	PF00069	0.621
MOD_CK2_1	336	342	PF00069	0.583
MOD_CK2_1	471	477	PF00069	0.455
MOD_CK2_1	623	629	PF00069	0.657
MOD_CK2_1	630	636	PF00069	0.606
MOD_CK2_1	637	643	PF00069	0.519
MOD_CK2_1	861	867	PF00069	0.626
MOD_CK2_1	945	951	PF00069	0.311
MOD_CMANNOS	346	349	PF00535	0.593
MOD_GlcNHglycan	118	122	PF01048	0.478
MOD_GlcNHglycan	12	15	PF01048	0.516
MOD_GlcNHglycan	161	164	PF01048	0.649
MOD_GlcNHglycan	165	168	PF01048	0.736
MOD_GlcNHglycan	18	21	PF01048	0.494
MOD_GlcNHglycan	226	229	PF01048	0.529
MOD_GlcNHglycan	233	236	PF01048	0.603
MOD_GlcNHglycan	246	249	PF01048	0.655
MOD_GlcNHglycan	291	294	PF01048	0.535
MOD_GlcNHglycan	298	301	PF01048	0.509
MOD_GlcNHglycan	321	324	PF01048	0.563
MOD_GlcNHglycan	504	508	PF01048	0.678
MOD_GlcNHglycan	562	565	PF01048	0.593
MOD_GlcNHglycan	567	570	PF01048	0.749
MOD_GlcNHglycan	609	612	PF01048	0.772
MOD_GlcNHglycan	655	658	PF01048	0.500
MOD_GlcNHglycan	727	730	PF01048	0.641
MOD_GlcNHglycan	741	744	PF01048	0.508
MOD_GlcNHglycan	850	853	PF01048	0.572
MOD_GlcNHglycan	951	954	PF01048	0.360
MOD_GSK3_1	123	130	PF00069	0.517
MOD_GSK3_1	137	144	PF00069	0.541
MOD_GSK3_1	159	166	PF00069	0.648
MOD_GSK3_1	16	23	PF00069	0.485
MOD_GSK3_1	192	199	PF00069	0.652
MOD_GSK3_1	219	226	PF00069	0.653
MOD_GSK3_1	243	250	PF00069	0.534
MOD_GSK3_1	261	268	PF00069	0.739
MOD_GSK3_1	309	316	PF00069	0.597
MOD_GSK3_1	319	326	PF00069	0.662
MOD_GSK3_1	355	362	PF00069	0.710
MOD_GSK3_1	398	405	PF00069	0.534
MOD_GSK3_1	428	435	PF00069	0.639
MOD_GSK3_1	560	567	PF00069	0.714
MOD_GSK3_1	607	614	PF00069	0.668
MOD_GSK3_1	720	727	PF00069	0.745
MOD_GSK3_1	76	83	PF00069	0.522
MOD_GSK3_1	814	821	PF00069	0.757
MOD_GSK3_1	854	861	PF00069	0.557
MOD_GSK3_1	945	952	PF00069	0.300
MOD_GSK3_1	984	991	PF00069	0.207
MOD_N-GLC_1	255	260	PF02516	0.526
MOD_N-GLC_1	444	449	PF02516	0.409
MOD_N-GLC_1	724	729	PF02516	0.464
MOD_N-GLC_1	991	996	PF02516	0.300
MOD_NEK2_1	1	6	PF00069	0.536
MOD_NEK2_1	117	122	PF00069	0.476
MOD_NEK2_1	200	205	PF00069	0.591
MOD_NEK2_1	219	224	PF00069	0.725
MOD_NEK2_1	286	291	PF00069	0.619
MOD_NEK2_1	296	301	PF00069	0.534
MOD_NEK2_1	317	322	PF00069	0.534
MOD_NEK2_1	325	330	PF00069	0.470
MOD_NEK2_1	412	417	PF00069	0.478
MOD_NEK2_1	455	460	PF00069	0.545
MOD_NEK2_1	612	617	PF00069	0.647
MOD_NEK2_1	719	724	PF00069	0.719
MOD_NEK2_1	971	976	PF00069	0.352
MOD_NEK2_1	984	989	PF00069	0.291
MOD_NEK2_1	996	1001	PF00069	0.291
MOD_NEK2_2	1011	1016	PF00069	0.300
MOD_NEK2_2	127	132	PF00069	0.634
MOD_NEK2_2	630	635	PF00069	0.605
MOD_NEK2_2	895	900	PF00069	0.314
MOD_PIKK_1	428	434	PF00454	0.660
MOD_PIKK_1	612	618	PF00454	0.648
MOD_PIKK_1	672	678	PF00454	0.542
MOD_PIKK_1	991	997	PF00454	0.300
MOD_PK_1	1027	1033	PF00069	0.279
MOD_PKA_1	572	578	PF00069	0.594
MOD_PKA_2	147	153	PF00069	0.553
MOD_PKA_2	20	26	PF00069	0.487
MOD_PKA_2	268	274	PF00069	0.605
MOD_PKA_2	464	470	PF00069	0.654
MOD_PKA_2	481	487	PF00069	0.647
MOD_PKA_2	572	578	PF00069	0.594
MOD_PKA_2	87	93	PF00069	0.651
MOD_PKA_2	925	931	PF00069	0.360
MOD_Plk_1	444	450	PF00069	0.560
MOD_Plk_1	551	557	PF00069	0.545
MOD_Plk_2-3	304	310	PF00069	0.551
MOD_Plk_2-3	759	765	PF00069	0.630
MOD_Plk_4	1011	1017	PF00069	0.300
MOD_Plk_4	147	153	PF00069	0.500
MOD_Plk_4	21	27	PF00069	0.486
MOD_Plk_4	325	331	PF00069	0.455
MOD_Plk_4	791	797	PF00069	0.496
MOD_Plk_4	820	826	PF00069	0.532
MOD_ProDKin_1	1039	1045	PF00069	0.360
MOD_ProDKin_1	123	129	PF00069	0.530
MOD_ProDKin_1	13	19	PF00069	0.603
MOD_ProDKin_1	192	198	PF00069	0.674
MOD_ProDKin_1	226	232	PF00069	0.664
MOD_ProDKin_1	421	427	PF00069	0.669
MOD_ProDKin_1	558	564	PF00069	0.668
MOD_ProDKin_1	623	629	PF00069	0.671
MOD_ProDKin_1	682	688	PF00069	0.514
MOD_ProDKin_1	818	824	PF00069	0.684
MOD_ProDKin_1	858	864	PF00069	0.615
MOD_ProDKin_1	882	888	PF00069	0.487
MOD_SUMO_rev_2	1035	1041	PF00179	0.294
MOD_SUMO_rev_2	675	681	PF00179	0.571
TRG_DiLeu_BaEn_3	146	152	PF01217	0.472
TRG_DiLeu_BaEn_4	763	769	PF01217	0.636
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.404
TRG_ENDOCYTIC_2	305	308	PF00928	0.484
TRG_ENDOCYTIC_2	489	492	PF00928	0.575
TRG_ENDOCYTIC_2	514	517	PF00928	0.558
TRG_ENDOCYTIC_2	896	899	PF00928	0.360
TRG_ENDOCYTIC_2	924	927	PF00928	0.300
TRG_ENDOCYTIC_2	98	101	PF00928	0.593
TRG_ER_diArg_1	204	206	PF00400	0.625
TRG_ER_diArg_1	354	357	PF00400	0.541
TRG_ER_diArg_1	442	444	PF00400	0.652
TRG_ER_diArg_1	492	495	PF00400	0.599
TRG_ER_diArg_1	571	573	PF00400	0.594
TRG_ER_diArg_1	585	587	PF00400	0.740
TRG_ER_diArg_1	668	670	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	747	751	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	871	876	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF65	Leptomonas seymouri	50%	88%
A0A3Q8IB03	Leishmania donovani	74%	100%
A4HXW2	Leishmania infantum	74%	100%
C9ZZU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ARM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QDV4	Leishmania major	76%	98%