Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9J5_LEIBR

TriTrypDb:

LbrM.18.0930 , LBRM2903_180015000

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9J5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.732
CLV_C14_Caspase3-7	383	387	PF00656	0.728
CLV_NRD_NRD_1	299	301	PF00675	0.473
CLV_NRD_NRD_1	404	406	PF00675	0.737
CLV_NRD_NRD_1	423	425	PF00675	0.619
CLV_NRD_NRD_1	443	445	PF00675	0.353
CLV_NRD_NRD_1	512	514	PF00675	0.621
CLV_PCSK_KEX2_1	404	406	PF00082	0.636
CLV_PCSK_KEX2_1	423	425	PF00082	0.707
CLV_PCSK_KEX2_1	438	440	PF00082	0.452
CLV_PCSK_KEX2_1	442	444	PF00082	0.385
CLV_PCSK_KEX2_1	512	514	PF00082	0.644
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.560
CLV_PCSK_PC7_1	439	445	PF00082	0.469
CLV_PCSK_SKI1_1	263	267	PF00082	0.532
CLV_PCSK_SKI1_1	423	427	PF00082	0.716
CLV_PCSK_SKI1_1	81	85	PF00082	0.442
DEG_APCC_DBOX_1	422	430	PF00400	0.523
DEG_Nend_Nbox_1	1	3	PF02207	0.357
DEG_SCF_FBW7_1	215	220	PF00400	0.512
DEG_SPOP_SBC_1	217	221	PF00917	0.514
DOC_ANK_TNKS_1	511	518	PF00023	0.572
DOC_CKS1_1	175	180	PF01111	0.395
DOC_MAPK_HePTP_8	7	19	PF00069	0.508
DOC_MAPK_MEF2A_6	10	19	PF00069	0.485
DOC_MAPK_MEF2A_6	149	156	PF00069	0.479
DOC_MAPK_MEF2A_6	254	261	PF00069	0.515
DOC_MAPK_MEF2A_6	30	37	PF00069	0.363
DOC_MAPK_MEF2A_6	351	360	PF00069	0.593
DOC_MAPK_MEF2A_6	57	66	PF00069	0.554
DOC_MAPK_NFAT4_5	254	262	PF00069	0.339
DOC_MAPK_RevD_3	509	525	PF00069	0.384
DOC_PP4_FxxP_1	261	264	PF00568	0.542
DOC_PP4_FxxP_1	533	536	PF00568	0.417
DOC_USP7_MATH_1	137	141	PF00917	0.699
DOC_USP7_MATH_1	205	209	PF00917	0.749
DOC_USP7_MATH_1	211	215	PF00917	0.739
DOC_USP7_MATH_1	217	221	PF00917	0.761
DOC_USP7_MATH_1	225	229	PF00917	0.699
DOC_USP7_MATH_1	342	346	PF00917	0.675
DOC_USP7_MATH_1	378	382	PF00917	0.744
DOC_USP7_MATH_1	9	13	PF00917	0.451
DOC_USP7_UBL2_3	445	449	PF12436	0.686
DOC_USP7_UBL2_3	520	524	PF12436	0.583
DOC_WW_Pin1_4	174	179	PF00397	0.387
DOC_WW_Pin1_4	213	218	PF00397	0.691
DOC_WW_Pin1_4	221	226	PF00397	0.726
DOC_WW_Pin1_4	399	404	PF00397	0.655
DOC_WW_Pin1_4	424	429	PF00397	0.569
DOC_WW_Pin1_4	498	503	PF00397	0.609
DOC_WW_Pin1_4	52	57	PF00397	0.694
LIG_14-3-3_CanoR_1	110	115	PF00244	0.691
LIG_14-3-3_CanoR_1	188	195	PF00244	0.559
LIG_14-3-3_CanoR_1	280	289	PF00244	0.586
LIG_14-3-3_CanoR_1	3	8	PF00244	0.523
LIG_14-3-3_CanoR_1	404	413	PF00244	0.778
LIG_14-3-3_CanoR_1	417	426	PF00244	0.684
LIG_14-3-3_CanoR_1	50	56	PF00244	0.476
LIG_14-3-3_CanoR_1	91	95	PF00244	0.500
LIG_Actin_WH2_2	69	87	PF00022	0.462
LIG_BIR_III_4	169	173	PF00653	0.553
LIG_BRCT_BRCA1_1	91	95	PF00533	0.474
LIG_DCNL_PONY_1	1	4	PF03556	0.351
LIG_EH1_1	476	484	PF00400	0.516
LIG_eIF4E_1	477	483	PF01652	0.464
LIG_FHA_1	11	17	PF00498	0.367
LIG_FHA_1	169	175	PF00498	0.538
LIG_FHA_1	254	260	PF00498	0.445
LIG_FHA_1	284	290	PF00498	0.497
LIG_FHA_1	291	297	PF00498	0.481
LIG_FHA_1	319	325	PF00498	0.645
LIG_FHA_1	32	38	PF00498	0.359
LIG_FHA_1	43	49	PF00498	0.487
LIG_FHA_1	470	476	PF00498	0.510
LIG_FHA_1	529	535	PF00498	0.440
LIG_FHA_2	118	124	PF00498	0.720
LIG_FHA_2	155	161	PF00498	0.507
LIG_LIR_Apic_2	258	264	PF02991	0.523
LIG_LIR_Apic_2	531	536	PF02991	0.418
LIG_LIR_Gen_1	123	133	PF02991	0.655
LIG_LIR_Gen_1	357	367	PF02991	0.529
LIG_LIR_Nem_3	123	129	PF02991	0.634
LIG_LIR_Nem_3	21	25	PF02991	0.542
LIG_LIR_Nem_3	357	363	PF02991	0.500
LIG_LIR_Nem_3	79	83	PF02991	0.394
LIG_MYND_3	515	519	PF01753	0.598
LIG_NRBOX	505	511	PF00104	0.614
LIG_PCNA_yPIPBox_3	497	510	PF02747	0.372
LIG_PDZ_Class_1	537	542	PF00595	0.475
LIG_SH2_CRK	22	26	PF00017	0.552
LIG_SH2_CRK	80	84	PF00017	0.383
LIG_SH2_STAP1	166	170	PF00017	0.566
LIG_SH2_STAP1	526	530	PF00017	0.436
LIG_SH2_STAT5	28	31	PF00017	0.515
LIG_SH2_STAT5	36	39	PF00017	0.480
LIG_SH3_3	172	178	PF00018	0.259
LIG_SH3_3	219	225	PF00018	0.719
LIG_SH3_3	38	44	PF00018	0.415
LIG_SUMO_SIM_anti_2	472	478	PF11976	0.381
LIG_SUMO_SIM_anti_2	58	67	PF11976	0.383
LIG_SUMO_SIM_par_1	15	21	PF11976	0.322
LIG_SUMO_SIM_par_1	255	260	PF11976	0.503
LIG_SUMO_SIM_par_1	535	540	PF11976	0.421
LIG_TRAF2_1	326	329	PF00917	0.477
LIG_TYR_ITIM	20	25	PF00017	0.515
LIG_UBA3_1	1	10	PF00899	0.329
MOD_CDK_SPK_2	399	404	PF00069	0.523
MOD_CDK_SPK_2	52	57	PF00069	0.732
MOD_CDK_SPxK_1	399	405	PF00069	0.520
MOD_CDK_SPxxK_3	498	505	PF00069	0.594
MOD_CK1_1	103	109	PF00069	0.680
MOD_CK1_1	117	123	PF00069	0.553
MOD_CK1_1	136	142	PF00069	0.557
MOD_CK1_1	144	150	PF00069	0.597
MOD_CK1_1	18	24	PF00069	0.333
MOD_CK1_1	213	219	PF00069	0.639
MOD_CK1_1	345	351	PF00069	0.582
MOD_CK1_1	387	393	PF00069	0.647
MOD_CK1_1	397	403	PF00069	0.624
MOD_CK1_1	459	465	PF00069	0.726
MOD_CK1_1	484	490	PF00069	0.486
MOD_CK1_1	55	61	PF00069	0.684
MOD_CK2_1	242	248	PF00069	0.589
MOD_CK2_1	323	329	PF00069	0.576
MOD_CK2_1	365	371	PF00069	0.663
MOD_DYRK1A_RPxSP_1	424	428	PF00069	0.527
MOD_GlcNHglycan	135	138	PF01048	0.685
MOD_GlcNHglycan	143	146	PF01048	0.656
MOD_GlcNHglycan	202	205	PF01048	0.597
MOD_GlcNHglycan	207	210	PF01048	0.619
MOD_GlcNHglycan	227	230	PF01048	0.696
MOD_GlcNHglycan	325	328	PF01048	0.667
MOD_GlcNHglycan	337	340	PF01048	0.658
MOD_GlcNHglycan	380	383	PF01048	0.695
MOD_GlcNHglycan	396	399	PF01048	0.601
MOD_GlcNHglycan	406	409	PF01048	0.614
MOD_GlcNHglycan	483	486	PF01048	0.423
MOD_GSK3_1	110	117	PF00069	0.560
MOD_GSK3_1	133	140	PF00069	0.690
MOD_GSK3_1	150	157	PF00069	0.511
MOD_GSK3_1	187	194	PF00069	0.515
MOD_GSK3_1	205	212	PF00069	0.543
MOD_GSK3_1	213	220	PF00069	0.730
MOD_GSK3_1	221	228	PF00069	0.726
MOD_GSK3_1	31	38	PF00069	0.356
MOD_GSK3_1	314	321	PF00069	0.696
MOD_GSK3_1	345	352	PF00069	0.680
MOD_GSK3_1	384	391	PF00069	0.724
MOD_GSK3_1	51	58	PF00069	0.396
MOD_GSK3_1	99	106	PF00069	0.571
MOD_N-GLC_1	117	122	PF02516	0.502
MOD_N-GLC_1	140	145	PF02516	0.657
MOD_N-GLC_1	209	214	PF02516	0.747
MOD_N-GLC_1	318	323	PF02516	0.469
MOD_N-GLC_1	384	389	PF02516	0.736
MOD_N-GLC_1	430	435	PF02516	0.500
MOD_N-GLC_1	498	503	PF02516	0.568
MOD_N-GLC_1	60	65	PF02516	0.637
MOD_N-GLC_1	99	104	PF02516	0.440
MOD_NEK2_1	124	129	PF00069	0.636
MOD_NEK2_1	135	140	PF00069	0.721
MOD_NEK2_1	154	159	PF00069	0.235
MOD_NEK2_1	237	242	PF00069	0.339
MOD_NEK2_1	281	286	PF00069	0.608
MOD_NEK2_1	335	340	PF00069	0.690
MOD_NEK2_1	389	394	PF00069	0.753
MOD_NEK2_1	412	417	PF00069	0.632
MOD_NEK2_1	429	434	PF00069	0.490
MOD_NEK2_1	483	488	PF00069	0.426
MOD_NEK2_1	99	104	PF00069	0.527
MOD_PIKK_1	144	150	PF00454	0.735
MOD_PIKK_1	290	296	PF00454	0.573
MOD_PIKK_1	412	418	PF00454	0.506
MOD_PK_1	110	116	PF00069	0.470
MOD_PKA_1	404	410	PF00069	0.660
MOD_PKA_2	187	193	PF00069	0.502
MOD_PKA_2	253	259	PF00069	0.393
MOD_PKA_2	387	393	PF00069	0.780
MOD_PKA_2	404	410	PF00069	0.550
MOD_PKA_2	51	57	PF00069	0.476
MOD_PKA_2	90	96	PF00069	0.503
MOD_PKB_1	108	116	PF00069	0.692
MOD_Plk_1	117	123	PF00069	0.676
MOD_Plk_1	31	37	PF00069	0.356
MOD_Plk_1	384	390	PF00069	0.528
MOD_Plk_1	60	66	PF00069	0.623
MOD_Plk_1	99	105	PF00069	0.442
MOD_Plk_4	15	21	PF00069	0.322
MOD_Plk_4	150	156	PF00069	0.494
MOD_Plk_4	218	224	PF00069	0.739
MOD_Plk_4	528	534	PF00069	0.421
MOD_Plk_4	60	66	PF00069	0.440
MOD_Plk_4	90	96	PF00069	0.574
MOD_ProDKin_1	174	180	PF00069	0.393
MOD_ProDKin_1	213	219	PF00069	0.692
MOD_ProDKin_1	221	227	PF00069	0.723
MOD_ProDKin_1	399	405	PF00069	0.652
MOD_ProDKin_1	424	430	PF00069	0.567
MOD_ProDKin_1	498	504	PF00069	0.602
MOD_ProDKin_1	52	58	PF00069	0.691
TRG_DiLeu_BaEn_4	311	317	PF01217	0.566
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.268
TRG_ENDOCYTIC_2	22	25	PF00928	0.435
TRG_ENDOCYTIC_2	80	83	PF00928	0.387
TRG_ER_diArg_1	108	111	PF00400	0.580
TRG_ER_diArg_1	403	405	PF00400	0.658
TRG_ER_diArg_1	442	444	PF00400	0.557
TRG_ER_diArg_1	511	513	PF00400	0.592
TRG_NES_CRM1_1	60	73	PF08389	0.452
TRG_PTS1	539	542	PF00515	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ2	Leptomonas seymouri	48%	93%
A0A1X0P774	Trypanosomatidae	29%	100%
A0A3Q8IB16	Leishmania donovani	76%	100%
A0A422P1T0	Trypanosoma rangeli	27%	100%
A4HXW1	Leishmania infantum	76%	100%
C9ZZU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QDV5	Leishmania major	74%	99%
V5BRR9	Trypanosoma cruzi	28%	100%