Putative ethanolamine phosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ethanolamine phosphotransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H9J2_LEIBR

TriTrypDb:

LbrM.18.0900 , LBRM2903_180014400

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H9J2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9J2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0019637	organophosphate metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0044249	cellular biosynthetic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046337	phosphatidylethanolamine metabolic process	6	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004307	ethanolaminephosphotransferase activity	6	6
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	11
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.440
CLV_NRD_NRD_1	137	139	PF00675	0.240
CLV_PCSK_KEX2_1	137	139	PF00082	0.240
CLV_PCSK_SKI1_1	204	208	PF00082	0.318
DEG_SCF_FBW7_1	10	17	PF00400	0.592
DEG_SPOP_SBC_1	338	342	PF00917	0.294
DOC_AGCK_PIF_2	29	34	PF00069	0.533
DOC_CDC14_PxL_1	91	99	PF14671	0.313
DOC_CKS1_1	11	16	PF01111	0.642
DOC_CYCLIN_yClb1_LxF_4	294	300	PF00134	0.289
DOC_MAPK_FxFP_2	327	330	PF00069	0.311
DOC_MAPK_gen_1	253	263	PF00069	0.334
DOC_MAPK_gen_1	280	289	PF00069	0.445
DOC_MAPK_MEF2A_6	282	291	PF00069	0.410
DOC_PP1_RVXF_1	273	280	PF00149	0.253
DOC_PP4_FxxP_1	108	111	PF00568	0.378
DOC_PP4_FxxP_1	327	330	PF00568	0.311
DOC_USP7_MATH_1	14	18	PF00917	0.581
DOC_USP7_MATH_1	226	230	PF00917	0.408
DOC_USP7_MATH_1	315	319	PF00917	0.417
DOC_USP7_MATH_1	338	342	PF00917	0.294
DOC_WW_Pin1_4	10	15	PF00397	0.536
DOC_WW_Pin1_4	100	105	PF00397	0.342
DOC_WW_Pin1_4	107	112	PF00397	0.331
DOC_WW_Pin1_4	3	8	PF00397	0.556
LIG_14-3-3_CanoR_1	204	209	PF00244	0.489
LIG_14-3-3_CanoR_1	275	280	PF00244	0.552
LIG_14-3-3_CanoR_1	355	361	PF00244	0.533
LIG_APCC_ABBA_1	28	33	PF00400	0.505
LIG_APCC_ABBA_1	303	308	PF00400	0.406
LIG_BRCT_BRCA1_1	295	299	PF00533	0.289
LIG_BRCT_BRCA1_1	54	58	PF00533	0.196
LIG_Clathr_ClatBox_1	394	398	PF01394	0.321
LIG_CSL_BTD_1	219	222	PF09270	0.355
LIG_deltaCOP1_diTrp_1	235	242	PF00928	0.237
LIG_FHA_1	101	107	PF00498	0.401
LIG_FHA_1	11	17	PF00498	0.612
LIG_FHA_1	140	146	PF00498	0.446
LIG_FHA_1	155	161	PF00498	0.393
LIG_FHA_1	228	234	PF00498	0.374
LIG_FHA_1	357	363	PF00498	0.539
LIG_FHA_2	205	211	PF00498	0.525
LIG_LIR_Apic_2	250	254	PF02991	0.233
LIG_LIR_Apic_2	3	7	PF02991	0.630
LIG_LIR_Gen_1	25	34	PF02991	0.576
LIG_LIR_Gen_1	296	305	PF02991	0.238
LIG_LIR_Gen_1	55	64	PF02991	0.248
LIG_LIR_Nem_3	218	224	PF02991	0.287
LIG_LIR_Nem_3	246	251	PF02991	0.370
LIG_LIR_Nem_3	25	29	PF02991	0.551
LIG_LIR_Nem_3	259	265	PF02991	0.218
LIG_LIR_Nem_3	272	277	PF02991	0.310
LIG_LIR_Nem_3	278	284	PF02991	0.494
LIG_LIR_Nem_3	296	302	PF02991	0.190
LIG_LIR_Nem_3	328	332	PF02991	0.240
LIG_LIR_Nem_3	55	61	PF02991	0.233
LIG_LYPXL_yS_3	329	332	PF13949	0.296
LIG_Pex14_2	54	58	PF04695	0.435
LIG_PTB_Apo_2	393	400	PF02174	0.331
LIG_SH2_CRK	32	36	PF00017	0.526
LIG_SH2_NCK_1	265	269	PF00017	0.289
LIG_SH2_SRC	148	151	PF00017	0.440
LIG_SH2_SRC	32	35	PF00017	0.525
LIG_SH2_STAP1	32	36	PF00017	0.503
LIG_SH2_STAT3	34	37	PF00017	0.531
LIG_SH2_STAT5	125	128	PF00017	0.301
LIG_SH2_STAT5	148	151	PF00017	0.440
LIG_SH2_STAT5	251	254	PF00017	0.327
LIG_SH2_STAT5	26	29	PF00017	0.523
LIG_SH2_STAT5	262	265	PF00017	0.248
LIG_SH2_STAT5	309	312	PF00017	0.311
LIG_SH2_STAT5	322	325	PF00017	0.305
LIG_SH2_STAT5	34	37	PF00017	0.526
LIG_SH3_3	101	107	PF00018	0.317
LIG_SH3_3	355	361	PF00018	0.535
LIG_SH3_3	4	10	PF00018	0.566
LIG_SH3_3	83	89	PF00018	0.416
LIG_SH3_5	30	34	PF00018	0.534
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.391
LIG_SUMO_SIM_anti_2	59	66	PF11976	0.308
LIG_SUMO_SIM_par_1	59	66	PF11976	0.308
LIG_SUMO_SIM_par_1	95	101	PF11976	0.281
LIG_TRFH_1	26	30	PF08558	0.276
LIG_TRFH_1	322	326	PF08558	0.419
MOD_CK1_1	158	164	PF00069	0.276
MOD_CK1_1	244	250	PF00069	0.493
MOD_CK1_1	3	9	PF00069	0.449
MOD_CK2_1	204	210	PF00069	0.324
MOD_GlcNHglycan	142	145	PF01048	0.196
MOD_GlcNHglycan	16	19	PF01048	0.467
MOD_GSK3_1	10	17	PF00069	0.602
MOD_GSK3_1	154	161	PF00069	0.276
MOD_GSK3_1	243	250	PF00069	0.429
MOD_GSK3_1	289	296	PF00069	0.379
MOD_GSK3_1	333	340	PF00069	0.294
MOD_GSK3_1	52	59	PF00069	0.363
MOD_N-GLC_1	244	249	PF02516	0.354
MOD_NEK2_1	117	122	PF00069	0.451
MOD_NEK2_1	159	164	PF00069	0.281
MOD_NEK2_1	168	173	PF00069	0.268
MOD_NEK2_1	175	180	PF00069	0.250
MOD_NEK2_1	188	193	PF00069	0.319
MOD_NEK2_1	215	220	PF00069	0.299
MOD_NEK2_1	63	68	PF00069	0.339
MOD_PIKK_1	401	407	PF00454	0.431
MOD_PKA_1	140	146	PF00069	0.276
MOD_PKA_1	401	407	PF00069	0.431
MOD_Plk_1	244	250	PF00069	0.426
MOD_Plk_4	109	115	PF00069	0.293
MOD_Plk_4	155	161	PF00069	0.241
MOD_Plk_4	18	24	PF00069	0.365
MOD_Plk_4	183	189	PF00069	0.373
MOD_Plk_4	215	221	PF00069	0.330
MOD_Plk_4	247	253	PF00069	0.495
MOD_Plk_4	269	275	PF00069	0.311
MOD_Plk_4	293	299	PF00069	0.267
MOD_Plk_4	340	346	PF00069	0.277
MOD_Plk_4	39	45	PF00069	0.415
MOD_Plk_4	46	52	PF00069	0.303
MOD_Plk_4	53	59	PF00069	0.214
MOD_Plk_4	81	87	PF00069	0.530
MOD_ProDKin_1	10	16	PF00069	0.406
MOD_ProDKin_1	100	106	PF00069	0.418
MOD_ProDKin_1	107	113	PF00069	0.330
MOD_ProDKin_1	3	9	PF00069	0.435
TRG_DiLeu_BaEn_2	194	200	PF01217	0.316
TRG_ENDOCYTIC_2	26	29	PF00928	0.411
TRG_ENDOCYTIC_2	32	35	PF00928	0.336
TRG_ENDOCYTIC_2	329	332	PF00928	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V7	Leptomonas seymouri	62%	94%
A0A0S4J4C6	Bodo saltans	42%	100%
A0A1X0P7R6	Trypanosomatidae	47%	98%
A0A3Q8IJQ4	Leishmania donovani	78%	100%
A0A3R7N2B7	Trypanosoma rangeli	47%	99%
A4HXV5	Leishmania infantum	78%	100%
C9ZZU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ARL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QDW1	Leishmania major	77%	100%