Ribosomal protein S8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosomal protein S8, putative

Species:

Leishmania braziliensis

UniProt:

A4H9J1_LEIBR

TriTrypDb:

LbrM.18.0890 , LBRM2903_180014300

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H9J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9J1

PDB structure(s): 7ane_c

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.641
CLV_NRD_NRD_1	162	164	PF00675	0.676
CLV_NRD_NRD_1	180	182	PF00675	0.510
CLV_NRD_NRD_1	259	261	PF00675	0.282
CLV_NRD_NRD_1	332	334	PF00675	0.282
CLV_PCSK_KEX2_1	162	164	PF00082	0.676
CLV_PCSK_KEX2_1	180	182	PF00082	0.489
CLV_PCSK_KEX2_1	232	234	PF00082	0.470
CLV_PCSK_KEX2_1	261	263	PF00082	0.282
CLV_PCSK_KEX2_1	332	334	PF00082	0.282
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.470
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.282
CLV_PCSK_SKI1_1	117	121	PF00082	0.648
CLV_PCSK_SKI1_1	201	205	PF00082	0.486
CLV_PCSK_SKI1_1	277	281	PF00082	0.334
CLV_PCSK_SKI1_1	332	336	PF00082	0.226
CLV_PCSK_SKI1_1	62	66	PF00082	0.667
DEG_APCC_DBOX_1	143	151	PF00400	0.471
DOC_CKS1_1	242	247	PF01111	0.402
DOC_CKS1_1	52	57	PF01111	0.431
DOC_CYCLIN_RxL_1	273	281	PF00134	0.586
DOC_CYCLIN_RxL_1	329	337	PF00134	0.426
DOC_MAPK_gen_1	260	266	PF00069	0.482
DOC_PP1_RVXF_1	199	205	PF00149	0.501
DOC_PP2B_PxIxI_1	307	313	PF00149	0.562
DOC_PP4_FxxP_1	52	55	PF00568	0.429
DOC_SPAK_OSR1_1	262	266	PF12202	0.496
DOC_USP7_MATH_1	166	170	PF00917	0.638
DOC_USP7_MATH_1	32	36	PF00917	0.437
DOC_USP7_MATH_1	6	10	PF00917	0.447
DOC_USP7_MATH_1	86	90	PF00917	0.683
DOC_USP7_UBL2_3	232	236	PF12436	0.582
DOC_WW_Pin1_4	241	246	PF00397	0.410
DOC_WW_Pin1_4	324	329	PF00397	0.482
DOC_WW_Pin1_4	47	52	PF00397	0.422
LIG_BRCT_BRCA1_1	49	53	PF00533	0.687
LIG_deltaCOP1_diTrp_1	237	240	PF00928	0.546
LIG_FHA_1	237	243	PF00498	0.476
LIG_FHA_1	307	313	PF00498	0.482
LIG_FHA_1	335	341	PF00498	0.475
LIG_FHA_1	52	58	PF00498	0.429
LIG_FHA_2	320	326	PF00498	0.482
LIG_LIR_Apic_2	216	220	PF02991	0.468
LIG_LIR_Apic_2	50	55	PF02991	0.424
LIG_LIR_Gen_1	237	247	PF02991	0.512
LIG_LIR_Gen_1	70	80	PF02991	0.629
LIG_LIR_LC3C_4	54	58	PF02991	0.426
LIG_LIR_Nem_3	237	243	PF02991	0.486
LIG_LIR_Nem_3	50	56	PF02991	0.426
LIG_LIR_Nem_3	70	75	PF02991	0.603
LIG_MLH1_MIPbox_1	49	53	PF16413	0.687
LIG_NRBOX	146	152	PF00104	0.515
LIG_Rb_pABgroove_1	241	249	PF01858	0.227
LIG_SH2_CRK	217	221	PF00017	0.346
LIG_SH2_NCK_1	217	221	PF00017	0.477
LIG_SH2_STAT5	303	306	PF00017	0.482
LIG_SH2_STAT5	347	350	PF00017	0.482
LIG_SH3_1	192	198	PF00018	0.543
LIG_SH3_3	180	186	PF00018	0.592
LIG_SH3_3	192	198	PF00018	0.543
LIG_SH3_3	239	245	PF00018	0.452
LIG_SH3_3	261	267	PF00018	0.482
LIG_SH3_3	309	315	PF00018	0.475
LIG_SH3_3	42	48	PF00018	0.433
LIG_SH3_3	54	60	PF00018	0.391
LIG_UBA3_1	356	364	PF00899	0.513
MOD_CDK_SPK_2	324	329	PF00069	0.482
MOD_CK1_1	110	116	PF00069	0.502
MOD_CK1_1	88	94	PF00069	0.737
MOD_CK2_1	134	140	PF00069	0.572
MOD_CK2_1	265	271	PF00069	0.482
MOD_CK2_1	319	325	PF00069	0.482
MOD_Cter_Amidation	120	123	PF01082	0.524
MOD_GlcNHglycan	168	171	PF01048	0.701
MOD_GlcNHglycan	172	175	PF01048	0.729
MOD_GlcNHglycan	36	39	PF01048	0.432
MOD_GlcNHglycan	67	70	PF01048	0.591
MOD_GlcNHglycan	81	84	PF01048	0.604
MOD_GlcNHglycan	94	97	PF01048	0.634
MOD_GSK3_1	166	173	PF00069	0.451
MOD_GSK3_1	265	272	PF00069	0.482
MOD_GSK3_1	47	54	PF00069	0.424
MOD_GSK3_1	8	15	PF00069	0.452
MOD_GSK3_1	85	92	PF00069	0.731
MOD_GSK3_1	98	105	PF00069	0.533
MOD_NEK2_1	24	29	PF00069	0.439
MOD_NEK2_1	334	339	PF00069	0.460
MOD_NEK2_1	65	70	PF00069	0.516
MOD_NEK2_2	103	108	PF00069	0.490
MOD_NEK2_2	8	13	PF00069	0.453
MOD_PIKK_1	218	224	PF00454	0.487
MOD_PIKK_1	6	12	PF00454	0.449
MOD_PKA_2	12	18	PF00069	0.455
MOD_PKB_1	252	260	PF00069	0.496
MOD_Plk_1	134	140	PF00069	0.572
MOD_Plk_1	236	242	PF00069	0.540
MOD_Plk_2-3	314	320	PF00069	0.492
MOD_Plk_4	12	18	PF00069	0.455
MOD_Plk_4	125	131	PF00069	0.500
MOD_ProDKin_1	241	247	PF00069	0.409
MOD_ProDKin_1	324	330	PF00069	0.482
MOD_ProDKin_1	47	53	PF00069	0.426
MOD_SUMO_rev_2	294	304	PF00179	0.482
MOD_SUMO_rev_2	314	322	PF00179	0.350
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.484
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.542
TRG_ER_diArg_1	180	182	PF00400	0.508
TRG_ER_diArg_1	260	263	PF00400	0.482
TRG_ER_diArg_1	331	333	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I854	Leptomonas seymouri	81%	100%
A0A1X0P6W5	Trypanosomatidae	78%	100%
A0A3S7WUX4	Leishmania donovani	86%	100%
A0A422P1R7	Trypanosoma rangeli	74%	100%
A4HXV4	Leishmania infantum	86%	100%
C9ZZU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9ARL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QDW2	Leishmania major	84%	97%
V5DN42	Trypanosoma cruzi	74%	100%