C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc-finger double-stranded RNA-binding, putative

Species:

Leishmania braziliensis

UniProt:

A4H9I7_LEIBR

TriTrypDb:

LbrM.18.0850 , LBRM2903_180013900

Length:

110

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9I7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	54	56	PF00675	0.365
CLV_NRD_NRD_1	87	89	PF00675	0.417
CLV_PCSK_KEX2_1	59	61	PF00082	0.594
CLV_PCSK_KEX2_1	87	89	PF00082	0.426
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.549
CLV_PCSK_PC7_1	55	61	PF00082	0.207
DEG_SPOP_SBC_1	7	11	PF00917	0.510
DOC_MAPK_gen_1	87	95	PF00069	0.425
DOC_MAPK_MEF2A_6	87	95	PF00069	0.345
DOC_MAPK_RevD_3	75	89	PF00069	0.478
DOC_USP7_MATH_1	17	21	PF00917	0.660
DOC_USP7_MATH_1	36	40	PF00917	0.433
DOC_USP7_MATH_1	5	9	PF00917	0.561
DOC_USP7_UBL2_3	52	56	PF12436	0.435
DOC_USP7_UBL2_3	68	72	PF12436	0.397
DOC_WW_Pin1_4	75	80	PF00397	0.608
LIG_14-3-3_CanoR_1	30	34	PF00244	0.553
LIG_Actin_WH2_2	89	104	PF00022	0.504
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_BRCT_BRCA1_1	38	42	PF00533	0.438
LIG_FHA_2	76	82	PF00498	0.430
LIG_LIR_Gen_1	31	42	PF02991	0.219
LIG_LIR_Gen_1	80	91	PF02991	0.606
LIG_LIR_Nem_3	31	37	PF02991	0.343
LIG_LIR_Nem_3	80	86	PF02991	0.607
LIG_NRP_CendR_1	107	110	PF00754	0.466
LIG_SH2_CRK	34	38	PF00017	0.506
LIG_SH2_STAP1	46	50	PF00017	0.405
LIG_SH2_STAT5	34	37	PF00017	0.463
MOD_CK1_1	20	26	PF00069	0.556
MOD_CK1_1	8	14	PF00069	0.483
MOD_GlcNHglycan	10	13	PF01048	0.573
MOD_GlcNHglycan	18	22	PF01048	0.685
MOD_GlcNHglycan	3	6	PF01048	0.500
MOD_GlcNHglycan	60	63	PF01048	0.508
MOD_GSK3_1	1	8	PF00069	0.563
MOD_GSK3_1	101	108	PF00069	0.564
MOD_GSK3_1	17	24	PF00069	0.569
MOD_GSK3_1	36	43	PF00069	0.508
MOD_NEK2_1	1	6	PF00069	0.561
MOD_NEK2_1	42	47	PF00069	0.544
MOD_NEK2_2	21	26	PF00069	0.476
MOD_PKA_1	58	64	PF00069	0.476
MOD_PKA_2	29	35	PF00069	0.463
MOD_Plk_1	17	23	PF00069	0.468
MOD_Plk_1	28	34	PF00069	0.355
MOD_Plk_4	29	35	PF00069	0.536
MOD_ProDKin_1	75	81	PF00069	0.602
MOD_SUMO_rev_2	99	108	PF00179	0.671
TRG_ENDOCYTIC_2	34	37	PF00928	0.506
TRG_ER_diArg_1	86	88	PF00400	0.416
TRG_NLS_MonoExtC_3	54	59	PF00514	0.508
TRG_NLS_MonoExtN_4	52	59	PF00514	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P725	Trypanosomatidae	55%	100%
A0A3Q8I9Z0	Leishmania donovani	84%	100%
A4HXV0	Leishmania infantum	85%	100%
E9ARL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QDW6	Leishmania major	76%	100%
V5BM68	Trypanosoma cruzi	55%	100%