Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H9I6_LEIBR

TriTrypDb:

LbrM.18.0840 , LBRM2903_180013800

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9I6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.655
CLV_NRD_NRD_1	412	414	PF00675	0.696
CLV_NRD_NRD_1	518	520	PF00675	0.682
CLV_PCSK_FUR_1	410	414	PF00082	0.686
CLV_PCSK_KEX2_1	115	117	PF00082	0.633
CLV_PCSK_KEX2_1	412	414	PF00082	0.696
CLV_PCSK_KEX2_1	518	520	PF00082	0.682
CLV_PCSK_SKI1_1	221	225	PF00082	0.537
CLV_PCSK_SKI1_1	232	236	PF00082	0.572
DEG_Nend_Nbox_1	1	3	PF02207	0.521
DOC_PP2B_LxvP_1	202	205	PF13499	0.512
DOC_PP2B_LxvP_1	247	250	PF13499	0.560
DOC_PP4_FxxP_1	311	314	PF00568	0.367
DOC_PP4_FxxP_1	33	36	PF00568	0.498
DOC_PP4_FxxP_1	466	469	PF00568	0.631
DOC_PP4_FxxP_1	475	478	PF00568	0.584
DOC_PP4_MxPP_1	476	479	PF00568	0.535
DOC_USP7_MATH_1	159	163	PF00917	0.783
DOC_USP7_MATH_1	205	209	PF00917	0.678
DOC_USP7_MATH_1	223	227	PF00917	0.473
DOC_USP7_MATH_1	239	243	PF00917	0.491
DOC_USP7_MATH_1	433	437	PF00917	0.709
DOC_USP7_MATH_1	484	488	PF00917	0.728
DOC_USP7_MATH_1	501	505	PF00917	0.538
DOC_USP7_MATH_1	59	63	PF00917	0.816
DOC_WW_Pin1_4	337	342	PF00397	0.685
DOC_WW_Pin1_4	415	420	PF00397	0.755
DOC_WW_Pin1_4	482	487	PF00397	0.818
DOC_WW_Pin1_4	79	84	PF00397	0.697
LIG_14-3-3_CanoR_1	10	14	PF00244	0.524
LIG_14-3-3_CanoR_1	115	123	PF00244	0.762
LIG_14-3-3_CanoR_1	128	137	PF00244	0.526
LIG_14-3-3_CanoR_1	209	215	PF00244	0.462
LIG_14-3-3_CanoR_1	225	231	PF00244	0.580
LIG_14-3-3_CanoR_1	238	244	PF00244	0.371
LIG_14-3-3_CanoR_1	268	276	PF00244	0.585
LIG_14-3-3_CanoR_1	289	295	PF00244	0.378
LIG_14-3-3_CanoR_1	383	390	PF00244	0.831
LIG_14-3-3_CanoR_1	410	419	PF00244	0.804
LIG_14-3-3_CanoR_1	45	51	PF00244	0.685
LIG_14-3-3_CanoR_1	453	459	PF00244	0.663
LIG_Actin_WH2_2	210	227	PF00022	0.453
LIG_CaM_IQ_9	224	240	PF13499	0.398
LIG_DCNL_PONY_1	1	4	PF03556	0.522
LIG_deltaCOP1_diTrp_1	317	325	PF00928	0.489
LIG_deltaCOP1_diTrp_1	443	450	PF00928	0.664
LIG_EH1_1	21	29	PF00400	0.736
LIG_FHA_1	13	19	PF00498	0.644
LIG_FHA_1	211	217	PF00498	0.397
LIG_FHA_1	23	29	PF00498	0.619
LIG_FHA_1	251	257	PF00498	0.556
LIG_FHA_1	355	361	PF00498	0.586
LIG_FHA_1	390	396	PF00498	0.598
LIG_FHA_1	87	93	PF00498	0.757
LIG_FHA_2	168	174	PF00498	0.629
LIG_FHA_2	181	187	PF00498	0.460
LIG_FHA_2	458	464	PF00498	0.656
LIG_FXI_DFP_1	447	451	PF00024	0.674
LIG_GBD_Chelix_1	174	182	PF00786	0.370
LIG_LIR_Apic_2	31	36	PF02991	0.496
LIG_LIR_Apic_2	463	469	PF02991	0.609
LIG_LIR_Apic_2	473	478	PF02991	0.623
LIG_LIR_Apic_2	511	516	PF02991	0.652
LIG_LIR_Gen_1	139	150	PF02991	0.584
LIG_LIR_Gen_1	296	305	PF02991	0.545
LIG_LIR_Gen_1	317	326	PF02991	0.590
LIG_LIR_Gen_1	460	469	PF02991	0.663
LIG_LIR_Nem_3	124	130	PF02991	0.746
LIG_LIR_Nem_3	296	301	PF02991	0.540
LIG_LIR_Nem_3	306	311	PF02991	0.522
LIG_LIR_Nem_3	31	35	PF02991	0.591
LIG_LIR_Nem_3	317	323	PF02991	0.501
LIG_LIR_Nem_3	460	465	PF02991	0.658
LIG_NRBOX	173	179	PF00104	0.574
LIG_NRBOX	242	248	PF00104	0.547
LIG_PTB_Apo_2	506	513	PF02174	0.539
LIG_SH2_CRK	456	460	PF00017	0.532
LIG_SH2_CRK	513	517	PF00017	0.780
LIG_SH2_NCK_1	456	460	PF00017	0.532
LIG_SH2_NCK_1	481	485	PF00017	0.775
LIG_SH2_STAP1	295	299	PF00017	0.553
LIG_SH2_STAP1	462	466	PF00017	0.660
LIG_SH2_STAT5	295	298	PF00017	0.596
LIG_SH2_STAT5	32	35	PF00017	0.750
LIG_SH2_STAT5	456	459	PF00017	0.531
LIG_SH2_STAT5	481	484	PF00017	0.772
LIG_SH2_STAT5	513	516	PF00017	0.780
LIG_SH3_3	264	270	PF00018	0.737
LIG_SH3_3	31	37	PF00018	0.499
LIG_SH3_3	328	334	PF00018	0.458
LIG_SUMO_SIM_anti_2	172	180	PF11976	0.616
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.387
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.424
LIG_SUMO_SIM_par_1	172	180	PF11976	0.541
LIG_SUMO_SIM_par_1	252	258	PF11976	0.649
LIG_TRAF2_1	184	187	PF00917	0.610
LIG_WRC_WIRS_1	164	169	PF05994	0.579
LIG_WW_1	478	481	PF00397	0.754
MOD_CDK_SPxK_1	415	421	PF00069	0.687
MOD_CK1_1	100	106	PF00069	0.606
MOD_CK1_1	180	186	PF00069	0.668
MOD_CK1_1	242	248	PF00069	0.595
MOD_CK1_1	272	278	PF00069	0.704
MOD_CK1_1	290	296	PF00069	0.451
MOD_CK1_1	347	353	PF00069	0.599
MOD_CK1_1	394	400	PF00069	0.677
MOD_CK1_1	402	408	PF00069	0.593
MOD_CK1_1	415	421	PF00069	0.828
MOD_CK1_1	46	52	PF00069	0.654
MOD_CK1_1	511	517	PF00069	0.559
MOD_CK1_1	63	69	PF00069	0.743
MOD_CK1_1	79	85	PF00069	0.579
MOD_CK1_1	86	92	PF00069	0.810
MOD_CK2_1	180	186	PF00069	0.536
MOD_CK2_1	402	408	PF00069	0.810
MOD_CK2_1	411	417	PF00069	0.609
MOD_CK2_1	85	91	PF00069	0.829
MOD_GlcNHglycan	276	279	PF01048	0.768
MOD_GlcNHglycan	352	355	PF01048	0.664
MOD_GlcNHglycan	403	407	PF01048	0.717
MOD_GlcNHglycan	472	475	PF01048	0.677
MOD_GlcNHglycan	488	491	PF01048	0.680
MOD_GlcNHglycan	493	496	PF01048	0.699
MOD_GlcNHglycan	503	506	PF01048	0.639
MOD_GlcNHglycan	62	65	PF01048	0.653
MOD_GSK3_1	111	118	PF00069	0.615
MOD_GSK3_1	159	166	PF00069	0.746
MOD_GSK3_1	177	184	PF00069	0.462
MOD_GSK3_1	223	230	PF00069	0.551
MOD_GSK3_1	272	279	PF00069	0.598
MOD_GSK3_1	289	296	PF00069	0.502
MOD_GSK3_1	350	357	PF00069	0.592
MOD_GSK3_1	389	396	PF00069	0.780
MOD_GSK3_1	411	418	PF00069	0.812
MOD_GSK3_1	482	489	PF00069	0.635
MOD_GSK3_1	501	508	PF00069	0.570
MOD_GSK3_1	59	66	PF00069	0.727
MOD_GSK3_1	79	86	PF00069	0.779
MOD_N-GLC_1	508	513	PF02516	0.541
MOD_NEK2_1	153	158	PF00069	0.569
MOD_NEK2_1	177	182	PF00069	0.519
MOD_NEK2_1	224	229	PF00069	0.610
MOD_NEK2_1	255	260	PF00069	0.482
MOD_NEK2_1	276	281	PF00069	0.615
MOD_NEK2_1	28	33	PF00069	0.632
MOD_NEK2_1	288	293	PF00069	0.508
MOD_NEK2_1	360	365	PF00069	0.614
MOD_NEK2_1	382	387	PF00069	0.601
MOD_NEK2_1	92	97	PF00069	0.772
MOD_NEK2_2	9	14	PF00069	0.520
MOD_PIKK_1	224	230	PF00454	0.609
MOD_PIKK_1	344	350	PF00454	0.598
MOD_PIKK_1	90	96	PF00454	0.670
MOD_PKA_1	115	121	PF00069	0.577
MOD_PKA_1	412	418	PF00069	0.682
MOD_PKA_2	100	106	PF00069	0.678
MOD_PKA_2	114	120	PF00069	0.572
MOD_PKA_2	167	173	PF00069	0.677
MOD_PKA_2	224	230	PF00069	0.609
MOD_PKA_2	288	294	PF00069	0.369
MOD_PKA_2	382	388	PF00069	0.592
MOD_PKA_2	411	417	PF00069	0.720
MOD_PKA_2	454	460	PF00069	0.508
MOD_PKA_2	9	15	PF00069	0.518
MOD_PKB_1	410	418	PF00069	0.683
MOD_Plk_1	140	146	PF00069	0.605
MOD_Plk_1	22	28	PF00069	0.735
MOD_Plk_1	402	408	PF00069	0.591
MOD_Plk_1	508	514	PF00069	0.609
MOD_Plk_4	122	128	PF00069	0.752
MOD_Plk_4	177	183	PF00069	0.632
MOD_Plk_4	242	248	PF00069	0.547
MOD_Plk_4	250	256	PF00069	0.579
MOD_Plk_4	290	296	PF00069	0.549
MOD_Plk_4	457	463	PF00069	0.654
MOD_Plk_4	508	514	PF00069	0.609
MOD_ProDKin_1	337	343	PF00069	0.686
MOD_ProDKin_1	415	421	PF00069	0.756
MOD_ProDKin_1	482	488	PF00069	0.819
MOD_ProDKin_1	79	85	PF00069	0.698
TRG_DiLeu_BaEn_1	252	257	PF01217	0.423
TRG_ENDOCYTIC_2	32	35	PF00928	0.711
TRG_ENDOCYTIC_2	447	450	PF00928	0.673
TRG_ENDOCYTIC_2	462	465	PF00928	0.660
TRG_ER_diArg_1	409	412	PF00400	0.706
TRG_ER_diArg_1	452	455	PF00400	0.776
TRG_ER_diArg_1	518	521	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K4	Leptomonas seymouri	39%	99%
A0A3Q8IE86	Leishmania donovani	59%	96%
A4HXU9	Leishmania infantum	59%	96%
E9ARL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	97%
Q4QDW7	Leishmania major	61%	100%