Putative dynein-light chain-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein light chain Tctex-type, putative

Species:

Leishmania braziliensis

UniProt:

A4H9I4_LEIBR

TriTrypDb:

LbrM.18.0820 , LBRM2903_180013600

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4H9I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9I4

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.569
CLV_NRD_NRD_1	212	214	PF00675	0.331
CLV_PCSK_KEX2_1	42	44	PF00082	0.635
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.558
CLV_PCSK_SKI1_1	201	205	PF00082	0.416
CLV_PCSK_SKI1_1	42	46	PF00082	0.729
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.416
DOC_MAPK_gen_1	213	221	PF00069	0.324
DOC_PP2B_LxvP_1	142	145	PF13499	0.529
DOC_USP7_MATH_1	130	134	PF00917	0.539
DOC_USP7_MATH_1	146	150	PF00917	0.588
DOC_USP7_MATH_1	81	85	PF00917	0.700
DOC_WW_Pin1_4	120	125	PF00397	0.445
DOC_WW_Pin1_4	157	162	PF00397	0.597
DOC_WW_Pin1_4	71	76	PF00397	0.576
LIG_14-3-3_CanoR_1	108	118	PF00244	0.520
LIG_14-3-3_CanoR_1	157	161	PF00244	0.589
LIG_14-3-3_CanoR_1	32	40	PF00244	0.625
LIG_14-3-3_CanoR_1	43	52	PF00244	0.618
LIG_Actin_WH2_2	17	34	PF00022	0.542
LIG_APCC_ABBA_1	122	127	PF00400	0.473
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_BIR_III_4	129	133	PF00653	0.507
LIG_BRCT_BRCA1_1	122	126	PF00533	0.460
LIG_EH1_1	204	212	PF00400	0.323
LIG_FHA_1	158	164	PF00498	0.567
LIG_FHA_1	26	32	PF00498	0.611
LIG_FHA_2	43	49	PF00498	0.566
LIG_LIR_Apic_2	223	229	PF02991	0.416
LIG_LIR_Gen_1	182	192	PF02991	0.416
LIG_LIR_Gen_1	249	255	PF02991	0.368
LIG_LIR_Nem_3	182	187	PF02991	0.416
LIG_LIR_Nem_3	249	255	PF02991	0.368
LIG_MLH1_MIPbox_1	122	126	PF16413	0.460
LIG_SH2_CRK	245	249	PF00017	0.297
LIG_SH2_NCK_1	245	249	PF00017	0.473
LIG_SH2_STAT5	125	128	PF00017	0.523
LIG_SH3_3	145	151	PF00018	0.685
LIG_SUMO_SIM_anti_2	182	191	PF11976	0.416
LIG_UBA3_1	192	201	PF00899	0.367
MOD_CDC14_SPxK_1	74	77	PF00782	0.563
MOD_CDK_SPxK_1	71	77	PF00069	0.579
MOD_CK1_1	149	155	PF00069	0.721
MOD_CK1_1	6	12	PF00069	0.738
MOD_CK1_1	84	90	PF00069	0.629
MOD_CK2_1	188	194	PF00069	0.248
MOD_CK2_1	33	39	PF00069	0.537
MOD_CK2_1	42	48	PF00069	0.548
MOD_DYRK1A_RPxSP_1	157	161	PF00069	0.553
MOD_GlcNHglycan	132	135	PF01048	0.618
MOD_GlcNHglycan	148	151	PF01048	0.738
MOD_GlcNHglycan	239	243	PF01048	0.340
MOD_GlcNHglycan	35	38	PF01048	0.649
MOD_GlcNHglycan	85	89	PF01048	0.714
MOD_GSK3_1	27	34	PF00069	0.752
MOD_GSK3_1	3	10	PF00069	0.675
MOD_GSK3_1	38	45	PF00069	0.518
MOD_N-GLC_1	19	24	PF02516	0.531
MOD_N-GLC_1	3	8	PF02516	0.707
MOD_NEK2_1	19	24	PF00069	0.667
MOD_NEK2_1	31	36	PF00069	0.740
MOD_NEK2_2	246	251	PF00069	0.297
MOD_PKA_1	42	48	PF00069	0.562
MOD_PKA_2	156	162	PF00069	0.628
MOD_PKA_2	31	37	PF00069	0.706
MOD_PKA_2	42	48	PF00069	0.648
MOD_Plk_1	19	25	PF00069	0.559
MOD_Plk_4	188	194	PF00069	0.248
MOD_Plk_4	246	252	PF00069	0.324
MOD_ProDKin_1	120	126	PF00069	0.446
MOD_ProDKin_1	157	163	PF00069	0.593
MOD_ProDKin_1	71	77	PF00069	0.579
MOD_SUMO_for_1	179	182	PF00179	0.416
MOD_SUMO_rev_2	107	117	PF00179	0.536
TRG_DiLeu_BaEn_1	183	188	PF01217	0.416
TRG_ENDOCYTIC_2	176	179	PF00928	0.351
TRG_ENDOCYTIC_2	227	230	PF00928	0.487
TRG_ENDOCYTIC_2	245	248	PF00928	0.205

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P6W1	Trypanosomatidae	46%	100%
A0A3S7WUW6	Leishmania donovani	70%	100%
A4HXU8	Leishmania infantum	70%	100%
E9ARL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QDW9	Leishmania major	70%	97%