Origin recognition complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9I3_LEIBR

TriTrypDb:

LbrM.18.0810 , LBRM2903_180013500

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4H9I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9I3

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.732
CLV_C14_Caspase3-7	398	402	PF00656	0.563
CLV_NRD_NRD_1	183	185	PF00675	0.793
CLV_NRD_NRD_1	200	202	PF00675	0.709
CLV_NRD_NRD_1	208	210	PF00675	0.722
CLV_NRD_NRD_1	439	441	PF00675	0.616
CLV_NRD_NRD_1	606	608	PF00675	0.593
CLV_NRD_NRD_1	70	72	PF00675	0.561
CLV_PCSK_FUR_1	181	185	PF00082	0.822
CLV_PCSK_KEX2_1	183	185	PF00082	0.793

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN4	Leptomonas seymouri	53%	76%
A0A3S5H733	Leishmania donovani	79%	100%
A4HXU7	Leishmania infantum	79%	100%
E9ARK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QDX0	Leishmania major	78%	100%

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