Origin recognition complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9I3_LEIBR

TriTrypDb:

LbrM.18.0810 , LBRM2903_180013500

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9I3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.732
CLV_C14_Caspase3-7	398	402	PF00656	0.563
CLV_NRD_NRD_1	183	185	PF00675	0.793
CLV_NRD_NRD_1	200	202	PF00675	0.709
CLV_NRD_NRD_1	208	210	PF00675	0.722
CLV_NRD_NRD_1	439	441	PF00675	0.616
CLV_NRD_NRD_1	606	608	PF00675	0.593
CLV_NRD_NRD_1	70	72	PF00675	0.561
CLV_PCSK_FUR_1	181	185	PF00082	0.822
CLV_PCSK_KEX2_1	183	185	PF00082	0.793
CLV_PCSK_KEX2_1	200	202	PF00082	0.753
CLV_PCSK_KEX2_1	208	210	PF00082	0.796
CLV_PCSK_KEX2_1	334	336	PF00082	0.601
CLV_PCSK_KEX2_1	439	441	PF00082	0.616
CLV_PCSK_KEX2_1	606	608	PF00082	0.593
CLV_PCSK_KEX2_1	70	72	PF00082	0.561
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.601
CLV_PCSK_PC7_1	330	336	PF00082	0.607
CLV_PCSK_SKI1_1	264	268	PF00082	0.370
CLV_PCSK_SKI1_1	355	359	PF00082	0.694
CLV_PCSK_SKI1_1	606	610	PF00082	0.591
CLV_PCSK_SKI1_1	742	746	PF00082	0.581
CLV_PCSK_SKI1_1	785	789	PF00082	0.539
CLV_PCSK_SKI1_1	821	825	PF00082	0.521
CLV_PCSK_SKI1_1	83	87	PF00082	0.648
CLV_Separin_Metazoa	530	534	PF03568	0.612
CLV_Separin_Metazoa	845	849	PF03568	0.493
DEG_APCC_DBOX_1	438	446	PF00400	0.653
DEG_APCC_DBOX_1	557	565	PF00400	0.445
DEG_APCC_DBOX_1	606	614	PF00400	0.600
DEG_APCC_DBOX_1	741	749	PF00400	0.581
DEG_APCC_DBOX_1	796	804	PF00400	0.539
DEG_APCC_DBOX_1	820	828	PF00400	0.511
DEG_SPOP_SBC_1	244	248	PF00917	0.632
DOC_CYCLIN_RxL_1	261	271	PF00134	0.369
DOC_CYCLIN_RxL_1	54	68	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	684	690	PF00134	0.597
DOC_CYCLIN_yCln2_LP_2	720	723	PF00134	0.648
DOC_MAPK_DCC_7	710	720	PF00069	0.788
DOC_MAPK_gen_1	819	827	PF00069	0.619
DOC_MAPK_MEF2A_6	742	749	PF00069	0.476
DOC_PP2B_LxvP_1	684	687	PF13499	0.592
DOC_PP2B_LxvP_1	720	723	PF13499	0.679
DOC_USP7_MATH_1	148	152	PF00917	0.597
DOC_USP7_MATH_1	210	214	PF00917	0.704
DOC_USP7_MATH_1	219	223	PF00917	0.773
DOC_USP7_MATH_1	491	495	PF00917	0.714
DOC_USP7_MATH_1	515	519	PF00917	0.709
DOC_USP7_MATH_1	53	57	PF00917	0.596
DOC_USP7_MATH_1	701	705	PF00917	0.597
DOC_USP7_MATH_2	631	637	PF00917	0.562
DOC_WW_Pin1_4	102	107	PF00397	0.514
DOC_WW_Pin1_4	13	18	PF00397	0.788
DOC_WW_Pin1_4	191	196	PF00397	0.623
DOC_WW_Pin1_4	448	453	PF00397	0.645
DOC_WW_Pin1_4	496	501	PF00397	0.704
DOC_WW_Pin1_4	641	646	PF00397	0.535
DOC_WW_Pin1_4	69	74	PF00397	0.657
LIG_14-3-3_CanoR_1	181	191	PF00244	0.832
LIG_14-3-3_CanoR_1	339	347	PF00244	0.624
LIG_14-3-3_CanoR_1	397	406	PF00244	0.648
LIG_14-3-3_CanoR_1	439	448	PF00244	0.578
LIG_14-3-3_CanoR_1	476	482	PF00244	0.734
LIG_14-3-3_CanoR_1	506	511	PF00244	0.657
LIG_14-3-3_CanoR_1	558	562	PF00244	0.560
LIG_14-3-3_CanoR_1	71	77	PF00244	0.530
LIG_14-3-3_CanoR_1	848	853	PF00244	0.608
LIG_Actin_WH2_2	788	804	PF00022	0.626
LIG_APCC_ABBAyCdc20_2	666	672	PF00400	0.551
LIG_BRCT_BRCA1_1	442	446	PF00533	0.545
LIG_BRCT_BRCA1_1	498	502	PF00533	0.807
LIG_Clathr_ClatBox_1	128	132	PF01394	0.609
LIG_Clathr_ClatBox_1	445	449	PF01394	0.546
LIG_EH1_1	149	157	PF00400	0.556
LIG_EH1_1	58	66	PF00400	0.574
LIG_eIF4E_1	295	301	PF01652	0.521
LIG_EVH1_2	686	690	PF00568	0.546
LIG_FHA_1	140	146	PF00498	0.563
LIG_FHA_1	186	192	PF00498	0.658
LIG_FHA_1	246	252	PF00498	0.627
LIG_FHA_1	398	404	PF00498	0.486
LIG_FHA_1	452	458	PF00498	0.749
LIG_FHA_1	505	511	PF00498	0.771
LIG_FHA_1	518	524	PF00498	0.470
LIG_FHA_1	754	760	PF00498	0.530
LIG_FHA_2	429	435	PF00498	0.613
LIG_FHA_2	568	574	PF00498	0.693
LIG_FHA_2	761	767	PF00498	0.535
LIG_GBD_Chelix_1	564	572	PF00786	0.673
LIG_GBD_Chelix_1	95	103	PF00786	0.489
LIG_LIR_Apic_2	707	711	PF02991	0.763
LIG_LIR_Nem_3	122	128	PF02991	0.493
LIG_LIR_Nem_3	26	32	PF02991	0.619
LIG_LIR_Nem_3	343	349	PF02991	0.631
LIG_NRBOX	353	359	PF00104	0.600
LIG_NRBOX	724	730	PF00104	0.698
LIG_PCNA_PIPBox_1	583	592	PF02747	0.452
LIG_PCNA_yPIPBox_3	405	418	PF02747	0.443
LIG_PDZ_Class_1	848	853	PF00595	0.608
LIG_Pex14_2	125	129	PF04695	0.497
LIG_Rb_pABgroove_1	440	448	PF01858	0.512
LIG_SH2_CRK	29	33	PF00017	0.610
LIG_SH2_CRK	708	712	PF00017	0.766
LIG_SH2_PTP2	346	349	PF00017	0.618
LIG_SH2_STAT5	116	119	PF00017	0.625
LIG_SH2_STAT5	250	253	PF00017	0.641
LIG_SH2_STAT5	295	298	PF00017	0.515
LIG_SH2_STAT5	346	349	PF00017	0.570
LIG_SH3_1	345	351	PF00018	0.626
LIG_SH3_3	142	148	PF00018	0.554
LIG_SH3_3	345	351	PF00018	0.569
LIG_SH3_3	618	624	PF00018	0.777
LIG_Sin3_3	744	751	PF02671	0.335
LIG_SUMO_SIM_anti_2	743	749	PF11976	0.473
LIG_SUMO_SIM_par_1	265	271	PF11976	0.495
LIG_SUMO_SIM_par_1	644	650	PF11976	0.495
LIG_TYR_ITIM	748	753	PF00017	0.472
LIG_UBA3_1	266	270	PF00899	0.488
LIG_UBA3_1	824	830	PF00899	0.609
LIG_ULM_U2AF65_1	200	205	PF00076	0.829
LIG_WRC_WIRS_1	99	104	PF05994	0.594
MOD_CDK_SPxK_1	191	197	PF00069	0.590
MOD_CK1_1	105	111	PF00069	0.525
MOD_CK1_1	185	191	PF00069	0.732
MOD_CK1_1	246	252	PF00069	0.627
MOD_CK1_1	338	344	PF00069	0.621
MOD_CK1_1	428	434	PF00069	0.544
MOD_CK1_1	496	502	PF00069	0.719
MOD_CK1_1	509	515	PF00069	0.666
MOD_CK1_1	517	523	PF00069	0.465
MOD_CK1_1	556	562	PF00069	0.513
MOD_CK1_1	563	569	PF00069	0.521
MOD_CK1_1	576	582	PF00069	0.660
MOD_CK1_1	6	12	PF00069	0.653
MOD_CK1_1	774	780	PF00069	0.567
MOD_CK2_1	13	19	PF00069	0.764
MOD_CK2_1	228	234	PF00069	0.746
MOD_CK2_1	428	434	PF00069	0.609
MOD_CK2_1	567	573	PF00069	0.685
MOD_CK2_1	647	653	PF00069	0.492
MOD_CK2_1	701	707	PF00069	0.828
MOD_Cter_Amidation	604	607	PF01082	0.579
MOD_GlcNHglycan	107	110	PF01048	0.626
MOD_GlcNHglycan	210	213	PF01048	0.668
MOD_GlcNHglycan	230	233	PF01048	0.614
MOD_GlcNHglycan	256	259	PF01048	0.453
MOD_GlcNHglycan	297	300	PF01048	0.516
MOD_GlcNHglycan	309	312	PF01048	0.700
MOD_GlcNHglycan	313	316	PF01048	0.637
MOD_GlcNHglycan	323	326	PF01048	0.577
MOD_GlcNHglycan	470	473	PF01048	0.681
MOD_GlcNHglycan	491	494	PF01048	0.613
MOD_GlcNHglycan	55	58	PF01048	0.567
MOD_GlcNHglycan	594	597	PF01048	0.714
MOD_GlcNHglycan	6	9	PF01048	0.797
MOD_GlcNHglycan	603	606	PF01048	0.639
MOD_GlcNHglycan	756	759	PF01048	0.654
MOD_GSK3_1	199	206	PF00069	0.658
MOD_GSK3_1	210	217	PF00069	0.656
MOD_GSK3_1	238	245	PF00069	0.672
MOD_GSK3_1	268	275	PF00069	0.502
MOD_GSK3_1	28	35	PF00069	0.618
MOD_GSK3_1	307	314	PF00069	0.535
MOD_GSK3_1	334	341	PF00069	0.610
MOD_GSK3_1	387	394	PF00069	0.414
MOD_GSK3_1	470	477	PF00069	0.818
MOD_GSK3_1	489	496	PF00069	0.509
MOD_GSK3_1	500	507	PF00069	0.703
MOD_GSK3_1	553	560	PF00069	0.614
MOD_GSK3_1	563	570	PF00069	0.587
MOD_GSK3_1	573	580	PF00069	0.568
MOD_GSK3_1	660	667	PF00069	0.620
MOD_GSK3_1	770	777	PF00069	0.546
MOD_GSK3_1	98	105	PF00069	0.594
MOD_N-GLC_1	574	579	PF02516	0.732
MOD_N-GLC_1	701	706	PF02516	0.735
MOD_N-GLC_2	676	678	PF02516	0.550
MOD_NEK2_1	117	122	PF00069	0.595
MOD_NEK2_1	243	248	PF00069	0.644
MOD_NEK2_1	268	273	PF00069	0.504
MOD_NEK2_1	32	37	PF00069	0.697
MOD_NEK2_1	358	363	PF00069	0.596
MOD_NEK2_1	514	519	PF00069	0.668
MOD_NEK2_1	601	606	PF00069	0.615
MOD_NEK2_1	690	695	PF00069	0.570
MOD_NEK2_1	775	780	PF00069	0.511
MOD_NEK2_1	823	828	PF00069	0.501
MOD_NEK2_2	148	153	PF00069	0.555
MOD_NEK2_2	28	33	PF00069	0.615
MOD_OFUCOSY	40	47	PF10250	0.599
MOD_PIKK_1	368	374	PF00454	0.556
MOD_PIKK_1	463	469	PF00454	0.630
MOD_PIKK_1	480	486	PF00454	0.538
MOD_PIKK_1	805	811	PF00454	0.554
MOD_PK_1	506	512	PF00069	0.716
MOD_PKA_1	183	189	PF00069	0.625
MOD_PKA_1	208	214	PF00069	0.579
MOD_PKA_1	334	340	PF00069	0.607
MOD_PKA_2	182	188	PF00069	0.861
MOD_PKA_2	199	205	PF00069	0.534
MOD_PKA_2	208	214	PF00069	0.741
MOD_PKA_2	3	9	PF00069	0.580
MOD_PKA_2	32	38	PF00069	0.601
MOD_PKA_2	334	340	PF00069	0.607
MOD_PKA_2	475	481	PF00069	0.797
MOD_PKA_2	489	495	PF00069	0.558
MOD_PKA_2	53	59	PF00069	0.586
MOD_PKA_2	557	563	PF00069	0.593
MOD_PKB_1	181	189	PF00069	0.856
MOD_PKB_1	201	209	PF00069	0.685
MOD_Plk_1	428	434	PF00069	0.609
MOD_Plk_1	760	766	PF00069	0.646
MOD_Plk_2-3	220	226	PF00069	0.718
MOD_Plk_2-3	567	573	PF00069	0.685
MOD_Plk_4	238	244	PF00069	0.696
MOD_Plk_4	246	252	PF00069	0.617
MOD_Plk_4	272	278	PF00069	0.497
MOD_Plk_4	316	322	PF00069	0.585
MOD_Plk_4	361	367	PF00069	0.479
MOD_Plk_4	441	447	PF00069	0.670
MOD_Plk_4	509	515	PF00069	0.686
MOD_Plk_4	560	566	PF00069	0.477
MOD_Plk_4	578	584	PF00069	0.533
MOD_Plk_4	716	722	PF00069	0.663
MOD_Plk_4	72	78	PF00069	0.514
MOD_Plk_4	823	829	PF00069	0.507
MOD_Plk_4	98	104	PF00069	0.593
MOD_ProDKin_1	102	108	PF00069	0.509
MOD_ProDKin_1	13	19	PF00069	0.787
MOD_ProDKin_1	191	197	PF00069	0.625
MOD_ProDKin_1	448	454	PF00069	0.646
MOD_ProDKin_1	496	502	PF00069	0.703
MOD_ProDKin_1	641	647	PF00069	0.531
MOD_ProDKin_1	69	75	PF00069	0.651
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.625
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.584
TRG_DiLeu_BaLyEn_6	790	795	PF01217	0.511
TRG_DiLeu_BaLyEn_6	796	801	PF01217	0.542
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.299
TRG_ENDOCYTIC_2	29	32	PF00928	0.616
TRG_ENDOCYTIC_2	346	349	PF00928	0.618
TRG_ENDOCYTIC_2	750	753	PF00928	0.474
TRG_ER_diArg_1	181	184	PF00400	0.860
TRG_ER_diArg_1	200	203	PF00400	0.740
TRG_ER_diArg_1	373	376	PF00400	0.571
TRG_ER_diArg_1	396	399	PF00400	0.615
TRG_ER_diArg_1	606	608	PF00400	0.593
TRG_ER_diArg_1	613	616	PF00400	0.613
TRG_ER_diArg_1	681	684	PF00400	0.555
TRG_ER_diArg_1	69	71	PF00400	0.562
TRG_ER_FFAT_2	496	507	PF00635	0.802
TRG_Pf-PMV_PEXEL_1	433	438	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN4	Leptomonas seymouri	53%	76%
A0A3S5H733	Leishmania donovani	79%	100%
A4HXU7	Leishmania infantum	79%	100%
E9ARK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QDX0	Leishmania major	78%	100%