LeishMANIAdb
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acidPPc domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
acidPPc domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4H9I2_LEIBR
TriTrypDb:
LbrM.18.0800 , LBRM2903_180013400
Length:
307

Annotations

LeishMANIAdb annotations

Distinctively related to eukaryotic PLPP enzymes.. This family of protens expanded considerably in Kinetoplastids (might be due to metabolic dependence on host lipids)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

A4H9I2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9I2

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 15
GO:0006644 phospholipid metabolic process 4 15
GO:0006793 phosphorus metabolic process 3 15
GO:0006796 phosphate-containing compound metabolic process 4 15
GO:0008152 metabolic process 1 15
GO:0009987 cellular process 1 15
GO:0019637 organophosphate metabolic process 3 15
GO:0044237 cellular metabolic process 2 15
GO:0044238 primary metabolic process 2 15
GO:0044255 cellular lipid metabolic process 3 15
GO:0071704 organic substance metabolic process 2 15
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 43 47 PF00656 0.313
CLV_NRD_NRD_1 39 41 PF00675 0.427
CLV_PCSK_KEX2_1 279 281 PF00082 0.413
CLV_PCSK_KEX2_1 4 6 PF00082 0.318
CLV_PCSK_PC1ET2_1 279 281 PF00082 0.259
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.318
CLV_PCSK_SKI1_1 186 190 PF00082 0.210
CLV_PCSK_SKI1_1 56 60 PF00082 0.474
DEG_APCC_DBOX_1 191 199 PF00400 0.446
DEG_SPOP_SBC_1 285 289 PF00917 0.505
DOC_CYCLIN_yCln2_LP_2 203 209 PF00134 0.286
DOC_CYCLIN_yCln2_LP_2 290 296 PF00134 0.533
DOC_MAPK_gen_1 153 162 PF00069 0.238
DOC_MAPK_gen_1 186 195 PF00069 0.416
DOC_MAPK_MEF2A_6 14 23 PF00069 0.512
DOC_MAPK_MEF2A_6 192 200 PF00069 0.512
DOC_MAPK_MEF2A_6 90 97 PF00069 0.506
DOC_MAPK_NFAT4_5 90 98 PF00069 0.525
DOC_PP1_RVXF_1 157 163 PF00149 0.186
DOC_PP1_RVXF_1 38 45 PF00149 0.378
DOC_PP2B_LxvP_1 203 206 PF13499 0.311
DOC_USP7_UBL2_3 260 264 PF12436 0.504
DOC_WW_Pin1_4 292 297 PF00397 0.569
LIG_14-3-3_CanoR_1 159 163 PF00244 0.177
LIG_14-3-3_CanoR_1 213 221 PF00244 0.269
LIG_Actin_WH2_2 175 191 PF00022 0.413
LIG_eIF4E_1 75 81 PF01652 0.391
LIG_FHA_1 195 201 PF00498 0.371
LIG_FHA_1 206 212 PF00498 0.314
LIG_FHA_1 285 291 PF00498 0.694
LIG_FHA_1 53 59 PF00498 0.297
LIG_FHA_2 250 256 PF00498 0.566
LIG_FHA_2 52 58 PF00498 0.220
LIG_GBD_Chelix_1 225 233 PF00786 0.325
LIG_GBD_Chelix_1 66 74 PF00786 0.334
LIG_LIR_Apic_2 172 177 PF02991 0.264
LIG_LIR_Apic_2 82 87 PF02991 0.587
LIG_LIR_Gen_1 140 150 PF02991 0.252
LIG_LIR_Gen_1 17 26 PF02991 0.319
LIG_LIR_Nem_3 169 174 PF02991 0.255
LIG_LIR_Nem_3 17 21 PF02991 0.301
LIG_LIR_Nem_3 57 62 PF02991 0.273
LIG_NRBOX 180 186 PF00104 0.180
LIG_REV1ctd_RIR_1 8 15 PF16727 0.434
LIG_SH2_CRK 62 66 PF00017 0.350
LIG_SH2_PTP2 174 177 PF00017 0.431
LIG_SH2_SRC 174 177 PF00017 0.338
LIG_SH2_STAP1 62 66 PF00017 0.350
LIG_SH2_STAT5 174 177 PF00017 0.313
LIG_SH2_STAT5 18 21 PF00017 0.240
LIG_SH2_STAT5 180 183 PF00017 0.252
LIG_SH2_STAT5 75 78 PF00017 0.228
LIG_SH3_3 290 296 PF00018 0.683
LIG_SUMO_SIM_anti_2 197 202 PF11976 0.264
LIG_SUMO_SIM_par_1 194 199 PF11976 0.385
LIG_SUMO_SIM_par_1 207 212 PF11976 0.316
LIG_SUMO_SIM_par_1 300 305 PF11976 0.531
LIG_UBA3_1 181 189 PF00899 0.180
LIG_WRC_WIRS_1 240 245 PF05994 0.309
LIG_WW_3 297 301 PF00397 0.523
MOD_CK1_1 161 167 PF00069 0.177
MOD_CK1_1 212 218 PF00069 0.216
MOD_CK1_1 45 51 PF00069 0.238
MOD_CK2_1 280 286 PF00069 0.512
MOD_CK2_1 51 57 PF00069 0.339
MOD_GlcNHglycan 163 166 PF01048 0.416
MOD_GlcNHglycan 171 174 PF01048 0.263
MOD_GSK3_1 205 212 PF00069 0.326
MOD_GSK3_1 235 242 PF00069 0.307
MOD_GSK3_1 254 261 PF00069 0.454
MOD_GSK3_1 26 33 PF00069 0.243
MOD_GSK3_1 274 281 PF00069 0.600
MOD_N-GLC_1 115 120 PF02516 0.295
MOD_NEK2_1 184 189 PF00069 0.283
MOD_NEK2_1 225 230 PF00069 0.315
MOD_NEK2_2 249 254 PF00069 0.552
MOD_PK_1 280 286 PF00069 0.617
MOD_PKA_2 158 164 PF00069 0.177
MOD_PKA_2 212 218 PF00069 0.269
MOD_PKA_2 243 249 PF00069 0.517
MOD_Plk_1 249 255 PF00069 0.577
MOD_Plk_1 285 291 PF00069 0.654
MOD_Plk_1 45 51 PF00069 0.239
MOD_Plk_4 196 202 PF00069 0.239
MOD_Plk_4 235 241 PF00069 0.275
MOD_Plk_4 243 249 PF00069 0.499
MOD_Plk_4 26 32 PF00069 0.222
MOD_Plk_4 280 286 PF00069 0.617
MOD_Plk_4 60 66 PF00069 0.295
MOD_ProDKin_1 292 298 PF00069 0.563
MOD_SUMO_rev_2 255 261 PF00179 0.484
TRG_DiLeu_BaLyEn_6 199 204 PF01217 0.261
TRG_ENDOCYTIC_2 18 21 PF00928 0.319
TRG_ENDOCYTIC_2 62 65 PF00928 0.350
TRG_ER_diArg_1 124 127 PF00400 0.220

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P344 Leptomonas seymouri 30% 78%
A0A0N1I1J3 Leptomonas seymouri 66% 98%
A0A0S4IVL2 Bodo saltans 31% 86%
A0A0S4JH63 Bodo saltans 35% 100%
A0A1X0P677 Trypanosomatidae 35% 100%
A0A1X0P6S8 Trypanosomatidae 36% 92%
A0A1X0P729 Trypanosomatidae 49% 100%
A0A3Q8ID01 Leishmania donovani 73% 83%
A0A3Q8IK66 Leishmania donovani 29% 77%
A0A3S5IRX0 Trypanosoma rangeli 36% 100%
A4HA84 Leishmania braziliensis 31% 77%
A4HXR8 Leishmania infantum 73% 83%
A4HYG7 Leishmania infantum 29% 77%
C9ZUG5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 92%
C9ZZW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 93%
E9AS87 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 77%
O08564 Rattus norvegicus 28% 100%
O14495 Homo sapiens 29% 99%
O43688 Homo sapiens 26% 100%
O88956 Cavia porcellus 29% 100%
P60588 Sus scrofa 27% 100%
P97544 Rattus norvegicus 27% 98%
Q05521 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
Q2HJ61 Bos taurus 25% 100%
Q3SZE3 Bos taurus 28% 99%
Q4QD76 Leishmania major 30% 100%
Q61469 Mus musculus 25% 100%
Q86AF0 Dictyostelium discoideum 27% 84%
Q8K593 Rattus norvegicus 27% 100%
Q99JY8 Mus musculus 26% 98%
Q9DAX2 Mus musculus 25% 100%
Q9UUA6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
Q9V576 Drosophila melanogaster 27% 81%
Q9ZU49 Arabidopsis thaliana 24% 94%
V5B5J9 Trypanosoma cruzi 33% 100%
V5BM01 Trypanosoma cruzi 37% 97%
V5BWA7 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS