Citrate synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Citrate synthase

Gene product:

citrate synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4H9H9_LEIBR

TriTrypDb:

LbrM.18.0770 , LBRM2903_180012900

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005759	mitochondrial matrix	5	4
GO:0020023	kinetoplast	2	2
GO:0031974	membrane-enclosed lumen	2	4
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	4
GO:0070013	intracellular organelle lumen	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4H9H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9H9

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0006082	organic acid metabolic process	3	1
GO:0006099	tricarboxylic acid cycle	3	4
GO:0006101	citrate metabolic process	7	1
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	4
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	2
GO:0072350	tricarboxylic acid metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016740	transferase activity	2	16
GO:0016746	acyltransferase activity	3	16
GO:0046912	acyltransferase activity, acyl groups converted into alkyl on transfer	4	16
GO:0004108	citrate (Si)-synthase activity	6	2
GO:0036440	citrate synthase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.310
CLV_NRD_NRD_1	338	340	PF00675	0.388
CLV_PCSK_KEX2_1	119	121	PF00082	0.310
CLV_PCSK_KEX2_1	15	17	PF00082	0.568
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.491
CLV_PCSK_SKI1_1	290	294	PF00082	0.333
CLV_PCSK_SKI1_1	438	442	PF00082	0.451
CLV_PCSK_SKI1_1	49	53	PF00082	0.296
DEG_SPOP_SBC_1	252	256	PF00917	0.597
DOC_ANK_TNKS_1	297	304	PF00023	0.584
DOC_CYCLIN_RxL_1	287	297	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	262	268	PF00134	0.553
DOC_MAPK_gen_1	119	126	PF00069	0.546
DOC_MAPK_gen_1	28	36	PF00069	0.381
DOC_MAPK_gen_1	298	306	PF00069	0.496
DOC_MAPK_MEF2A_6	236	243	PF00069	0.530
DOC_USP7_MATH_1	207	211	PF00917	0.555
DOC_WW_Pin1_4	185	190	PF00397	0.511
LIG_14-3-3_CanoR_1	344	351	PF00244	0.519
LIG_Actin_WH2_2	2	17	PF00022	0.341
LIG_APCC_ABBA_1	239	244	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.453
LIG_deltaCOP1_diTrp_1	213	220	PF00928	0.498
LIG_FHA_1	186	192	PF00498	0.528
LIG_FHA_1	252	258	PF00498	0.498
LIG_FHA_1	318	324	PF00498	0.536
LIG_FHA_1	440	446	PF00498	0.553
LIG_FHA_1	50	56	PF00498	0.501
LIG_FHA_1	99	105	PF00498	0.515
LIG_FHA_2	170	176	PF00498	0.588
LIG_FHA_2	21	27	PF00498	0.368
LIG_FHA_2	401	407	PF00498	0.429
LIG_FHA_2	71	77	PF00498	0.496
LIG_FHA_2	88	94	PF00498	0.496
LIG_IBAR_NPY_1	384	386	PF08397	0.588
LIG_LIR_Gen_1	155	164	PF02991	0.562
LIG_LIR_Gen_1	230	239	PF02991	0.487
LIG_LIR_Gen_1	263	273	PF02991	0.510
LIG_LIR_Gen_1	320	329	PF02991	0.496
LIG_LIR_Gen_1	342	353	PF02991	0.505
LIG_LIR_Nem_3	155	159	PF02991	0.552
LIG_LIR_Nem_3	171	176	PF02991	0.468
LIG_LIR_Nem_3	263	269	PF02991	0.496
LIG_LIR_Nem_3	320	324	PF02991	0.496
LIG_LIR_Nem_3	342	348	PF02991	0.506
LIG_LIR_Nem_3	359	365	PF02991	0.535
LIG_LIR_Nem_3	404	410	PF02991	0.468
LIG_LIR_Nem_3	93	99	PF02991	0.553
LIG_LYPXL_yS_3	386	389	PF13949	0.588
LIG_LYPXL_yS_3	408	411	PF13949	0.477
LIG_NRBOX	288	294	PF00104	0.575
LIG_PDZ_Class_3	448	453	PF00595	0.362
LIG_Pex14_1	216	220	PF04695	0.496
LIG_PTB_Apo_2	363	370	PF02174	0.588
LIG_PTB_Phospho_1	363	369	PF10480	0.588
LIG_SH2_CRK	196	200	PF00017	0.431
LIG_SH2_CRK	345	349	PF00017	0.548
LIG_SH2_NCK_1	196	200	PF00017	0.429
LIG_SH2_SRC	56	59	PF00017	0.553
LIG_SH2_STAP1	156	160	PF00017	0.588
LIG_SH2_STAP1	319	323	PF00017	0.584
LIG_SH2_STAT5	238	241	PF00017	0.514
LIG_SH2_STAT5	266	269	PF00017	0.496
LIG_SH2_STAT5	291	294	PF00017	0.496
LIG_SH2_STAT5	319	322	PF00017	0.584
LIG_SH2_STAT5	345	348	PF00017	0.496
LIG_SH2_STAT5	449	452	PF00017	0.577
LIG_SH2_STAT5	45	48	PF00017	0.337
LIG_SH3_3	52	58	PF00018	0.545
LIG_SH3_3	79	85	PF00018	0.563
LIG_SUMO_SIM_par_1	149	155	PF11976	0.590
LIG_TRAF2_1	284	287	PF00917	0.498
LIG_UBA3_1	292	300	PF00899	0.337
LIG_UBA3_1	361	370	PF00899	0.341
MOD_CK1_1	168	174	PF00069	0.337
MOD_CK1_1	209	215	PF00069	0.313
MOD_CK1_1	251	257	PF00069	0.356
MOD_CK1_1	260	266	PF00069	0.310
MOD_CK1_1	37	43	PF00069	0.336
MOD_CK1_1	4	10	PF00069	0.583
MOD_CK1_1	439	445	PF00069	0.452
MOD_CK2_1	14	20	PF00069	0.355
MOD_CK2_1	169	175	PF00069	0.466
MOD_CK2_1	207	213	PF00069	0.396
MOD_CK2_1	70	76	PF00069	0.337
MOD_CK2_1	87	93	PF00069	0.337
MOD_GlcNHglycan	250	253	PF01048	0.359
MOD_GlcNHglycan	259	262	PF01048	0.364
MOD_GlcNHglycan	269	272	PF01048	0.382
MOD_GlcNHglycan	325	328	PF01048	0.466
MOD_GlcNHglycan	392	395	PF01048	0.337
MOD_GSK3_1	137	144	PF00069	0.336
MOD_GSK3_1	165	172	PF00069	0.375
MOD_GSK3_1	248	255	PF00069	0.342
MOD_N-GLC_1	168	173	PF02516	0.263
MOD_N-GLC_1	218	223	PF02516	0.286
MOD_N-GLC_1	248	253	PF02516	0.337
MOD_N-GLC_1	70	75	PF02516	0.247
MOD_N-GLC_2	305	307	PF02516	0.242
MOD_N-GLC_2	350	352	PF02516	0.437
MOD_N-GLC_2	86	88	PF02516	0.242
MOD_NEK2_1	1	6	PF00069	0.545
MOD_NEK2_1	14	19	PF00069	0.402
MOD_NEK2_1	237	242	PF00069	0.382
MOD_NEK2_1	257	262	PF00069	0.337
MOD_NEK2_1	267	272	PF00069	0.356
MOD_NEK2_1	323	328	PF00069	0.466
MOD_NEK2_1	412	417	PF00069	0.342
MOD_PIKK_1	282	288	PF00454	0.233
MOD_PK_1	436	442	PF00069	0.476
MOD_PKA_2	197	203	PF00069	0.382
MOD_PKA_2	343	349	PF00069	0.376
MOD_PKB_1	68	76	PF00069	0.356
MOD_Plk_1	168	174	PF00069	0.353
MOD_Plk_1	178	184	PF00069	0.359
MOD_Plk_1	37	43	PF00069	0.470
MOD_Plk_1	70	76	PF00069	0.382
MOD_Plk_2-3	20	26	PF00069	0.361
MOD_Plk_4	1	7	PF00069	0.432
MOD_Plk_4	169	175	PF00069	0.476
MOD_Plk_4	253	259	PF00069	0.340
MOD_Plk_4	56	62	PF00069	0.345
MOD_ProDKin_1	185	191	PF00069	0.358
MOD_SUMO_rev_2	3	11	PF00179	0.303
TRG_ENDOCYTIC_2	156	159	PF00928	0.466
TRG_ENDOCYTIC_2	196	199	PF00928	0.236
TRG_ENDOCYTIC_2	238	241	PF00928	0.341
TRG_ENDOCYTIC_2	266	269	PF00928	0.356
TRG_ENDOCYTIC_2	345	348	PF00928	0.349
TRG_ENDOCYTIC_2	369	372	PF00928	0.337
TRG_ENDOCYTIC_2	386	389	PF00928	0.337
TRG_ENDOCYTIC_2	407	410	PF00928	0.345
TRG_ENDOCYTIC_2	45	48	PF00928	0.431
TRG_ER_diArg_1	69	72	PF00400	0.337
TRG_NES_CRM1_1	89	103	PF08389	0.466
TRG_NLS_MonoExtC_3	14	20	PF00514	0.450
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I014	Leptomonas seymouri	83%	96%
A0A0S3QTD0	Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6)	48%	100%
A0A1X0P7W7	Trypanosomatidae	65%	96%
A0A3Q8IB05	Leishmania donovani	85%	100%
A0A3Q8IB38	Leishmania donovani	85%	96%
A0A422P1U5	Trypanosoma rangeli	66%	96%
A4H9H8	Leishmania braziliensis	98%	100%
A4HXU4	Leishmania infantum	85%	96%
A4HXU5	Leishmania infantum	85%	100%
B0YD89	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	47%	97%
C7C435	Fusarium solani	46%	96%
C7C436	Gibberella moniliformis	47%	96%
C9ZZW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	94%
D4GS06	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	29%	100%
E9ARK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	96%
E9ARK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O00098	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	56%	96%
O33915	Rhizobium meliloti (strain 1021)	26%	100%
O34002	Antarctic bacterium DS2-3R	26%	100%
O68883	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	100%
O75390	Homo sapiens	53%	97%
O80433	Daucus carota	54%	96%
P00889	Sus scrofa	53%	98%
P00890	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	95%
P08679	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	98%
P09948	Rickettsia prowazekii (strain Madrid E)	24%	100%
P0ABH7	Escherichia coli (strain K12)	26%	100%
P0ABH8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	26%	100%
P0C1Z2	Macaca fascicularis	53%	97%
P14165	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	25%	100%
P18789	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	25%	100%
P20115	Arabidopsis thaliana	52%	96%
P20901	Acetobacter aceti	25%	100%
P20902	Acinetobacter calcoaceticus subsp. anitratus	25%	100%
P23007	Gallus gallus	52%	100%
P24118	Tetrahymena thermophila	46%	98%
P27660	Weizmannia coagulans	26%	100%
P31660	Escherichia coli (strain K12)	25%	100%
P34085	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	56%	97%
P34575	Caenorhabditis elegans	52%	97%
P39119	Bacillus subtilis (strain 168)	24%	100%
P39120	Bacillus subtilis (strain 168)	24%	100%
P42457	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	26%	100%
P43635	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	93%
P45858	Bacillus subtilis (strain 168)	24%	100%
P49298	Citrus maxima	51%	96%
P49299	Cucurbita maxima	25%	88%
P51031	Bartonella bacilliformis	25%	100%
P51032	Bartonella elizabethae	26%	100%
P51033	Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)	25%	100%
P51034	Bartonella quintana (strain Toulouse)	26%	100%
P51036	Bartonella vinsonii	26%	100%
P51037	Rhizobium tropici	26%	100%
P51038	Rhizobium tropici	26%	100%
P51039	Rickettsia australis	24%	100%
P51040	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	24%	100%
P51041	Rickettsia canadensis	24%	100%
P51042	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	24%	100%
P51043	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	24%	100%
P51044	Aspergillus niger	55%	95%
P51045	Acidithiobacillus ferridurans	24%	100%
P56062	Helicobacter pylori (strain ATCC 700392 / 26695)	28%	100%
P79024	Candida tropicalis	53%	97%
P80148	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	24%	100%
P83372	Fragaria ananassa	50%	97%
P94325	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	25%	100%
P9WPD4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WPD5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
Q0GNE0	Iguana iguana	52%	97%
Q0GNE1	Amblyrhynchus cristatus	52%	97%
Q0QHL3	Glossina morsitans morsitans	53%	97%
Q10306	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	94%
Q16P20	Aedes aegypti	53%	97%
Q17GM7	Aedes aegypti	53%	97%
Q1RGV8	Rickettsia bellii (strain RML369-C)	25%	100%
Q28DK1	Xenopus tropicalis	55%	97%
Q29RK1	Bos taurus	53%	97%
Q2TXF1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
Q43175	Solanum tuberosum	49%	96%
Q4QDX2	Leishmania major	83%	100%
Q4QDX3	Leishmania major	84%	100%
Q4S5X1	Tetraodon nigroviridis	52%	97%
Q50I20	Neosartorya fumigata	47%	97%
Q53554	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	25%	100%
Q553V1	Dictyostelium discoideum	54%	98%
Q56063	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	25%	100%
Q59136	Rickettsia conorii subsp. caspia (strain A-167)	24%	100%
Q59198	Bartonella doshiae	25%	100%
Q59258	Bartonella taylorii	26%	100%
Q59730	Rickettsia akari	24%	100%
Q59732	Rickettsia africae (strain ESF-5)	24%	100%
Q59734	Rickettsia bellii	25%	100%
Q59741	Rickettsia helvetica	25%	100%
Q59742	Rickettsia japonica	24%	100%
Q59748	Rickettsia massiliae	24%	100%
Q59759	Rickettsia parkeri	24%	100%
Q59768	Rickettsia rhipicephali	24%	100%
Q59776	Rickettsia slovaca (strain 13-B)	24%	100%
Q59778	Rickettsia sibirica (strain ATCC VR-151 / 246)	24%	100%
Q59939	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	27%	100%
Q59977	Synechocystis sp. (strain PCC 6803 / Kazusa)	26%	100%
Q61JF9	Caenorhabditis briggsae	52%	97%
Q6C793	Yarrowia lipolytica (strain CLIB 122 / E 150)	52%	97%
Q6S9V5	Kajikia audax	52%	97%
Q6S9V6	Xiphias gladius	53%	97%
Q6S9V7	Katsuwonus pelamis	53%	97%
Q6S9V8	Thunnus obesus	53%	97%
Q6S9V9	Thunnus albacares	53%	97%
Q7ZVY5	Danio rerio	54%	97%
Q7ZWZ5	Xenopus laevis	55%	97%
Q86AV6	Dictyostelium discoideum	26%	88%
Q8EJW2	Shewanella oneidensis (strain MR-1)	24%	100%
Q8MQU6	Dictyostelium discoideum	23%	92%
Q8NSH7	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	25%	100%
Q8NSL1	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	27%	100%
Q8VHF5	Rattus norvegicus	53%	97%
Q937N9	Cupriavidus necator	25%	100%
Q9CZU6	Mus musculus	54%	98%
Q9LXS6	Arabidopsis thaliana	26%	88%
Q9LXS7	Arabidopsis thaliana	22%	94%
Q9M1D3	Arabidopsis thaliana	52%	98%
Q9RWB2	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	28%	100%
Q9SJH7	Arabidopsis thaliana	25%	89%
Q9TEM3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	45%	98%
Q9W401	Drosophila melanogaster	56%	98%
Q9ZN37	Helicobacter pylori (strain J99 / ATCC 700824)	28%	100%
V5BWC7	Trypanosoma cruzi	64%	96%