Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9H7_LEIBR

TriTrypDb:

LbrM.18.0750 , LBRM2903_180012500

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9H7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.659
CLV_C14_Caspase3-7	5	9	PF00656	0.542
CLV_C14_Caspase3-7	513	517	PF00656	0.519
CLV_C14_Caspase3-7	622	626	PF00656	0.725
CLV_NRD_NRD_1	264	266	PF00675	0.642
CLV_NRD_NRD_1	372	374	PF00675	0.602
CLV_NRD_NRD_1	628	630	PF00675	0.652
CLV_NRD_NRD_1	65	67	PF00675	0.683
CLV_NRD_NRD_1	696	698	PF00675	0.730
CLV_NRD_NRD_1	865	867	PF00675	0.615
CLV_NRD_NRD_1	883	885	PF00675	0.682
CLV_PCSK_FUR_1	862	866	PF00082	0.522
CLV_PCSK_KEX2_1	372	374	PF00082	0.571
CLV_PCSK_KEX2_1	468	470	PF00082	0.565
CLV_PCSK_KEX2_1	65	67	PF00082	0.683
CLV_PCSK_KEX2_1	696	698	PF00082	0.730
CLV_PCSK_KEX2_1	864	866	PF00082	0.546
CLV_PCSK_KEX2_1	883	885	PF00082	0.691
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.565
CLV_PCSK_PC7_1	692	698	PF00082	0.842
CLV_PCSK_SKI1_1	355	359	PF00082	0.608
CLV_PCSK_SKI1_1	629	633	PF00082	0.756
CLV_PCSK_SKI1_1	828	832	PF00082	0.475
CLV_PCSK_SKI1_1	865	869	PF00082	0.508
CLV_PCSK_SKI1_1	95	99	PF00082	0.726
DEG_APCC_DBOX_1	268	276	PF00400	0.659
DEG_SPOP_SBC_1	107	111	PF00917	0.559
DEG_SPOP_SBC_1	182	186	PF00917	0.566
DEG_SPOP_SBC_1	311	315	PF00917	0.529
DEG_SPOP_SBC_1	662	666	PF00917	0.557
DOC_CDC14_PxL_1	267	275	PF14671	0.567
DOC_CKS1_1	790	795	PF01111	0.538
DOC_CKS1_1	843	848	PF01111	0.611
DOC_CYCLIN_RxL_1	823	836	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.558
DOC_MAPK_DCC_7	265	275	PF00069	0.580
DOC_MAPK_gen_1	17	26	PF00069	0.567
DOC_MAPK_gen_1	265	275	PF00069	0.588
DOC_MAPK_gen_1	556	565	PF00069	0.551
DOC_MAPK_gen_1	65	72	PF00069	0.534
DOC_MAPK_gen_1	700	708	PF00069	0.570
DOC_MAPK_HePTP_8	410	422	PF00069	0.567
DOC_MAPK_HePTP_8	660	672	PF00069	0.570
DOC_MAPK_MEF2A_6	266	275	PF00069	0.573
DOC_MAPK_MEF2A_6	413	422	PF00069	0.668
DOC_MAPK_MEF2A_6	558	567	PF00069	0.586
DOC_MAPK_MEF2A_6	663	672	PF00069	0.573
DOC_MAPK_MEF2A_6	700	708	PF00069	0.570
DOC_PP1_RVXF_1	72	79	PF00149	0.528
DOC_PP2B_LxvP_1	157	160	PF13499	0.707
DOC_PP2B_LxvP_1	24	27	PF13499	0.556
DOC_PP2B_LxvP_1	609	612	PF13499	0.615
DOC_PP2B_LxvP_1	640	643	PF13499	0.690
DOC_PP2B_LxvP_1	766	769	PF13499	0.542
DOC_PP2B_LxvP_1	799	802	PF13499	0.641
DOC_PP4_FxxP_1	376	379	PF00568	0.680
DOC_PP4_FxxP_1	422	425	PF00568	0.459
DOC_USP7_MATH_1	105	109	PF00917	0.697
DOC_USP7_MATH_1	182	186	PF00917	0.566
DOC_USP7_MATH_1	196	200	PF00917	0.474
DOC_USP7_MATH_1	30	34	PF00917	0.793
DOC_USP7_MATH_1	311	315	PF00917	0.679
DOC_USP7_MATH_1	322	326	PF00917	0.716
DOC_USP7_MATH_1	377	381	PF00917	0.596
DOC_USP7_MATH_1	547	551	PF00917	0.645
DOC_USP7_MATH_1	612	616	PF00917	0.625
DOC_USP7_MATH_1	662	666	PF00917	0.627
DOC_USP7_MATH_1	802	806	PF00917	0.580
DOC_USP7_MATH_1	867	871	PF00917	0.471
DOC_USP7_UBL2_3	393	397	PF12436	0.554
DOC_WW_Pin1_4	151	156	PF00397	0.695
DOC_WW_Pin1_4	164	169	PF00397	0.697
DOC_WW_Pin1_4	178	183	PF00397	0.658
DOC_WW_Pin1_4	205	210	PF00397	0.550
DOC_WW_Pin1_4	307	312	PF00397	0.703
DOC_WW_Pin1_4	421	426	PF00397	0.459
DOC_WW_Pin1_4	459	464	PF00397	0.729
DOC_WW_Pin1_4	535	540	PF00397	0.600
DOC_WW_Pin1_4	548	553	PF00397	0.726
DOC_WW_Pin1_4	573	578	PF00397	0.812
DOC_WW_Pin1_4	670	675	PF00397	0.796
DOC_WW_Pin1_4	687	692	PF00397	0.783
DOC_WW_Pin1_4	789	794	PF00397	0.532
DOC_WW_Pin1_4	821	826	PF00397	0.504
DOC_WW_Pin1_4	842	847	PF00397	0.623
LIG_14-3-3_CanoR_1	115	121	PF00244	0.716
LIG_14-3-3_CanoR_1	219	228	PF00244	0.622
LIG_14-3-3_CanoR_1	236	242	PF00244	0.552
LIG_14-3-3_CanoR_1	355	361	PF00244	0.680
LIG_14-3-3_CanoR_1	409	413	PF00244	0.676
LIG_14-3-3_CanoR_1	49	55	PF00244	0.786
LIG_14-3-3_CanoR_1	558	565	PF00244	0.627
LIG_14-3-3_CanoR_1	588	597	PF00244	0.568
LIG_14-3-3_CanoR_1	605	610	PF00244	0.624
LIG_14-3-3_CanoR_1	629	639	PF00244	0.826
LIG_14-3-3_CanoR_1	692	698	PF00244	0.758
LIG_14-3-3_CanoR_1	727	734	PF00244	0.581
LIG_14-3-3_CanoR_1	866	874	PF00244	0.471
LIG_Actin_WH2_2	398	415	PF00022	0.692
LIG_FHA_1	145	151	PF00498	0.686
LIG_FHA_1	165	171	PF00498	0.486
LIG_FHA_1	223	229	PF00498	0.502
LIG_FHA_1	281	287	PF00498	0.683
LIG_FHA_1	558	564	PF00498	0.625
LIG_FHA_1	626	632	PF00498	0.636
LIG_FHA_1	843	849	PF00498	0.539
LIG_FHA_2	336	342	PF00498	0.498
LIG_FHA_2	454	460	PF00498	0.771
LIG_FHA_2	590	596	PF00498	0.557
LIG_FHA_2	620	626	PF00498	0.778
LIG_FHA_2	811	817	PF00498	0.512
LIG_FXI_DFP_1	720	724	PF00024	0.564
LIG_HCF-1_HBM_1	493	496	PF13415	0.402
LIG_Integrin_RGD_1	6	8	PF01839	0.543
LIG_LIR_Apic_2	411	417	PF02991	0.686
LIG_LIR_Gen_1	755	765	PF02991	0.445
LIG_LIR_LC3C_4	798	801	PF02991	0.532
LIG_LIR_Nem_3	303	308	PF02991	0.577
LIG_LIR_Nem_3	482	487	PF02991	0.572
LIG_LIR_Nem_3	755	760	PF02991	0.602
LIG_MYND_1	151	155	PF01753	0.557
LIG_SH2_CRK	477	481	PF00017	0.558
LIG_SH2_SRC	487	490	PF00017	0.556
LIG_SH2_SRC	841	844	PF00017	0.584
LIG_SH2_STAT5	298	301	PF00017	0.596
LIG_SH2_STAT5	308	311	PF00017	0.638
LIG_SH2_STAT5	487	490	PF00017	0.556
LIG_SH2_STAT5	761	764	PF00017	0.674
LIG_SH3_2	96	101	PF14604	0.572
LIG_SH3_3	12	18	PF00018	0.697
LIG_SH3_3	173	179	PF00018	0.797
LIG_SH3_3	24	30	PF00018	0.741
LIG_SH3_3	268	274	PF00018	0.653
LIG_SH3_3	671	677	PF00018	0.823
LIG_SH3_3	69	75	PF00018	0.557
LIG_SH3_3	710	716	PF00018	0.541
LIG_SH3_3	766	772	PF00018	0.648
LIG_SH3_3	787	793	PF00018	0.522
LIG_SH3_3	840	846	PF00018	0.590
LIG_SH3_3	93	99	PF00018	0.664
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.572
LIG_SUMO_SIM_anti_2	416	422	PF11976	0.557
LIG_SUMO_SIM_anti_2	67	74	PF11976	0.532
LIG_SUMO_SIM_anti_2	787	792	PF11976	0.505
LIG_SUMO_SIM_par_1	273	279	PF11976	0.538
LIG_SUMO_SIM_par_1	282	288	PF11976	0.576
LIG_SUMO_SIM_par_1	716	722	PF11976	0.553
LIG_SUMO_SIM_par_1	787	792	PF11976	0.474
LIG_SUMO_SIM_par_1	810	816	PF11976	0.525
LIG_SUMO_SIM_par_1	828	836	PF11976	0.405
LIG_TRAF2_1	462	465	PF00917	0.562
LIG_TYR_ITIM	475	480	PF00017	0.570
LIG_WRC_WIRS_1	488	493	PF05994	0.656
MOD_CDK_SPK_2	687	692	PF00069	0.597
MOD_CDK_SPxxK_3	183	190	PF00069	0.572
MOD_CDK_SPxxK_3	789	796	PF00069	0.488
MOD_CDK_SPxxK_3	821	828	PF00069	0.378
MOD_CK1_1	108	114	PF00069	0.584
MOD_CK1_1	116	122	PF00069	0.550
MOD_CK1_1	164	170	PF00069	0.632
MOD_CK1_1	180	186	PF00069	0.736
MOD_CK1_1	204	210	PF00069	0.622
MOD_CK1_1	310	316	PF00069	0.724
MOD_CK1_1	325	331	PF00069	0.597
MOD_CK1_1	408	414	PF00069	0.631
MOD_CK1_1	458	464	PF00069	0.682
MOD_CK1_1	48	54	PF00069	0.549
MOD_CK1_1	576	582	PF00069	0.824
MOD_CK1_1	661	667	PF00069	0.682
MOD_CK1_1	68	74	PF00069	0.637
MOD_CK1_1	680	686	PF00069	0.747
MOD_CK2_1	107	113	PF00069	0.637
MOD_CK2_1	207	213	PF00069	0.550
MOD_CK2_1	453	459	PF00069	0.768
MOD_CK2_1	487	493	PF00069	0.553
MOD_CK2_1	867	873	PF00069	0.477
MOD_GlcNHglycan	110	113	PF01048	0.672
MOD_GlcNHglycan	122	125	PF01048	0.525
MOD_GlcNHglycan	163	166	PF01048	0.559
MOD_GlcNHglycan	203	206	PF01048	0.555
MOD_GlcNHglycan	258	261	PF01048	0.560
MOD_GlcNHglycan	345	349	PF01048	0.519
MOD_GlcNHglycan	50	53	PF01048	0.753
MOD_GlcNHglycan	512	515	PF01048	0.662
MOD_GlcNHglycan	660	663	PF01048	0.742
MOD_GlcNHglycan	665	668	PF01048	0.689
MOD_GlcNHglycan	754	757	PF01048	0.614
MOD_GSK3_1	107	114	PF00069	0.658
MOD_GSK3_1	116	123	PF00069	0.635
MOD_GSK3_1	151	158	PF00069	0.689
MOD_GSK3_1	177	184	PF00069	0.591
MOD_GSK3_1	201	208	PF00069	0.696
MOD_GSK3_1	250	257	PF00069	0.649
MOD_GSK3_1	276	283	PF00069	0.667
MOD_GSK3_1	307	314	PF00069	0.740
MOD_GSK3_1	325	332	PF00069	0.478
MOD_GSK3_1	455	462	PF00069	0.672
MOD_GSK3_1	515	522	PF00069	0.611
MOD_GSK3_1	529	536	PF00069	0.550
MOD_GSK3_1	573	580	PF00069	0.732
MOD_GSK3_1	596	603	PF00069	0.707
MOD_GSK3_1	625	632	PF00069	0.792
MOD_GSK3_1	658	665	PF00069	0.640
MOD_GSK3_1	687	694	PF00069	0.702
MOD_GSK3_1	723	730	PF00069	0.703
MOD_GSK3_1	817	824	PF00069	0.497
MOD_N-GLC_1	289	294	PF02516	0.580
MOD_NEK2_1	106	111	PF00069	0.565
MOD_NEK2_1	237	242	PF00069	0.698
MOD_NEK2_1	312	317	PF00069	0.602
MOD_NEK2_1	335	340	PF00069	0.469
MOD_NEK2_1	563	568	PF00069	0.769
MOD_NEK2_1	619	624	PF00069	0.823
MOD_NEK2_1	723	728	PF00069	0.600
MOD_NEK2_1	784	789	PF00069	0.419
MOD_NEK2_1	848	853	PF00069	0.451
MOD_NEK2_1	89	94	PF00069	0.782
MOD_PIKK_1	222	228	PF00454	0.473
MOD_PIKK_1	363	369	PF00454	0.653
MOD_PIKK_1	40	46	PF00454	0.544
MOD_PIKK_1	524	530	PF00454	0.719
MOD_PIKK_1	557	563	PF00454	0.596
MOD_PIKK_1	612	618	PF00454	0.583
MOD_PIKK_1	691	697	PF00454	0.669
MOD_PIKK_1	767	773	PF00454	0.742
MOD_PKA_1	629	635	PF00069	0.786
MOD_PKA_1	65	71	PF00069	0.678
MOD_PKA_2	114	120	PF00069	0.735
MOD_PKA_2	220	226	PF00069	0.614
MOD_PKA_2	235	241	PF00069	0.599
MOD_PKA_2	408	414	PF00069	0.702
MOD_PKA_2	48	54	PF00069	0.748
MOD_PKA_2	557	563	PF00069	0.755
MOD_PKA_2	604	610	PF00069	0.694
MOD_PKA_2	65	71	PF00069	0.639
MOD_PKA_2	691	697	PF00069	0.758
MOD_PKA_2	737	743	PF00069	0.650
MOD_PKA_2	89	95	PF00069	0.781
MOD_Plk_1	244	250	PF00069	0.597
MOD_Plk_1	40	46	PF00069	0.544
MOD_Plk_1	68	74	PF00069	0.637
MOD_Plk_1	723	729	PF00069	0.570
MOD_Plk_4	244	250	PF00069	0.682
MOD_Plk_4	280	286	PF00069	0.685
MOD_Plk_4	377	383	PF00069	0.620
MOD_Plk_4	487	493	PF00069	0.553
MOD_Plk_4	596	602	PF00069	0.711
MOD_Plk_4	68	74	PF00069	0.534
MOD_Plk_4	779	785	PF00069	0.625
MOD_Plk_4	817	823	PF00069	0.545
MOD_ProDKin_1	151	157	PF00069	0.697
MOD_ProDKin_1	164	170	PF00069	0.700
MOD_ProDKin_1	178	184	PF00069	0.660
MOD_ProDKin_1	205	211	PF00069	0.551
MOD_ProDKin_1	307	313	PF00069	0.706
MOD_ProDKin_1	421	427	PF00069	0.469
MOD_ProDKin_1	459	465	PF00069	0.729
MOD_ProDKin_1	535	541	PF00069	0.601
MOD_ProDKin_1	548	554	PF00069	0.723
MOD_ProDKin_1	573	579	PF00069	0.814
MOD_ProDKin_1	670	676	PF00069	0.789
MOD_ProDKin_1	687	693	PF00069	0.785
MOD_ProDKin_1	789	795	PF00069	0.535
MOD_ProDKin_1	821	827	PF00069	0.502
MOD_ProDKin_1	842	848	PF00069	0.611
MOD_SUMO_rev_2	885	892	PF00179	0.549
TRG_DiLeu_BaEn_1	416	421	PF01217	0.557
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.573
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.568
TRG_DiLeu_BaLyEn_6	568	573	PF01217	0.779
TRG_DiLeu_BaLyEn_6	825	830	PF01217	0.398
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.773
TRG_ENDOCYTIC_2	477	480	PF00928	0.559
TRG_ER_diArg_1	16	19	PF00400	0.692
TRG_ER_diArg_1	372	375	PF00400	0.598
TRG_ER_diArg_1	435	438	PF00400	0.661
TRG_ER_diArg_1	696	698	PF00400	0.731
TRG_ER_diArg_1	861	864	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G3	Leptomonas seymouri	32%	100%
A0A3S7WUV1	Leishmania donovani	63%	100%
A4HXU3	Leishmania infantum	63%	100%
E9ARK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4QDX4	Leishmania major	60%	95%