HEAT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HEAT repeats, putative

Species:

Leishmania braziliensis

UniProt:

A4H9H6_LEIBR

TriTrypDb:

LbrM.18.0740 , LBRM2903_180012400

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9H6

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.352
CLV_C14_Caspase3-7	670	674	PF00656	0.527
CLV_C14_Caspase3-7	9	13	PF00656	0.574
CLV_NRD_NRD_1	210	212	PF00675	0.383
CLV_NRD_NRD_1	367	369	PF00675	0.312
CLV_PCSK_KEX2_1	210	212	PF00082	0.519
CLV_PCSK_KEX2_1	406	408	PF00082	0.451
CLV_PCSK_KEX2_1	450	452	PF00082	0.496
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.451
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.474
CLV_PCSK_SKI1_1	231	235	PF00082	0.423
CLV_PCSK_SKI1_1	313	317	PF00082	0.422
CLV_PCSK_SKI1_1	46	50	PF00082	0.334
CLV_PCSK_SKI1_1	516	520	PF00082	0.401
CLV_PCSK_SKI1_1	526	530	PF00082	0.340
CLV_PCSK_SKI1_1	574	578	PF00082	0.400
CLV_PCSK_SKI1_1	85	89	PF00082	0.303
CLV_Separin_Metazoa	265	269	PF03568	0.272
CLV_Separin_Metazoa	310	314	PF03568	0.479
DEG_APCC_DBOX_1	424	432	PF00400	0.333
DEG_SCF_TRCP1_1	645	650	PF00400	0.636
DEG_SPOP_SBC_1	484	488	PF00917	0.353
DEG_SPOP_SBC_1	692	696	PF00917	0.534
DOC_CKS1_1	419	424	PF01111	0.482
DOC_CKS1_1	682	687	PF01111	0.534
DOC_CYCLIN_RxL_1	412	421	PF00134	0.469
DOC_MAPK_gen_1	450	457	PF00069	0.459
DOC_MAPK_MEF2A_6	231	240	PF00069	0.380
DOC_MAPK_MEF2A_6	450	459	PF00069	0.339
DOC_MAPK_NFAT4_5	231	239	PF00069	0.474
DOC_PP1_RVXF_1	266	272	PF00149	0.479
DOC_PP1_RVXF_1	359	366	PF00149	0.339
DOC_PP4_FxxP_1	271	274	PF00568	0.467
DOC_USP7_MATH_1	291	295	PF00917	0.375
DOC_USP7_MATH_1	319	323	PF00917	0.405
DOC_USP7_MATH_1	436	440	PF00917	0.402
DOC_USP7_MATH_1	471	475	PF00917	0.407
DOC_USP7_MATH_1	685	689	PF00917	0.622
DOC_WW_Pin1_4	305	310	PF00397	0.380
DOC_WW_Pin1_4	324	329	PF00397	0.523
DOC_WW_Pin1_4	418	423	PF00397	0.540
DOC_WW_Pin1_4	457	462	PF00397	0.434
DOC_WW_Pin1_4	647	652	PF00397	0.787
DOC_WW_Pin1_4	671	676	PF00397	0.525
DOC_WW_Pin1_4	681	686	PF00397	0.515
LIG_14-3-3_CanoR_1	210	214	PF00244	0.376
LIG_14-3-3_CanoR_1	231	237	PF00244	0.469
LIG_14-3-3_CanoR_1	297	303	PF00244	0.393
LIG_14-3-3_CanoR_1	313	320	PF00244	0.419
LIG_14-3-3_CanoR_1	368	372	PF00244	0.332
LIG_14-3-3_CanoR_1	385	393	PF00244	0.371
LIG_14-3-3_CanoR_1	485	490	PF00244	0.348
LIG_Actin_WH2_2	564	580	PF00022	0.292
LIG_APCC_ABBA_1	312	317	PF00400	0.339
LIG_BIR_III_2	79	83	PF00653	0.440
LIG_BRCT_BRCA1_1	462	466	PF00533	0.475
LIG_EH1_1	375	383	PF00400	0.376
LIG_FHA_1	1	7	PF00498	0.708
LIG_FHA_1	189	195	PF00498	0.415
LIG_FHA_1	531	537	PF00498	0.381
LIG_FHA_1	562	568	PF00498	0.485
LIG_FHA_1	617	623	PF00498	0.649
LIG_FHA_1	682	688	PF00498	0.533
LIG_FHA_1	693	699	PF00498	0.565
LIG_FHA_2	116	122	PF00498	0.473
LIG_FHA_2	223	229	PF00498	0.445
LIG_GBD_Chelix_1	173	181	PF00786	0.303
LIG_LIR_Gen_1	105	116	PF02991	0.314
LIG_LIR_Gen_1	118	128	PF02991	0.327
LIG_LIR_Gen_1	235	245	PF02991	0.475
LIG_LIR_Gen_1	289	299	PF02991	0.379
LIG_LIR_Gen_1	347	357	PF02991	0.374
LIG_LIR_Gen_1	414	423	PF02991	0.433
LIG_LIR_LC3C_4	564	568	PF02991	0.481
LIG_LIR_Nem_3	105	111	PF02991	0.320
LIG_LIR_Nem_3	118	123	PF02991	0.305
LIG_LIR_Nem_3	16	22	PF02991	0.469
LIG_LIR_Nem_3	168	173	PF02991	0.359
LIG_LIR_Nem_3	235	240	PF02991	0.468
LIG_LIR_Nem_3	289	295	PF02991	0.382
LIG_LIR_Nem_3	330	335	PF02991	0.367
LIG_LIR_Nem_3	414	419	PF02991	0.328
LIG_LIR_Nem_3	463	469	PF02991	0.468
LIG_LIR_Nem_3	486	492	PF02991	0.465
LIG_LIR_Nem_3	504	510	PF02991	0.434
LIG_LIR_Nem_3	56	62	PF02991	0.331
LIG_NRBOX	294	300	PF00104	0.458
LIG_PCNA_PIPBox_1	109	118	PF02747	0.402
LIG_PCNA_PIPBox_1	230	239	PF02747	0.365
LIG_PCNA_PIPBox_1	86	95	PF02747	0.456
LIG_PCNA_yPIPBox_3	85	93	PF02747	0.456
LIG_Pex14_2	185	189	PF04695	0.479
LIG_SH2_CRK	108	112	PF00017	0.396
LIG_SH2_CRK	170	174	PF00017	0.348
LIG_SH2_CRK	335	339	PF00017	0.459
LIG_SH2_GRB2like	507	510	PF00017	0.490
LIG_SH2_NCK_1	489	493	PF00017	0.457
LIG_SH2_PTP2	237	240	PF00017	0.356
LIG_SH2_SRC	489	492	PF00017	0.459
LIG_SH2_SRC	62	65	PF00017	0.481
LIG_SH2_STAP1	356	360	PF00017	0.334
LIG_SH2_STAP1	62	66	PF00017	0.480
LIG_SH2_STAT5	237	240	PF00017	0.372
LIG_SH2_STAT5	332	335	PF00017	0.426
LIG_SH2_STAT5	510	513	PF00017	0.408
LIG_SH2_STAT5	531	534	PF00017	0.310
LIG_SH3_3	322	328	PF00018	0.539
LIG_SH3_3	458	464	PF00018	0.430
LIG_Sin3_3	416	423	PF02671	0.479
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.337
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.379
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.458
LIG_SUMO_SIM_anti_2	590	596	PF11976	0.517
LIG_SUMO_SIM_par_1	131	136	PF11976	0.470
LIG_SUMO_SIM_par_1	190	197	PF11976	0.472
LIG_SUMO_SIM_par_1	46	52	PF11976	0.412
LIG_SUMO_SIM_par_1	468	474	PF11976	0.473
LIG_TRAF2_1	13	16	PF00917	0.625
LIG_TRAF2_1	225	228	PF00917	0.519
LIG_TRAF2_1	600	603	PF00917	0.580
LIG_UBA3_1	398	406	PF00899	0.470
LIG_UBA3_1	549	555	PF00899	0.436
LIG_WRC_WIRS_1	73	78	PF05994	0.487
MOD_CDK_SPxxK_3	418	425	PF00069	0.517
MOD_CK1_1	187	193	PF00069	0.483
MOD_CK1_1	202	208	PF00069	0.322
MOD_CK1_1	327	333	PF00069	0.484
MOD_CK1_1	40	46	PF00069	0.346
MOD_CK1_1	460	466	PF00069	0.421
MOD_CK1_1	65	71	PF00069	0.497
MOD_CK1_1	681	687	PF00069	0.767
MOD_CK1_1	694	700	PF00069	0.719
MOD_CK2_1	115	121	PF00069	0.479
MOD_CK2_1	222	228	PF00069	0.459
MOD_CK2_1	371	377	PF00069	0.310
MOD_CK2_1	477	483	PF00069	0.366
MOD_CK2_1	484	490	PF00069	0.331
MOD_GlcNHglycan	260	263	PF01048	0.516
MOD_GlcNHglycan	546	549	PF01048	0.519
MOD_GlcNHglycan	64	67	PF01048	0.429
MOD_GlcNHglycan	645	648	PF01048	0.637
MOD_GlcNHglycan	687	690	PF01048	0.808
MOD_GSK3_1	184	191	PF00069	0.481
MOD_GSK3_1	199	206	PF00069	0.374
MOD_GSK3_1	232	239	PF00069	0.391
MOD_GSK3_1	301	308	PF00069	0.390
MOD_GSK3_1	367	374	PF00069	0.326
MOD_GSK3_1	643	650	PF00069	0.634
MOD_GSK3_1	681	688	PF00069	0.757
MOD_N-GLC_1	202	207	PF02516	0.359
MOD_N-GLC_1	622	627	PF02516	0.467
MOD_N-GLC_1	671	676	PF02516	0.525
MOD_NEK2_1	189	194	PF00069	0.446
MOD_NEK2_1	236	241	PF00069	0.374
MOD_NEK2_1	298	303	PF00069	0.369
MOD_NEK2_1	371	376	PF00069	0.316
MOD_NEK2_1	381	386	PF00069	0.400
MOD_NEK2_1	477	482	PF00069	0.365
MOD_NEK2_1	53	58	PF00069	0.380
MOD_NEK2_1	577	582	PF00069	0.418
MOD_NEK2_1	6	11	PF00069	0.547
MOD_NEK2_1	72	77	PF00069	0.297
MOD_PIKK_1	598	604	PF00454	0.577
MOD_PIKK_1	616	622	PF00454	0.633
MOD_PIKK_1	678	684	PF00454	0.527
MOD_PIKK_1	7	13	PF00454	0.578
MOD_PIKK_1	74	80	PF00454	0.494
MOD_PKA_2	209	215	PF00069	0.377
MOD_PKA_2	367	373	PF00069	0.353
MOD_PKA_2	384	390	PF00069	0.383
MOD_PKA_2	484	490	PF00069	0.349
MOD_PKA_2	577	583	PF00069	0.347
MOD_Plk_1	202	208	PF00069	0.352
MOD_Plk_1	24	30	PF00069	0.369
MOD_Plk_1	281	287	PF00069	0.398
MOD_Plk_1	40	46	PF00069	0.451
MOD_Plk_1	477	483	PF00069	0.376
MOD_Plk_4	189	195	PF00069	0.404
MOD_Plk_4	232	238	PF00069	0.415
MOD_Plk_4	355	361	PF00069	0.327
MOD_Plk_4	465	471	PF00069	0.357
MOD_Plk_4	477	483	PF00069	0.381
MOD_Plk_4	510	516	PF00069	0.404
MOD_ProDKin_1	305	311	PF00069	0.373
MOD_ProDKin_1	324	330	PF00069	0.512
MOD_ProDKin_1	418	424	PF00069	0.534
MOD_ProDKin_1	457	463	PF00069	0.428
MOD_ProDKin_1	647	653	PF00069	0.787
MOD_ProDKin_1	671	677	PF00069	0.527
MOD_ProDKin_1	681	687	PF00069	0.515
TRG_DiLeu_BaEn_1	377	382	PF01217	0.471
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.449
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.340
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.342
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.333
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.353
TRG_ENDOCYTIC_2	108	111	PF00928	0.309
TRG_ENDOCYTIC_2	170	173	PF00928	0.360
TRG_ENDOCYTIC_2	237	240	PF00928	0.372
TRG_ENDOCYTIC_2	292	295	PF00928	0.350
TRG_ENDOCYTIC_2	356	359	PF00928	0.337
TRG_ENDOCYTIC_2	489	492	PF00928	0.459
TRG_ER_diArg_1	209	211	PF00400	0.516
TRG_ER_diArg_1	287	290	PF00400	0.502
TRG_ER_diArg_1	442	445	PF00400	0.424
TRG_ER_diArg_1	523	526	PF00400	0.428
TRG_NES_CRM1_1	26	39	PF08389	0.492
TRG_NES_CRM1_1	426	440	PF08389	0.366
TRG_NES_CRM1_1	90	102	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHR7	Leptomonas seymouri	87%	97%
A0A0S4J1S0	Bodo saltans	54%	100%
A0A1X0P6U3	Trypanosomatidae	58%	100%
A0A3Q8IBL0	Leishmania donovani	23%	100%
A0A3R7KDP1	Trypanosoma rangeli	55%	100%
A0A3S7WUV3	Leishmania donovani	93%	100%
A4HXU2	Leishmania infantum	93%	100%
A4HYP6	Leishmania infantum	23%	100%
C9ZZW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AIC2	Leishmania braziliensis	25%	100%
E9ARK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P30153	Homo sapiens	21%	100%
P30154	Homo sapiens	21%	100%
P36179	Drosophila melanogaster	22%	100%
P54612	Sus scrofa	21%	100%
P54613	Sus scrofa	21%	100%
Q32PI5	Bos taurus	21%	100%
Q38950	Arabidopsis thaliana	22%	100%
Q38951	Arabidopsis thaliana	22%	100%
Q4QCX5	Leishmania major	23%	100%
Q4QDX5	Leishmania major	93%	100%
Q4QQT4	Rattus norvegicus	20%	100%
Q54QR9	Dictyostelium discoideum	23%	100%
Q76MZ3	Mus musculus	21%	100%
V5DN32	Trypanosoma cruzi	54%	100%