Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H9H3_LEIBR

TriTrypDb:

LbrM.18.0710 , LBRM2903_180011900

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9H3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	457	461	PF00656	0.556
CLV_C14_Caspase3-7	481	485	PF00656	0.440
CLV_NRD_NRD_1	10	12	PF00675	0.794
CLV_NRD_NRD_1	170	172	PF00675	0.839
CLV_NRD_NRD_1	184	186	PF00675	0.638
CLV_NRD_NRD_1	350	352	PF00675	0.758
CLV_NRD_NRD_1	37	39	PF00675	0.770
CLV_NRD_NRD_1	380	382	PF00675	0.642
CLV_NRD_NRD_1	449	451	PF00675	0.715
CLV_NRD_NRD_1	516	518	PF00675	0.555
CLV_NRD_NRD_1	537	539	PF00675	0.744
CLV_NRD_NRD_1	83	85	PF00675	0.614
CLV_PCSK_KEX2_1	170	172	PF00082	0.839
CLV_PCSK_KEX2_1	184	186	PF00082	0.638
CLV_PCSK_KEX2_1	350	352	PF00082	0.758
CLV_PCSK_KEX2_1	36	38	PF00082	0.761
CLV_PCSK_KEX2_1	379	381	PF00082	0.793
CLV_PCSK_KEX2_1	449	451	PF00082	0.715
CLV_PCSK_KEX2_1	516	518	PF00082	0.555
CLV_PCSK_KEX2_1	537	539	PF00082	0.744
CLV_PCSK_KEX2_1	83	85	PF00082	0.614
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.761
CLV_PCSK_PC7_1	512	518	PF00082	0.540
CLV_PCSK_PC7_1	79	85	PF00082	0.608
CLV_PCSK_SKI1_1	24	28	PF00082	0.776
CLV_PCSK_SKI1_1	494	498	PF00082	0.550
CLV_PCSK_SKI1_1	512	516	PF00082	0.535
CLV_PCSK_SKI1_1	537	541	PF00082	0.743
CLV_PCSK_SKI1_1	65	69	PF00082	0.594
DEG_APCC_DBOX_1	357	365	PF00400	0.836
DEG_APCC_DBOX_1	471	479	PF00400	0.502
DEG_APCC_DBOX_1	516	524	PF00400	0.556
DEG_Nend_UBRbox_3	1	3	PF02207	0.506
DEG_SCF_FBW7_1	94	101	PF00400	0.844
DEG_SPOP_SBC_1	245	249	PF00917	0.803
DEG_SPOP_SBC_1	397	401	PF00917	0.562
DEG_SPOP_SBC_1	406	410	PF00917	0.561
DEG_SPOP_SBC_1	455	459	PF00917	0.637
DOC_CDC14_PxL_1	68	76	PF14671	0.579
DOC_MAPK_gen_1	21	29	PF00069	0.778
DOC_MAPK_gen_1	488	497	PF00069	0.429
DOC_PP1_RVXF_1	492	498	PF00149	0.434
DOC_PP2B_LxvP_1	267	270	PF13499	0.585
DOC_PP2B_LxvP_1	74	77	PF13499	0.700
DOC_PP4_FxxP_1	113	116	PF00568	0.600
DOC_USP7_MATH_1	118	122	PF00917	0.610
DOC_USP7_MATH_1	165	169	PF00917	0.586
DOC_USP7_MATH_1	189	193	PF00917	0.621
DOC_USP7_MATH_1	208	212	PF00917	0.548
DOC_USP7_MATH_1	237	241	PF00917	0.732
DOC_USP7_MATH_1	245	249	PF00917	0.810
DOC_USP7_MATH_1	281	285	PF00917	0.669
DOC_USP7_MATH_1	397	401	PF00917	0.701
DOC_USP7_MATH_1	406	410	PF00917	0.813
DOC_USP7_MATH_1	455	459	PF00917	0.751
DOC_USP7_MATH_1	464	468	PF00917	0.710
DOC_USP7_MATH_1	98	102	PF00917	0.802
DOC_USP7_UBL2_3	65	69	PF12436	0.847
DOC_WW_Pin1_4	104	109	PF00397	0.646
DOC_WW_Pin1_4	112	117	PF00397	0.536
DOC_WW_Pin1_4	120	125	PF00397	0.599
DOC_WW_Pin1_4	201	206	PF00397	0.827
DOC_WW_Pin1_4	231	236	PF00397	0.619
DOC_WW_Pin1_4	277	282	PF00397	0.762
DOC_WW_Pin1_4	290	295	PF00397	0.678
DOC_WW_Pin1_4	351	356	PF00397	0.812
DOC_WW_Pin1_4	460	465	PF00397	0.769
DOC_WW_Pin1_4	84	89	PF00397	0.738
DOC_WW_Pin1_4	94	99	PF00397	0.659
LIG_14-3-3_CanoR_1	207	213	PF00244	0.791
LIG_14-3-3_CanoR_1	273	281	PF00244	0.775
LIG_14-3-3_CanoR_1	396	403	PF00244	0.620
LIG_14-3-3_CanoR_1	472	480	PF00244	0.535
LIG_14-3-3_CanoR_1	53	57	PF00244	0.638
LIG_BRCT_BRCA1_1	365	369	PF00533	0.765
LIG_CSL_BTD_1	108	111	PF09270	0.827
LIG_FHA_1	409	415	PF00498	0.625
LIG_FHA_1	475	481	PF00498	0.684
LIG_FHA_2	479	485	PF00498	0.449
LIG_LIR_Apic_2	55	59	PF02991	0.587
LIG_LIR_Gen_1	441	451	PF02991	0.445
LIG_LIR_Nem_3	107	112	PF02991	0.814
LIG_LIR_Nem_3	144	150	PF02991	0.858
LIG_LIR_Nem_3	441	447	PF02991	0.435
LIG_MLH1_MIPbox_1	366	370	PF16413	0.812
LIG_MYND_1	312	316	PF01753	0.589
LIG_MYND_1	72	76	PF01753	0.704
LIG_NRBOX	474	480	PF00104	0.490
LIG_Pex14_1	109	113	PF04695	0.835
LIG_Pex14_2	365	369	PF04695	0.816
LIG_REV1ctd_RIR_1	367	373	PF16727	0.802
LIG_SH2_CRK	444	448	PF00017	0.441
LIG_SH2_GRB2like	333	336	PF00017	0.556
LIG_SH2_SRC	333	336	PF00017	0.556
LIG_SH2_SRC	4	7	PF00017	0.752
LIG_SH2_STAT5	333	336	PF00017	0.556
LIG_SH2_STAT5	4	7	PF00017	0.752
LIG_SH2_STAT5	444	447	PF00017	0.436
LIG_SH2_STAT5	549	552	PF00017	0.756
LIG_SH3_1	70	76	PF00018	0.574
LIG_SH3_2	19	24	PF14604	0.546
LIG_SH3_2	205	210	PF14604	0.553
LIG_SH3_2	294	299	PF14604	0.741
LIG_SH3_3	105	111	PF00018	0.828
LIG_SH3_3	16	22	PF00018	0.554
LIG_SH3_3	202	208	PF00018	0.691
LIG_SH3_3	239	245	PF00018	0.579
LIG_SH3_3	291	297	PF00018	0.838
LIG_SH3_3	310	316	PF00018	0.530
LIG_SH3_3	349	355	PF00018	0.846
LIG_SH3_3	356	362	PF00018	0.735
LIG_SH3_3	70	76	PF00018	0.793
LIG_SH3_3	82	88	PF00018	0.697
LIG_SUMO_SIM_anti_2	258	265	PF11976	0.574
LIG_SUMO_SIM_par_1	284	290	PF11976	0.603
LIG_SUMO_SIM_par_1	476	482	PF11976	0.492
LIG_TRAF2_1	522	525	PF00917	0.547
LIG_WW_3	296	300	PF00397	0.712
LIG_WW_3	76	80	PF00397	0.835
MOD_CDC14_SPxK_1	123	126	PF00782	0.608
MOD_CDC14_SPxK_1	204	207	PF00782	0.811
MOD_CDC14_SPxK_1	296	299	PF00782	0.706
MOD_CDK_SPxK_1	120	126	PF00069	0.612
MOD_CDK_SPxK_1	201	207	PF00069	0.826
MOD_CDK_SPxK_1	293	299	PF00069	0.703
MOD_CDK_SPxxK_3	351	358	PF00069	0.812
MOD_CK1_1	119	125	PF00069	0.766
MOD_CK1_1	192	198	PF00069	0.713
MOD_CK1_1	231	237	PF00069	0.586
MOD_CK1_1	275	281	PF00069	0.841
MOD_CK1_1	282	288	PF00069	0.736
MOD_CK1_1	290	296	PF00069	0.596
MOD_CK1_1	354	360	PF00069	0.786
MOD_CK1_1	363	369	PF00069	0.726
MOD_CK1_1	399	405	PF00069	0.751
MOD_CK1_1	408	414	PF00069	0.781
MOD_CK1_1	458	464	PF00069	0.801
MOD_CK1_1	467	473	PF00069	0.629
MOD_CK1_1	7	13	PF00069	0.528
MOD_CK2_1	190	196	PF00069	0.867
MOD_CK2_1	256	262	PF00069	0.826
MOD_CK2_1	28	34	PF00069	0.655
MOD_CK2_1	519	525	PF00069	0.555
MOD_CMANNOS	213	216	PF00535	0.762
MOD_DYRK1A_RPxSP_1	351	355	PF00069	0.812
MOD_DYRK1A_RPxSP_1	84	88	PF00069	0.859
MOD_GlcNHglycan	157	161	PF01048	0.570
MOD_GlcNHglycan	192	195	PF01048	0.865
MOD_GlcNHglycan	196	200	PF01048	0.796
MOD_GlcNHglycan	230	233	PF01048	0.583
MOD_GlcNHglycan	281	284	PF01048	0.695
MOD_GlcNHglycan	289	292	PF01048	0.577
MOD_GlcNHglycan	366	369	PF01048	0.810
MOD_GlcNHglycan	404	407	PF01048	0.831
MOD_GlcNHglycan	460	463	PF01048	0.586
MOD_GlcNHglycan	48	51	PF01048	0.686
MOD_GlcNHglycan	512	515	PF01048	0.576
MOD_GSK3_1	112	119	PF00069	0.537
MOD_GSK3_1	142	149	PF00069	0.691
MOD_GSK3_1	227	234	PF00069	0.829
MOD_GSK3_1	252	259	PF00069	0.727
MOD_GSK3_1	275	282	PF00069	0.808
MOD_GSK3_1	360	367	PF00069	0.794
MOD_GSK3_1	398	405	PF00069	0.776
MOD_GSK3_1	454	461	PF00069	0.792
MOD_GSK3_1	464	471	PF00069	0.632
MOD_GSK3_1	474	481	PF00069	0.409
MOD_GSK3_1	48	55	PF00069	0.586
MOD_GSK3_1	94	101	PF00069	0.844
MOD_N-GLC_1	432	437	PF02516	0.713
MOD_NEK2_1	190	195	PF00069	0.751
MOD_NEK2_1	246	251	PF00069	0.588
MOD_NEK2_1	28	33	PF00069	0.756
MOD_NEK2_1	364	369	PF00069	0.818
MOD_NEK2_1	454	459	PF00069	0.547
MOD_NEK2_1	52	57	PF00069	0.695
MOD_PKA_2	130	136	PF00069	0.850
MOD_PKA_2	142	148	PF00069	0.651
MOD_PKA_2	20	26	PF00069	0.790
MOD_PKA_2	272	278	PF00069	0.781
MOD_PKA_2	357	363	PF00069	0.837
MOD_PKA_2	383	389	PF00069	0.814
MOD_PKA_2	471	477	PF00069	0.558
MOD_PKA_2	52	58	PF00069	0.606
MOD_Plk_1	325	331	PF00069	0.569
MOD_Plk_1	432	438	PF00069	0.708
MOD_Plk_2-3	432	438	PF00069	0.495
MOD_Plk_4	282	288	PF00069	0.600
MOD_Plk_4	360	366	PF00069	0.826
MOD_Plk_4	474	480	PF00069	0.490
MOD_Plk_4	98	104	PF00069	0.620
MOD_ProDKin_1	104	110	PF00069	0.647
MOD_ProDKin_1	112	118	PF00069	0.536
MOD_ProDKin_1	120	126	PF00069	0.600
MOD_ProDKin_1	201	207	PF00069	0.826
MOD_ProDKin_1	231	237	PF00069	0.619
MOD_ProDKin_1	277	283	PF00069	0.763
MOD_ProDKin_1	290	296	PF00069	0.678
MOD_ProDKin_1	351	357	PF00069	0.812
MOD_ProDKin_1	460	466	PF00069	0.767
MOD_ProDKin_1	84	90	PF00069	0.740
MOD_ProDKin_1	94	100	PF00069	0.658
MOD_SUMO_rev_2	460	470	PF00179	0.770
TRG_ENDOCYTIC_2	444	447	PF00928	0.431
TRG_ER_diArg_1	170	172	PF00400	0.839
TRG_ER_diArg_1	350	352	PF00400	0.758
TRG_ER_diArg_1	37	40	PF00400	0.519
TRG_ER_diArg_1	378	381	PF00400	0.552
TRG_ER_diArg_1	449	451	PF00400	0.715
TRG_ER_diArg_1	536	538	PF00400	0.757
TRG_ER_diArg_1	83	85	PF00400	0.614
TRG_NLS_MonoExtC_3	35	40	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.707
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.730

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WV31	Leishmania donovani	61%	100%
A4HXT9	Leishmania infantum	62%	100%
E9ARK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	99%
Q4QDX8	Leishmania major	61%	99%