Putative 60S ribosomal protein L10a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L10a, putative

Species:

Leishmania braziliensis

UniProt:

A4H9H2_LEIBR

TriTrypDb:

LbrM.18.0700 , LBRM2903_180011800

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	12
GO:0032991	protein-containing complex	1	12
GO:0044391	ribosomal subunit	3	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1

Expansion

Sequence features

A4H9H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9H2

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.338
CLV_PCSK_KEX2_1	44	46	PF00082	0.327
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.327
CLV_PCSK_SKI1_1	157	161	PF00082	0.343
CLV_PCSK_SKI1_1	23	27	PF00082	0.327
CLV_PCSK_SKI1_1	95	99	PF00082	0.313
DOC_CDC14_PxL_1	114	122	PF14671	0.311
DOC_CYCLIN_RxL_1	153	164	PF00134	0.320
DOC_MAPK_gen_1	21	31	PF00069	0.330
DOC_MAPK_gen_1	42	52	PF00069	0.361
DOC_MAPK_gen_1	57	64	PF00069	0.327
DOC_MAPK_MEF2A_6	177	186	PF00069	0.311
DOC_MAPK_MEF2A_6	24	33	PF00069	0.327
DOC_MAPK_MEF2A_6	57	64	PF00069	0.327
DOC_MAPK_NFAT4_5	26	34	PF00069	0.257
DOC_PP2B_LxvP_1	50	53	PF13499	0.453
DOC_USP7_MATH_1	137	141	PF00917	0.453
DOC_USP7_UBL2_3	153	157	PF12436	0.311
DOC_USP7_UBL2_3	88	92	PF12436	0.311
DOC_USP7_UBL2_3	94	98	PF12436	0.311
DOC_WW_Pin1_4	133	138	PF00397	0.453
DOC_WW_Pin1_4	2	7	PF00397	0.399
LIG_14-3-3_CanoR_1	149	153	PF00244	0.453
LIG_14-3-3_CanoR_1	57	63	PF00244	0.327
LIG_Actin_WH2_2	141	159	PF00022	0.311
LIG_Actin_WH2_2	183	201	PF00022	0.311
LIG_BIR_II_1	1	5	PF00653	0.506
LIG_FHA_1	140	146	PF00498	0.326
LIG_FHA_1	59	65	PF00498	0.327
LIG_FHA_2	6	12	PF00498	0.595
LIG_NRBOX	186	192	PF00104	0.311
LIG_SH2_STAP1	104	108	PF00017	0.343
LIG_SH2_STAT3	38	41	PF00017	0.327
LIG_SH2_STAT5	202	205	PF00017	0.345
LIG_SH3_3	131	137	PF00018	0.453
LIG_SH3_3	52	58	PF00018	0.350
LIG_SUMO_SIM_par_1	142	151	PF11976	0.349
MOD_CK1_1	2	8	PF00069	0.394
MOD_CK2_1	133	139	PF00069	0.342
MOD_CK2_1	5	11	PF00069	0.603
MOD_GlcNHglycan	199	202	PF01048	0.345
MOD_GlcNHglycan	46	49	PF01048	0.327
MOD_GSK3_1	109	116	PF00069	0.403
MOD_GSK3_1	133	140	PF00069	0.453
MOD_N-GLC_2	54	56	PF02516	0.371
MOD_NEK2_1	148	153	PF00069	0.358
MOD_NEK2_1	186	191	PF00069	0.328
MOD_NEK2_1	46	51	PF00069	0.327
MOD_PKA_1	44	50	PF00069	0.351
MOD_PKA_2	148	154	PF00069	0.473
MOD_PKA_2	44	50	PF00069	0.327
MOD_PKA_2	58	64	PF00069	0.327
MOD_Plk_4	109	115	PF00069	0.328
MOD_Plk_4	186	192	PF00069	0.357
MOD_ProDKin_1	133	139	PF00069	0.453
MOD_ProDKin_1	2	8	PF00069	0.394
MOD_SUMO_for_1	74	77	PF00179	0.369
MOD_SUMO_rev_2	20	25	PF00179	0.352
MOD_SUMO_rev_2	85	90	PF00179	0.336
TRG_DiLeu_BaEn_4	85	91	PF01217	0.322
TRG_ENDOCYTIC_2	104	107	PF00928	0.343
TRG_ER_diArg_1	57	60	PF00400	0.327
TRG_NES_CRM1_1	7	22	PF08389	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKG0	Leptomonas seymouri	92%	100%
A0A0S4J1H1	Bodo saltans	73%	88%
A0A0S4JHJ4	Bodo saltans	83%	100%
A0A1X0P4H6	Trypanosomatidae	87%	100%
A0A3R7JXU7	Trypanosoma rangeli	89%	100%
A0A3S5H732	Leishmania donovani	95%	100%
A0B922	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	30%	100%
A0RX07	Cenarchaeum symbiosum (strain A)	28%	100%
A1AX78	Ruthia magnifica subsp. Calyptogena magnifica	28%	93%
A1RRR1	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	26%	96%
A1RWQ3	Thermofilum pendens (strain DSM 2475 / Hrk 5)	28%	95%
A1WVD2	Halorhodospira halophila (strain DSM 244 / SL1)	28%	93%
A2BN64	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	26%	99%
A2STT9	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	30%	100%
A3CSJ6	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	30%	100%
A3DNI1	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	27%	100%
A3MX83	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	28%	96%
A4FZS7	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	28%	100%
A4HPP4	Leishmania braziliensis	100%	100%
A4HXT8	Leishmania infantum	95%	100%
A4WL88	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	28%	96%
A4YH88	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	26%	98%
A5U9X7	Haemophilus influenzae (strain PittEE)	29%	93%
A5UH21	Haemophilus influenzae (strain PittGG)	28%	93%
A5UKU9	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	30%	100%
A6UTF9	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	28%	100%
A6VIQ0	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	29%	100%
A6VKC8	Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z)	28%	93%
A7IAK4	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	29%	100%
A9A837	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	29%	100%
B0R4W2	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	23%	100%
B1L6L3	Korarchaeum cryptofilum (strain OPF8)	26%	95%
B1YAC8	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	29%	96%
B5FC91	Aliivibrio fischeri (strain MJ11)	26%	91%
B7F845	Oryza sativa subsp. japonica	58%	99%
B8B9K6	Oryza sativa subsp. indica	58%	99%
B9LTD6	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	23%	100%
C9ZZX2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
E9ARK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O14363	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	57%	99%
O15613	Entamoeba histolytica	42%	100%
O27716	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	29%	100%
O28782	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	100%
O52704	Methanothermococcus thermolithotrophicus	30%	100%
O57782	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	27%	98%
O74836	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	56%	99%
P0CX43	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	99%
P0CX44	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	99%
P12738	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	24%	100%
P13575	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	23%	100%
P15824	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	27%	100%
P35024	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	26%	97%
P41199	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	25%	100%
P44342	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	93%
P53026	Mus musculus	55%	99%
P53027	Sus scrofa	53%	100%
P53028	Trypanosoma brucei rhodesiense	87%	100%
P54050	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	98%
P59230	Arabidopsis thaliana	58%	99%
P59231	Arabidopsis thaliana	57%	99%
P62906	Homo sapiens	56%	99%
P62907	Rattus norvegicus	56%	99%
P96038	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	28%	98%
Q0W050	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	28%	100%
Q12UP9	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	26%	100%
Q18G90	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	26%	100%
Q2FQ32	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	29%	100%
Q2NEW1	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	29%	100%
Q3ILQ3	Pseudoalteromonas translucida (strain TAC 125)	27%	91%
Q3INI6	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	23%	100%
Q3J8Q4	Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)	26%	93%
Q46EU8	Methanosarcina barkeri (strain Fusaro / DSM 804)	25%	100%
Q4QDX9	Leishmania major	95%	100%
Q4QN32	Haemophilus influenzae (strain 86-028NP)	28%	93%
Q4R5P3	Macaca fascicularis	55%	99%
Q5E234	Aliivibrio fischeri (strain ATCC 700601 / ES114)	26%	91%
Q5E9E6	Bos taurus	56%	99%
Q5JH35	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	30%	99%
Q5PBG7	Anaplasma marginale (strain St. Maries)	27%	99%
Q65W45	Mannheimia succiniciproducens (strain MBEL55E)	29%	93%
Q6FRF5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	54%	99%
Q6L1X9	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	28%	100%
Q6M0L0	Methanococcus maripaludis (strain S2 / LL)	28%	100%
Q6PC69	Danio rerio	57%	99%
Q74M51	Nanoarchaeum equitans (strain Kin4-M)	28%	100%
Q755D9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	54%	99%
Q7MGR5	Vibrio vulnificus (strain YJ016)	26%	92%
Q7RZS0	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	53%	99%
Q7ZYS8	Xenopus laevis	56%	99%
Q86L05	Dictyostelium discoideum	50%	99%
Q8DD23	Vibrio vulnificus (strain CMCP6)	26%	92%
Q8PY52	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	26%	100%
Q8SRY5	Encephalitozoon cuniculi (strain GB-M1)	24%	98%
Q8TI81	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	25%	100%
Q8TX51	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	26%	100%
Q8TZJ9	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	26%	99%
Q8VZB9	Arabidopsis thaliana	58%	99%
Q8ZTT4	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	28%	96%
Q90YV8	Ictalurus punctatus	56%	99%
Q963B6	Spodoptera frugiperda	57%	99%
Q971J1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	28%	98%
Q97BN2	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	27%	99%
Q9CK86	Pasteurella multocida (strain Pm70)	29%	93%
Q9HL71	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	26%	99%
Q9N4I4	Caenorhabditis elegans	56%	99%
Q9SW75	Chlamydomonas reinhardtii	55%	100%
Q9UVJ4	Candida albicans (strain SC5314 / ATCC MYA-2876)	54%	99%
Q9UWR8	Pyrococcus abyssi (strain GE5 / Orsay)	26%	98%
Q9VTP4	Drosophila melanogaster	56%	99%
Q9Y8J2	Methanococcus voltae	27%	100%
Q9Y9W6	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	26%	99%