RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in Ran binding protein and others/FYVE zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4H9G8_LEIBR

TriTrypDb:

LbrM.18.0660 , LBRM2903_180011400

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9G8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	485	489	PF00656	0.528
CLV_C14_Caspase3-7	490	494	PF00656	0.527
CLV_NRD_NRD_1	247	249	PF00675	0.457
CLV_NRD_NRD_1	258	260	PF00675	0.463
CLV_NRD_NRD_1	520	522	PF00675	0.377
CLV_NRD_NRD_1	582	584	PF00675	0.283
CLV_NRD_NRD_1	632	634	PF00675	0.591
CLV_PCSK_FUR_1	245	249	PF00082	0.485
CLV_PCSK_KEX2_1	247	249	PF00082	0.481
CLV_PCSK_KEX2_1	477	479	PF00082	0.683
CLV_PCSK_KEX2_1	530	532	PF00082	0.416
CLV_PCSK_KEX2_1	582	584	PF00082	0.287
CLV_PCSK_KEX2_1	632	634	PF00082	0.547
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.683
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.416
DEG_APCC_DBOX_1	236	244	PF00400	0.439
DEG_APCC_DBOX_1	274	282	PF00400	0.377
DEG_MDM2_SWIB_1	380	388	PF02201	0.514
DEG_Nend_UBRbox_3	1	3	PF02207	0.685
DEG_SPOP_SBC_1	198	202	PF00917	0.588
DEG_SPOP_SBC_1	374	378	PF00917	0.675
DOC_CKS1_1	68	73	PF01111	0.503
DOC_PP2B_LxvP_1	129	132	PF13499	0.523
DOC_PP4_FxxP_1	27	30	PF00568	0.674
DOC_PP4_FxxP_1	515	518	PF00568	0.377
DOC_PP4_MxPP_1	134	137	PF00568	0.525
DOC_USP7_MATH_1	121	125	PF00917	0.754
DOC_USP7_MATH_1	156	160	PF00917	0.603
DOC_USP7_MATH_1	198	202	PF00917	0.740
DOC_USP7_MATH_1	226	230	PF00917	0.698
DOC_USP7_MATH_1	318	322	PF00917	0.647
DOC_USP7_MATH_1	349	353	PF00917	0.495
DOC_USP7_MATH_1	360	364	PF00917	0.548
DOC_USP7_MATH_1	430	434	PF00917	0.713
DOC_USP7_MATH_1	460	464	PF00917	0.449
DOC_USP7_MATH_1	595	599	PF00917	0.377
DOC_USP7_UBL2_3	397	401	PF12436	0.471
DOC_USP7_UBL2_3	473	477	PF12436	0.526
DOC_USP7_UBL2_3	626	630	PF12436	0.493
DOC_WW_Pin1_4	110	115	PF00397	0.703
DOC_WW_Pin1_4	123	128	PF00397	0.694
DOC_WW_Pin1_4	314	319	PF00397	0.719
DOC_WW_Pin1_4	352	357	PF00397	0.460
DOC_WW_Pin1_4	358	363	PF00397	0.630
DOC_WW_Pin1_4	375	380	PF00397	0.514
DOC_WW_Pin1_4	408	413	PF00397	0.462
DOC_WW_Pin1_4	67	72	PF00397	0.711
LIG_14-3-3_CanoR_1	290	296	PF00244	0.564
LIG_BIR_III_2	155	159	PF00653	0.497
LIG_BRCT_BRCA1_1	376	380	PF00533	0.420
LIG_FHA_1	412	418	PF00498	0.665
LIG_FHA_1	576	582	PF00498	0.348
LIG_FHA_1	68	74	PF00498	0.502
LIG_IBAR_NPY_1	2	4	PF08397	0.681
LIG_LIR_Apic_2	101	105	PF02991	0.572
LIG_LIR_Apic_2	113	118	PF02991	0.797
LIG_LIR_Apic_2	24	30	PF02991	0.667
LIG_LIR_Apic_2	291	296	PF02991	0.428
LIG_LIR_Apic_2	512	518	PF02991	0.326
LIG_LIR_Apic_2	598	603	PF02991	0.377
LIG_LIR_Gen_1	50	58	PF02991	0.665
LIG_LIR_Gen_1	575	581	PF02991	0.348
LIG_LIR_Nem_3	50	54	PF02991	0.688
LIG_LIR_Nem_3	575	580	PF02991	0.319
LIG_LIR_Nem_3	76	80	PF02991	0.503
LIG_Pex14_2	380	384	PF04695	0.515
LIG_PTAP_UEV_1	157	162	PF05743	0.491
LIG_SH2_CRK	102	106	PF00017	0.688
LIG_SH2_CRK	115	119	PF00017	0.653
LIG_SH2_CRK	293	297	PF00017	0.622
LIG_SH2_CRK	5	9	PF00017	0.567
LIG_SH2_CRK	51	55	PF00017	0.694
LIG_SH2_CRK	600	604	PF00017	0.348
LIG_SH2_GRB2like	80	83	PF00017	0.506
LIG_SH2_NCK_1	102	106	PF00017	0.574
LIG_SH2_NCK_1	293	297	PF00017	0.622
LIG_SH2_NCK_1	5	9	PF00017	0.567
LIG_SH2_NCK_1	58	62	PF00017	0.799
LIG_SH2_PTP2	40	43	PF00017	0.577
LIG_SH2_STAP1	179	183	PF00017	0.514
LIG_SH2_STAP1	535	539	PF00017	0.498
LIG_SH2_STAT3	179	182	PF00017	0.536
LIG_SH2_STAT5	293	296	PF00017	0.612
LIG_SH2_STAT5	40	43	PF00017	0.577
LIG_SH2_STAT5	591	594	PF00017	0.317
LIG_SH3_1	115	121	PF00018	0.742
LIG_SH3_1	40	46	PF00018	0.573
LIG_SH3_3	115	121	PF00018	0.644
LIG_SH3_3	135	141	PF00018	0.573
LIG_SH3_3	155	161	PF00018	0.674
LIG_SH3_3	210	216	PF00018	0.662
LIG_SH3_3	389	395	PF00018	0.431
LIG_SH3_3	40	46	PF00018	0.629
LIG_SH3_3	414	420	PF00018	0.693
LIG_SH3_3	433	439	PF00018	0.664
LIG_SH3_3	65	71	PF00018	0.557
LIG_SUMO_SIM_par_1	211	217	PF11976	0.482
LIG_TRAF2_1	231	234	PF00917	0.563
LIG_TRAF2_1	548	551	PF00917	0.554
LIG_WRC_WIRS_1	271	276	PF05994	0.366
LIG_WRC_WIRS_1	446	451	PF05994	0.500
LIG_WW_1	48	51	PF00397	0.626
LIG_WW_2	436	439	PF00397	0.603
MOD_CDK_SPxxK_3	352	359	PF00069	0.391
MOD_CK1_1	125	131	PF00069	0.805
MOD_CK1_1	17	23	PF00069	0.665
MOD_CK1_1	199	205	PF00069	0.576
MOD_CK1_1	270	276	PF00069	0.291
MOD_CK1_1	288	294	PF00069	0.406
MOD_CK1_1	314	320	PF00069	0.598
MOD_CK1_1	352	358	PF00069	0.530
MOD_CK1_1	445	451	PF00069	0.452
MOD_CK1_1	486	492	PF00069	0.609
MOD_CK1_1	501	507	PF00069	0.485
MOD_CK1_1	598	604	PF00069	0.348
MOD_CK1_1	86	92	PF00069	0.692
MOD_CK2_1	228	234	PF00069	0.585
MOD_CK2_1	493	499	PF00069	0.516
MOD_CK2_1	563	569	PF00069	0.377
MOD_Cter_Amidation	519	522	PF01082	0.377
MOD_GlcNHglycan	110	113	PF01048	0.728
MOD_GlcNHglycan	158	161	PF01048	0.725
MOD_GlcNHglycan	201	204	PF01048	0.795
MOD_GlcNHglycan	207	210	PF01048	0.761
MOD_GlcNHglycan	223	226	PF01048	0.562
MOD_GlcNHglycan	230	233	PF01048	0.485
MOD_GlcNHglycan	290	293	PF01048	0.624
MOD_GlcNHglycan	313	316	PF01048	0.627
MOD_GlcNHglycan	352	355	PF01048	0.511
MOD_GlcNHglycan	362	365	PF01048	0.595
MOD_GlcNHglycan	403	406	PF01048	0.562
MOD_GlcNHglycan	432	435	PF01048	0.624
MOD_GlcNHglycan	453	456	PF01048	0.418
MOD_GlcNHglycan	462	465	PF01048	0.469
MOD_GlcNHglycan	495	498	PF01048	0.565
MOD_GlcNHglycan	59	62	PF01048	0.694
MOD_GlcNHglycan	88	91	PF01048	0.730
MOD_GSK3_1	121	128	PF00069	0.761
MOD_GSK3_1	197	204	PF00069	0.675
MOD_GSK3_1	263	270	PF00069	0.206
MOD_GSK3_1	314	321	PF00069	0.594
MOD_GSK3_1	374	381	PF00069	0.526
MOD_GSK3_1	411	418	PF00069	0.530
MOD_GSK3_1	445	452	PF00069	0.465
MOD_GSK3_1	483	490	PF00069	0.551
MOD_GSK3_1	53	60	PF00069	0.699
MOD_GSK3_1	598	605	PF00069	0.386
MOD_N-GLC_1	121	126	PF02516	0.507
MOD_N-GLC_1	408	413	PF02516	0.481
MOD_N-GLC_1	421	426	PF02516	0.630
MOD_N-GLC_1	430	435	PF02516	0.465
MOD_N-GLC_1	483	488	PF02516	0.517
MOD_N-GLC_1	598	603	PF02516	0.293
MOD_N-GLC_1	83	88	PF02516	0.712
MOD_N-GLC_2	571	573	PF02516	0.283
MOD_NEK2_1	285	290	PF00069	0.334
MOD_NEK2_1	449	454	PF00069	0.420
MOD_NEK2_2	83	88	PF00069	0.687
MOD_PKA_2	17	23	PF00069	0.665
MOD_PKA_2	350	356	PF00069	0.537
MOD_PKA_2	486	492	PF00069	0.657
MOD_Plk_1	449	455	PF00069	0.534
MOD_Plk_1	563	569	PF00069	0.377
MOD_Plk_1	598	604	PF00069	0.384
MOD_Plk_1	83	89	PF00069	0.655
MOD_Plk_2-3	563	569	PF00069	0.377
MOD_Plk_4	125	131	PF00069	0.573
MOD_Plk_4	437	443	PF00069	0.516
MOD_Plk_4	511	517	PF00069	0.377
MOD_Plk_4	83	89	PF00069	0.707
MOD_ProDKin_1	110	116	PF00069	0.706
MOD_ProDKin_1	123	129	PF00069	0.698
MOD_ProDKin_1	314	320	PF00069	0.716
MOD_ProDKin_1	352	358	PF00069	0.471
MOD_ProDKin_1	375	381	PF00069	0.550
MOD_ProDKin_1	408	414	PF00069	0.472
MOD_ProDKin_1	67	73	PF00069	0.713
MOD_SUMO_for_1	281	284	PF00179	0.377
MOD_SUMO_for_1	548	551	PF00179	0.592
MOD_SUMO_rev_2	623	628	PF00179	0.510
TRG_DiLeu_BaEn_4	233	239	PF01217	0.515
TRG_ENDOCYTIC_2	51	54	PF00928	0.689
TRG_ER_diArg_1	244	247	PF00400	0.460
TRG_ER_diArg_1	581	583	PF00400	0.377
TRG_ER_diArg_1	632	634	PF00400	0.547
TRG_NLS_MonoExtC_3	628	633	PF00514	0.525
TRG_NLS_MonoExtN_4	626	633	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D5	Leptomonas seymouri	54%	100%
A0A0S4J4U6	Bodo saltans	33%	92%
A0A3Q8I9Y5	Leishmania donovani	80%	100%
A4HXT6	Leishmania infantum	80%	100%
C9ZZX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ARJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QDY1	Leishmania major	80%	99%