Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9G7_LEIBR

TriTrypDb:

LbrM.18.0650 , LBRM2903_180011300

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H9G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9G7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.637
CLV_PCSK_SKI1_1	199	203	PF00082	0.247
DEG_Nend_UBRbox_2	1	3	PF02207	0.638
DOC_CKS1_1	113	118	PF01111	0.608
DOC_CKS1_1	156	161	PF01111	0.570
DOC_CKS1_1	303	308	PF01111	0.617
DOC_CKS1_1	330	335	PF01111	0.517
DOC_CKS1_1	402	407	PF01111	0.624
DOC_CKS1_1	62	67	PF01111	0.479
DOC_PP1_RVXF_1	254	260	PF00149	0.415
DOC_PP4_FxxP_1	259	262	PF00568	0.458
DOC_USP7_MATH_1	102	106	PF00917	0.609
DOC_USP7_MATH_1	129	133	PF00917	0.585
DOC_USP7_MATH_1	238	242	PF00917	0.458
DOC_USP7_MATH_1	260	264	PF00917	0.552
DOC_USP7_MATH_1	322	326	PF00917	0.499
DOC_USP7_MATH_1	44	48	PF00917	0.541
DOC_WW_Pin1_4	112	117	PF00397	0.617
DOC_WW_Pin1_4	144	149	PF00397	0.573
DOC_WW_Pin1_4	155	160	PF00397	0.588
DOC_WW_Pin1_4	27	32	PF00397	0.583
DOC_WW_Pin1_4	302	307	PF00397	0.754
DOC_WW_Pin1_4	329	334	PF00397	0.671
DOC_WW_Pin1_4	34	39	PF00397	0.664
DOC_WW_Pin1_4	361	366	PF00397	0.617
DOC_WW_Pin1_4	401	406	PF00397	0.630
DOC_WW_Pin1_4	52	57	PF00397	0.440
DOC_WW_Pin1_4	61	66	PF00397	0.580
LIG_14-3-3_CanoR_1	140	148	PF00244	0.658
LIG_14-3-3_CanoR_1	237	243	PF00244	0.473
LIG_14-3-3_CanoR_1	266	273	PF00244	0.460
LIG_AP2alpha_2	406	408	PF02296	0.484
LIG_BRCT_BRCA1_1	108	112	PF00533	0.620
LIG_BRCT_BRCA1_1	181	185	PF00533	0.434
LIG_BRCT_BRCA1_1	92	96	PF00533	0.619
LIG_FHA_1	152	158	PF00498	0.589
LIG_FHA_1	250	256	PF00498	0.447
LIG_FHA_1	6	12	PF00498	0.499
LIG_FHA_2	364	370	PF00498	0.631
LIG_Integrin_isoDGR_2	218	220	PF01839	0.247
LIG_LIR_Apic_2	302	306	PF02991	0.618
LIG_LIR_Nem_3	224	229	PF02991	0.447
LIG_LIR_Nem_3	93	99	PF02991	0.559
LIG_MLH1_MIPbox_1	108	112	PF16413	0.622
LIG_SH2_CRK	113	117	PF00017	0.543
LIG_SH2_CRK	303	307	PF00017	0.618
LIG_SH2_NCK_1	113	117	PF00017	0.608
LIG_SH2_NCK_1	12	16	PF00017	0.644
LIG_SH2_NCK_1	297	301	PF00017	0.603
LIG_SH2_NCK_1	303	307	PF00017	0.531
LIG_SH2_STAP1	127	131	PF00017	0.539
LIG_SH2_STAP1	297	301	PF00017	0.579
LIG_SH2_STAT5	32	35	PF00017	0.629
LIG_SH2_STAT5	349	352	PF00017	0.581
LIG_SH2_STAT5	392	395	PF00017	0.563
LIG_SH2_STAT5	403	406	PF00017	0.562
LIG_SH2_STAT5	63	66	PF00017	0.511
LIG_SH3_3	244	250	PF00018	0.574
LIG_SH3_3	267	273	PF00018	0.459
LIG_SH3_3	285	291	PF00018	0.624
LIG_SH3_3	337	343	PF00018	0.528
LIG_SH3_3	59	65	PF00018	0.567
LIG_UBA3_1	208	212	PF00899	0.447
MOD_CK1_1	10	16	PF00069	0.622
MOD_CK1_1	221	227	PF00069	0.447
MOD_CK1_1	231	237	PF00069	0.447
MOD_CK1_1	268	274	PF00069	0.507
MOD_CK1_1	277	283	PF00069	0.458
MOD_CK1_1	34	40	PF00069	0.599
MOD_CK1_1	361	367	PF00069	0.576
MOD_CK1_1	412	418	PF00069	0.505
MOD_CK1_1	55	61	PF00069	0.584
MOD_CK1_1	90	96	PF00069	0.618
MOD_CK2_1	204	210	PF00069	0.494
MOD_CK2_1	238	244	PF00069	0.473
MOD_GlcNHglycan	104	107	PF01048	0.584
MOD_GlcNHglycan	108	111	PF01048	0.638
MOD_GlcNHglycan	127	130	PF01048	0.678
MOD_GlcNHglycan	13	16	PF01048	0.576
MOD_GlcNHglycan	131	134	PF01048	0.536
MOD_GlcNHglycan	172	175	PF01048	0.501
MOD_GlcNHglycan	223	226	PF01048	0.247
MOD_GlcNHglycan	232	236	PF01048	0.247
MOD_GlcNHglycan	276	279	PF01048	0.567
MOD_GlcNHglycan	285	288	PF01048	0.492
MOD_GlcNHglycan	69	72	PF01048	0.450
MOD_GlcNHglycan	96	99	PF01048	0.601
MOD_GSK3_1	102	109	PF00069	0.456
MOD_GSK3_1	111	118	PF00069	0.580
MOD_GSK3_1	125	132	PF00069	0.618
MOD_GSK3_1	140	147	PF00069	0.483
MOD_GSK3_1	151	158	PF00069	0.605
MOD_GSK3_1	16	23	PF00069	0.533
MOD_GSK3_1	261	268	PF00069	0.549
MOD_GSK3_1	27	34	PF00069	0.652
MOD_GSK3_1	274	281	PF00069	0.533
MOD_GSK3_1	322	329	PF00069	0.700
MOD_GSK3_1	359	366	PF00069	0.571
MOD_GSK3_1	393	400	PF00069	0.483
MOD_GSK3_1	408	415	PF00069	0.471
MOD_GSK3_1	54	61	PF00069	0.571
MOD_GSK3_1	63	70	PF00069	0.629
MOD_GSK3_1	7	14	PF00069	0.583
MOD_GSK3_1	87	94	PF00069	0.600
MOD_N-GLC_1	129	134	PF02516	0.532
MOD_N-GLC_1	20	25	PF02516	0.615
MOD_N-GLC_1	34	39	PF02516	0.460
MOD_N-GLC_1	87	92	PF02516	0.598
MOD_NEK2_1	11	16	PF00069	0.542
MOD_NEK2_1	111	116	PF00069	0.641
MOD_NEK2_1	358	363	PF00069	0.583
MOD_NEK2_1	408	413	PF00069	0.779
MOD_NEK2_1	87	92	PF00069	0.612
MOD_PIKK_1	115	121	PF00454	0.465
MOD_PIKK_1	151	157	PF00454	0.598
MOD_PIKK_1	265	271	PF00454	0.451
MOD_PIKK_1	393	399	PF00454	0.515
MOD_PIKK_1	409	415	PF00454	0.469
MOD_PIKK_1	5	11	PF00454	0.566
MOD_PIKK_1	87	93	PF00454	0.571
MOD_PKA_2	265	271	PF00069	0.454
MOD_Plk_1	20	26	PF00069	0.492
MOD_Plk_4	204	210	PF00069	0.494
MOD_Plk_4	278	284	PF00069	0.619
MOD_Plk_4	58	64	PF00069	0.570
MOD_Plk_4	7	13	PF00069	0.721
MOD_ProDKin_1	112	118	PF00069	0.616
MOD_ProDKin_1	144	150	PF00069	0.575
MOD_ProDKin_1	155	161	PF00069	0.585
MOD_ProDKin_1	27	33	PF00069	0.583
MOD_ProDKin_1	302	308	PF00069	0.753
MOD_ProDKin_1	329	335	PF00069	0.672
MOD_ProDKin_1	34	40	PF00069	0.666
MOD_ProDKin_1	361	367	PF00069	0.615
MOD_ProDKin_1	401	407	PF00069	0.625
MOD_ProDKin_1	52	58	PF00069	0.444
MOD_ProDKin_1	61	67	PF00069	0.577
MOD_SUMO_rev_2	207	214	PF00179	0.392
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.247

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z4	Leptomonas seymouri	44%	87%
A0A3S7WUU6	Leishmania donovani	80%	100%
A4HXT4	Leishmania infantum	80%	100%
E9ARJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QDY3	Leishmania major	79%	97%
Q74ZS6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	22%	73%