Putative peroxisomal enoyl-coa hydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisomal enoyl-coa hydratase, putative

Species:

Leishmania braziliensis

UniProt:

A4H9G6_LEIBR

TriTrypDb:

LbrM.18.0640 , LBRM2903_180011200

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9G6

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	9
GO:0006629	lipid metabolic process	3	9
GO:0006631	fatty acid metabolic process	4	9
GO:0006635	fatty acid beta-oxidation	6	9
GO:0008152	metabolic process	1	9
GO:0009056	catabolic process	2	9
GO:0009062	fatty acid catabolic process	5	9
GO:0009987	cellular process	1	9
GO:0016042	lipid catabolic process	4	9
GO:0016054	organic acid catabolic process	4	9
GO:0019395	fatty acid oxidation	5	9
GO:0019752	carboxylic acid metabolic process	5	9
GO:0030258	lipid modification	4	9
GO:0032787	monocarboxylic acid metabolic process	6	9
GO:0034440	lipid oxidation	5	9
GO:0043436	oxoacid metabolic process	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044242	cellular lipid catabolic process	4	9
GO:0044248	cellular catabolic process	3	9
GO:0044255	cellular lipid metabolic process	3	9
GO:0044281	small molecule metabolic process	2	9
GO:0044282	small molecule catabolic process	3	9
GO:0046395	carboxylic acid catabolic process	5	9
GO:0071704	organic substance metabolic process	2	9
GO:0072329	monocarboxylic acid catabolic process	6	9
GO:1901575	organic substance catabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004300	enoyl-CoA hydratase activity	5	6
GO:0016829	lyase activity	2	6
GO:0016835	carbon-oxygen lyase activity	3	6
GO:0016836	hydro-lyase activity	4	6
GO:0016853	isomerase activity	2	1
GO:0016860	intramolecular oxidoreductase activity	3	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	1
GO:0051750	delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.381
CLV_PCSK_KEX2_1	301	303	PF00082	0.410
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.381
CLV_PCSK_SKI1_1	260	264	PF00082	0.398
DEG_Nend_UBRbox_1	1	4	PF02207	0.592
DOC_CYCLIN_RxL_1	204	215	PF00134	0.350
DOC_CYCLIN_RxL_1	43	52	PF00134	0.336
DOC_MAPK_gen_1	46	53	PF00069	0.488
DOC_PP1_RVXF_1	205	212	PF00149	0.350
DOC_WW_Pin1_4	249	254	PF00397	0.317
LIG_14-3-3_CanoR_1	170	178	PF00244	0.345
LIG_14-3-3_CanoR_1	269	277	PF00244	0.427
LIG_APCC_ABBA_1	303	308	PF00400	0.235
LIG_APCC_ABBAyCdc20_2	302	308	PF00400	0.392
LIG_CaM_IQ_9	121	137	PF13499	0.410
LIG_FHA_1	159	165	PF00498	0.289
LIG_FHA_1	175	181	PF00498	0.467
LIG_FHA_1	204	210	PF00498	0.445
LIG_FHA_1	257	263	PF00498	0.458
LIG_FHA_1	61	67	PF00498	0.325
LIG_FHA_2	210	216	PF00498	0.410
LIG_FHA_2	271	277	PF00498	0.437
LIG_LIR_Gen_1	232	241	PF02991	0.293
LIG_LIR_Nem_3	215	219	PF02991	0.443
LIG_LIR_Nem_3	232	237	PF02991	0.412
LIG_NRBOX	61	67	PF00104	0.432
LIG_RPA_C_Fungi	237	249	PF08784	0.350
LIG_SH2_CRK	234	238	PF00017	0.289
LIG_SH2_STAP1	234	238	PF00017	0.289
LIG_SH2_STAT5	171	174	PF00017	0.392
LIG_SH2_STAT5	55	58	PF00017	0.300
LIG_SH3_2	41	46	PF14604	0.515
LIG_SH3_3	38	44	PF00018	0.534
LIG_SUMO_SIM_par_1	32	38	PF11976	0.450
MOD_CK1_1	162	168	PF00069	0.316
MOD_CK1_1	97	103	PF00069	0.534
MOD_CK2_1	176	182	PF00069	0.350
MOD_CK2_1	270	276	PF00069	0.429
MOD_GlcNHglycan	102	105	PF01048	0.574
MOD_GlcNHglycan	164	167	PF01048	0.321
MOD_GlcNHglycan	233	237	PF01048	0.297
MOD_GlcNHglycan	37	40	PF01048	0.464
MOD_GlcNHglycan	8	11	PF01048	0.536
MOD_GlcNHglycan	87	90	PF01048	0.340
MOD_GlcNHglycan	96	99	PF01048	0.453
MOD_GSK3_1	110	117	PF00069	0.583
MOD_GSK3_1	158	165	PF00069	0.350
MOD_GSK3_1	170	177	PF00069	0.187
MOD_GSK3_1	60	67	PF00069	0.496
MOD_N-GLC_1	311	316	PF02516	0.464
MOD_NEK2_1	114	119	PF00069	0.586
MOD_NEK2_1	209	214	PF00069	0.316
MOD_NEK2_2	176	181	PF00069	0.410
MOD_PKA_2	169	175	PF00069	0.406
MOD_Plk_1	232	238	PF00069	0.235
MOD_Plk_4	12	18	PF00069	0.496
MOD_Plk_4	159	165	PF00069	0.289
MOD_ProDKin_1	249	255	PF00069	0.317
MOD_SUMO_rev_2	113	120	PF00179	0.428
MOD_SUMO_rev_2	215	224	PF00179	0.337
MOD_SUMO_rev_2	24	33	PF00179	0.557
TRG_DiLeu_BaEn_1	61	66	PF01217	0.432
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.554
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.337
TRG_ENDOCYTIC_2	234	237	PF00928	0.410
TRG_ER_diArg_1	143	146	PF00400	0.350
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVP1	Leptomonas seymouri	71%	100%
A0A0S4IPV6	Bodo saltans	25%	100%
A0A0S4J4R9	Bodo saltans	43%	97%
A0A0S4JCT1	Bodo saltans	26%	100%
A0A3Q8IIZ5	Leishmania donovani	29%	100%
A0A3S7WUX8	Leishmania donovani	85%	100%
A4HHN0	Leishmania braziliensis	29%	100%
A4HXT3	Leishmania infantum	85%	100%
A4I4U5	Leishmania infantum	29%	100%
A4YI89	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	27%	100%
A8ALR7	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	27%	100%
B4TIG9	Salmonella heidelberg (strain SL476)	27%	100%
B4TWR3	Salmonella schwarzengrund (strain CVM19633)	27%	100%
B5R1Q9	Salmonella enteritidis PT4 (strain P125109)	27%	100%
B5RGA4	Salmonella gallinarum (strain 287/91 / NCTC 13346)	27%	100%
D0A2C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AE93	Leishmania major	29%	100%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ARJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O35459	Mus musculus	36%	99%
P52045	Escherichia coli (strain K12)	25%	100%
P64015	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	27%	100%
P76082	Escherichia coli (strain K12)	27%	100%
P94549	Bacillus subtilis (strain 168)	26%	100%
P9WNP0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WNP1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q13011	Homo sapiens	36%	98%
Q1ZXF1	Dictyostelium discoideum	26%	100%
Q2TBT3	Bos taurus	27%	100%
Q3TLP5	Mus musculus	26%	100%
Q4QDY4	Leishmania major	86%	100%
Q52995	Rhizobium meliloti (strain 1021)	25%	100%
Q5RFG0	Pongo abelii	36%	98%
Q62651	Rattus norvegicus	36%	99%
Q6NL24	Arabidopsis thaliana	27%	100%
Q86YB7	Homo sapiens	26%	100%
Q8ZRX5	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	27%	100%
Q9FHR8	Arabidopsis thaliana	35%	100%
V5BWB9	Trypanosoma cruzi	45%	88%
V5DTT7	Trypanosoma cruzi	27%	100%