V-type proton ATPase subunit C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar ATP synthase subunit c, putative

Species:

Leishmania braziliensis

UniProt:

A4H9G4_LEIBR

TriTrypDb:

LbrM.18.0620 , LBRM2903_180011000

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	12
GO:0033180	proton-transporting V-type ATPase, V1 domain	4	12
GO:0098796	membrane protein complex	2	12
GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain	5	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9G4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005215	transporter activity	1	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015078	proton transmembrane transporter activity	5	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0015399	primary active transmembrane transporter activity	4	12
GO:0016787	hydrolase activity	2	8
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022853	active monoatomic ion transmembrane transporter activity	4	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	12
GO:0042626	ATPase-coupled transmembrane transporter activity	2	12
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	12
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	12
GO:0140657	ATP-dependent activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.367
CLV_NRD_NRD_1	272	274	PF00675	0.360
CLV_NRD_NRD_1	283	285	PF00675	0.334
CLV_NRD_NRD_1	370	372	PF00675	0.369
CLV_PCSK_FUR_1	284	288	PF00082	0.367
CLV_PCSK_KEX2_1	286	288	PF00082	0.364
CLV_PCSK_KEX2_1	372	374	PF00082	0.451
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.353
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.451
CLV_PCSK_SKI1_1	141	145	PF00082	0.386
CLV_PCSK_SKI1_1	175	179	PF00082	0.351
CLV_PCSK_SKI1_1	21	25	PF00082	0.713
CLV_PCSK_SKI1_1	26	30	PF00082	0.728
CLV_PCSK_SKI1_1	315	319	PF00082	0.371
DOC_CDC14_PxL_1	39	47	PF14671	0.386
DOC_CKS1_1	381	386	PF01111	0.436
DOC_MAPK_DCC_7	72	81	PF00069	0.367
DOC_MAPK_gen_1	193	201	PF00069	0.351
DOC_MAPK_gen_1	202	210	PF00069	0.351
DOC_MAPK_gen_1	313	322	PF00069	0.332
DOC_MAPK_MEF2A_6	354	362	PF00069	0.365
DOC_MAPK_MEF2A_6	72	81	PF00069	0.367
DOC_PP1_RVXF_1	24	30	PF00149	0.525
DOC_PP2B_LxvP_1	360	363	PF13499	0.472
DOC_PP2B_LxvP_1	40	43	PF13499	0.386
DOC_PP4_FxxP_1	349	352	PF00568	0.436
DOC_PP4_FxxP_1	74	77	PF00568	0.351
DOC_USP7_MATH_1	230	234	PF00917	0.258
DOC_USP7_MATH_1	401	405	PF00917	0.408
DOC_USP7_UBL2_3	306	310	PF12436	0.246
DOC_WW_Pin1_4	380	385	PF00397	0.370
LIG_14-3-3_CanoR_1	120	128	PF00244	0.362
LIG_14-3-3_CanoR_1	165	174	PF00244	0.498
LIG_Actin_WH2_2	332	350	PF00022	0.351
LIG_APCC_ABBA_1	339	344	PF00400	0.351
LIG_BRCT_BRCA1_1	33	37	PF00533	0.418
LIG_deltaCOP1_diTrp_1	238	244	PF00928	0.351
LIG_FHA_1	11	17	PF00498	0.516
LIG_FHA_1	123	129	PF00498	0.472
LIG_FHA_1	219	225	PF00498	0.344
LIG_FHA_1	22	28	PF00498	0.698
LIG_FHA_1	294	300	PF00498	0.472
LIG_FHA_1	326	332	PF00498	0.457
LIG_FHA_1	391	397	PF00498	0.513
LIG_FHA_2	166	172	PF00498	0.385
LIG_HP1_1	401	405	PF01393	0.424
LIG_LIR_Apic_2	248	252	PF02991	0.351
LIG_LIR_Gen_1	161	170	PF02991	0.442
LIG_LIR_Gen_1	226	235	PF02991	0.352
LIG_LIR_Gen_1	298	307	PF02991	0.507
LIG_LIR_Gen_1	34	45	PF02991	0.368
LIG_LIR_Gen_1	399	410	PF02991	0.408
LIG_LIR_Gen_1	4	11	PF02991	0.712
LIG_LIR_Gen_1	54	64	PF02991	0.168
LIG_LIR_Nem_3	161	166	PF02991	0.402
LIG_LIR_Nem_3	226	231	PF02991	0.352
LIG_LIR_Nem_3	298	304	PF02991	0.507
LIG_LIR_Nem_3	34	40	PF02991	0.428
LIG_LIR_Nem_3	399	405	PF02991	0.416
LIG_LIR_Nem_3	4	8	PF02991	0.712
LIG_LIR_Nem_3	54	60	PF02991	0.168
LIG_LIR_Nem_3	70	74	PF02991	0.314
LIG_LYPXL_S_1	377	381	PF13949	0.367
LIG_LYPXL_yS_3	378	381	PF13949	0.367
LIG_LYPXL_yS_3	400	403	PF13949	0.461
LIG_NRBOX	317	323	PF00104	0.436
LIG_Pex14_1	239	243	PF04695	0.351
LIG_SH2_PTP2	249	252	PF00017	0.472
LIG_SH2_PTP2	402	405	PF00017	0.382
LIG_SH2_STAP1	57	61	PF00017	0.472
LIG_SH2_STAT5	139	142	PF00017	0.367
LIG_SH2_STAT5	249	252	PF00017	0.430
LIG_SH2_STAT5	264	267	PF00017	0.354
LIG_SH2_STAT5	288	291	PF00017	0.428
LIG_SH2_STAT5	326	329	PF00017	0.351
LIG_SH2_STAT5	330	333	PF00017	0.341
LIG_SH2_STAT5	402	405	PF00017	0.382
LIG_SH2_STAT5	44	47	PF00017	0.462
LIG_SH2_STAT5	5	8	PF00017	0.498
LIG_SH3_3	226	232	PF00018	0.386
LIG_TRFH_1	349	353	PF08558	0.351
LIG_UBA3_1	7	12	PF00899	0.661
LIG_WRC_WIRS_1	123	128	PF05994	0.472
LIG_WW_3	351	355	PF00397	0.351
MOD_CK1_1	10	16	PF00069	0.517
MOD_CK1_1	121	127	PF00069	0.386
MOD_CK1_1	48	54	PF00069	0.434
MOD_CK2_1	155	161	PF00069	0.331
MOD_CK2_1	166	172	PF00069	0.368
MOD_CK2_1	297	303	PF00069	0.356
MOD_CK2_1	83	89	PF00069	0.351
MOD_GlcNHglycan	113	118	PF01048	0.453
MOD_GlcNHglycan	135	138	PF01048	0.435
MOD_GlcNHglycan	232	235	PF01048	0.246
MOD_GlcNHglycan	53	56	PF01048	0.436
MOD_GSK3_1	10	17	PF00069	0.504
MOD_GSK3_1	118	125	PF00069	0.397
MOD_GSK3_1	128	135	PF00069	0.299
MOD_GSK3_1	293	300	PF00069	0.436
MOD_GSK3_1	401	408	PF00069	0.429
MOD_N-GLC_1	128	133	PF02516	0.365
MOD_N-GLC_1	166	171	PF02516	0.455
MOD_N-GLC_1	181	186	PF02516	0.192
MOD_N-GLC_1	197	202	PF02516	0.365
MOD_NEK2_1	101	106	PF00069	0.435
MOD_NEK2_1	112	117	PF00069	0.362
MOD_NEK2_1	143	148	PF00069	0.366
MOD_NEK2_1	223	228	PF00069	0.351
MOD_NEK2_1	33	38	PF00069	0.558
MOD_NEK2_1	405	410	PF00069	0.462
MOD_NEK2_1	67	72	PF00069	0.498
MOD_NEK2_2	197	202	PF00069	0.386
MOD_NEK2_2	401	406	PF00069	0.415
MOD_PIKK_1	128	134	PF00454	0.408
MOD_PIKK_1	45	51	PF00454	0.410
MOD_PK_1	118	124	PF00069	0.370
MOD_Plk_1	101	107	PF00069	0.382
MOD_Plk_1	197	203	PF00069	0.367
MOD_Plk_1	297	303	PF00069	0.248
MOD_Plk_2-3	297	303	PF00069	0.240
MOD_Plk_4	14	20	PF00069	0.745
MOD_Plk_4	155	161	PF00069	0.292
MOD_Plk_4	206	212	PF00069	0.381
MOD_Plk_4	223	229	PF00069	0.401
MOD_Plk_4	239	245	PF00069	0.269
MOD_Plk_4	265	271	PF00069	0.361
MOD_Plk_4	33	39	PF00069	0.537
MOD_Plk_4	83	89	PF00069	0.351
MOD_ProDKin_1	380	386	PF00069	0.370
MOD_SUMO_rev_2	146	155	PF00179	0.472
MOD_SUMO_rev_2	277	282	PF00179	0.367
MOD_SUMO_rev_2	297	307	PF00179	0.168
MOD_SUMO_rev_2	312	318	PF00179	0.424
TRG_ENDOCYTIC_2	243	246	PF00928	0.351
TRG_ENDOCYTIC_2	319	322	PF00928	0.386
TRG_ENDOCYTIC_2	378	381	PF00928	0.367
TRG_ENDOCYTIC_2	400	403	PF00928	0.416
TRG_ENDOCYTIC_2	5	8	PF00928	0.694
TRG_ENDOCYTIC_2	57	60	PF00928	0.436
TRG_ER_diArg_1	370	373	PF00400	0.472
TRG_NES_CRM1_1	32	46	PF08389	0.382
TRG_NES_CRM1_1	380	392	PF08389	0.659
TRG_NLS_Bipartite_1	273	289	PF00514	0.351
TRG_NLS_MonoCore_2	283	288	PF00514	0.367
TRG_NLS_MonoExtN_4	284	289	PF00514	0.351
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2N6	Leptomonas seymouri	85%	100%
A0A0S4IV71	Bodo saltans	54%	98%
A0A1X0P723	Trypanosomatidae	69%	100%
A0A3S5IRA4	Trypanosoma rangeli	64%	100%
A0A3S7WV19	Leishmania donovani	88%	100%
A4HXT1	Leishmania infantum	88%	100%
D0A063	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9ARJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P21282	Bos taurus	31%	100%
P21283	Homo sapiens	31%	100%
P31412	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P54648	Dictyostelium discoideum	28%	100%
Q4QDY6	Leishmania major	85%	100%
Q4R5H9	Macaca fascicularis	31%	100%
Q5FVI6	Rattus norvegicus	31%	100%
Q5RDQ7	Pongo abelii	31%	100%
Q5XH14	Xenopus laevis	31%	100%
Q5XIY6	Danio rerio	32%	100%
Q612A4	Caenorhabditis briggsae	28%	100%
Q6P4Y9	Xenopus tropicalis	31%	100%
Q7T385	Danio rerio	30%	100%
Q9HDW6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q9NDR5	Ascidia sydneiensis samea	31%	100%
Q9SCB9	Hordeum vulgare	30%	100%
Q9SDS7	Arabidopsis thaliana	30%	100%
Q9U5N1	Manduca sexta	29%	100%
Q9XXU9	Caenorhabditis elegans	28%	100%
Q9Z1G3	Mus musculus	31%	100%
V5B6H3	Trypanosoma cruzi	67%	100%