Coatomer subunit delta

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9G3_LEIBR

TriTrypDb:

LbrM.18.0610 , LBRM2903_180010900

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 6
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.473
CLV_NRD_NRD_1	293	295	PF00675	0.557
CLV_NRD_NRD_1	297	299	PF00675	0.540
CLV_NRD_NRD_1	302	304	PF00675	0.480
CLV_NRD_NRD_1	332	334	PF00675	0.621
CLV_PCSK_KEX2_1	293	295	PF00082	0.541
CLV_PCSK_KEX2_1	332	334	PF00082	0.621
CLV_PCSK_KEX2_1	42	44	PF00082	0.493
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.312
CLV_PCSK_SKI1_1	227	231	PF00082	0.600
CLV_PCSK_SKI1_1	263	267	PF00082	0.483
CLV_PCSK_SKI1_1	306	310	PF00082	0.497
CLV_PCSK_SKI1_1	316	320	PF00082	0.547
CLV_PCSK_SKI1_1	343	347	PF00082	0.519
CLV_PCSK_SKI1_1	43	47	PF00082	0.508
DEG_Nend_Nbox_1	1	3	PF02207	0.407
DEG_SCF_FBW7_1	155	161	PF00400	0.575
DOC_CKS1_1	155	160	PF01111	0.519
DOC_MAPK_gen_1	298	310	PF00069	0.572
DOC_MAPK_gen_1	332	341	PF00069	0.593
DOC_PP1_RVXF_1	341	348	PF00149	0.558
DOC_PP1_RVXF_1	85	92	PF00149	0.489
DOC_PP2B_LxvP_1	219	222	PF13499	0.403
DOC_USP7_MATH_1	203	207	PF00917	0.715
DOC_USP7_UBL2_3	300	304	PF12436	0.646
DOC_WW_Pin1_4	154	159	PF00397	0.530
DOC_WW_Pin1_4	196	201	PF00397	0.507
DOC_WW_Pin1_4	209	214	PF00397	0.636
LIG_14-3-3_CanoR_1	122	127	PF00244	0.491
LIG_14-3-3_CanoR_1	192	202	PF00244	0.479
LIG_14-3-3_CanoR_1	240	247	PF00244	0.522
LIG_14-3-3_CanoR_1	306	311	PF00244	0.566
LIG_BRCT_BRCA1_1	160	164	PF00533	0.496
LIG_FHA_1	176	182	PF00498	0.518
LIG_FHA_1	197	203	PF00498	0.489
LIG_FHA_1	50	56	PF00498	0.466
LIG_FHA_2	307	313	PF00498	0.579
LIG_LIR_Gen_1	20	30	PF02991	0.462
LIG_LIR_Gen_1	212	222	PF02991	0.564
LIG_LIR_Gen_1	344	350	PF02991	0.566
LIG_LIR_Gen_1	70	80	PF02991	0.521
LIG_LIR_Nem_3	128	133	PF02991	0.553
LIG_LIR_Nem_3	20	26	PF02991	0.460
LIG_LIR_Nem_3	212	217	PF02991	0.569
LIG_LIR_Nem_3	344	350	PF02991	0.582
LIG_LIR_Nem_3	70	76	PF02991	0.500
LIG_PDZ_Class_1	345	350	PF00595	0.609
LIG_SH2_CRK	135	139	PF00017	0.517
LIG_SH2_CRK	23	27	PF00017	0.421
LIG_SH2_CRK	99	103	PF00017	0.521
LIG_SH2_GRB2like	59	62	PF00017	0.545
LIG_SH2_NCK_1	135	139	PF00017	0.478
LIG_SH2_NCK_1	23	27	PF00017	0.380
LIG_SH2_PTP2	73	76	PF00017	0.515
LIG_SH2_STAT5	115	118	PF00017	0.381
LIG_SH2_STAT5	135	138	PF00017	0.428
LIG_SH2_STAT5	185	188	PF00017	0.629
LIG_SH2_STAT5	250	253	PF00017	0.555
LIG_SH2_STAT5	59	62	PF00017	0.504
LIG_SH2_STAT5	66	69	PF00017	0.440
LIG_SH2_STAT5	73	76	PF00017	0.290
LIG_SH3_3	152	158	PF00018	0.507
LIG_SH3_3	197	203	PF00018	0.750
LIG_TRAF2_1	254	257	PF00917	0.572
LIG_TYR_ITIM	133	138	PF00017	0.290
LIG_TYR_ITIM	21	26	PF00017	0.494
LIG_UBA3_1	229	237	PF00899	0.379
LIG_WRC_WIRS_1	127	132	PF05994	0.539
MOD_CK1_1	103	109	PF00069	0.433
MOD_CK1_1	125	131	PF00069	0.426
MOD_CK1_1	137	143	PF00069	0.341
MOD_CK1_1	175	181	PF00069	0.529
MOD_CK1_1	206	212	PF00069	0.649
MOD_CK2_1	103	109	PF00069	0.336
MOD_CK2_1	251	257	PF00069	0.569
MOD_CK2_1	306	312	PF00069	0.595
MOD_Cter_Amidation	120	123	PF01082	0.468
MOD_GlcNHglycan	139	142	PF01048	0.456
MOD_GlcNHglycan	165	168	PF01048	0.406
MOD_GlcNHglycan	206	209	PF01048	0.457
MOD_GlcNHglycan	252	256	PF01048	0.642
MOD_GSK3_1	122	129	PF00069	0.429
MOD_GSK3_1	133	140	PF00069	0.356
MOD_GSK3_1	154	161	PF00069	0.485
MOD_GSK3_1	172	179	PF00069	0.392
MOD_GSK3_1	306	313	PF00069	0.484
MOD_GSK3_1	49	56	PF00069	0.464
MOD_N-GLC_1	153	158	PF02516	0.515
MOD_N-GLC_1	175	180	PF02516	0.510
MOD_NEK2_1	133	138	PF00069	0.432
MOD_NEK2_1	153	158	PF00069	0.506
MOD_NEK2_1	163	168	PF00069	0.520
MOD_NEK2_1	310	315	PF00069	0.537
MOD_NEK2_1	75	80	PF00069	0.478
MOD_NEK2_2	146	151	PF00069	0.387
MOD_PK_1	122	128	PF00069	0.532
MOD_PK_1	37	43	PF00069	0.348
MOD_PKA_1	122	128	PF00069	0.407
MOD_PKA_2	191	197	PF00069	0.667
MOD_PKA_2	239	245	PF00069	0.566
MOD_Plk_1	37	43	PF00069	0.532
MOD_Plk_2-3	337	343	PF00069	0.386
MOD_Plk_4	122	128	PF00069	0.471
MOD_Plk_4	158	164	PF00069	0.464
MOD_ProDKin_1	154	160	PF00069	0.526
MOD_ProDKin_1	196	202	PF00069	0.496
MOD_ProDKin_1	209	215	PF00069	0.630
MOD_SUMO_for_1	67	70	PF00179	0.491
MOD_SUMO_rev_2	223	230	PF00179	0.633
MOD_SUMO_rev_2	82	89	PF00179	0.530
TRG_DiLeu_BaEn_1	112	117	PF01217	0.433
TRG_DiLeu_BaEn_1	226	231	PF01217	0.369
TRG_ENDOCYTIC_2	135	138	PF00928	0.508
TRG_ENDOCYTIC_2	23	26	PF00928	0.491
TRG_ENDOCYTIC_2	73	76	PF00928	0.527
TRG_ENDOCYTIC_2	99	102	PF00928	0.522
TRG_ER_diArg_1	331	333	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN8	Leptomonas seymouri	47%	80%
A0A0S4J078	Bodo saltans	23%	75%
A0A1X0P6U2	Trypanosomatidae	27%	79%
A0A3S7WUV0	Leishmania donovani	73%	99%
A0A422NJ54	Trypanosoma rangeli	28%	78%
A4HXT0	Leishmania infantum	73%	99%
D0A062	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	78%
E9ARJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	98%
Q4QDY7	Leishmania major	71%	100%