TMEM135_C_rich domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9G2_LEIBR

TriTrypDb:

LbrM.18.0600 , LBRM2903_180010800

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0016020	membrane	2	7
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H9G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9G2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	440	444	PF00656	0.420
CLV_NRD_NRD_1	284	286	PF00675	0.377
CLV_NRD_NRD_1	351	353	PF00675	0.322
CLV_NRD_NRD_1	409	411	PF00675	0.651
CLV_PCSK_KEX2_1	283	285	PF00082	0.421
CLV_PCSK_KEX2_1	349	351	PF00082	0.346
CLV_PCSK_KEX2_1	409	411	PF00082	0.651
CLV_PCSK_KEX2_1	52	54	PF00082	0.503
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.372
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.503
CLV_PCSK_PC7_1	405	411	PF00082	0.477
CLV_PCSK_SKI1_1	144	148	PF00082	0.618
CLV_PCSK_SKI1_1	260	264	PF00082	0.536
CLV_PCSK_SKI1_1	285	289	PF00082	0.389
CLV_PCSK_SKI1_1	299	303	PF00082	0.203
CLV_PCSK_SKI1_1	331	335	PF00082	0.447
CLV_PCSK_SKI1_1	365	369	PF00082	0.369
CLV_PCSK_SKI1_1	412	416	PF00082	0.596
CLV_PCSK_SKI1_1	57	61	PF00082	0.617
CLV_PCSK_SKI1_1	74	78	PF00082	0.484
CLV_PCSK_SKI1_1	94	98	PF00082	0.593
DEG_APCC_DBOX_1	143	151	PF00400	0.425
DEG_APCC_DBOX_1	411	419	PF00400	0.410
DEG_APCC_DBOX_1	56	64	PF00400	0.467
DEG_Nend_UBRbox_3	1	3	PF02207	0.771
DOC_CYCLIN_yClb5_NLxxxL_5	368	377	PF00134	0.616
DOC_MAPK_gen_1	123	133	PF00069	0.327
DOC_MAPK_gen_1	349	357	PF00069	0.517
DOC_MAPK_gen_1	409	419	PF00069	0.441
DOC_MAPK_HePTP_8	407	419	PF00069	0.437
DOC_MAPK_MEF2A_6	126	135	PF00069	0.302
DOC_MAPK_MEF2A_6	24	31	PF00069	0.608
DOC_MAPK_MEF2A_6	260	267	PF00069	0.278
DOC_MAPK_MEF2A_6	349	357	PF00069	0.529
DOC_MAPK_MEF2A_6	410	419	PF00069	0.439
DOC_MAPK_NFAT4_5	126	134	PF00069	0.319
DOC_MAPK_NFAT4_5	350	358	PF00069	0.442
DOC_MAPK_NFAT4_5	412	420	PF00069	0.440
DOC_USP7_MATH_1	335	339	PF00917	0.415
DOC_USP7_MATH_1	363	367	PF00917	0.504
DOC_USP7_MATH_1	424	428	PF00917	0.538
DOC_USP7_MATH_1	433	437	PF00917	0.584
DOC_USP7_MATH_2	64	70	PF00917	0.442
DOC_USP7_UBL2_3	24	28	PF12436	0.594
DOC_USP7_UBL2_3	458	462	PF12436	0.625
DOC_USP7_UBL2_3	48	52	PF12436	0.465
DOC_WW_Pin1_4	113	118	PF00397	0.269
DOC_WW_Pin1_4	420	425	PF00397	0.484
DOC_WW_Pin1_4	429	434	PF00397	0.545
DOC_WW_Pin1_4	450	455	PF00397	0.442
LIG_14-3-3_CanoR_1	136	142	PF00244	0.332
LIG_14-3-3_CanoR_1	193	198	PF00244	0.372
LIG_14-3-3_CanoR_1	274	279	PF00244	0.544
LIG_14-3-3_CanoR_1	409	419	PF00244	0.441
LIG_14-3-3_CanoR_1	89	93	PF00244	0.366
LIG_Actin_WH2_2	303	319	PF00022	0.475
LIG_BRCT_BRCA1_1	101	105	PF00533	0.422
LIG_BRCT_BRCA1_1	317	321	PF00533	0.339
LIG_BRCT_BRCA1_1	391	395	PF00533	0.372
LIG_BRCT_BRCA1_1	55	59	PF00533	0.428
LIG_BRCT_BRCA1_1	83	87	PF00533	0.397
LIG_EH1_1	256	264	PF00400	0.296
LIG_EH1_1	295	303	PF00400	0.456
LIG_eIF4E_1	159	165	PF01652	0.302
LIG_eIF4E_1	270	276	PF01652	0.358
LIG_FHA_1	24	30	PF00498	0.622
LIG_FHA_1	286	292	PF00498	0.600
LIG_FHA_1	293	299	PF00498	0.598
LIG_FHA_1	328	334	PF00498	0.353
LIG_FHA_1	368	374	PF00498	0.574
LIG_FHA_1	385	391	PF00498	0.319
LIG_FHA_1	466	472	PF00498	0.563
LIG_FHA_2	123	129	PF00498	0.322
LIG_FHA_2	194	200	PF00498	0.385
LIG_FHA_2	342	348	PF00498	0.328
LIG_GBD_Chelix_1	308	316	PF00786	0.223
LIG_LIR_Gen_1	102	113	PF02991	0.401
LIG_LIR_Gen_1	34	44	PF02991	0.449
LIG_LIR_Gen_1	65	73	PF02991	0.418
LIG_LIR_Nem_3	102	108	PF02991	0.437
LIG_LIR_Nem_3	156	162	PF02991	0.336
LIG_LIR_Nem_3	186	190	PF02991	0.350
LIG_LIR_Nem_3	34	39	PF02991	0.427
LIG_LIR_Nem_3	392	398	PF02991	0.361
LIG_LIR_Nem_3	65	70	PF02991	0.410
LIG_LIR_Nem_3	77	82	PF02991	0.326
LIG_NRBOX	414	420	PF00104	0.413
LIG_PCNA_PIPBox_1	361	370	PF02747	0.564
LIG_Pex14_1	253	257	PF04695	0.396
LIG_Pex14_1	75	79	PF04695	0.350
LIG_PTB_Apo_2	30	37	PF02174	0.603
LIG_PTB_Phospho_1	30	36	PF10480	0.605
LIG_SH2_CRK	160	164	PF00017	0.309
LIG_SH2_CRK	174	178	PF00017	0.295
LIG_SH2_CRK	36	40	PF00017	0.413
LIG_SH2_NCK_1	36	40	PF00017	0.385
LIG_SH2_PTP2	311	314	PF00017	0.358
LIG_SH2_STAP1	160	164	PF00017	0.324
LIG_SH2_STAP1	248	252	PF00017	0.437
LIG_SH2_STAT3	270	273	PF00017	0.223
LIG_SH2_STAT5	132	135	PF00017	0.322
LIG_SH2_STAT5	220	223	PF00017	0.407
LIG_SH2_STAT5	311	314	PF00017	0.384
LIG_SH2_STAT5	358	361	PF00017	0.503
LIG_SH2_STAT5	389	392	PF00017	0.343
LIG_SH3_3	145	151	PF00018	0.344
LIG_SUMO_SIM_anti_2	161	166	PF11976	0.323
LIG_SUMO_SIM_par_1	467	474	PF11976	0.483
LIG_TRAF2_1	427	430	PF00917	0.531
LIG_TYR_ITIM	172	177	PF00017	0.348
LIG_UBA3_1	146	152	PF00899	0.575
LIG_UBA3_1	43	52	PF00899	0.245
LIG_UBA3_1	92	97	PF00899	0.365
LIG_WRC_WIRS_1	364	369	PF05994	0.394
LIG_WRC_WIRS_1	82	87	PF05994	0.461
MOD_CK1_1	137	143	PF00069	0.483
MOD_CK1_1	246	252	PF00069	0.431
MOD_CK1_1	292	298	PF00069	0.421
MOD_CK1_1	467	473	PF00069	0.674
MOD_CK1_1	6	12	PF00069	0.575
MOD_CK2_1	122	128	PF00069	0.428
MOD_CK2_1	193	199	PF00069	0.520
MOD_CK2_1	341	347	PF00069	0.328
MOD_CK2_1	424	430	PF00069	0.665
MOD_CK2_1	5	11	PF00069	0.558
MOD_GlcNHglycan	113	116	PF01048	0.476
MOD_GlcNHglycan	136	139	PF01048	0.467
MOD_GlcNHglycan	168	171	PF01048	0.277
MOD_GlcNHglycan	205	208	PF01048	0.466
MOD_GlcNHglycan	245	248	PF01048	0.542
MOD_GlcNHglycan	317	320	PF01048	0.425
MOD_GlcNHglycan	435	438	PF01048	0.784
MOD_GlcNHglycan	443	446	PF01048	0.777
MOD_GSK3_1	179	186	PF00069	0.428
MOD_GSK3_1	19	26	PF00069	0.584
MOD_GSK3_1	285	292	PF00069	0.512
MOD_GSK3_1	297	304	PF00069	0.240
MOD_GSK3_1	3	10	PF00069	0.701
MOD_GSK3_1	327	334	PF00069	0.451
MOD_GSK3_1	363	370	PF00069	0.385
MOD_GSK3_1	420	427	PF00069	0.660
MOD_GSK3_1	429	436	PF00069	0.753
MOD_GSK3_1	437	444	PF00069	0.738
MOD_GSK3_1	452	459	PF00069	0.560
MOD_GSK3_1	467	474	PF00069	0.515
MOD_GSK3_1	62	69	PF00069	0.504
MOD_GSK3_1	88	95	PF00069	0.487
MOD_LATS_1	17	23	PF00433	0.403
MOD_NEK2_1	134	139	PF00069	0.466
MOD_NEK2_1	165	170	PF00069	0.372
MOD_NEK2_1	23	28	PF00069	0.463
MOD_NEK2_1	301	306	PF00069	0.391
MOD_NEK2_1	357	362	PF00069	0.423
MOD_NEK2_1	367	372	PF00069	0.351
MOD_NEK2_1	384	389	PF00069	0.281
MOD_NEK2_1	92	97	PF00069	0.446
MOD_NEK2_2	173	178	PF00069	0.247
MOD_NEK2_2	81	86	PF00069	0.403
MOD_PIKK_1	139	145	PF00454	0.522
MOD_PIKK_1	367	373	PF00454	0.401
MOD_PKA_2	192	198	PF00069	0.478
MOD_PKA_2	31	37	PF00069	0.406
MOD_PKA_2	88	94	PF00069	0.477
MOD_PKB_1	283	291	PF00069	0.568
MOD_Plk_2-3	66	72	PF00069	0.426
MOD_Plk_4	104	110	PF00069	0.455
MOD_Plk_4	173	179	PF00069	0.289
MOD_Plk_4	274	280	PF00069	0.525
MOD_Plk_4	302	308	PF00069	0.275
MOD_Plk_4	31	37	PF00069	0.423
MOD_Plk_4	341	347	PF00069	0.328
MOD_Plk_4	384	390	PF00069	0.392
MOD_Plk_4	74	80	PF00069	0.434
MOD_Plk_4	88	94	PF00069	0.442
MOD_ProDKin_1	113	119	PF00069	0.324
MOD_ProDKin_1	420	426	PF00069	0.628
MOD_ProDKin_1	429	435	PF00069	0.704
MOD_ProDKin_1	450	456	PF00069	0.562
TRG_DiLeu_BaEn_1	402	407	PF01217	0.539
TRG_DiLeu_BaEn_4	402	408	PF01217	0.540
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.525
TRG_DiLeu_LyEn_5	402	407	PF01217	0.313
TRG_ENDOCYTIC_2	132	135	PF00928	0.413
TRG_ENDOCYTIC_2	159	162	PF00928	0.376
TRG_ENDOCYTIC_2	174	177	PF00928	0.350
TRG_ENDOCYTIC_2	187	190	PF00928	0.389
TRG_ENDOCYTIC_2	311	314	PF00928	0.425
TRG_ENDOCYTIC_2	358	361	PF00928	0.382
TRG_ENDOCYTIC_2	36	39	PF00928	0.413
TRG_ER_diArg_1	283	285	PF00400	0.557
TRG_ER_diArg_1	350	352	PF00400	0.445
TRG_ER_diArg_1	373	376	PF00400	0.531
TRG_ER_diArg_1	409	412	PF00400	0.502
TRG_NLS_MonoCore_2	348	353	PF00514	0.299
TRG_NLS_MonoExtC_3	348	354	PF00514	0.295
TRG_NLS_MonoExtN_4	348	353	PF00514	0.299
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXD2	Leptomonas seymouri	70%	99%
A0A0S4IY50	Bodo saltans	34%	100%
A0A1X0P7N6	Trypanosomatidae	46%	100%
A0A3R7MN24	Trypanosoma rangeli	42%	100%
A0A3S7WUW0	Leishmania donovani	82%	93%
A4HXS9	Leishmania infantum	82%	93%
D0A061	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ARJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	94%
Q4QDY8	Leishmania major	81%	100%
V5BWB3	Trypanosoma cruzi	42%	100%