C-CAP/cofactor C-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin cofactor C domain-containing protein RP2, putative

Species:

Leishmania braziliensis

UniProt:

A4H9G1_LEIBR

TriTrypDb:

LbrM.18.0590 , LBRM2903_180010700

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H9G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9G1

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0034453	microtubule anchoring	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	11
GO:0008047	enzyme activator activity	3	11
GO:0030234	enzyme regulator activity	2	11
GO:0030695	GTPase regulator activity	4	11
GO:0060589	nucleoside-triphosphatase regulator activity	3	11
GO:0098772	molecular function regulator activity	1	11
GO:0140677	molecular function activator activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.379
CLV_NRD_NRD_1	290	292	PF00675	0.309
CLV_PCSK_KEX2_1	182	184	PF00082	0.504
CLV_PCSK_KEX2_1	290	292	PF00082	0.309
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.504
CLV_PCSK_SKI1_1	240	244	PF00082	0.279
CLV_PCSK_SKI1_1	290	294	PF00082	0.191
CLV_PCSK_SKI1_1	61	65	PF00082	0.448
DEG_SPOP_SBC_1	402	406	PF00917	0.594
DEG_SPOP_SBC_1	433	437	PF00917	0.784
DOC_CYCLIN_RxL_1	85	93	PF00134	0.579
DOC_MAPK_gen_1	237	246	PF00069	0.275
DOC_MAPK_gen_1	252	261	PF00069	0.234
DOC_MAPK_HePTP_8	234	246	PF00069	0.277
DOC_MAPK_HePTP_8	251	263	PF00069	0.217
DOC_MAPK_MEF2A_6	237	246	PF00069	0.277
DOC_MAPK_MEF2A_6	254	263	PF00069	0.217
DOC_PP2B_LxvP_1	284	287	PF13499	0.298
DOC_USP7_MATH_1	360	364	PF00917	0.411
DOC_USP7_MATH_1	403	407	PF00917	0.723
DOC_USP7_MATH_1	423	427	PF00917	0.628
DOC_USP7_MATH_1	441	445	PF00917	0.678
DOC_USP7_MATH_1	457	461	PF00917	0.579
DOC_USP7_MATH_1	479	483	PF00917	0.499
DOC_USP7_MATH_1	486	490	PF00917	0.485
DOC_WW_Pin1_4	140	145	PF00397	0.719
DOC_WW_Pin1_4	309	314	PF00397	0.421
DOC_WW_Pin1_4	384	389	PF00397	0.574
DOC_WW_Pin1_4	429	434	PF00397	0.521
LIG_14-3-3_CanoR_1	337	342	PF00244	0.519
LIG_Actin_WH2_2	89	104	PF00022	0.587
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_CAP-Gly_1	516	522	PF01302	0.592
LIG_DLG_GKlike_1	337	344	PF00625	0.302
LIG_FHA_1	130	136	PF00498	0.569
LIG_FHA_1	153	159	PF00498	0.671
LIG_FHA_1	172	178	PF00498	0.401
LIG_FHA_1	204	210	PF00498	0.312
LIG_FHA_1	241	247	PF00498	0.298
LIG_FHA_1	265	271	PF00498	0.269
LIG_FHA_1	55	61	PF00498	0.577
LIG_FHA_1	7	13	PF00498	0.477
LIG_FHA_1	84	90	PF00498	0.425
LIG_FHA_2	101	107	PF00498	0.491
LIG_FHA_2	151	157	PF00498	0.754
LIG_FHA_2	159	165	PF00498	0.750
LIG_FHA_2	214	220	PF00498	0.264
LIG_FHA_2	263	269	PF00498	0.279
LIG_FHA_2	3	9	PF00498	0.568
LIG_FHA_2	310	316	PF00498	0.374
LIG_LIR_Gen_1	495	504	PF02991	0.623
LIG_LIR_Nem_3	278	282	PF02991	0.390
LIG_LIR_Nem_3	335	341	PF02991	0.440
LIG_LIR_Nem_3	495	500	PF02991	0.605
LIG_LIR_Nem_3	76	80	PF02991	0.454
LIG_PDZ_Class_3	517	522	PF00595	0.577
LIG_Pex14_2	176	180	PF04695	0.352
LIG_Pex14_2	323	327	PF04695	0.438
LIG_PTB_Apo_2	491	498	PF02174	0.714
LIG_PTB_Phospho_1	491	497	PF10480	0.714
LIG_SH2_NCK_1	449	453	PF00017	0.517
LIG_SH2_SRC	449	452	PF00017	0.515
LIG_SH2_STAP1	85	89	PF00017	0.419
LIG_SH2_STAT5	175	178	PF00017	0.358
LIG_SH2_STAT5	200	203	PF00017	0.343
LIG_SH2_STAT5	262	265	PF00017	0.296
LIG_SH2_STAT5	77	80	PF00017	0.408
LIG_SH2_STAT5	85	88	PF00017	0.454
LIG_SH3_3	310	316	PF00018	0.405
LIG_SH3_3	322	328	PF00018	0.325
LIG_SH3_3	470	476	PF00018	0.690
LIG_SH3_3	50	56	PF00018	0.551
LIG_SUMO_SIM_anti_2	69	76	PF11976	0.488
LIG_SUMO_SIM_par_1	395	401	PF11976	0.647
LIG_SUMO_SIM_par_1	56	62	PF11976	0.547
LIG_TRAF2_1	147	150	PF00917	0.654
LIG_TYR_ITIM	78	83	PF00017	0.508
LIG_WRC_WIRS_1	497	502	PF05994	0.620
MOD_CK1_1	363	369	PF00069	0.491
MOD_CK1_1	426	432	PF00069	0.710
MOD_CK1_1	437	443	PF00069	0.721
MOD_CK2_1	100	106	PF00069	0.518
MOD_CK2_1	150	156	PF00069	0.744
MOD_CK2_1	2	8	PF00069	0.620
MOD_CK2_1	309	315	PF00069	0.510
MOD_CK2_1	439	445	PF00069	0.783
MOD_GlcNHglycan	103	106	PF01048	0.521
MOD_GlcNHglycan	123	126	PF01048	0.530
MOD_GlcNHglycan	18	22	PF01048	0.440
MOD_GlcNHglycan	191	194	PF01048	0.408
MOD_GlcNHglycan	365	368	PF01048	0.527
MOD_GlcNHglycan	405	408	PF01048	0.615
MOD_GlcNHglycan	412	415	PF01048	0.800
MOD_GlcNHglycan	427	431	PF01048	0.654
MOD_GlcNHglycan	436	439	PF01048	0.722
MOD_GlcNHglycan	45	48	PF01048	0.667
MOD_GlcNHglycan	459	462	PF01048	0.653
MOD_GlcNHglycan	468	471	PF01048	0.561
MOD_GlcNHglycan	481	484	PF01048	0.619
MOD_GlcNHglycan	488	491	PF01048	0.624
MOD_GSK3_1	134	141	PF00069	0.673
MOD_GSK3_1	171	178	PF00069	0.419
MOD_GSK3_1	199	206	PF00069	0.424
MOD_GSK3_1	2	9	PF00069	0.555
MOD_GSK3_1	271	278	PF00069	0.383
MOD_GSK3_1	398	405	PF00069	0.516
MOD_GSK3_1	428	435	PF00069	0.746
MOD_GSK3_1	436	443	PF00069	0.661
MOD_N-GLC_1	171	176	PF02516	0.460
MOD_N-GLC_1	240	245	PF02516	0.324
MOD_N-GLC_1	368	373	PF02516	0.518
MOD_N-GLC_1	43	48	PF02516	0.467
MOD_NEK2_1	1	6	PF00069	0.442
MOD_NEK2_1	17	22	PF00069	0.535
MOD_NEK2_1	83	88	PF00069	0.447
MOD_NEK2_2	230	235	PF00069	0.264
MOD_PKA_2	101	107	PF00069	0.498
MOD_PKA_2	129	135	PF00069	0.470
MOD_Plk_1	170	176	PF00069	0.422
MOD_Plk_1	240	246	PF00069	0.324
MOD_Plk_1	368	374	PF00069	0.526
MOD_Plk_1	495	501	PF00069	0.711
MOD_Plk_1	69	75	PF00069	0.508
MOD_Plk_2-3	152	158	PF00069	0.505
MOD_Plk_2-3	213	219	PF00069	0.264
MOD_Plk_2-3	421	427	PF00069	0.742
MOD_Plk_2-3	496	502	PF00069	0.723
MOD_Plk_4	171	177	PF00069	0.388
MOD_Plk_4	2	8	PF00069	0.667
MOD_Plk_4	230	236	PF00069	0.264
MOD_Plk_4	69	75	PF00069	0.456
MOD_ProDKin_1	140	146	PF00069	0.721
MOD_ProDKin_1	309	315	PF00069	0.417
MOD_ProDKin_1	384	390	PF00069	0.576
MOD_ProDKin_1	429	435	PF00069	0.521
MOD_SUMO_rev_2	295	302	PF00179	0.324
TRG_DiLeu_BaEn_1	221	226	PF01217	0.279
TRG_DiLeu_BaEn_1	349	354	PF01217	0.344
TRG_DiLeu_BaEn_2	230	236	PF01217	0.279
TRG_DiLeu_BaEn_4	351	357	PF01217	0.403
TRG_ENDOCYTIC_2	23	26	PF00928	0.599
TRG_ENDOCYTIC_2	341	344	PF00928	0.303
TRG_ENDOCYTIC_2	497	500	PF00928	0.624
TRG_ENDOCYTIC_2	80	83	PF00928	0.492
TRG_ER_diArg_1	251	254	PF00400	0.264
TRG_ER_diArg_1	289	291	PF00400	0.313
TRG_NLS_MonoExtN_4	179	185	PF00514	0.426
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	290	295	PF00026	0.191
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z4	Leptomonas seymouri	68%	100%
A0A0S4J201	Bodo saltans	47%	100%
A0A1X0P6T6	Trypanosomatidae	53%	100%
A0A3R7NEX5	Trypanosoma rangeli	53%	100%
A0A3S5H730	Leishmania donovani	79%	99%
A4HXS8	Leishmania infantum	79%	99%
D0A060	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ARJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
V5BRP2	Trypanosoma cruzi	50%	100%