Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9G0_LEIBR

TriTrypDb:

LbrM.18.0580 , LBRM2903_180010600

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9G0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.763
CLV_C14_Caspase3-7	402	406	PF00656	0.580
CLV_NRD_NRD_1	139	141	PF00675	0.546
CLV_NRD_NRD_1	29	31	PF00675	0.782
CLV_NRD_NRD_1	355	357	PF00675	0.437
CLV_NRD_NRD_1	358	360	PF00675	0.438
CLV_NRD_NRD_1	467	469	PF00675	0.541
CLV_NRD_NRD_1	492	494	PF00675	0.490
CLV_NRD_NRD_1	586	588	PF00675	0.464
CLV_PCSK_FUR_1	356	360	PF00082	0.443
CLV_PCSK_FUR_1	465	469	PF00082	0.384
CLV_PCSK_KEX2_1	139	141	PF00082	0.574
CLV_PCSK_KEX2_1	29	31	PF00082	0.782
CLV_PCSK_KEX2_1	357	359	PF00082	0.446
CLV_PCSK_KEX2_1	467	469	PF00082	0.544
CLV_PCSK_KEX2_1	492	494	PF00082	0.490
CLV_PCSK_KEX2_1	585	587	PF00082	0.471
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.504
CLV_PCSK_SKI1_1	140	144	PF00082	0.541
CLV_PCSK_SKI1_1	212	216	PF00082	0.707
CLV_PCSK_SKI1_1	374	378	PF00082	0.455
CLV_PCSK_SKI1_1	468	472	PF00082	0.500
CLV_PCSK_SKI1_1	539	543	PF00082	0.446
CLV_Separin_Metazoa	476	480	PF03568	0.482
CLV_Separin_Metazoa	534	538	PF03568	0.375
DEG_APCC_DBOX_1	467	475	PF00400	0.499
DEG_Nend_UBRbox_2	1	3	PF02207	0.526
DEG_SCF_FBW7_1	124	130	PF00400	0.504
DEG_SCF_FBW7_1	147	152	PF00400	0.541
DEG_SCF_FBW7_2	526	533	PF00400	0.445
DOC_CDC14_PxL_1	251	259	PF14671	0.531
DOC_CKS1_1	124	129	PF01111	0.502
DOC_CKS1_1	527	532	PF01111	0.417
DOC_CYCLIN_yCln2_LP_2	520	526	PF00134	0.633
DOC_MAPK_gen_1	585	594	PF00069	0.431
DOC_MAPK_MEF2A_6	548	556	PF00069	0.368
DOC_MAPK_MEF2A_6	79	86	PF00069	0.502
DOC_PP1_SILK_1	389	394	PF00149	0.458
DOC_PP2B_LxvP_1	520	523	PF13499	0.634
DOC_USP7_MATH_1	111	115	PF00917	0.531
DOC_USP7_MATH_1	127	131	PF00917	0.630
DOC_USP7_MATH_1	149	153	PF00917	0.673
DOC_USP7_MATH_1	182	186	PF00917	0.711
DOC_USP7_MATH_1	19	23	PF00917	0.675
DOC_USP7_MATH_1	191	195	PF00917	0.681
DOC_USP7_MATH_1	210	214	PF00917	0.521
DOC_USP7_MATH_1	228	232	PF00917	0.491
DOC_USP7_MATH_1	262	266	PF00917	0.793
DOC_USP7_MATH_1	287	291	PF00917	0.487
DOC_WW_Pin1_4	123	128	PF00397	0.527
DOC_WW_Pin1_4	145	150	PF00397	0.560
DOC_WW_Pin1_4	171	176	PF00397	0.654
DOC_WW_Pin1_4	178	183	PF00397	0.628
DOC_WW_Pin1_4	193	198	PF00397	0.720
DOC_WW_Pin1_4	201	206	PF00397	0.599
DOC_WW_Pin1_4	224	229	PF00397	0.689
DOC_WW_Pin1_4	394	399	PF00397	0.531
DOC_WW_Pin1_4	427	432	PF00397	0.404
DOC_WW_Pin1_4	43	48	PF00397	0.670
DOC_WW_Pin1_4	526	531	PF00397	0.698
DOC_WW_Pin1_4	57	62	PF00397	0.705
LIG_14-3-3_CanoR_1	183	191	PF00244	0.649
LIG_14-3-3_CanoR_1	223	228	PF00244	0.521
LIG_14-3-3_CanoR_1	289	294	PF00244	0.512
LIG_14-3-3_CanoR_1	29	34	PF00244	0.679
LIG_14-3-3_CanoR_1	393	398	PF00244	0.509
LIG_14-3-3_CanoR_1	448	456	PF00244	0.496
LIG_14-3-3_CanoR_1	585	595	PF00244	0.491
LIG_14-3-3_CterR_2	609	612	PF00244	0.455
LIG_Actin_WH2_2	434	452	PF00022	0.485
LIG_APCC_ABBA_1	247	252	PF00400	0.626
LIG_BIR_III_2	252	256	PF00653	0.502
LIG_CaM_IQ_9	481	496	PF13499	0.481
LIG_Clathr_ClatBox_1	553	557	PF01394	0.344
LIG_EVH1_1	522	526	PF00568	0.464
LIG_FHA_1	217	223	PF00498	0.703
LIG_FHA_1	230	236	PF00498	0.643
LIG_FHA_1	298	304	PF00498	0.441
LIG_FHA_1	375	381	PF00498	0.516
LIG_FHA_1	416	422	PF00498	0.476
LIG_FHA_1	433	439	PF00498	0.482
LIG_FHA_1	587	593	PF00498	0.487
LIG_FHA_1	96	102	PF00498	0.527
LIG_LIR_Gen_1	296	304	PF02991	0.390
LIG_LIR_Nem_3	237	243	PF02991	0.472
LIG_LIR_Nem_3	296	302	PF02991	0.610
LIG_PROFILIN_1	205	211	PF00235	0.504
LIG_SH2_CRK	78	82	PF00017	0.671
LIG_SH2_STAP1	559	563	PF00017	0.491
LIG_SH2_STAP1	570	574	PF00017	0.469
LIG_SH2_STAT3	595	598	PF00017	0.420
LIG_SH2_STAT5	234	237	PF00017	0.668
LIG_SH2_STAT5	490	493	PF00017	0.491
LIG_SH3_2	207	212	PF14604	0.682
LIG_SH3_3	121	127	PF00018	0.537
LIG_SH3_3	194	200	PF00018	0.704
LIG_SH3_3	202	208	PF00018	0.660
LIG_SH3_3	41	47	PF00018	0.612
LIG_SH3_3	520	526	PF00018	0.705
LIG_TRAF2_1	270	273	PF00917	0.700
LIG_TRAF2_1	304	307	PF00917	0.396
LIG_TRAF2_1	531	534	PF00917	0.532
LIG_TRAF2_1	577	580	PF00917	0.356
MOD_CDK_SPK_2	178	183	PF00069	0.559
MOD_CDK_SPK_2	224	229	PF00069	0.521
MOD_CDK_SPxxK_3	171	178	PF00069	0.636
MOD_CDK_SPxxK_3	43	50	PF00069	0.512
MOD_CK1_1	174	180	PF00069	0.806
MOD_CK1_1	181	187	PF00069	0.714
MOD_CK1_1	192	198	PF00069	0.579
MOD_CK1_1	285	291	PF00069	0.646
MOD_CK1_1	46	52	PF00069	0.503
MOD_CK1_1	461	467	PF00069	0.506
MOD_CK1_1	96	102	PF00069	0.690
MOD_CK2_1	100	106	PF00069	0.543
MOD_CK2_1	161	167	PF00069	0.536
MOD_CK2_1	267	273	PF00069	0.553
MOD_CK2_1	427	433	PF00069	0.563
MOD_CK2_1	528	534	PF00069	0.538
MOD_CK2_1	555	561	PF00069	0.482
MOD_CK2_1	594	600	PF00069	0.485
MOD_GlcNHglycan	106	110	PF01048	0.774
MOD_GlcNHglycan	11	14	PF01048	0.599
MOD_GlcNHglycan	191	194	PF01048	0.711
MOD_GlcNHglycan	275	278	PF01048	0.566
MOD_GlcNHglycan	402	405	PF01048	0.629
MOD_GlcNHglycan	424	427	PF01048	0.565
MOD_GlcNHglycan	512	515	PF01048	0.433
MOD_GlcNHglycan	517	520	PF01048	0.447
MOD_GlcNHglycan	67	70	PF01048	0.716
MOD_GlcNHglycan	71	74	PF01048	0.653
MOD_GSK3_1	123	130	PF00069	0.546
MOD_GSK3_1	145	152	PF00069	0.621
MOD_GSK3_1	161	168	PF00069	0.704
MOD_GSK3_1	174	181	PF00069	0.742
MOD_GSK3_1	185	192	PF00069	0.634
MOD_GSK3_1	224	231	PF00069	0.760
MOD_GSK3_1	278	285	PF00069	0.637
MOD_GSK3_1	46	53	PF00069	0.623
MOD_GSK3_1	557	564	PF00069	0.324
MOD_GSK3_1	594	601	PF00069	0.467
MOD_GSK3_1	65	72	PF00069	0.648
MOD_GSK3_1	89	96	PF00069	0.770
MOD_LATS_1	154	160	PF00433	0.624
MOD_N-GLC_1	19	24	PF02516	0.497
MOD_N-GLC_2	102	104	PF02516	0.589
MOD_NEK2_1	100	105	PF00069	0.542
MOD_NEK2_1	112	117	PF00069	0.493
MOD_NEK2_1	282	287	PF00069	0.746
MOD_NEK2_1	392	397	PF00069	0.578
MOD_NEK2_1	422	427	PF00069	0.616
MOD_NEK2_1	594	599	PF00069	0.468
MOD_NEK2_2	210	215	PF00069	0.706
MOD_PIKK_1	19	25	PF00454	0.731
MOD_PIKK_1	594	600	PF00454	0.485
MOD_PIKK_1	93	99	PF00454	0.683
MOD_PKA_1	29	35	PF00069	0.679
MOD_PKA_1	585	591	PF00069	0.431
MOD_PKA_2	182	188	PF00069	0.630
MOD_PKA_2	222	228	PF00069	0.522
MOD_PKA_2	29	35	PF00069	0.679
MOD_PKA_2	392	398	PF00069	0.611
MOD_PKA_2	461	467	PF00069	0.483
MOD_PKA_2	488	494	PF00069	0.426
MOD_PKA_2	585	591	PF00069	0.431
MOD_PKB_1	446	454	PF00069	0.503
MOD_Plk_1	156	162	PF00069	0.532
MOD_Plk_1	278	284	PF00069	0.547
MOD_Plk_1	500	506	PF00069	0.331
MOD_Plk_1	561	567	PF00069	0.473
MOD_Plk_2-3	557	563	PF00069	0.324
MOD_Plk_4	113	119	PF00069	0.696
MOD_Plk_4	185	191	PF00069	0.528
MOD_Plk_4	96	102	PF00069	0.520
MOD_ProDKin_1	123	129	PF00069	0.529
MOD_ProDKin_1	145	151	PF00069	0.564
MOD_ProDKin_1	171	177	PF00069	0.653
MOD_ProDKin_1	178	184	PF00069	0.626
MOD_ProDKin_1	193	199	PF00069	0.720
MOD_ProDKin_1	201	207	PF00069	0.596
MOD_ProDKin_1	224	230	PF00069	0.689
MOD_ProDKin_1	394	400	PF00069	0.532
MOD_ProDKin_1	427	433	PF00069	0.395
MOD_ProDKin_1	43	49	PF00069	0.668
MOD_ProDKin_1	526	532	PF00069	0.694
MOD_ProDKin_1	57	63	PF00069	0.704
MOD_SUMO_for_1	378	381	PF00179	0.544
TRG_DiLeu_BaEn_1	549	554	PF01217	0.345
TRG_DiLeu_BaEn_4	371	377	PF01217	0.498
TRG_DiLeu_BaEn_4	500	506	PF01217	0.482
TRG_DiLeu_BaEn_4	533	539	PF01217	0.528
TRG_ER_diArg_1	138	140	PF00400	0.549
TRG_ER_diArg_1	29	31	PF00400	0.782
TRG_ER_diArg_1	356	359	PF00400	0.443
TRG_ER_diArg_1	465	468	PF00400	0.488
TRG_ER_diArg_1	536	539	PF00400	0.411
TRG_ER_diArg_1	55	58	PF00400	0.764
TRG_ER_diArg_1	565	568	PF00400	0.437
TRG_ER_diArg_1	585	587	PF00400	0.308
TRG_ER_diArg_1	606	609	PF00400	0.408
TRG_NLS_MonoExtN_4	356	361	PF00514	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z2	Leptomonas seymouri	56%	94%
A0A3Q8IAX8	Leishmania donovani	67%	82%
A0A422NJ18	Trypanosoma rangeli	29%	100%
A4HXS7	Leishmania infantum	67%	82%
E9ARI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	83%
Q4QDZ0	Leishmania major	68%	100%