Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9F8_LEIBR

TriTrypDb:

LbrM.18.0560 , LBRM2903_180010400

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9F8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.591
CLV_NRD_NRD_1	240	242	PF00675	0.521
CLV_NRD_NRD_1	251	253	PF00675	0.494
CLV_NRD_NRD_1	419	421	PF00675	0.457
CLV_PCSK_FUR_1	417	421	PF00082	0.447
CLV_PCSK_KEX2_1	107	109	PF00082	0.547
CLV_PCSK_KEX2_1	240	242	PF00082	0.521
CLV_PCSK_KEX2_1	251	253	PF00082	0.416
CLV_PCSK_KEX2_1	30	32	PF00082	0.635
CLV_PCSK_KEX2_1	416	418	PF00082	0.406
CLV_PCSK_KEX2_1	419	421	PF00082	0.456
CLV_PCSK_KEX2_1	75	77	PF00082	0.579
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.561
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.309
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.674
CLV_PCSK_PC7_1	71	77	PF00082	0.473
CLV_PCSK_SKI1_1	254	258	PF00082	0.461
CLV_PCSK_SKI1_1	290	294	PF00082	0.361
CLV_Separin_Metazoa	294	298	PF03568	0.479
DEG_APCC_DBOX_1	289	297	PF00400	0.353
DEG_SPOP_SBC_1	171	175	PF00917	0.455
DEG_SPOP_SBC_1	58	62	PF00917	0.460
DOC_CKS1_1	356	361	PF01111	0.509
DOC_MAPK_gen_1	107	114	PF00069	0.616
DOC_MAPK_RevD_3	403	418	PF00069	0.283
DOC_PP1_RVXF_1	91	97	PF00149	0.584
DOC_PP4_FxxP_1	222	225	PF00568	0.467
DOC_USP7_MATH_1	186	190	PF00917	0.565
DOC_USP7_MATH_1	324	328	PF00917	0.637
DOC_USP7_MATH_1	48	52	PF00917	0.689
DOC_USP7_MATH_1	57	61	PF00917	0.646
DOC_USP7_MATH_1	79	83	PF00917	0.712
DOC_WW_Pin1_4	180	185	PF00397	0.470
DOC_WW_Pin1_4	347	352	PF00397	0.638
DOC_WW_Pin1_4	355	360	PF00397	0.467
LIG_14-3-3_CanoR_1	107	114	PF00244	0.525
LIG_14-3-3_CanoR_1	122	130	PF00244	0.386
LIG_14-3-3_CanoR_1	251	260	PF00244	0.497
LIG_BRCT_BRCA1_1	219	223	PF00533	0.228
LIG_deltaCOP1_diTrp_1	139	147	PF00928	0.489
LIG_deltaCOP1_diTrp_1	250	257	PF00928	0.443
LIG_FHA_1	126	132	PF00498	0.483
LIG_FHA_1	175	181	PF00498	0.571
LIG_FHA_1	317	323	PF00498	0.511
LIG_FHA_1	330	336	PF00498	0.437
LIG_FHA_1	348	354	PF00498	0.628
LIG_FHA_2	159	165	PF00498	0.522
LIG_FHA_2	329	335	PF00498	0.592
LIG_LIR_Apic_2	220	225	PF02991	0.238
LIG_LIR_Gen_1	211	221	PF02991	0.459
LIG_LIR_Gen_1	255	265	PF02991	0.533
LIG_LIR_Gen_1	366	374	PF02991	0.355
LIG_LIR_Gen_1	399	408	PF02991	0.377
LIG_LIR_Gen_1	95	105	PF02991	0.459
LIG_LIR_Nem_3	211	216	PF02991	0.481
LIG_LIR_Nem_3	255	260	PF02991	0.511
LIG_LIR_Nem_3	366	370	PF02991	0.362
LIG_LIR_Nem_3	399	405	PF02991	0.379
LIG_LIR_Nem_3	95	99	PF02991	0.463
LIG_MLH1_MIPbox_1	219	223	PF16413	0.228
LIG_PCNA_PIPBox_1	22	31	PF02747	0.489
LIG_PCNA_yPIPBox_3	15	29	PF02747	0.493
LIG_Pex14_1	253	257	PF04695	0.475
LIG_SH2_CRK	367	371	PF00017	0.359
LIG_SH2_CRK	402	406	PF00017	0.379
LIG_SH2_STAP1	367	371	PF00017	0.359
LIG_SH2_STAP1	402	406	PF00017	0.379
LIG_SH2_STAT5	130	133	PF00017	0.377
LIG_SH2_STAT5	259	262	PF00017	0.482
LIG_SH3_3	182	188	PF00018	0.606
LIG_SH3_3	222	228	PF00018	0.476
LIG_SH3_3	348	354	PF00018	0.605
LIG_SH3_3	356	362	PF00018	0.476
LIG_SUMO_SIM_par_1	2	7	PF11976	0.483
LIG_SUMO_SIM_par_1	404	410	PF11976	0.488
LIG_TRAF2_1	309	312	PF00917	0.467
LIG_TYR_ITIM	365	370	PF00017	0.369
LIG_UBA3_1	370	379	PF00899	0.368
MOD_CK1_1	110	116	PF00069	0.672
MOD_CK1_1	163	169	PF00069	0.532
MOD_CK1_1	178	184	PF00069	0.460
MOD_CK1_1	243	249	PF00069	0.654
MOD_CK1_1	333	339	PF00069	0.666
MOD_CK1_1	343	349	PF00069	0.692
MOD_CK1_1	366	372	PF00069	0.489
MOD_CK1_1	381	387	PF00069	0.233
MOD_CK1_1	53	59	PF00069	0.593
MOD_CK1_1	82	88	PF00069	0.696
MOD_CK2_1	158	164	PF00069	0.532
MOD_CK2_1	244	250	PF00069	0.602
MOD_CK2_1	369	375	PF00069	0.288
MOD_CK2_1	37	43	PF00069	0.627
MOD_GlcNHglycan	116	119	PF01048	0.628
MOD_GlcNHglycan	123	126	PF01048	0.506
MOD_GlcNHglycan	164	168	PF01048	0.463
MOD_GlcNHglycan	188	191	PF01048	0.578
MOD_GlcNHglycan	200	203	PF01048	0.364
MOD_GlcNHglycan	208	211	PF01048	0.441
MOD_GlcNHglycan	219	222	PF01048	0.300
MOD_GlcNHglycan	245	249	PF01048	0.632
MOD_GlcNHglycan	254	257	PF01048	0.461
MOD_GlcNHglycan	33	36	PF01048	0.572
MOD_GlcNHglycan	383	386	PF01048	0.457
MOD_GlcNHglycan	55	58	PF01048	0.681
MOD_GlcNHglycan	77	80	PF01048	0.714
MOD_GlcNHglycan	81	84	PF01048	0.690
MOD_GSK3_1	110	117	PF00069	0.558
MOD_GSK3_1	121	128	PF00069	0.361
MOD_GSK3_1	170	177	PF00069	0.588
MOD_GSK3_1	240	247	PF00069	0.498
MOD_GSK3_1	324	331	PF00069	0.595
MOD_GSK3_1	333	340	PF00069	0.656
MOD_GSK3_1	343	350	PF00069	0.682
MOD_GSK3_1	354	361	PF00069	0.538
MOD_GSK3_1	366	373	PF00069	0.508
MOD_GSK3_1	44	51	PF00069	0.666
MOD_GSK3_1	53	60	PF00069	0.580
MOD_GSK3_1	75	82	PF00069	0.578
MOD_N-GLC_2	277	279	PF02516	0.314
MOD_NEK2_1	10	15	PF00069	0.495
MOD_NEK2_1	341	346	PF00069	0.478
MOD_NEK2_1	37	42	PF00069	0.515
MOD_NEK2_1	407	412	PF00069	0.421
MOD_NEK2_1	49	54	PF00069	0.486
MOD_PKA_1	107	113	PF00069	0.703
MOD_PKA_1	240	246	PF00069	0.468
MOD_PKA_1	75	81	PF00069	0.670
MOD_PKA_2	107	113	PF00069	0.533
MOD_PKA_2	121	127	PF00069	0.328
MOD_PKA_2	240	246	PF00069	0.617
MOD_PKA_2	75	81	PF00069	0.701
MOD_Plk_1	125	131	PF00069	0.492
MOD_Plk_1	148	154	PF00069	0.488
MOD_Plk_1	269	275	PF00069	0.531
MOD_Plk_1	322	328	PF00069	0.520
MOD_Plk_4	175	181	PF00069	0.657
MOD_Plk_4	366	372	PF00069	0.383
MOD_ProDKin_1	180	186	PF00069	0.468
MOD_ProDKin_1	347	353	PF00069	0.636
MOD_ProDKin_1	355	361	PF00069	0.461
TRG_DiLeu_BaEn_1	211	216	PF01217	0.405
TRG_ENDOCYTIC_2	367	370	PF00928	0.363
TRG_ENDOCYTIC_2	402	405	PF00928	0.372
TRG_ER_diArg_1	240	242	PF00400	0.386
TRG_ER_diArg_1	251	253	PF00400	0.299
TRG_ER_diArg_1	417	420	PF00400	0.468
TRG_NLS_MonoCore_2	415	420	PF00514	0.318
TRG_NLS_MonoExtC_3	415	420	PF00514	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D0	Leptomonas seymouri	53%	98%
A0A1X0P6Z6	Trypanosomatidae	39%	100%
A0A3Q8IB26	Leishmania donovani	78%	100%
A0A422NJ49	Trypanosoma rangeli	37%	100%
A4HXS5	Leishmania infantum	78%	100%
D0A057	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ARI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QDZ2	Leishmania major	78%	100%
V5BRN6	Trypanosoma cruzi	33%	100%