BTB_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

btb/poz domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9F7_LEIBR

TriTrypDb:

LbrM.18.0550 , LBRM2903_180010300

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9F7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0043933	protein-containing complex organization	4	7
GO:0051259	protein complex oligomerization	6	7
GO:0051260	protein homooligomerization	7	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.314
CLV_NRD_NRD_1	126	128	PF00675	0.481
CLV_NRD_NRD_1	247	249	PF00675	0.476
CLV_NRD_NRD_1	36	38	PF00675	0.304
CLV_PCSK_KEX2_1	126	128	PF00082	0.456
CLV_PCSK_KEX2_1	247	249	PF00082	0.476
CLV_PCSK_KEX2_1	36	38	PF00082	0.304
CLV_PCSK_PC7_1	122	128	PF00082	0.339
CLV_PCSK_SKI1_1	122	126	PF00082	0.345
CLV_PCSK_SKI1_1	181	185	PF00082	0.624
CLV_PCSK_SKI1_1	191	195	PF00082	0.589
CLV_PCSK_SKI1_1	248	252	PF00082	0.522
CLV_PCSK_SKI1_1	284	288	PF00082	0.382
CLV_PCSK_SKI1_1	41	45	PF00082	0.369
DEG_APCC_DBOX_1	36	44	PF00400	0.304
DEG_SPOP_SBC_1	166	170	PF00917	0.521
DEG_SPOP_SBC_1	210	214	PF00917	0.564
DOC_CYCLIN_RxL_1	281	288	PF00134	0.399
DOC_MAPK_DCC_7	231	241	PF00069	0.430
DOC_MAPK_gen_1	282	289	PF00069	0.452
DOC_MAPK_MEF2A_6	282	289	PF00069	0.452
DOC_PP1_RVXF_1	245	252	PF00149	0.493
DOC_PP2B_LxvP_1	287	290	PF13499	0.388
DOC_PP2B_LxvP_1	86	89	PF13499	0.304
DOC_USP7_MATH_1	160	164	PF00917	0.537
DOC_USP7_MATH_1	166	170	PF00917	0.507
DOC_USP7_MATH_1	210	214	PF00917	0.657
DOC_USP7_MATH_1	219	223	PF00917	0.548
DOC_WW_Pin1_4	138	143	PF00397	0.411
DOC_WW_Pin1_4	158	163	PF00397	0.641
DOC_WW_Pin1_4	167	172	PF00397	0.539
DOC_WW_Pin1_4	217	222	PF00397	0.508
LIG_14-3-3_CanoR_1	181	190	PF00244	0.511
LIG_14-3-3_CanoR_1	284	290	PF00244	0.389
LIG_14-3-3_CanoR_1	36	41	PF00244	0.369
LIG_APCC_ABBAyCdc20_2	247	253	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.504
LIG_CSL_BTD_1	135	138	PF09270	0.383
LIG_FHA_1	192	198	PF00498	0.653
LIG_FHA_1	202	208	PF00498	0.570
LIG_FHA_1	263	269	PF00498	0.328
LIG_FHA_2	37	43	PF00498	0.373
LIG_LIR_Gen_1	94	102	PF02991	0.454
LIG_LIR_Nem_3	101	107	PF02991	0.375
LIG_LIR_Nem_3	72	77	PF02991	0.308
LIG_LIR_Nem_3	94	98	PF02991	0.340
LIG_SH2_CRK	105	109	PF00017	0.227
LIG_SH2_NCK_1	105	109	PF00017	0.504
LIG_SH2_SRC	76	79	PF00017	0.358
LIG_SH2_STAT5	134	137	PF00017	0.386
LIG_SH2_STAT5	33	36	PF00017	0.304
LIG_SH2_STAT5	38	41	PF00017	0.304
LIG_SH2_STAT5	76	79	PF00017	0.304
LIG_SH2_STAT5	80	83	PF00017	0.304
LIG_SH3_1	231	237	PF00018	0.430
LIG_SH3_3	132	138	PF00018	0.384
LIG_SH3_3	159	165	PF00018	0.741
LIG_SH3_3	231	237	PF00018	0.604
LIG_SUMO_SIM_par_1	264	269	PF11976	0.436
LIG_TYR_ITIM	102	107	PF00017	0.369
LIG_WW_2	234	237	PF00397	0.549
MOD_CK1_1	152	158	PF00069	0.580
MOD_CK1_1	222	228	PF00069	0.543
MOD_CK2_1	110	116	PF00069	0.413
MOD_CK2_1	36	42	PF00069	0.373
MOD_Cter_Amidation	245	248	PF01082	0.496
MOD_GlcNHglycan	1	4	PF01048	0.492
MOD_GlcNHglycan	151	154	PF01048	0.627
MOD_GlcNHglycan	176	179	PF01048	0.581
MOD_GlcNHglycan	214	217	PF01048	0.731
MOD_GlcNHglycan	224	227	PF01048	0.613
MOD_GlcNHglycan	244	247	PF01048	0.534
MOD_GSK3_1	148	155	PF00069	0.549
MOD_GSK3_1	172	179	PF00069	0.614
MOD_GSK3_1	217	224	PF00069	0.621
MOD_GSK3_1	262	269	PF00069	0.486
MOD_GSK3_1	28	35	PF00069	0.377
MOD_NEK2_1	110	115	PF00069	0.441
MOD_NEK2_1	120	125	PF00069	0.387
MOD_NEK2_1	251	256	PF00069	0.436
MOD_NEK2_1	32	37	PF00069	0.304
MOD_NEK2_1	8	13	PF00069	0.469
MOD_PIKK_1	160	166	PF00454	0.521
MOD_PIKK_1	251	257	PF00454	0.424
MOD_PKA_1	36	42	PF00069	0.369
MOD_PKA_2	251	257	PF00069	0.424
MOD_PKA_2	36	42	PF00069	0.369
MOD_Plk_1	110	116	PF00069	0.449
MOD_Plk_4	110	116	PF00069	0.449
MOD_Plk_4	262	268	PF00069	0.390
MOD_Plk_4	28	34	PF00069	0.369
MOD_Plk_4	3	9	PF00069	0.445
MOD_Plk_4	61	67	PF00069	0.304
MOD_Plk_4	69	75	PF00069	0.304
MOD_ProDKin_1	138	144	PF00069	0.420
MOD_ProDKin_1	158	164	PF00069	0.642
MOD_ProDKin_1	167	173	PF00069	0.537
MOD_ProDKin_1	217	223	PF00069	0.508
MOD_SUMO_rev_2	141	149	PF00179	0.484
TRG_DiLeu_BaEn_1	94	99	PF01217	0.304
TRG_DiLeu_BaEn_2	60	66	PF01217	0.304
TRG_ENDOCYTIC_2	104	107	PF00928	0.511
TRG_ER_diArg_1	125	127	PF00400	0.471
TRG_ER_diArg_1	247	249	PF00400	0.476
TRG_ER_diArg_1	282	285	PF00400	0.458
TRG_ER_diArg_1	36	38	PF00400	0.369
TRG_Pf-PMV_PEXEL_1	195	200	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z1	Leptomonas seymouri	54%	100%
A0A3S5H729	Leishmania donovani	77%	100%
A4HXS4	Leishmania infantum	78%	100%
E9ARI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QDZ3	Leishmania major	78%	98%