Uracil-DNA glycosylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

uracil-DNA-glycosylase, putative

Species:

Leishmania braziliensis

UniProt:

A4H9F6_LEIBR

TriTrypDb:

LbrM.18.0540 , LBRM2903_180010200

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0005739	mitochondrion	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H9F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9F6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006284	base-excision repair	6	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004844	uracil DNA N-glycosylase activity	6	8
GO:0016787	hydrolase activity	2	8
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	8
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	8
GO:0019104	DNA N-glycosylase activity	4	8
GO:0097506	deaminated base DNA N-glycosylase activity	5	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.302
CLV_NRD_NRD_1	49	51	PF00675	0.643
CLV_NRD_NRD_1	62	64	PF00675	0.622
CLV_PCSK_KEX2_1	316	318	PF00082	0.200
CLV_PCSK_KEX2_1	62	64	PF00082	0.797
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.200
CLV_PCSK_SKI1_1	146	150	PF00082	0.430
CLV_PCSK_SKI1_1	159	163	PF00082	0.493
CLV_PCSK_SKI1_1	177	181	PF00082	0.407
CLV_PCSK_SKI1_1	196	200	PF00082	0.262
CLV_PCSK_SKI1_1	236	240	PF00082	0.264
CLV_PCSK_SKI1_1	3	7	PF00082	0.590
CLV_PCSK_SKI1_1	302	306	PF00082	0.284
CLV_PCSK_SKI1_1	51	55	PF00082	0.783
DEG_APCC_DBOX_1	145	153	PF00400	0.468
DEG_Nend_UBRbox_3	1	3	PF02207	0.674
DOC_CYCLIN_yClb1_LxF_4	300	305	PF00134	0.560
DOC_MAPK_gen_1	158	165	PF00069	0.453
DOC_MAPK_gen_1	173	180	PF00069	0.394
DOC_PP1_RVXF_1	300	306	PF00149	0.466
DOC_PP2B_LxvP_1	368	371	PF13499	0.309
DOC_PP4_FxxP_1	148	151	PF00568	0.387
DOC_PP4_FxxP_1	245	248	PF00568	0.464
DOC_USP7_MATH_1	113	117	PF00917	0.620
DOC_USP7_MATH_1	120	124	PF00917	0.686
DOC_USP7_MATH_1	125	129	PF00917	0.651
DOC_USP7_MATH_1	189	193	PF00917	0.322
DOC_USP7_MATH_1	87	91	PF00917	0.739
DOC_WW_Pin1_4	330	335	PF00397	0.464
DOC_WW_Pin1_4	44	49	PF00397	0.696
LIG_14-3-3_CanoR_1	115	120	PF00244	0.616
LIG_14-3-3_CanoR_1	345	354	PF00244	0.388
LIG_14-3-3_CanoR_1	356	364	PF00244	0.232
LIG_BRCT_BRCA1_1	191	195	PF00533	0.437
LIG_CtBP_PxDLS_1	228	232	PF00389	0.523
LIG_deltaCOP1_diTrp_1	144	148	PF00928	0.401
LIG_deltaCOP1_diTrp_1	155	162	PF00928	0.408
LIG_FHA_1	237	243	PF00498	0.457
LIG_FHA_1	265	271	PF00498	0.453
LIG_FHA_1	286	292	PF00498	0.446
LIG_FHA_2	139	145	PF00498	0.463
LIG_FHA_2	2	8	PF00498	0.601
LIG_FHA_2	33	39	PF00498	0.508
LIG_FHA_2	53	59	PF00498	0.745
LIG_LIR_Apic_2	147	151	PF02991	0.433
LIG_LIR_Gen_1	185	195	PF02991	0.363
LIG_LIR_Gen_1	206	214	PF02991	0.480
LIG_LIR_Gen_1	281	292	PF02991	0.522
LIG_LIR_Nem_3	144	148	PF02991	0.404
LIG_LIR_Nem_3	185	190	PF02991	0.361
LIG_LIR_Nem_3	192	198	PF02991	0.349
LIG_LIR_Nem_3	206	211	PF02991	0.407
LIG_LIR_Nem_3	281	287	PF02991	0.488
LIG_MAD2	199	207	PF02301	0.464
LIG_NRBOX	302	308	PF00104	0.560
LIG_PCNA_yPIPBox_3	2	11	PF02747	0.640
LIG_Pex14_2	6	10	PF04695	0.724
LIG_SH2_STAT3	311	314	PF00017	0.560
LIG_SH2_STAT5	252	255	PF00017	0.464
LIG_SH3_3	175	181	PF00018	0.396
LIG_SH3_3	220	226	PF00018	0.466
LIG_SH3_3	86	92	PF00018	0.508
LIG_SH3_3	93	99	PF00018	0.668
LIG_SUMO_SIM_par_1	266	271	PF11976	0.464
LIG_TRAF2_1	99	102	PF00917	0.594
LIG_TRAF2_2	99	104	PF00917	0.538
LIG_UBA3_1	5	11	PF00899	0.508
LIG_WW_3	47	51	PF00397	0.509
MOD_CDC14_SPxK_1	47	50	PF00782	0.744
MOD_CDK_SPxK_1	44	50	PF00069	0.756
MOD_CDK_SPxxK_3	44	51	PF00069	0.759
MOD_CK1_1	114	120	PF00069	0.760
MOD_CK1_1	128	134	PF00069	0.405
MOD_CK1_1	14	20	PF00069	0.674
MOD_CK1_1	279	285	PF00069	0.490
MOD_CK1_1	33	39	PF00069	0.675
MOD_CK1_1	333	339	PF00069	0.446
MOD_CK2_1	138	144	PF00069	0.474
MOD_CK2_1	252	258	PF00069	0.523
MOD_CK2_1	52	58	PF00069	0.745
MOD_CK2_1	62	68	PF00069	0.721
MOD_GlcNHglycan	122	125	PF01048	0.599
MOD_GlcNHglycan	14	17	PF01048	0.700
MOD_GlcNHglycan	281	284	PF01048	0.309
MOD_GlcNHglycan	335	338	PF01048	0.249
MOD_GlcNHglycan	347	350	PF01048	0.252
MOD_GSK3_1	10	17	PF00069	0.505
MOD_GSK3_1	111	118	PF00069	0.698
MOD_GSK3_1	125	132	PF00069	0.473
MOD_GSK3_1	274	281	PF00069	0.506
MOD_GSK3_1	52	59	PF00069	0.697
MOD_LATS_1	61	67	PF00433	0.539
MOD_N-GLC_1	111	116	PF02516	0.522
MOD_N-GLC_1	264	269	PF02516	0.264
MOD_N-GLC_1	39	44	PF02516	0.532
MOD_N-GLC_2	191	193	PF02516	0.431
MOD_NEK2_1	1	6	PF00069	0.630
MOD_NEK2_1	217	222	PF00069	0.464
MOD_NEK2_1	264	269	PF00069	0.448
MOD_NEK2_1	318	323	PF00069	0.440
MOD_NEK2_1	32	37	PF00069	0.663
MOD_NEK2_1	85	90	PF00069	0.696
MOD_PIKK_1	293	299	PF00454	0.523
MOD_PIKK_1	52	58	PF00454	0.538
MOD_PKA_1	62	68	PF00069	0.538
MOD_PKA_2	114	120	PF00069	0.658
MOD_PKA_2	355	361	PF00069	0.290
MOD_PKA_2	61	67	PF00069	0.744
MOD_PKA_2	68	74	PF00069	0.663
MOD_PKB_1	28	36	PF00069	0.535
MOD_Plk_1	264	270	PF00069	0.464
MOD_Plk_1	39	45	PF00069	0.530
MOD_Plk_1	85	91	PF00069	0.697
MOD_Plk_4	1	7	PF00069	0.733
MOD_ProDKin_1	330	336	PF00069	0.464
MOD_ProDKin_1	44	50	PF00069	0.696
MOD_SUMO_rev_2	104	113	PF00179	0.536
TRG_DiLeu_BaEn_1	258	263	PF01217	0.446
TRG_DiLeu_BaEn_2	143	149	PF01217	0.475
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.388
TRG_ENDOCYTIC_2	208	211	PF00928	0.464
TRG_ENDOCYTIC_2	235	238	PF00928	0.488
TRG_ENDOCYTIC_2	363	366	PF00928	0.259
TRG_NES_CRM1_1	259	271	PF08389	0.523
TRG_NES_CRM1_1	352	365	PF08389	0.381
TRG_NLS_MonoExtC_3	314	320	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK50	Leptomonas seymouri	54%	89%
A0A1X0P6S1	Trypanosomatidae	55%	100%
A0A3R7L167	Trypanosoma rangeli	55%	100%
A0A3S7WUW8	Leishmania donovani	75%	95%
A4HXS3	Leishmania infantum	76%	95%
E9ARI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
P53766	Dictyostelium discoideum	43%	100%
Q5UPT2	Acanthamoeba polyphaga mimivirus	31%	100%
Q8NQU9	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	38%	100%