Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paralyzed flagella protein 20

Species:

Leishmania braziliensis

UniProt:

A4H9F5_LEIBR

TriTrypDb:

LbrM.18.0530 , LBRM2903_180010100

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H9F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9F5

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0060294	cilium movement involved in cell motility	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	213	215	PF00675	0.526
CLV_NRD_NRD_1	271	273	PF00675	0.652
CLV_PCSK_KEX2_1	213	215	PF00082	0.503
CLV_PCSK_KEX2_1	270	272	PF00082	0.695
CLV_PCSK_PC7_1	209	215	PF00082	0.499
CLV_PCSK_SKI1_1	202	206	PF00082	0.380
CLV_PCSK_SKI1_1	406	410	PF00082	0.221
CLV_PCSK_SKI1_1	523	527	PF00082	0.163
CLV_PCSK_SKI1_1	72	76	PF00082	0.461
DOC_CYCLIN_RxL_1	199	208	PF00134	0.427
DOC_CYCLIN_RxL_1	520	530	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	106	112	PF00134	0.432
DOC_MAPK_gen_1	200	207	PF00069	0.399
DOC_PP2B_LxvP_1	50	53	PF13499	0.629
DOC_PP2B_LxvP_1	61	64	PF13499	0.558
DOC_PP4_FxxP_1	292	295	PF00568	0.531
DOC_SPAK_OSR1_1	608	612	PF12202	0.431
DOC_USP7_MATH_1	21	25	PF00917	0.487
DOC_USP7_MATH_1	344	348	PF00917	0.515
DOC_USP7_MATH_1	358	362	PF00917	0.455
DOC_USP7_MATH_1	376	380	PF00917	0.393
DOC_USP7_MATH_1	400	404	PF00917	0.421
DOC_USP7_MATH_1	569	573	PF00917	0.387
DOC_USP7_MATH_1	596	600	PF00917	0.563
DOC_WW_Pin1_4	2	7	PF00397	0.661
DOC_WW_Pin1_4	273	278	PF00397	0.664
DOC_WW_Pin1_4	324	329	PF00397	0.726
LIG_14-3-3_CanoR_1	157	164	PF00244	0.553
LIG_14-3-3_CanoR_1	271	277	PF00244	0.665
LIG_14-3-3_CanoR_1	367	372	PF00244	0.565
LIG_14-3-3_CanoR_1	41	45	PF00244	0.562
LIG_14-3-3_CanoR_1	417	423	PF00244	0.457
LIG_14-3-3_CanoR_1	461	465	PF00244	0.453
LIG_14-3-3_CanoR_1	82	88	PF00244	0.427
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BRCT_BRCA1_1	598	602	PF00533	0.537
LIG_BRCT_BRCA1_1	605	609	PF00533	0.405
LIG_Clathr_ClatBox_1	204	208	PF01394	0.406
LIG_Clathr_ClatBox_1	546	550	PF01394	0.478
LIG_deltaCOP1_diTrp_1	331	338	PF00928	0.390
LIG_EVH1_1	52	56	PF00568	0.538
LIG_FHA_1	116	122	PF00498	0.347
LIG_FHA_1	138	144	PF00498	0.329
LIG_FHA_1	304	310	PF00498	0.568
LIG_FHA_1	340	346	PF00498	0.452
LIG_FHA_1	405	411	PF00498	0.421
LIG_FHA_1	424	430	PF00498	0.421
LIG_FHA_1	435	441	PF00498	0.392
LIG_FHA_1	447	453	PF00498	0.421
LIG_FHA_1	478	484	PF00498	0.421
LIG_FHA_1	5	11	PF00498	0.704
LIG_FHA_1	55	61	PF00498	0.654
LIG_FHA_1	574	580	PF00498	0.341
LIG_FHA_1	586	592	PF00498	0.238
LIG_FHA_1	79	85	PF00498	0.467
LIG_FHA_2	185	191	PF00498	0.403
LIG_FHA_2	3	9	PF00498	0.666
LIG_LIR_Apic_2	289	295	PF02991	0.548
LIG_LIR_Nem_3	473	479	PF02991	0.506
LIG_NRBOX	169	175	PF00104	0.482
LIG_PCNA_yPIPBox_3	162	174	PF02747	0.542
LIG_PDZ_Class_2	618	623	PF00595	0.453
LIG_PDZ_Wminus1_1	621	623	PF00595	0.453
LIG_Pex14_1	430	434	PF04695	0.421
LIG_Pex14_2	70	74	PF04695	0.420
LIG_Pex14_2	87	91	PF04695	0.426
LIG_PTB_Apo_2	70	77	PF02174	0.399
LIG_PTB_Phospho_1	70	76	PF10480	0.394
LIG_RPA_C_Fungi	536	548	PF08784	0.458
LIG_SH2_CRK	479	483	PF00017	0.272
LIG_SH2_GRB2like	479	482	PF00017	0.194
LIG_SH2_STAP1	479	483	PF00017	0.194
LIG_SH2_STAT5	479	482	PF00017	0.285
LIG_SH2_STAT5	92	95	PF00017	0.379
LIG_SH3_3	106	112	PF00018	0.565
LIG_SH3_3	241	247	PF00018	0.713
LIG_SH3_3	317	323	PF00018	0.492
LIG_SH3_3	349	355	PF00018	0.302
LIG_SH3_3	50	56	PF00018	0.538
LIG_SUMO_SIM_par_1	203	208	PF11976	0.403
LIG_SUMO_SIM_par_1	578	585	PF11976	0.366
LIG_TYR_ITIM	477	482	PF00017	0.177
LIG_UBA3_1	204	211	PF00899	0.387
LIG_WRC_WIRS_1	84	89	PF05994	0.370
MOD_CK1_1	2	8	PF00069	0.747
MOD_CK1_1	203	209	PF00069	0.509
MOD_CK1_1	259	265	PF00069	0.708
MOD_CK1_1	275	281	PF00069	0.591
MOD_CK1_1	324	330	PF00069	0.574
MOD_CK1_1	423	429	PF00069	0.412
MOD_CK1_1	528	534	PF00069	0.392
MOD_CK1_1	585	591	PF00069	0.243
MOD_CK1_1	612	618	PF00069	0.277
MOD_CK2_1	184	190	PF00069	0.409
MOD_GlcNHglycan	261	264	PF01048	0.674
MOD_GlcNHglycan	311	314	PF01048	0.683
MOD_GlcNHglycan	323	326	PF01048	0.608
MOD_GlcNHglycan	358	361	PF01048	0.337
MOD_GlcNHglycan	378	381	PF01048	0.234
MOD_GlcNHglycan	402	405	PF01048	0.258
MOD_GlcNHglycan	422	425	PF01048	0.129
MOD_GlcNHglycan	442	445	PF01048	0.258
MOD_GlcNHglycan	486	489	PF01048	0.258
MOD_GlcNHglycan	611	614	PF01048	0.341
MOD_GSK3_1	184	191	PF00069	0.533
MOD_GSK3_1	255	262	PF00069	0.699
MOD_GSK3_1	275	282	PF00069	0.682
MOD_GSK3_1	339	346	PF00069	0.324
MOD_GSK3_1	358	365	PF00069	0.298
MOD_GSK3_1	381	388	PF00069	0.266
MOD_GSK3_1	394	401	PF00069	0.286
MOD_GSK3_1	4	11	PF00069	0.672
MOD_GSK3_1	498	505	PF00069	0.492
MOD_GSK3_1	521	528	PF00069	0.427
MOD_GSK3_1	569	576	PF00069	0.339
MOD_GSK3_1	611	618	PF00069	0.412
MOD_GSK3_1	98	105	PF00069	0.562
MOD_N-GLC_2	416	418	PF02516	0.172
MOD_NEK2_1	1	6	PF00069	0.671
MOD_NEK2_1	188	193	PF00069	0.528
MOD_NEK2_1	237	242	PF00069	0.592
MOD_NEK2_1	343	348	PF00069	0.337
MOD_NEK2_1	398	403	PF00069	0.258
MOD_NEK2_1	40	45	PF00069	0.527
MOD_NEK2_1	434	439	PF00069	0.273
MOD_NEK2_1	440	445	PF00069	0.304
MOD_NEK2_1	446	451	PF00069	0.310
MOD_NEK2_1	482	487	PF00069	0.307
MOD_NEK2_1	602	607	PF00069	0.285
MOD_NEK2_1	609	614	PF00069	0.308
MOD_NEK2_1	80	85	PF00069	0.539
MOD_NEK2_2	238	243	PF00069	0.521
MOD_NEK2_2	404	409	PF00069	0.258
MOD_NEK2_2	460	465	PF00069	0.277
MOD_PIKK_1	144	150	PF00454	0.550
MOD_PIKK_1	528	534	PF00454	0.390
MOD_PKA_2	156	162	PF00069	0.432
MOD_PKA_2	168	174	PF00069	0.386
MOD_PKA_2	366	372	PF00069	0.396
MOD_PKA_2	394	400	PF00069	0.390
MOD_PKA_2	40	46	PF00069	0.562
MOD_PKA_2	460	466	PF00069	0.302
MOD_PKB_1	270	278	PF00069	0.510
MOD_Plk_1	102	108	PF00069	0.636
MOD_Plk_1	333	339	PF00069	0.334
MOD_Plk_1	404	410	PF00069	0.258
MOD_Plk_1	582	588	PF00069	0.366
MOD_Plk_1	615	621	PF00069	0.370
MOD_Plk_4	200	206	PF00069	0.422
MOD_Plk_4	394	400	PF00069	0.258
MOD_Plk_4	425	431	PF00069	0.232
MOD_Plk_4	472	478	PF00069	0.437
MOD_Plk_4	582	588	PF00069	0.387
MOD_ProDKin_1	2	8	PF00069	0.664
MOD_ProDKin_1	273	279	PF00069	0.664
MOD_ProDKin_1	324	330	PF00069	0.715
TRG_DiLeu_BaEn_1	436	441	PF01217	0.223
TRG_DiLeu_BaEn_2	287	293	PF01217	0.623
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.534
TRG_ENDOCYTIC_2	479	482	PF00928	0.219
TRG_ER_diArg_1	212	214	PF00400	0.507
TRG_ER_diArg_1	270	272	PF00400	0.515
TRG_NES_CRM1_1	36	49	PF08389	0.569
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN2	Leptomonas seymouri	69%	97%
A0A0S4JA64	Bodo saltans	44%	100%
A0A1X0P716	Trypanosomatidae	51%	100%
A0A3R7NP23	Trypanosoma rangeli	50%	100%
A0A3S7WR72	Leishmania donovani	28%	100%
A0A3S7WUV4	Leishmania donovani	84%	100%
A1C7E4	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	25%	89%
A2R3Z3	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	22%	95%
A4H666	Leishmania braziliensis	30%	100%
A4HUJ0	Leishmania infantum	28%	100%
A4HXS2	Leishmania infantum	84%	100%
D0A054	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ARI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
G5EF68	Caenorhabditis elegans	20%	96%
Q4QDZ5	Leishmania major	83%	100%
Q4QHD6	Leishmania major	30%	100%
Q8K450	Mus musculus	33%	97%
Q8N0X2	Homo sapiens	32%	99%
Q9UTC7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%