Putative phosphatidic acid phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidic acid phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H9F1_LEIBR

TriTrypDb:

LbrM.18.0490 , LBRM2903_180013300

Length:

160

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H9F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9F1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008195	phosphatidate phosphatase activity	6	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	87	89	PF00675	0.650
CLV_PCSK_KEX2_1	87	89	PF00082	0.650
DEG_Nend_Nbox_1	1	3	PF02207	0.449
DOC_CKS1_1	151	156	PF01111	0.498
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.549
DOC_MAPK_DCC_7	95	105	PF00069	0.549
DOC_MAPK_gen_1	87	93	PF00069	0.396
DOC_PP1_RVXF_1	55	61	PF00149	0.650
DOC_PP2B_LxvP_1	103	106	PF13499	0.549
DOC_WW_Pin1_4	150	155	PF00397	0.492
DOC_WW_Pin1_4	98	103	PF00397	0.549
LIG_14-3-3_CanoR_1	140	144	PF00244	0.549
LIG_14-3-3_CanoR_1	57	61	PF00244	0.650
LIG_14-3-3_CanoR_1	88	94	PF00244	0.449
LIG_BRCT_BRCA1_1	65	69	PF00533	0.650
LIG_FHA_1	106	112	PF00498	0.427
LIG_FHA_1	132	138	PF00498	0.549
LIG_FHA_1	140	146	PF00498	0.409
LIG_FHA_1	147	153	PF00498	0.320
LIG_FHA_1	99	105	PF00498	0.549
LIG_LIR_Gen_1	48	53	PF02991	0.650
LIG_LIR_Gen_1	66	77	PF02991	0.234
LIG_LIR_Nem_3	153	159	PF02991	0.515
LIG_LIR_Nem_3	48	52	PF02991	0.650
LIG_LIR_Nem_3	66	72	PF02991	0.234
LIG_LIR_Nem_3	92	97	PF02991	0.549
LIG_OCRL_FandH_1	76	88	PF00620	0.549
LIG_PDZ_Class_2	155	160	PF00595	0.535
LIG_PTB_Apo_2	34	41	PF02174	0.650
LIG_SH2_STAT5	78	81	PF00017	0.549
LIG_SUMO_SIM_anti_2	13	18	PF11976	0.549
LIG_SUMO_SIM_par_1	107	112	PF11976	0.549
MOD_CDK_SPK_2	150	155	PF00069	0.492
MOD_CK1_1	59	65	PF00069	0.650
MOD_CK1_1	89	95	PF00069	0.449
MOD_GlcNHglycan	61	64	PF01048	0.449
MOD_GlcNHglycan	65	68	PF01048	0.400
MOD_GlcNHglycan	69	72	PF01048	0.409
MOD_GlcNHglycan	88	91	PF01048	0.412
MOD_GSK3_1	105	112	PF00069	0.549
MOD_GSK3_1	146	153	PF00069	0.506
MOD_GSK3_1	59	66	PF00069	0.650
MOD_GSK3_1	6	13	PF00069	0.549
MOD_N-GLC_1	40	45	PF02516	0.449
MOD_NEK2_1	125	130	PF00069	0.549
MOD_NEK2_1	40	45	PF00069	0.650
MOD_NEK2_1	86	91	PF00069	0.549
MOD_PKA_2	139	145	PF00069	0.549
MOD_PKA_2	56	62	PF00069	0.650
MOD_PKA_2	86	92	PF00069	0.549
MOD_Plk_1	40	46	PF00069	0.650
MOD_Plk_4	10	16	PF00069	0.549
MOD_Plk_4	125	131	PF00069	0.549
MOD_Plk_4	139	145	PF00069	0.304
MOD_Plk_4	89	95	PF00069	0.449
MOD_ProDKin_1	150	156	PF00069	0.498
MOD_ProDKin_1	98	104	PF00069	0.549
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.549
TRG_ER_diArg_1	26	29	PF00400	0.650
TRG_ER_diArg_1	86	88	PF00400	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
O08564	RAT	31%	57%
O14494	HUMAN	33%	56%
O14495	HUMAN	34%	51%
O88956	CAVPO	33%	56%
P60588	PIG	31%	56%
P97544	RAT	35%	51%
Q04396	YEAST	31%	58%
Q05521	YEAST	37%	55%
Q0VBU9	MOUSE	35%	59%
Q0WNG6	ARATH	31%	52%
Q2HJ61	BOVIN	34%	56%
Q3SZE3	BOVIN	33%	51%
Q3UMZ3	MOUSE	40%	62%
Q54PR7	DICDI	41%	59%
Q5VZY2	HUMAN	35%	59%
Q6GQ62	XENLA	38%	60%
Q86AF0	DICDI	31%	44%
Q8K593	RAT	34%	58%
Q8LFD1	ARATH	32%	44%
Q8MXL9	DICDI	29%	48%
Q8NEB5	HUMAN	40%	61%
Q99JY8	MOUSE	35%	51%
Q9DAX2	MOUSE	31%	58%
Q9UUA6	SCHPO	34%	57%
Q9V576	DROME	35%	42%
Q9XI60	ARATH	35%	55%
Q9ZU49	ARATH	31%	49%