Putative phosphatidic acid phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidic acid phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H9F0_LEIBR

TriTrypDb:

LbrM.18.0450 , LBRM2903_180013300 , LBRM2903_180013400

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H9F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9F0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0019637	organophosphate metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0008195	phosphatidate phosphatase activity	6	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	318	320	PF00675	0.357
CLV_NRD_NRD_1	90	92	PF00675	0.448
CLV_PCSK_KEX2_1	318	320	PF00082	0.357
CLV_PCSK_KEX2_1	90	92	PF00082	0.482
CLV_PCSK_SKI1_1	11	15	PF00082	0.370
CLV_PCSK_SKI1_1	225	229	PF00082	0.407
CLV_Separin_Metazoa	8	12	PF03568	0.488
DOC_ANK_TNKS_1	112	119	PF00023	0.621
DOC_CKS1_1	382	387	PF01111	0.455
DOC_CYCLIN_yCln2_LP_2	334	340	PF00134	0.388
DOC_MAPK_DCC_7	326	336	PF00069	0.388
DOC_MAPK_MEF2A_6	192	201	PF00069	0.623
DOC_PP1_RVXF_1	286	292	PF00149	0.299
DOC_PP1_RVXF_1	9	16	PF00149	0.612
DOC_PP2B_LxvP_1	334	337	PF13499	0.388
DOC_PP4_FxxP_1	132	135	PF00568	0.724
DOC_USP7_MATH_1	119	123	PF00917	0.667
DOC_USP7_MATH_1	138	142	PF00917	0.763
DOC_USP7_MATH_1	146	150	PF00917	0.779
DOC_USP7_MATH_1	204	208	PF00917	0.752
DOC_WW_Pin1_4	174	179	PF00397	0.738
DOC_WW_Pin1_4	329	334	PF00397	0.324
DOC_WW_Pin1_4	381	386	PF00397	0.450
DOC_WW_Pin1_4	55	60	PF00397	0.276
LIG_14-3-3_CanoR_1	288	292	PF00244	0.281
LIG_14-3-3_CanoR_1	319	325	PF00244	0.545
LIG_14-3-3_CanoR_1	371	375	PF00244	0.243
LIG_BRCT_BRCA1_1	296	300	PF00533	0.357
LIG_BRCT_BRCA1_1	49	53	PF00533	0.438
LIG_BRCT_BRCA1_1	57	61	PF00533	0.387
LIG_CaM_NSCaTE_8	64	71	PF13499	0.237
LIG_deltaCOP1_diTrp_1	43	53	PF00928	0.268
LIG_eIF4E_1	101	107	PF01652	0.555
LIG_FHA_1	103	109	PF00498	0.644
LIG_FHA_1	154	160	PF00498	0.810
LIG_FHA_1	163	169	PF00498	0.689
LIG_FHA_1	330	336	PF00498	0.448
LIG_FHA_1	337	343	PF00498	0.359
LIG_FHA_1	363	369	PF00498	0.357
LIG_FHA_1	371	377	PF00498	0.455
LIG_FHA_1	378	384	PF00498	0.583
LIG_FHA_1	61	67	PF00498	0.361
LIG_GBD_Chelix_1	75	83	PF00786	0.237
LIG_Integrin_RGD_1	187	189	PF01839	0.444
LIG_LIR_Apic_2	130	135	PF02991	0.717
LIG_LIR_Gen_1	230	241	PF02991	0.526
LIG_LIR_Gen_1	279	284	PF02991	0.300
LIG_LIR_Gen_1	297	308	PF02991	0.368
LIG_LIR_Gen_1	43	54	PF02991	0.269
LIG_LIR_Gen_1	63	72	PF02991	0.267
LIG_LIR_Nem_3	230	236	PF02991	0.489
LIG_LIR_Nem_3	279	283	PF02991	0.274
LIG_LIR_Nem_3	297	303	PF02991	0.276
LIG_LIR_Nem_3	323	328	PF02991	0.499
LIG_LIR_Nem_3	384	390	PF02991	0.505
LIG_LIR_Nem_3	43	49	PF02991	0.273
LIG_LIR_Nem_3	63	67	PF02991	0.230
LIG_OCRL_FandH_1	14	26	PF00620	0.485
LIG_OCRL_FandH_1	307	319	PF00620	0.237
LIG_PDZ_Class_2	386	391	PF00595	0.538
LIG_Pex14_2	12	16	PF04695	0.676
LIG_PTB_Apo_2	265	272	PF02174	0.352
LIG_REV1ctd_RIR_1	12	21	PF16727	0.552
LIG_SH2_SRC	101	104	PF00017	0.662
LIG_SH2_STAP1	229	233	PF00017	0.415
LIG_SH2_STAT5	21	24	PF00017	0.340
LIG_SH2_STAT5	217	220	PF00017	0.516
LIG_SH2_STAT5	229	232	PF00017	0.405
LIG_SH2_STAT5	309	312	PF00017	0.329
LIG_SH2_STAT5	40	43	PF00017	0.223
LIG_SH2_STAT5	77	80	PF00017	0.354
LIG_SH3_3	56	62	PF00018	0.271
LIG_SUMO_SIM_anti_2	105	111	PF11976	0.560
LIG_SUMO_SIM_anti_2	244	249	PF11976	0.237
LIG_SUMO_SIM_par_1	135	144	PF11976	0.700
LIG_SUMO_SIM_par_1	338	343	PF11976	0.359
LIG_TRAF2_1	155	158	PF00917	0.641
MOD_CDK_SPK_2	381	386	PF00069	0.450
MOD_CK1_1	140	146	PF00069	0.784
MOD_CK1_1	193	199	PF00069	0.725
MOD_CK1_1	206	212	PF00069	0.722
MOD_CK1_1	290	296	PF00069	0.236
MOD_CK1_1	320	326	PF00069	0.551
MOD_CK2_1	127	133	PF00069	0.739
MOD_CK2_1	148	154	PF00069	0.769
MOD_GlcNHglycan	150	153	PF01048	0.633
MOD_GlcNHglycan	174	177	PF01048	0.439
MOD_GlcNHglycan	193	196	PF01048	0.609
MOD_GlcNHglycan	206	209	PF01048	0.458
MOD_GlcNHglycan	292	295	PF01048	0.481
MOD_GlcNHglycan	296	299	PF01048	0.481
MOD_GlcNHglycan	300	303	PF01048	0.329
MOD_GlcNHglycan	319	322	PF01048	0.175
MOD_GlcNHglycan	69	72	PF01048	0.329
MOD_GSK3_1	137	144	PF00069	0.722
MOD_GSK3_1	193	200	PF00069	0.780
MOD_GSK3_1	237	244	PF00069	0.439
MOD_GSK3_1	290	297	PF00069	0.357
MOD_GSK3_1	336	343	PF00069	0.284
MOD_GSK3_1	377	384	PF00069	0.463
MOD_N-GLC_1	127	132	PF02516	0.428
MOD_N-GLC_1	147	152	PF02516	0.402
MOD_N-GLC_1	271	276	PF02516	0.439
MOD_NEK2_1	108	113	PF00069	0.662
MOD_NEK2_1	183	188	PF00069	0.710
MOD_NEK2_1	227	232	PF00069	0.474
MOD_NEK2_1	271	276	PF00069	0.215
MOD_NEK2_1	317	322	PF00069	0.534
MOD_NEK2_1	356	361	PF00069	0.308
MOD_NEK2_1	67	72	PF00069	0.276
MOD_NEK2_2	119	124	PF00069	0.647
MOD_NEK2_2	62	67	PF00069	0.277
MOD_PIKK_1	108	114	PF00454	0.589
MOD_PIKK_1	153	159	PF00454	0.772
MOD_PIKK_1	206	212	PF00454	0.593
MOD_PKA_2	191	197	PF00069	0.772
MOD_PKA_2	287	293	PF00069	0.281
MOD_PKA_2	317	323	PF00069	0.557
MOD_PKA_2	370	376	PF00069	0.349
MOD_Plk_1	102	108	PF00069	0.560
MOD_Plk_1	119	125	PF00069	0.644
MOD_Plk_1	271	277	PF00069	0.238
MOD_Plk_1	42	48	PF00069	0.317
MOD_Plk_4	102	108	PF00069	0.676
MOD_Plk_4	241	247	PF00069	0.274
MOD_Plk_4	320	326	PF00069	0.520
MOD_Plk_4	356	362	PF00069	0.248
MOD_Plk_4	370	376	PF00069	0.370
MOD_ProDKin_1	174	180	PF00069	0.739
MOD_ProDKin_1	329	335	PF00069	0.324
MOD_ProDKin_1	381	387	PF00069	0.453
MOD_ProDKin_1	55	61	PF00069	0.272
TRG_DiLeu_BaEn_2	7	13	PF01217	0.489
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.408
TRG_ENDOCYTIC_2	229	232	PF00928	0.496
TRG_ER_diArg_1	257	260	PF00400	0.281
TRG_ER_diArg_1	317	319	PF00400	0.557
TRG_ER_diArg_1	36	39	PF00400	0.271
TRG_NES_CRM1_1	8	20	PF08389	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I046	Leptomonas seymouri	43%	84%
A0A1X0P6S8	Trypanosomatidae	38%	100%
A0A3S7WUU8	Leishmania donovani	53%	94%
A0A422MQK2	Trypanosoma rangeli	38%	100%
A4H9E7	Leishmania braziliensis	99%	100%
A4HXR9	Leishmania infantum	54%	94%
C9ZUG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ARI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	99%
Q4QDZ8	Leishmania major	53%	100%