LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H9E6_LEIBR
TriTrypDb:
LbrM.18.0440 , LBRM2903_180013100 *
Length:
137

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9E6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9E6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 109 111 PF00675 0.565
CLV_NRD_NRD_1 115 117 PF00675 0.576
CLV_NRD_NRD_1 135 137 PF00675 0.640
CLV_NRD_NRD_1 4 6 PF00675 0.668
CLV_NRD_NRD_1 56 58 PF00675 0.665
CLV_NRD_NRD_1 75 77 PF00675 0.316
CLV_PCSK_KEX2_1 108 110 PF00082 0.566
CLV_PCSK_KEX2_1 115 117 PF00082 0.576
CLV_PCSK_KEX2_1 4 6 PF00082 0.668
CLV_PCSK_KEX2_1 56 58 PF00082 0.675
CLV_PCSK_KEX2_1 75 77 PF00082 0.331
CLV_PCSK_PC1ET2_1 56 58 PF00082 0.675
DEG_Nend_Nbox_1 1 3 PF02207 0.552
DOC_USP7_UBL2_3 51 55 PF12436 0.660
DOC_WW_Pin1_4 22 27 PF00397 0.666
DOC_WW_Pin1_4 60 65 PF00397 0.685
LIG_APCC_ABBA_1 62 67 PF00400 0.660
LIG_PCNA_PIPBox_1 77 86 PF02747 0.590
LIG_PCNA_yPIPBox_3 72 84 PF02747 0.592
LIG_PTAP_UEV_1 26 31 PF05743 0.455
LIG_SH2_SRC 60 63 PF00017 0.715
LIG_SH2_STAT5 112 115 PF00017 0.619
LIG_SH2_STAT5 60 63 PF00017 0.661
LIG_SH2_STAT5 83 86 PF00017 0.591
LIG_SH3_2 46 51 PF14604 0.654
LIG_SH3_3 24 30 PF00018 0.549
LIG_SH3_3 43 49 PF00018 0.594
LIG_SH3_3 86 92 PF00018 0.519
MOD_CK1_1 22 28 PF00069 0.692
MOD_CK1_1 63 69 PF00069 0.672
MOD_GlcNHglycan 27 30 PF01048 0.601
MOD_GSK3_1 21 28 PF00069 0.651
MOD_NEK2_1 21 26 PF00069 0.600
MOD_NEK2_1 34 39 PF00069 0.628
MOD_ProDKin_1 22 28 PF00069 0.668
MOD_ProDKin_1 60 66 PF00069 0.676
TRG_ER_diArg_1 107 110 PF00400 0.568
TRG_ER_diArg_1 3 5 PF00400 0.668
TRG_ER_diArg_1 57 60 PF00400 0.745
TRG_ER_diArg_1 75 78 PF00400 0.367
TRG_NLS_MonoCore_2 55 60 PF00514 0.689
TRG_NLS_MonoExtN_4 55 61 PF00514 0.620

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I151 Leptomonas seymouri 60% 99%
A0A1X0P882 Trypanosomatidae 45% 100%
A0A3S7WUT1 Leishmania donovani 80% 100%
A4HXR7 Leishmania infantum 81% 100%
D0A049 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9ARH9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4QE00 Leishmania major 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS