NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9E5_LEIBR

TriTrypDb:

LbrM.18.0430 , LBRM2903_180013200

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H9E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9E5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.564
CLV_NRD_NRD_1	3	5	PF00675	0.586
CLV_PCSK_KEX2_1	140	142	PF00082	0.632
CLV_PCSK_KEX2_1	3	5	PF00082	0.586
CLV_PCSK_KEX2_1	86	88	PF00082	0.576
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.632
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.601
CLV_PCSK_SKI1_1	4	8	PF00082	0.639
DEG_Nend_Nbox_1	1	3	PF02207	0.594
DEG_SCF_FBW7_1	192	198	PF00400	0.616
DEG_SPOP_SBC_1	195	199	PF00917	0.507
DOC_CKS1_1	192	197	PF01111	0.620
DOC_CKS1_1	48	53	PF01111	0.530
DOC_PP4_FxxP_1	48	51	PF00568	0.533
DOC_USP7_MATH_1	155	159	PF00917	0.425
DOC_USP7_MATH_1	195	199	PF00917	0.624
DOC_WW_Pin1_4	111	116	PF00397	0.615
DOC_WW_Pin1_4	191	196	PF00397	0.619
DOC_WW_Pin1_4	47	52	PF00397	0.540
LIG_BRCT_BRCA1_1	157	161	PF00533	0.606
LIG_FHA_1	62	68	PF00498	0.592
LIG_FHA_2	47	53	PF00498	0.603
LIG_LIR_Apic_2	47	51	PF02991	0.537
LIG_LIR_Gen_1	55	63	PF02991	0.550
LIG_LIR_Nem_3	55	60	PF02991	0.557
LIG_SH2_STAT5	162	165	PF00017	0.593
LIG_SH2_STAT5	181	184	PF00017	0.433
LIG_SH3_3	151	157	PF00018	0.687
LIG_SH3_3	189	195	PF00018	0.544
LIG_TRAF2_1	126	129	PF00917	0.379
MOD_CDK_SPK_2	191	196	PF00069	0.463
MOD_CDK_SPxxK_3	111	118	PF00069	0.601
MOD_CK1_1	89	95	PF00069	0.656
MOD_CK2_1	46	52	PF00069	0.588
MOD_CK2_1	73	79	PF00069	0.666
MOD_GlcNHglycan	88	91	PF01048	0.632
MOD_GlcNHglycan	9	12	PF01048	0.619
MOD_GSK3_1	187	194	PF00069	0.629
MOD_GSK3_1	69	76	PF00069	0.549
MOD_GSK3_1	82	89	PF00069	0.415
MOD_N-GLC_1	111	116	PF02516	0.582
MOD_NEK2_1	7	12	PF00069	0.612
MOD_PIKK_1	156	162	PF00454	0.613
MOD_PKA_1	86	92	PF00069	0.564
MOD_PKA_2	165	171	PF00069	0.415
MOD_PKA_2	86	92	PF00069	0.492
MOD_Plk_4	73	79	PF00069	0.665
MOD_ProDKin_1	111	117	PF00069	0.604
MOD_ProDKin_1	191	197	PF00069	0.624
MOD_ProDKin_1	47	53	PF00069	0.549
MOD_SUMO_rev_2	184	193	PF00179	0.444
TRG_ENDOCYTIC_2	45	48	PF00928	0.470
TRG_ER_diArg_1	2	4	PF00400	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC40	Leptomonas seymouri	65%	100%
A0A0S4JE60	Bodo saltans	31%	100%
A0A1X0P7T6	Trypanosomatidae	36%	100%
A0A3Q8I9X5	Leishmania donovani	83%	100%
A4HXR6	Leishmania infantum	82%	100%
D0A048	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	70%
E9ARH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QE01	Leishmania major	83%	100%