Tubulin--tyrosine ligase-like protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin tyrosine ligase protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9E1_LEIBR

TriTrypDb:

LbrM.18.0390 , LBRM2903_180008900

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H9E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9E1

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0018095	protein polyglutamylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018200	peptidyl-glutamic acid modification	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016881	acid-amino acid ligase activity	4	1
GO:0070739	protein-glutamic acid ligase activity	3	1
GO:0070740	tubulin-glutamic acid ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.524
CLV_NRD_NRD_1	124	126	PF00675	0.237
CLV_NRD_NRD_1	157	159	PF00675	0.239
CLV_NRD_NRD_1	394	396	PF00675	0.417
CLV_NRD_NRD_1	4	6	PF00675	0.523
CLV_NRD_NRD_1	74	76	PF00675	0.239
CLV_PCSK_KEX2_1	124	126	PF00082	0.225
CLV_PCSK_KEX2_1	157	159	PF00082	0.292
CLV_PCSK_KEX2_1	394	396	PF00082	0.420
CLV_PCSK_KEX2_1	4	6	PF00082	0.516
CLV_PCSK_SKI1_1	14	18	PF00082	0.349
CLV_PCSK_SKI1_1	142	146	PF00082	0.225
CLV_PCSK_SKI1_1	158	162	PF00082	0.225
CLV_PCSK_SKI1_1	300	304	PF00082	0.299
CLV_PCSK_SKI1_1	325	329	PF00082	0.332
CLV_PCSK_SKI1_1	332	336	PF00082	0.340
CLV_PCSK_SKI1_1	81	85	PF00082	0.239
DEG_APCC_DBOX_1	260	268	PF00400	0.437
DEG_Nend_UBRbox_2	1	3	PF02207	0.694
DOC_CYCLIN_yClb5_NLxxxL_5	294	303	PF00134	0.530
DOC_MAPK_gen_1	124	132	PF00069	0.425
DOC_MAPK_gen_1	229	237	PF00069	0.425
DOC_MAPK_gen_1	4	13	PF00069	0.425
DOC_MAPK_MEF2A_6	229	237	PF00069	0.425
DOC_PP2B_LxvP_1	436	439	PF13499	0.543
DOC_PP2B_LxvP_1	443	446	PF13499	0.521
DOC_PP4_FxxP_1	110	113	PF00568	0.451
DOC_PP4_MxPP_1	133	136	PF00568	0.425
DOC_USP7_MATH_1	363	367	PF00917	0.437
DOC_USP7_MATH_1	414	418	PF00917	0.502
DOC_USP7_MATH_1	44	48	PF00917	0.462
DOC_USP7_UBL2_3	134	138	PF12436	0.437
DOC_USP7_UBL2_3	281	285	PF12436	0.425
DOC_USP7_UBL2_3	84	88	PF12436	0.425
DOC_WW_Pin1_4	361	366	PF00397	0.437
DOC_WW_Pin1_4	368	373	PF00397	0.437
LIG_14-3-3_CanoR_1	261	265	PF00244	0.425
LIG_deltaCOP1_diTrp_1	155	160	PF00928	0.524
LIG_deltaCOP1_diTrp_1	36	43	PF00928	0.311
LIG_EH1_1	327	335	PF00400	0.492
LIG_FHA_1	107	113	PF00498	0.440
LIG_FHA_1	127	133	PF00498	0.327
LIG_FHA_1	244	250	PF00498	0.451
LIG_FHA_1	310	316	PF00498	0.477
LIG_FHA_1	6	12	PF00498	0.537
LIG_FHA_2	18	24	PF00498	0.304
LIG_FHA_2	31	37	PF00498	0.344
LIG_FHA_2	369	375	PF00498	0.437
LIG_FHA_2	72	78	PF00498	0.425
LIG_IBAR_NPY_1	194	196	PF08397	0.363
LIG_IBAR_NPY_1	203	205	PF08397	0.345
LIG_LIR_Apic_2	109	113	PF02991	0.426
LIG_LIR_Gen_1	252	262	PF02991	0.425
LIG_LIR_Gen_1	268	279	PF02991	0.425
LIG_LIR_Gen_1	40	49	PF02991	0.316
LIG_LIR_Nem_3	115	119	PF02991	0.440
LIG_LIR_Nem_3	241	245	PF02991	0.428
LIG_LIR_Nem_3	252	257	PF02991	0.431
LIG_LIR_Nem_3	268	274	PF02991	0.425
LIG_LIR_Nem_3	282	286	PF02991	0.425
LIG_LIR_Nem_3	36	42	PF02991	0.314
LIG_LIR_Nem_3	51	56	PF02991	0.360
LIG_OCRL_FandH_1	159	171	PF00620	0.499
LIG_PCNA_PIPBox_1	321	330	PF02747	0.499
LIG_PCNA_yPIPBox_3	321	332	PF02747	0.499
LIG_Pex14_1	156	160	PF04695	0.425
LIG_Pex14_2	106	110	PF04695	0.445
LIG_Pex14_2	119	123	PF04695	0.417
LIG_Pex14_2	405	409	PF04695	0.348
LIG_SH2_CRK	242	246	PF00017	0.425
LIG_SH2_CRK	53	57	PF00017	0.509
LIG_SH2_NCK_1	286	290	PF00017	0.492
LIG_SH2_PTP2	236	239	PF00017	0.425
LIG_SH2_PTP2	271	274	PF00017	0.524
LIG_SH2_SRC	271	274	PF00017	0.524
LIG_SH2_STAP1	231	235	PF00017	0.437
LIG_SH2_STAP1	346	350	PF00017	0.437
LIG_SH2_STAT3	214	217	PF00017	0.425
LIG_SH2_STAT5	166	169	PF00017	0.524
LIG_SH2_STAT5	214	217	PF00017	0.425
LIG_SH2_STAT5	219	222	PF00017	0.425
LIG_SH2_STAT5	236	239	PF00017	0.425
LIG_SH2_STAT5	271	274	PF00017	0.524
LIG_SH2_STAT5	286	289	PF00017	0.437
LIG_SH2_STAT5	429	432	PF00017	0.435
LIG_SH3_4	134	141	PF00018	0.437
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.299
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.447
LIG_SUMO_SIM_par_1	384	390	PF11976	0.368
LIG_TRAF2_1	396	399	PF00917	0.546
LIG_WW_3	445	449	PF00397	0.448
MOD_CK1_1	148	154	PF00069	0.437
MOD_CK1_1	197	203	PF00069	0.537
MOD_CK1_1	421	427	PF00069	0.514
MOD_CK2_1	30	36	PF00069	0.392
MOD_CK2_1	393	399	PF00069	0.439
MOD_Cter_Amidation	227	230	PF01082	0.225
MOD_Cter_Amidation	392	395	PF01082	0.532
MOD_GlcNHglycan	169	172	PF01048	0.299
MOD_GlcNHglycan	185	188	PF01048	0.369
MOD_GlcNHglycan	191	194	PF01048	0.308
MOD_GlcNHglycan	196	199	PF01048	0.299
MOD_GlcNHglycan	289	292	PF01048	0.228
MOD_GlcNHglycan	395	398	PF01048	0.547
MOD_GSK3_1	361	368	PF00069	0.437
MOD_GSK3_1	414	421	PF00069	0.563
MOD_GSK3_1	71	78	PF00069	0.499
MOD_LATS_1	3	9	PF00433	0.613
MOD_N-GLC_1	361	366	PF02516	0.237
MOD_N-GLC_1	418	423	PF02516	0.535
MOD_N-GLC_1	452	457	PF02516	0.650
MOD_NEK2_1	145	150	PF00069	0.425
MOD_NEK2_1	167	172	PF00069	0.499
MOD_NEK2_1	17	22	PF00069	0.313
MOD_NEK2_1	238	243	PF00069	0.438
MOD_NEK2_1	249	254	PF00069	0.405
MOD_NEK2_1	303	308	PF00069	0.492
MOD_NEK2_1	358	363	PF00069	0.437
MOD_NEK2_1	425	430	PF00069	0.522
MOD_PIKK_1	148	154	PF00454	0.427
MOD_PIKK_1	418	424	PF00454	0.645
MOD_PIKK_1	438	444	PF00454	0.541
MOD_PKA_1	75	81	PF00069	0.499
MOD_PKA_2	17	23	PF00069	0.251
MOD_PKA_2	260	266	PF00069	0.425
MOD_PKA_2	3	9	PF00069	0.538
MOD_PKA_2	393	399	PF00069	0.439
MOD_Plk_1	267	273	PF00069	0.425
MOD_Plk_1	350	356	PF00069	0.499
MOD_Plk_1	44	50	PF00069	0.462
MOD_Plk_2-3	32	38	PF00069	0.440
MOD_Plk_4	126	132	PF00069	0.529
MOD_Plk_4	17	23	PF00069	0.317
MOD_Plk_4	243	249	PF00069	0.468
MOD_Plk_4	267	273	PF00069	0.425
MOD_Plk_4	421	427	PF00069	0.520
MOD_Plk_4	44	50	PF00069	0.460
MOD_Plk_4	75	81	PF00069	0.499
MOD_ProDKin_1	361	367	PF00069	0.437
MOD_ProDKin_1	368	374	PF00069	0.437
TRG_ENDOCYTIC_2	116	119	PF00928	0.425
TRG_ENDOCYTIC_2	236	239	PF00928	0.425
TRG_ENDOCYTIC_2	242	245	PF00928	0.425
TRG_ENDOCYTIC_2	271	274	PF00928	0.510
TRG_ENDOCYTIC_2	346	349	PF00928	0.438
TRG_ENDOCYTIC_2	53	56	PF00928	0.397
TRG_ER_diArg_1	123	125	PF00400	0.437
TRG_ER_diArg_1	156	158	PF00400	0.492
TRG_ER_diArg_1	25	28	PF00400	0.332
TRG_ER_diArg_1	4	7	PF00400	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P402	Leptomonas seymouri	84%	100%
A0A0N1I1A1	Leptomonas seymouri	23%	100%
A0A0N1IH77	Leptomonas seymouri	23%	83%
A0A0S4ISF0	Bodo saltans	25%	81%
A0A0S4J7C9	Bodo saltans	28%	69%
A0A0S4JEF0	Bodo saltans	39%	100%
A0A0S4KQK8	Bodo saltans	28%	70%
A0A1X0NFL2	Trypanosomatidae	22%	100%
A0A1X0NFU6	Trypanosomatidae	38%	87%
A0A1X0NZP1	Trypanosomatidae	37%	88%
A0A1X0P6A0	Trypanosomatidae	27%	69%
A0A1X0P705	Trypanosomatidae	66%	100%
A0A3Q8IDP1	Leishmania donovani	23%	86%
A0A3R7MY56	Trypanosoma rangeli	65%	100%
A0A3S5IS28	Trypanosoma rangeli	26%	72%
A0A3S7WUU3	Leishmania donovani	90%	98%
A0A422N932	Trypanosoma rangeli	34%	100%
A0A422NE52	Trypanosoma rangeli	23%	100%
A0A422NPL9	Trypanosoma rangeli	25%	75%
A0A422P136	Trypanosoma rangeli	27%	70%
A2APC3	Mus musculus	47%	100%
A4HG29	Leishmania braziliensis	22%	91%
A4HH59	Leishmania braziliensis	22%	73%
A4HXR2	Leishmania infantum	90%	99%
A4I351	Leishmania infantum	23%	97%
A4Q9E4	Mus musculus	25%	85%
B6DTF7	Bodo saltans	65%	100%
C9ZI96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	67%
C9ZJM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZPR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	88%
C9ZR25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	73%
C9ZYH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	70%
D0A044	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9ACW9	Leishmania major	22%	100%
E9ARH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AZF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	97%
O95922	Homo sapiens	40%	100%
P38160	Sus scrofa	24%	100%
P38584	Bos taurus	24%	100%
P38585	Mus musculus	24%	100%
Q09647	Caenorhabditis elegans	25%	77%
Q0VC71	Bos taurus	41%	100%
Q23SI8	Tetrahymena thermophila (strain SB210)	38%	100%
Q3SXZ7	Homo sapiens	43%	100%
Q3SZH6	Bos taurus	46%	100%
Q4QE05	Leishmania major	90%	100%
Q4R7H0	Macaca fascicularis	23%	74%
Q564U4	Caenorhabditis elegans	43%	100%
Q5PPI9	Rattus norvegicus	41%	100%
Q5XI57	Rattus norvegicus	24%	68%
Q641W7	Rattus norvegicus	46%	100%
Q6ZVT0	Homo sapiens	23%	68%
Q8NG68	Homo sapiens	24%	100%
Q91V51	Mus musculus	41%	100%
Q9BWV7	Homo sapiens	26%	78%
Q9QXJ0	Rattus norvegicus	24%	100%
V5ARK1	Trypanosoma cruzi	27%	98%
V5BLZ7	Trypanosoma cruzi	64%	100%
V5BVF5	Trypanosoma cruzi	24%	71%
V5D711	Trypanosoma cruzi	24%	100%