ATP12 chaperone protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP12 chaperone protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9D9_LEIBR

TriTrypDb:

LbrM.18.0370 , LBRM2903_180008700

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4H9D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9D9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043461	proton-transporting ATP synthase complex assembly	7	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070071	proton-transporting two-sector ATPase complex assembly	6	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly	8	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.612
CLV_NRD_NRD_1	151	153	PF00675	0.329
CLV_NRD_NRD_1	42	44	PF00675	0.554
CLV_NRD_NRD_1	73	75	PF00675	0.472
CLV_PCSK_KEX2_1	41	43	PF00082	0.552
CLV_PCSK_SKI1_1	152	156	PF00082	0.328
CLV_PCSK_SKI1_1	273	277	PF00082	0.418
CLV_PCSK_SKI1_1	356	360	PF00082	0.527
CLV_PCSK_SKI1_1	42	46	PF00082	0.616
CLV_Separin_Metazoa	368	372	PF03568	0.471
DEG_APCC_DBOX_1	272	280	PF00400	0.391
DEG_SCF_FBW7_1	262	269	PF00400	0.557
DEG_SPOP_SBC_1	16	20	PF00917	0.704
DOC_ANK_TNKS_1	254	261	PF00023	0.432
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.355
DOC_MAPK_gen_1	118	127	PF00069	0.520
DOC_MAPK_gen_1	155	165	PF00069	0.475
DOC_PP1_RVXF_1	124	130	PF00149	0.328
DOC_PP2B_LxvP_1	163	166	PF13499	0.328
DOC_PP2B_LxvP_1	188	191	PF13499	0.328
DOC_PP2B_LxvP_1	299	302	PF13499	0.354
DOC_PP4_FxxP_1	367	370	PF00568	0.461
DOC_USP7_MATH_1	10	14	PF00917	0.665
DOC_USP7_MATH_1	119	123	PF00917	0.659
DOC_USP7_MATH_1	15	19	PF00917	0.667
DOC_USP7_MATH_1	156	160	PF00917	0.328
DOC_USP7_MATH_1	164	168	PF00917	0.328
DOC_USP7_MATH_1	266	270	PF00917	0.400
DOC_WW_Pin1_4	17	22	PF00397	0.609
DOC_WW_Pin1_4	262	267	PF00397	0.511
LIG_14-3-3_CanoR_1	103	111	PF00244	0.613
LIG_14-3-3_CanoR_1	7	15	PF00244	0.623
LIG_14-3-3_CanoR_1	81	87	PF00244	0.383
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_BIR_III_3	1	5	PF00653	0.513
LIG_eIF4E_1	184	190	PF01652	0.314
LIG_FHA_1	180	186	PF00498	0.475
LIG_FHA_1	294	300	PF00498	0.347
LIG_FHA_1	352	358	PF00498	0.375
LIG_FHA_1	43	49	PF00498	0.585
LIG_FHA_1	67	73	PF00498	0.523
LIG_IBAR_NPY_1	282	284	PF08397	0.345
LIG_LIR_Gen_1	243	253	PF02991	0.305
LIG_LIR_Gen_1	334	344	PF02991	0.319
LIG_LIR_Nem_3	243	248	PF02991	0.235
LIG_LIR_Nem_3	334	339	PF02991	0.334
LIG_PDZ_Class_3	377	382	PF00595	0.621
LIG_SH2_CRK	284	288	PF00017	0.348
LIG_SH2_GRB2like	184	187	PF00017	0.314
LIG_SH2_STAP1	249	253	PF00017	0.514
LIG_SH2_STAT3	178	181	PF00017	0.344
LIG_SH2_STAT3	184	187	PF00017	0.344
LIG_SH2_STAT5	184	187	PF00017	0.345
LIG_SH2_STAT5	213	216	PF00017	0.328
LIG_SH2_STAT5	224	227	PF00017	0.328
LIG_SH3_1	55	61	PF00018	0.614
LIG_SH3_2	37	42	PF14604	0.568
LIG_SH3_3	307	313	PF00018	0.389
LIG_SH3_3	34	40	PF00018	0.558
LIG_SH3_3	55	61	PF00018	0.520
LIG_SH3_5	209	213	PF00018	0.328
LIG_SUMO_SIM_anti_2	131	136	PF11976	0.415
LIG_SUMO_SIM_par_1	133	139	PF11976	0.420
LIG_SUMO_SIM_par_1	159	168	PF11976	0.435
LIG_SUMO_SIM_par_1	301	307	PF11976	0.402
LIG_SUMO_SIM_par_1	308	314	PF11976	0.371
LIG_TRAF2_1	375	378	PF00917	0.674
LIG_WRC_WIRS_1	214	219	PF05994	0.328
MOD_CK1_1	106	112	PF00069	0.606
MOD_CK1_1	56	62	PF00069	0.558
MOD_CK1_1	80	86	PF00069	0.556
MOD_CK2_1	240	246	PF00069	0.367
MOD_CK2_1	323	329	PF00069	0.479
MOD_CK2_1	65	71	PF00069	0.506
MOD_Cter_Amidation	150	153	PF01082	0.328
MOD_GlcNHglycan	121	124	PF01048	0.550
MOD_GlcNHglycan	196	199	PF01048	0.319
MOD_GlcNHglycan	268	271	PF01048	0.298
MOD_GlcNHglycan	306	309	PF01048	0.537
MOD_GSK3_1	190	197	PF00069	0.323
MOD_GSK3_1	213	220	PF00069	0.262
MOD_GSK3_1	262	269	PF00069	0.565
MOD_GSK3_1	289	296	PF00069	0.439
MOD_GSK3_1	5	12	PF00069	0.652
MOD_GSK3_1	77	84	PF00069	0.488
MOD_GSK3_1	99	106	PF00069	0.614
MOD_N-GLC_1	98	103	PF02516	0.655
MOD_NEK2_1	113	118	PF00069	0.563
MOD_NEK2_1	157	162	PF00069	0.385
MOD_NEK2_1	289	294	PF00069	0.414
MOD_NEK2_1	295	300	PF00069	0.330
MOD_NEK2_1	53	58	PF00069	0.597
MOD_NEK2_1	9	14	PF00069	0.715
MOD_NEK2_2	213	218	PF00069	0.328
MOD_PIKK_1	157	163	PF00454	0.421
MOD_PKA_1	42	48	PF00069	0.552
MOD_PKA_2	119	125	PF00069	0.586
MOD_PKA_2	42	48	PF00069	0.552
MOD_PKA_2	80	86	PF00069	0.389
MOD_PKB_1	41	49	PF00069	0.681
MOD_Plk_1	106	112	PF00069	0.531
MOD_Plk_1	113	119	PF00069	0.564
MOD_Plk_1	77	83	PF00069	0.584
MOD_Plk_2-3	323	329	PF00069	0.576
MOD_Plk_4	106	112	PF00069	0.528
MOD_Plk_4	213	219	PF00069	0.322
MOD_Plk_4	295	301	PF00069	0.354
MOD_ProDKin_1	17	23	PF00069	0.610
MOD_ProDKin_1	262	268	PF00069	0.504
MOD_SUMO_rev_2	68	76	PF00179	0.493
TRG_ENDOCYTIC_2	284	287	PF00928	0.349
TRG_ENDOCYTIC_2	336	339	PF00928	0.421
TRG_ER_diArg_1	40	43	PF00400	0.548
TRG_NLS_MonoCore_2	37	42	PF00514	0.553
TRG_NLS_MonoExtC_3	37	42	PF00514	0.553
TRG_NLS_MonoExtN_4	37	42	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E1	Leptomonas seymouri	83%	98%
A0A1X0P7M1	Trypanosomatidae	67%	98%
A0A3R7KUB6	Trypanosoma rangeli	64%	98%
A0A3S7WUT0	Leishmania donovani	92%	100%
A4HXR0	Leishmania infantum	92%	100%
B6DTF4	Bodo saltans	65%	100%
D0A042	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9ARH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QE07	Leishmania major	92%	100%
V5BRM9	Trypanosoma cruzi	65%	97%