DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4475), putative

Species:

Leishmania braziliensis

UniProt:

A4H9D8_LEIBR

TriTrypDb:

LbrM.18.0360 , LBRM2903_180008600

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9D8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.612
CLV_NRD_NRD_1	257	259	PF00675	0.267
CLV_NRD_NRD_1	381	383	PF00675	0.670
CLV_NRD_NRD_1	45	47	PF00675	0.753
CLV_PCSK_KEX2_1	119	121	PF00082	0.612
CLV_PCSK_KEX2_1	257	259	PF00082	0.266
CLV_PCSK_KEX2_1	381	383	PF00082	0.595
CLV_PCSK_KEX2_1	432	434	PF00082	0.605
CLV_PCSK_KEX2_1	45	47	PF00082	0.753
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.461
CLV_PCSK_SKI1_1	119	123	PF00082	0.440
CLV_PCSK_SKI1_1	373	377	PF00082	0.583
CLV_PCSK_SKI1_1	4	8	PF00082	0.459
DEG_APCC_KENBOX_2	123	127	PF00400	0.450
DEG_SCF_FBW7_1	48	54	PF00400	0.465
DEG_SIAH_1	401	409	PF03145	0.461
DOC_CKS1_1	244	249	PF01111	0.411
DOC_CKS1_1	48	53	PF01111	0.467
DOC_PP1_RVXF_1	128	134	PF00149	0.469
DOC_USP7_MATH_1	181	185	PF00917	0.620
DOC_USP7_MATH_1	34	38	PF00917	0.577
DOC_USP7_MATH_1	380	384	PF00917	0.487
DOC_USP7_MATH_1	387	391	PF00917	0.469
DOC_USP7_MATH_1	39	43	PF00917	0.588
DOC_WW_Pin1_4	174	179	PF00397	0.529
DOC_WW_Pin1_4	243	248	PF00397	0.411
DOC_WW_Pin1_4	47	52	PF00397	0.616
DOC_WW_Pin1_4	8	13	PF00397	0.508
LIG_14-3-3_CanoR_1	14	20	PF00244	0.561
LIG_14-3-3_CanoR_1	211	221	PF00244	0.400
LIG_14-3-3_CanoR_1	33	43	PF00244	0.555
LIG_14-3-3_CanoR_1	382	391	PF00244	0.594
LIG_14-3-3_CanoR_1	425	431	PF00244	0.517
LIG_14-3-3_CanoR_1	449	454	PF00244	0.715
LIG_14-3-3_CanoR_1	45	49	PF00244	0.564
LIG_deltaCOP1_diTrp_1	252	261	PF00928	0.266
LIG_deltaCOP1_diTrp_1	305	315	PF00928	0.411
LIG_FHA_1	213	219	PF00498	0.383
LIG_FHA_1	370	376	PF00498	0.575
LIG_FHA_1	409	415	PF00498	0.662
LIG_FHA_2	244	250	PF00498	0.411
LIG_FHA_2	311	317	PF00498	0.257
LIG_FHA_2	98	104	PF00498	0.588
LIG_LIR_Apic_2	224	229	PF02991	0.285
LIG_LIR_Apic_2	429	434	PF02991	0.499
LIG_LIR_Gen_1	296	307	PF02991	0.325
LIG_LIR_Gen_1	420	431	PF02991	0.543
LIG_LIR_Nem_3	296	302	PF02991	0.300
LIG_LIR_Nem_3	330	335	PF02991	0.328
LIG_LIR_Nem_3	420	426	PF02991	0.555
LIG_Pex14_2	295	299	PF04695	0.281
LIG_SH2_CRK	240	244	PF00017	0.331
LIG_SH2_CRK	332	336	PF00017	0.461
LIG_SH2_CRK	423	427	PF00017	0.294
LIG_SH2_SRC	162	165	PF00017	0.305
LIG_SH2_STAT5	138	141	PF00017	0.316
LIG_SH2_STAT5	242	245	PF00017	0.283
LIG_SH2_STAT5	423	426	PF00017	0.431
LIG_SH3_1	241	247	PF00018	0.331
LIG_SH3_3	2	8	PF00018	0.459
LIG_SH3_3	241	247	PF00018	0.268
LIG_SH3_3	411	417	PF00018	0.491
LIG_SUMO_SIM_par_1	246	253	PF11976	0.411
LIG_SUMO_SIM_par_1	416	422	PF11976	0.441
LIG_TYR_ITIM	160	165	PF00017	0.443
LIG_TYR_ITIM	421	426	PF00017	0.292
MOD_CDC14_SPxK_1	11	14	PF00782	0.513
MOD_CDK_SPxK_1	174	180	PF00069	0.462
MOD_CDK_SPxK_1	8	14	PF00069	0.511
MOD_CK1_1	115	121	PF00069	0.407
MOD_CK1_1	24	30	PF00069	0.591
MOD_CK1_1	264	270	PF00069	0.325
MOD_CK1_1	293	299	PF00069	0.360
MOD_CK1_1	369	375	PF00069	0.580
MOD_CK1_1	383	389	PF00069	0.726
MOD_CK1_1	390	396	PF00069	0.479
MOD_CK1_1	44	50	PF00069	0.694
MOD_CK2_1	191	197	PF00069	0.461
MOD_CK2_1	243	249	PF00069	0.411
MOD_CK2_1	310	316	PF00069	0.257
MOD_CK2_1	97	103	PF00069	0.602
MOD_GlcNHglycan	149	152	PF01048	0.392
MOD_GlcNHglycan	184	187	PF01048	0.684
MOD_GlcNHglycan	265	269	PF01048	0.341
MOD_GlcNHglycan	292	295	PF01048	0.360
MOD_GlcNHglycan	296	299	PF01048	0.360
MOD_GlcNHglycan	36	39	PF01048	0.547
MOD_GlcNHglycan	385	388	PF01048	0.651
MOD_GlcNHglycan	402	405	PF01048	0.644
MOD_GlcNHglycan	55	58	PF01048	0.451
MOD_GSK3_1	212	219	PF00069	0.510
MOD_GSK3_1	290	297	PF00069	0.348
MOD_GSK3_1	310	317	PF00069	0.145
MOD_GSK3_1	369	376	PF00069	0.479
MOD_GSK3_1	383	390	PF00069	0.698
MOD_GSK3_1	47	54	PF00069	0.575
MOD_GSK3_1	6	13	PF00069	0.619
MOD_GSK3_1	82	89	PF00069	0.539
MOD_N-GLC_1	182	187	PF02516	0.669
MOD_N-GLC_1	369	374	PF02516	0.448
MOD_NEK2_1	426	431	PF00069	0.517
MOD_PIKK_1	82	88	PF00454	0.484
MOD_PKA_2	147	153	PF00069	0.520
MOD_PKA_2	191	197	PF00069	0.679
MOD_PKA_2	21	27	PF00069	0.679
MOD_PKA_2	210	216	PF00069	0.404
MOD_PKA_2	380	386	PF00069	0.696
MOD_PKA_2	387	393	PF00069	0.585
MOD_PKA_2	44	50	PF00069	0.560
MOD_PKA_2	448	454	PF00069	0.703
MOD_Plk_1	348	354	PF00069	0.467
MOD_Plk_4	21	27	PF00069	0.494
MOD_Plk_4	310	316	PF00069	0.266
MOD_Plk_4	426	432	PF00069	0.459
MOD_Plk_4	86	92	PF00069	0.578
MOD_ProDKin_1	174	180	PF00069	0.543
MOD_ProDKin_1	243	249	PF00069	0.411
MOD_ProDKin_1	47	53	PF00069	0.618
MOD_ProDKin_1	8	14	PF00069	0.511
TRG_ENDOCYTIC_2	162	165	PF00928	0.452
TRG_ENDOCYTIC_2	240	243	PF00928	0.411
TRG_ENDOCYTIC_2	332	335	PF00928	0.343
TRG_ENDOCYTIC_2	423	426	PF00928	0.436
TRG_ENDOCYTIC_2	67	70	PF00928	0.443
TRG_ER_diArg_1	119	121	PF00400	0.605
TRG_ER_diArg_1	284	287	PF00400	0.252
TRG_NES_CRM1_1	337	349	PF08389	0.376
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P400	Leptomonas seymouri	58%	100%
A0A1X0P6R6	Trypanosomatidae	43%	100%
A0A3Q8IAW5	Leishmania donovani	79%	100%
A0A422NWL4	Trypanosoma rangeli	41%	100%
A4HXQ9	Leishmania infantum	79%	100%
B6DTF3	Bodo saltans	32%	100%
D0A041	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ARH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QE08	Leishmania major	79%	100%
V5DN00	Trypanosoma cruzi	40%	100%