J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9D7_LEIBR

TriTrypDb:

LbrM.18.0350 , LBRM2903_180008500

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4H9D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.528
CLV_NRD_NRD_1	104	106	PF00675	0.717
CLV_NRD_NRD_1	12	14	PF00675	0.614
CLV_NRD_NRD_1	173	175	PF00675	0.649
CLV_NRD_NRD_1	217	219	PF00675	0.443
CLV_NRD_NRD_1	227	229	PF00675	0.456
CLV_NRD_NRD_1	73	75	PF00675	0.484
CLV_PCSK_KEX2_1	12	14	PF00082	0.614
CLV_PCSK_KEX2_1	173	175	PF00082	0.648
CLV_PCSK_SKI1_1	12	16	PF00082	0.674
CLV_PCSK_SKI1_1	202	206	PF00082	0.389
CLV_PCSK_SKI1_1	5	9	PF00082	0.670
DEG_APCC_DBOX_1	201	209	PF00400	0.381
DEG_MDM2_SWIB_1	190	197	PF02201	0.365
DOC_MAPK_MEF2A_6	202	209	PF00069	0.358
DOC_MAPK_NFAT4_5	202	210	PF00069	0.358
DOC_PP1_RVXF_1	20	26	PF00149	0.462
DOC_PP1_RVXF_1	200	207	PF00149	0.399
DOC_PP1_RVXF_1	3	9	PF00149	0.459
DOC_PP2B_LxvP_1	208	211	PF13499	0.481
DOC_PP4_FxxP_1	25	28	PF00568	0.355
DOC_SPAK_OSR1_1	189	193	PF12202	0.381
DOC_USP7_MATH_1	81	85	PF00917	0.299
DOC_USP7_UBL2_3	215	219	PF12436	0.693
DOC_USP7_UBL2_3	62	66	PF12436	0.275
LIG_14-3-3_CanoR_1	135	141	PF00244	0.449
LIG_14-3-3_CanoR_1	22	28	PF00244	0.455
LIG_14-3-3_CanoR_1	43	51	PF00244	0.445
LIG_Actin_WH2_1	189	204	PF00022	0.447
LIG_Actin_WH2_2	175	191	PF00022	0.421
LIG_AP2alpha_2	155	157	PF02296	0.492
LIG_BIR_III_4	79	83	PF00653	0.284
LIG_EH_1	174	178	PF12763	0.495
LIG_FHA_1	13	19	PF00498	0.540
LIG_FHA_1	147	153	PF00498	0.456
LIG_FHA_1	237	243	PF00498	0.710
LIG_IBAR_NPY_1	49	51	PF08397	0.272
LIG_LIR_Apic_2	24	28	PF02991	0.356
LIG_LIR_Gen_1	139	147	PF02991	0.438
LIG_LIR_Gen_1	93	102	PF02991	0.293
LIG_LIR_Nem_3	139	143	PF02991	0.447
LIG_LIR_Nem_3	85	91	PF02991	0.279
LIG_LIR_Nem_3	93	98	PF02991	0.272
LIG_MAD2	70	78	PF02301	0.284
LIG_PDZ_Class_2	240	245	PF00595	0.656
LIG_Pex14_1	194	198	PF04695	0.309
LIG_Pex14_2	190	194	PF04695	0.370
LIG_Pex14_2	209	213	PF04695	0.578
LIG_SH2_CRK	51	55	PF00017	0.276
LIG_SH2_CRK	69	73	PF00017	0.276
LIG_SH2_STAP1	140	144	PF00017	0.429
LIG_SH2_STAP1	51	55	PF00017	0.191
LIG_SH2_STAT5	128	131	PF00017	0.503
LIG_SH3_1	229	235	PF00018	0.670
LIG_SH3_1	75	81	PF00018	0.284
LIG_SH3_3	214	220	PF00018	0.600
LIG_SH3_3	227	233	PF00018	0.703
LIG_SH3_3	75	81	PF00018	0.284
LIG_SH3_4	215	222	PF00018	0.709
LIG_SUMO_SIM_par_1	52	58	PF11976	0.191
LIG_TRFH_1	206	210	PF08558	0.353
LIG_UBA3_1	205	212	PF00899	0.581
LIG_WW_3	215	219	PF00397	0.705
LIG_WW_3	220	224	PF00397	0.750
MOD_CK1_1	136	142	PF00069	0.455
MOD_CK1_1	34	40	PF00069	0.496
MOD_Cter_Amidation	226	229	PF01082	0.529
MOD_GlcNHglycan	109	113	PF01048	0.690
MOD_GlcNHglycan	123	126	PF01048	0.734
MOD_GlcNHglycan	33	36	PF01048	0.718
MOD_GlcNHglycan	99	102	PF01048	0.613
MOD_GSK3_1	129	136	PF00069	0.544
MOD_NEK2_1	1	6	PF00069	0.425
MOD_NEK2_1	126	131	PF00069	0.471
MOD_PIKK_1	37	43	PF00454	0.531
MOD_PKA_1	12	18	PF00069	0.456
MOD_PKA_2	12	18	PF00069	0.434
MOD_PKA_2	121	127	PF00069	0.454
MOD_PKA_2	21	27	PF00069	0.357
MOD_SUMO_for_1	211	214	PF00179	0.639
MOD_SUMO_rev_2	58	68	PF00179	0.299
MOD_SUMO_rev_2	79	88	PF00179	0.290
TRG_ENDOCYTIC_2	123	126	PF00928	0.461
TRG_ENDOCYTIC_2	140	143	PF00928	0.434
TRG_ENDOCYTIC_2	144	147	PF00928	0.415
TRG_ENDOCYTIC_2	51	54	PF00928	0.275
TRG_ENDOCYTIC_2	69	72	PF00928	0.276
TRG_ENDOCYTIC_2	95	98	PF00928	0.276
TRG_ER_diArg_1	11	13	PF00400	0.424
TRG_ER_diArg_1	172	174	PF00400	0.471
TRG_ER_diArg_1	225	228	PF00400	0.742

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA62	Leptomonas seymouri	70%	100%
A0A0S4IP06	Bodo saltans	31%	100%
A0A1X0NIB0	Trypanosomatidae	29%	100%
A0A1X0P719	Trypanosomatidae	61%	100%
A0A3Q8IAY4	Leishmania donovani	85%	100%
A0A3R7M6A3	Trypanosoma rangeli	60%	100%
A4HJV4	Leishmania braziliensis	28%	100%
A4HXQ8	Leishmania infantum	85%	100%
B6DTF2	Bodo saltans	51%	100%
D0A039	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9ARH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QE09	Leishmania major	85%	100%