DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania braziliensis

UniProt:

A4H9D6_LEIBR

TriTrypDb:

LbrM.18.0340 , LBRM2903_180008400

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9D6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.259
CLV_NRD_NRD_1	224	226	PF00675	0.581
CLV_NRD_NRD_1	254	256	PF00675	0.439
CLV_NRD_NRD_1	92	94	PF00675	0.259
CLV_PCSK_FUR_1	254	258	PF00082	0.464
CLV_PCSK_KEX2_1	250	252	PF00082	0.459
CLV_PCSK_KEX2_1	254	256	PF00082	0.414
CLV_PCSK_KEX2_1	73	75	PF00082	0.433
CLV_PCSK_KEX2_1	92	94	PF00082	0.152
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.607
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.553
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.441
CLV_Separin_Metazoa	129	133	PF03568	0.415
DEG_Nend_Nbox_1	1	3	PF02207	0.515
DOC_MAPK_gen_1	225	236	PF00069	0.445
DOC_MAPK_gen_1	73	81	PF00069	0.273
DOC_MAPK_MEF2A_6	132	140	PF00069	0.437
DOC_MAPK_MEF2A_6	74	83	PF00069	0.259
DOC_PP1_RVXF_1	42	49	PF00149	0.401
DOC_PP1_RVXF_1	90	97	PF00149	0.259
DOC_WW_Pin1_4	132	137	PF00397	0.492
LIG_14-3-3_CanoR_1	106	112	PF00244	0.254
LIG_14-3-3_CanoR_1	18	23	PF00244	0.423
LIG_14-3-3_CanoR_1	189	195	PF00244	0.373
LIG_14-3-3_CterR_2	257	260	PF00244	0.441
LIG_FHA_1	133	139	PF00498	0.574
LIG_FHA_1	3	9	PF00498	0.452
LIG_HP1_1	136	140	PF01393	0.406
LIG_LIR_Gen_1	17	26	PF02991	0.381
LIG_LIR_Nem_3	146	151	PF02991	0.404
LIG_LIR_Nem_3	17	22	PF02991	0.377
LIG_LIR_Nem_3	230	236	PF02991	0.413
LIG_Pex14_1	96	100	PF04695	0.273
LIG_Pex14_2	169	173	PF04695	0.259
LIG_SH2_CRK	63	67	PF00017	0.321
LIG_SH2_GRB2like	32	35	PF00017	0.435
LIG_SH2_STAP1	126	130	PF00017	0.481
LIG_SH2_STAT5	233	236	PF00017	0.454
LIG_SH2_STAT5	32	35	PF00017	0.375
LIG_SH3_3	196	202	PF00018	0.292
LIG_SUMO_SIM_par_1	135	142	PF11976	0.411
LIG_SUMO_SIM_par_1	161	167	PF11976	0.237
LIG_UBA3_1	147	156	PF00899	0.352
MOD_CK1_1	110	116	PF00069	0.262
MOD_CK1_1	164	170	PF00069	0.395
MOD_CK1_1	17	23	PF00069	0.388
MOD_CK2_1	236	242	PF00069	0.473
MOD_CK2_1	6	12	PF00069	0.310
MOD_Cter_Amidation	223	226	PF01082	0.353
MOD_Cter_Amidation	248	251	PF01082	0.609
MOD_GlcNHglycan	207	210	PF01048	0.275
MOD_GlcNHglycan	244	247	PF01048	0.431
MOD_GlcNHglycan	8	11	PF01048	0.481
MOD_GSK3_1	14	21	PF00069	0.434
MOD_GSK3_1	2	9	PF00069	0.487
MOD_GSK3_1	238	245	PF00069	0.441
MOD_GSK3_1	96	103	PF00069	0.241
MOD_N-GLC_1	107	112	PF02516	0.420
MOD_N-GLC_1	218	223	PF02516	0.421
MOD_N-GLC_1	33	38	PF02516	0.434
MOD_N-GLC_2	120	122	PF02516	0.273
MOD_NEK2_1	100	105	PF00069	0.261
MOD_NEK2_1	163	168	PF00069	0.259
MOD_NEK2_1	236	241	PF00069	0.487
MOD_NEK2_1	33	38	PF00069	0.359
MOD_NEK2_2	182	187	PF00069	0.266
MOD_PK_1	107	113	PF00069	0.292
MOD_PK_1	18	24	PF00069	0.420
MOD_PK_1	62	68	PF00069	0.397
MOD_PKA_2	17	23	PF00069	0.305
MOD_PKA_2	182	188	PF00069	0.271
MOD_PKA_2	2	8	PF00069	0.466
MOD_PKA_2	50	56	PF00069	0.349
MOD_Plk_1	107	113	PF00069	0.427
MOD_Plk_1	236	242	PF00069	0.393
MOD_Plk_1	33	39	PF00069	0.433
MOD_Plk_4	18	24	PF00069	0.420
MOD_Plk_4	62	68	PF00069	0.372
MOD_ProDKin_1	132	138	PF00069	0.490
TRG_DiLeu_BaEn_1	158	163	PF01217	0.185
TRG_ENDOCYTIC_2	233	236	PF00928	0.454
TRG_ENDOCYTIC_2	28	31	PF00928	0.379
TRG_ENDOCYTIC_2	63	66	PF00928	0.321
TRG_ER_diArg_1	186	189	PF00400	0.273
TRG_ER_diArg_1	253	255	PF00400	0.428
TRG_ER_diArg_1	92	94	PF00400	0.259
TRG_NLS_MonoExtN_4	253	259	PF00514	0.360
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIG6	Leptomonas seymouri	77%	100%
A0A0S4JHH1	Bodo saltans	51%	100%
A0A1X0P874	Trypanosomatidae	67%	100%
A0A3Q8IB20	Leishmania donovani	90%	100%
A0A422NWN7	Trypanosoma rangeli	70%	100%
D0A038	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AGQ2	Leishmania infantum	90%	100%
E9ARG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5B6F4	Trypanosoma cruzi	65%	100%