LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H9D5_LEIBR
TriTrypDb:
LbrM.18.0330 , LBRM2903_180008300
Length:
102

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H9D5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9D5

PDB structure(s): 7aih_BD , 7ane_BD

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 74 78 PF00656 0.342
CLV_C14_Caspase3-7 80 84 PF00656 0.299
CLV_NRD_NRD_1 49 51 PF00675 0.447
CLV_NRD_NRD_1 67 69 PF00675 0.482
CLV_PCSK_KEX2_1 49 51 PF00082 0.447
CLV_PCSK_KEX2_1 67 69 PF00082 0.482
DOC_WW_Pin1_4 86 91 PF00397 0.445
LIG_BIR_II_1 1 5 PF00653 0.358
LIG_BRCT_BRCA1_1 1 5 PF00533 0.358
LIG_FHA_2 72 78 PF00498 0.310
LIG_FHA_2 87 93 PF00498 0.472
LIG_LIR_Gen_1 71 81 PF02991 0.275
LIG_LIR_Nem_3 71 76 PF02991 0.352
LIG_Pex14_2 5 9 PF04695 0.367
LIG_REV1ctd_RIR_1 3 12 PF16727 0.353
LIG_SH2_CRK 26 30 PF00017 0.405
LIG_SH2_CRK 54 58 PF00017 0.287
LIG_SH2_STAT5 10 13 PF00017 0.343
MOD_CDK_SPxxK_3 86 93 PF00069 0.439
MOD_CK1_1 71 77 PF00069 0.304
MOD_GlcNHglycan 16 19 PF01048 0.476
MOD_GlcNHglycan 21 24 PF01048 0.477
MOD_GlcNHglycan 54 57 PF01048 0.422
MOD_N-GLC_1 14 19 PF02516 0.379
MOD_N-GLC_1 71 76 PF02516 0.257
MOD_NEK2_1 97 102 PF00069 0.563
MOD_OFUCOSY 61 66 PF10250 0.264
MOD_Plk_1 14 20 PF00069 0.415
MOD_Plk_1 71 77 PF00069 0.263
MOD_ProDKin_1 86 92 PF00069 0.441
MOD_SUMO_rev_2 77 86 PF00179 0.393
TRG_ENDOCYTIC_2 26 29 PF00928 0.414
TRG_ENDOCYTIC_2 54 57 PF00928 0.443
TRG_ER_diArg_1 67 69 PF00400 0.298

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HU10 Leptomonas seymouri 82% 100%
A0A1X0P7S7 Trypanosomatidae 63% 88%
A0A3R7KLJ1 Trypanosoma rangeli 62% 92%
A0A3S5H726 Leishmania donovani 85% 100%
A4HXQ7 Leishmania infantum 87% 100%
B6DTF0 Bodo saltans 50% 84%
D0A037 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 90%
E9ARG8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QE11 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS