NTF2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9D4_LEIBR

TriTrypDb:

LbrM.18.0320 , LBRM2903_180008200

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0005930	axoneme	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	1
GO:0043226	organelle	2	1
GO:0043229	intracellular organelle	3	1

Expansion

Sequence features

A4H9D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9D4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.595
CLV_NRD_NRD_1	214	216	PF00675	0.529
CLV_NRD_NRD_1	290	292	PF00675	0.639
CLV_NRD_NRD_1	346	348	PF00675	0.750
CLV_NRD_NRD_1	46	48	PF00675	0.394
CLV_PCSK_FUR_1	288	292	PF00082	0.494
CLV_PCSK_KEX2_1	288	290	PF00082	0.629
CLV_PCSK_SKI1_1	110	114	PF00082	0.368
CLV_PCSK_SKI1_1	216	220	PF00082	0.786
CLV_PCSK_SKI1_1	225	229	PF00082	0.739
CLV_PCSK_SKI1_1	293	297	PF00082	0.612
CLV_PCSK_SKI1_1	340	344	PF00082	0.472
DOC_CKS1_1	26	31	PF01111	0.533
DOC_CKS1_1	271	276	PF01111	0.490
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.555
DOC_MAPK_gen_1	47	55	PF00069	0.526
DOC_MAPK_MEF2A_6	9	17	PF00069	0.494
DOC_PP2B_LxvP_1	35	38	PF13499	0.353
DOC_USP7_MATH_1	143	147	PF00917	0.518
DOC_USP7_MATH_1	243	247	PF00917	0.627
DOC_USP7_UBL2_3	212	216	PF12436	0.731
DOC_USP7_UBL2_3	221	225	PF12436	0.642
DOC_USP7_UBL2_3	237	241	PF12436	0.787
DOC_USP7_UBL2_3	358	362	PF12436	0.767
DOC_USP7_UBL2_3	86	90	PF12436	0.550
DOC_WW_Pin1_4	134	139	PF00397	0.616
DOC_WW_Pin1_4	156	161	PF00397	0.529
DOC_WW_Pin1_4	25	30	PF00397	0.533
DOC_WW_Pin1_4	270	275	PF00397	0.527
LIG_14-3-3_CanoR_1	244	250	PF00244	0.655
LIG_14-3-3_CanoR_1	98	103	PF00244	0.332
LIG_Actin_WH2_2	314	331	PF00022	0.375
LIG_FHA_1	101	107	PF00498	0.424
LIG_FHA_1	113	119	PF00498	0.375
LIG_FHA_1	129	135	PF00498	0.671
LIG_FHA_1	21	27	PF00498	0.478
LIG_FHA_1	212	218	PF00498	0.529
LIG_FHA_1	294	300	PF00498	0.494
LIG_FHA_2	157	163	PF00498	0.517
LIG_FHA_2	22	28	PF00498	0.451
LIG_FHA_2	354	360	PF00498	0.677
LIG_LIR_Gen_1	301	311	PF02991	0.521
LIG_LIR_Nem_3	248	254	PF02991	0.546
LIG_LIR_Nem_3	301	307	PF02991	0.499
LIG_NRBOX	54	60	PF00104	0.600
LIG_RPA_C_Fungi	205	217	PF08784	0.527
LIG_SH2_CRK	22	26	PF00017	0.382
LIG_SH2_CRK	252	256	PF00017	0.441
LIG_SH2_NCK_1	125	129	PF00017	0.590
LIG_SH2_SRC	252	255	PF00017	0.500
LIG_SH2_SRC	36	39	PF00017	0.367
LIG_SH2_STAP1	22	26	PF00017	0.382
LIG_SH2_STAP1	252	256	PF00017	0.441
LIG_SH2_STAT5	22	25	PF00017	0.434
LIG_SH2_STAT5	36	39	PF00017	0.445
LIG_SH3_3	163	169	PF00018	0.654
LIG_SH3_3	23	29	PF00018	0.440
LIG_SH3_3	268	274	PF00018	0.530
LIG_TRAF2_1	155	158	PF00917	0.520
LIG_TYR_ITIM	249	254	PF00017	0.478
LIG_WRC_WIRS_1	43	48	PF05994	0.361
LIG_WW_3	241	245	PF00397	0.507
MOD_CDK_SPxxK_3	134	141	PF00069	0.654
MOD_CK1_1	185	191	PF00069	0.585
MOD_CK1_1	230	236	PF00069	0.724
MOD_CK1_1	57	63	PF00069	0.595
MOD_CK2_1	156	162	PF00069	0.517
MOD_CK2_1	174	180	PF00069	0.633
MOD_CK2_1	21	27	PF00069	0.443
MOD_CK2_1	259	265	PF00069	0.479
MOD_CK2_1	353	359	PF00069	0.682
MOD_GlcNHglycan	125	128	PF01048	0.645
MOD_GlcNHglycan	229	232	PF01048	0.677
MOD_GlcNHglycan	275	278	PF01048	0.535
MOD_GlcNHglycan	339	343	PF01048	0.631
MOD_GlcNHglycan	38	41	PF01048	0.560
MOD_GlcNHglycan	81	84	PF01048	0.527
MOD_GSK3_1	112	119	PF00069	0.454
MOD_GSK3_1	143	150	PF00069	0.503
MOD_GSK3_1	21	28	PF00069	0.378
MOD_GSK3_1	289	296	PF00069	0.620
MOD_GSK3_1	42	49	PF00069	0.555
MOD_GSK3_1	5	12	PF00069	0.622
MOD_GSK3_1	53	60	PF00069	0.522
MOD_GSK3_1	96	103	PF00069	0.507
MOD_NEK2_1	123	128	PF00069	0.541
MOD_NEK2_1	182	187	PF00069	0.608
MOD_NEK2_1	193	198	PF00069	0.722
MOD_NEK2_1	343	348	PF00069	0.511
MOD_NEK2_1	46	51	PF00069	0.419
MOD_NEK2_1	58	63	PF00069	0.530
MOD_NEK2_1	79	84	PF00069	0.537
MOD_NEK2_1	93	98	PF00069	0.341
MOD_NEK2_2	353	358	PF00069	0.531
MOD_PIKK_1	96	102	PF00454	0.547
MOD_PK_1	9	15	PF00069	0.319
MOD_PKA_1	289	295	PF00069	0.578
MOD_PKA_2	182	188	PF00069	0.544
MOD_PKA_2	198	204	PF00069	0.714
MOD_PKA_2	243	249	PF00069	0.677
MOD_PKA_2	289	295	PF00069	0.633
MOD_PKA_2	46	52	PF00069	0.371
MOD_Plk_1	143	149	PF00069	0.521
MOD_Plk_1	338	344	PF00069	0.465
MOD_Plk_1	53	59	PF00069	0.585
MOD_Plk_2-3	261	267	PF00069	0.368
MOD_Plk_4	21	27	PF00069	0.431
MOD_Plk_4	245	251	PF00069	0.677
MOD_Plk_4	54	60	PF00069	0.600
MOD_ProDKin_1	134	140	PF00069	0.619
MOD_ProDKin_1	156	162	PF00069	0.533
MOD_ProDKin_1	25	31	PF00069	0.534
MOD_ProDKin_1	270	276	PF00069	0.521
MOD_SUMO_for_1	284	287	PF00179	0.572
MOD_SUMO_for_1	357	360	PF00179	0.524
MOD_SUMO_rev_2	261	268	PF00179	0.605
MOD_SUMO_rev_2	359	363	PF00179	0.628
TRG_DiLeu_BaEn_1	54	59	PF01217	0.522
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.502
TRG_ENDOCYTIC_2	22	25	PF00928	0.375
TRG_ENDOCYTIC_2	251	254	PF00928	0.461
TRG_ER_diArg_1	288	291	PF00400	0.641
TRG_ER_diArg_1	69	72	PF00400	0.343
TRG_NLS_MonoExtN_4	169	176	PF00514	0.516
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAH4	Leptomonas seymouri	49%	91%
A0A3S7WUR4	Leishmania donovani	63%	95%
A4HXQ6	Leishmania infantum	63%	94%
D0A036	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	84%
E9ARG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	94%
Q4QE12	Leishmania major	67%	99%