Dephospho-CoA kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dephospho-CoA kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H9D3_LEIBR

TriTrypDb:

LbrM.18.0310 , LBRM2903_180008100

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9D3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006163	purine nucleotide metabolic process	5	10
GO:0006164	purine nucleotide biosynthetic process	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006753	nucleoside phosphate metabolic process	4	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009117	nucleotide metabolic process	5	10
GO:0009150	purine ribonucleotide metabolic process	6	10
GO:0009152	purine ribonucleotide biosynthetic process	7	10
GO:0009165	nucleotide biosynthetic process	6	10
GO:0009259	ribonucleotide metabolic process	5	10
GO:0009260	ribonucleotide biosynthetic process	6	10
GO:0009987	cellular process	1	10
GO:0015936	coenzyme A metabolic process	6	10
GO:0015937	coenzyme A biosynthetic process	7	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0019637	organophosphate metabolic process	3	10
GO:0019693	ribose phosphate metabolic process	4	10
GO:0033865	nucleoside bisphosphate metabolic process	5	10
GO:0033866	nucleoside bisphosphate biosynthetic process	6	10
GO:0033875	ribonucleoside bisphosphate metabolic process	6	10
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	10
GO:0034032	purine nucleoside bisphosphate metabolic process	5	10
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0044281	small molecule metabolic process	2	10
GO:0046390	ribose phosphate biosynthetic process	5	10
GO:0046483	heterocycle metabolic process	3	10
GO:0055086	nucleobase-containing small molecule metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0072521	purine-containing compound metabolic process	4	10
GO:0072522	purine-containing compound biosynthetic process	5	10
GO:0090407	organophosphate biosynthetic process	4	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901137	carbohydrate derivative biosynthetic process	4	10
GO:1901293	nucleoside phosphate biosynthetic process	5	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0016310	phosphorylation	5	4

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004140	dephospho-CoA kinase activity	5	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.447
CLV_NRD_NRD_1	156	158	PF00675	0.403
CLV_NRD_NRD_1	274	276	PF00675	0.365
CLV_NRD_NRD_1	55	57	PF00675	0.522
CLV_PCSK_KEX2_1	145	147	PF00082	0.467
CLV_PCSK_SKI1_1	145	149	PF00082	0.535
CLV_PCSK_SKI1_1	291	295	PF00082	0.387
DEG_APCC_DBOX_1	144	152	PF00400	0.468
DEG_MDM2_SWIB_1	325	333	PF02201	0.392
DEG_Nend_UBRbox_1	1	4	PF02207	0.534
DEG_SPOP_SBC_1	200	204	PF00917	0.517
DEG_SPOP_SBC_1	211	215	PF00917	0.512
DEG_SPOP_SBC_1	216	220	PF00917	0.487
DOC_CKS1_1	185	190	PF01111	0.442
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.437
DOC_MAPK_gen_1	145	153	PF00069	0.470
DOC_MAPK_gen_1	327	337	PF00069	0.478
DOC_MAPK_MEF2A_6	330	337	PF00069	0.503
DOC_PP1_RVXF_1	3	10	PF00149	0.523
DOC_PP2B_LxvP_1	103	106	PF13499	0.571
DOC_USP7_MATH_1	205	209	PF00917	0.614
DOC_USP7_MATH_1	211	215	PF00917	0.674
DOC_USP7_MATH_1	216	220	PF00917	0.669
DOC_USP7_MATH_1	222	226	PF00917	0.521
DOC_USP7_MATH_1	62	66	PF00917	0.626
DOC_USP7_UBL2_3	39	43	PF12436	0.487
DOC_WW_Pin1_4	184	189	PF00397	0.445
DOC_WW_Pin1_4	207	212	PF00397	0.715
DOC_WW_Pin1_4	256	261	PF00397	0.543
LIG_14-3-3_CanoR_1	281	288	PF00244	0.537
LIG_BRCT_BRCA1_1	47	51	PF00533	0.523
LIG_Clathr_ClatBox_1	232	236	PF01394	0.490
LIG_eIF4E_1	73	79	PF01652	0.505
LIG_FHA_1	169	175	PF00498	0.530
LIG_FHA_1	242	248	PF00498	0.540
LIG_FHA_1	307	313	PF00498	0.467
LIG_FHA_1	8	14	PF00498	0.403
LIG_FHA_1	98	104	PF00498	0.463
LIG_FHA_2	260	266	PF00498	0.561
LIG_Integrin_RGD_1	129	131	PF01839	0.547
LIG_LIR_Gen_1	176	185	PF02991	0.457
LIG_LIR_Nem_3	176	181	PF02991	0.534
LIG_PDZ_Class_2	332	337	PF00595	0.537
LIG_Pex14_2	325	329	PF04695	0.386
LIG_SH2_CRK	178	182	PF00017	0.539
LIG_SH2_CRK	92	96	PF00017	0.496
LIG_SH2_GRB2like	73	76	PF00017	0.488
LIG_SH2_SRC	73	76	PF00017	0.465
LIG_SH2_SRC	84	87	PF00017	0.398
LIG_SH2_STAT5	169	172	PF00017	0.450
LIG_SH2_STAT5	73	76	PF00017	0.430
LIG_SH3_3	113	119	PF00018	0.527
LIG_SH3_3	133	139	PF00018	0.484
LIG_SH3_3	185	191	PF00018	0.663
LIG_SH3_3	83	89	PF00018	0.408
LIG_SUMO_SIM_par_1	231	236	PF11976	0.348
LIG_SUMO_SIM_par_1	244	252	PF11976	0.497
LIG_TRAF2_1	58	61	PF00917	0.502
MOD_CK1_1	15	21	PF00069	0.417
MOD_CK1_1	192	198	PF00069	0.737
MOD_CK1_1	210	216	PF00069	0.665
MOD_CK1_1	217	223	PF00069	0.715
MOD_CK1_1	44	50	PF00069	0.743
MOD_CK1_1	67	73	PF00069	0.403
MOD_CK2_1	310	316	PF00069	0.462
MOD_GlcNHglycan	103	106	PF01048	0.553
MOD_GlcNHglycan	107	110	PF01048	0.646
MOD_GlcNHglycan	131	134	PF01048	0.717
MOD_GlcNHglycan	14	17	PF01048	0.406
MOD_GlcNHglycan	171	174	PF01048	0.380
MOD_GlcNHglycan	194	197	PF01048	0.723
MOD_GlcNHglycan	224	227	PF01048	0.595
MOD_GlcNHglycan	44	47	PF01048	0.694
MOD_GSK3_1	12	19	PF00069	0.422
MOD_GSK3_1	200	207	PF00069	0.697
MOD_GSK3_1	210	217	PF00069	0.722
MOD_GSK3_1	3	10	PF00069	0.419
MOD_GSK3_1	306	313	PF00069	0.434
MOD_GSK3_1	41	48	PF00069	0.741
MOD_GSK3_1	63	70	PF00069	0.432
MOD_GSK3_1	97	104	PF00069	0.494
MOD_NEK2_1	201	206	PF00069	0.529
MOD_NEK2_1	307	312	PF00069	0.470
MOD_NEK2_1	318	323	PF00069	0.224
MOD_NEK2_1	41	46	PF00069	0.475
MOD_NEK2_1	9	14	PF00069	0.428
MOD_PIKK_1	110	116	PF00454	0.756
MOD_PIKK_1	117	123	PF00454	0.662
MOD_PIKK_1	281	287	PF00454	0.508
MOD_PIKK_1	307	313	PF00454	0.526
MOD_Plk_1	307	313	PF00069	0.533
MOD_Plk_4	64	70	PF00069	0.438
MOD_ProDKin_1	184	190	PF00069	0.448
MOD_ProDKin_1	207	213	PF00069	0.716
MOD_ProDKin_1	256	262	PF00069	0.543
MOD_SUMO_for_1	174	177	PF00179	0.541
MOD_SUMO_rev_2	150	159	PF00179	0.480
TRG_DiLeu_BaEn_4	176	182	PF01217	0.309
TRG_ENDOCYTIC_2	178	181	PF00928	0.540
TRG_ENDOCYTIC_2	91	94	PF00928	0.409
TRG_ER_diArg_1	145	147	PF00400	0.566
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I144	Leptomonas seymouri	53%	100%
A0A0S4JER7	Bodo saltans	32%	100%
A0A1X0P6Q6	Trypanosomatidae	32%	100%
A0A3R7MR11	Trypanosoma rangeli	32%	100%
A0A3S7WUR7	Leishmania donovani	73%	100%
A4HXQ5	Leishmania infantum	73%	100%
E9ARG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QE13	Leishmania major	75%	100%