Exocyst complex protein EXO70

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9D2_LEIBR

TriTrypDb:

LbrM.18.0300 , LBRM2903_180008000

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9D2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	474	478	PF00656	0.539
CLV_C14_Caspase3-7	513	517	PF00656	0.724
CLV_C14_Caspase3-7	58	62	PF00656	0.593
CLV_NRD_NRD_1	133	135	PF00675	0.612
CLV_PCSK_SKI1_1	33	37	PF00082	0.634
CLV_PCSK_SKI1_1	449	453	PF00082	0.565
CLV_PCSK_SKI1_1	456	460	PF00082	0.481
CLV_PCSK_SKI1_1	582	586	PF00082	0.473
CLV_PCSK_SKI1_1	614	618	PF00082	0.511
CLV_PCSK_SKI1_1	670	674	PF00082	0.547
DEG_SPOP_SBC_1	291	295	PF00917	0.733
DOC_ANK_TNKS_1	356	363	PF00023	0.395
DOC_CDC14_PxL_1	165	173	PF14671	0.540
DOC_CKS1_1	337	342	PF01111	0.597
DOC_CKS1_1	431	436	PF01111	0.615
DOC_MAPK_DCC_7	562	572	PF00069	0.615
DOC_MAPK_gen_1	448	454	PF00069	0.642
DOC_MAPK_gen_1	522	531	PF00069	0.515
DOC_MAPK_gen_1	560	569	PF00069	0.638
DOC_MAPK_HePTP_8	527	539	PF00069	0.563
DOC_MAPK_MEF2A_6	114	122	PF00069	0.535
DOC_MAPK_MEF2A_6	177	186	PF00069	0.518
DOC_MAPK_MEF2A_6	357	365	PF00069	0.396
DOC_MAPK_MEF2A_6	408	417	PF00069	0.614
DOC_MAPK_MEF2A_6	453	462	PF00069	0.498
DOC_MAPK_MEF2A_6	522	531	PF00069	0.495
DOC_MAPK_MEF2A_6	670	677	PF00069	0.551
DOC_MAPK_NFAT4_5	522	530	PF00069	0.552
DOC_PP2B_LxvP_1	468	471	PF13499	0.545
DOC_PP4_FxxP_1	431	434	PF00568	0.365
DOC_PP4_FxxP_1	462	465	PF00568	0.550
DOC_PP4_FxxP_1	518	521	PF00568	0.657
DOC_USP7_MATH_1	256	260	PF00917	0.707
DOC_USP7_MATH_1	290	294	PF00917	0.736
DOC_USP7_MATH_1	306	310	PF00917	0.523
DOC_USP7_MATH_1	348	352	PF00917	0.418
DOC_USP7_MATH_1	447	451	PF00917	0.530
DOC_USP7_MATH_1	507	511	PF00917	0.635
DOC_USP7_MATH_1	561	565	PF00917	0.567
DOC_USP7_MATH_1	74	78	PF00917	0.746
DOC_USP7_UBL2_3	444	448	PF12436	0.681
DOC_WW_Pin1_4	151	156	PF00397	0.622
DOC_WW_Pin1_4	336	341	PF00397	0.604
DOC_WW_Pin1_4	396	401	PF00397	0.756
DOC_WW_Pin1_4	430	435	PF00397	0.594
DOC_WW_Pin1_4	45	50	PF00397	0.522
DOC_WW_Pin1_4	463	468	PF00397	0.421
DOC_WW_Pin1_4	517	522	PF00397	0.532
DOC_WW_Pin1_4	92	97	PF00397	0.597
LIG_14-3-3_CanoR_1	101	106	PF00244	0.720
LIG_14-3-3_CanoR_1	206	210	PF00244	0.494
LIG_14-3-3_CanoR_1	252	256	PF00244	0.709
LIG_14-3-3_CanoR_1	357	365	PF00244	0.531
LIG_14-3-3_CanoR_1	487	493	PF00244	0.532
LIG_14-3-3_CanoR_1	498	507	PF00244	0.541
LIG_14-3-3_CanoR_1	511	519	PF00244	0.516
LIG_14-3-3_CanoR_1	560	570	PF00244	0.657
LIG_14-3-3_CanoR_1	582	587	PF00244	0.481
LIG_14-3-3_CanoR_1	659	665	PF00244	0.415
LIG_Actin_WH2_2	18	35	PF00022	0.634
LIG_Actin_WH2_2	233	250	PF00022	0.559
LIG_APCC_ABBA_1	529	534	PF00400	0.485
LIG_BIR_II_1	1	5	PF00653	0.445
LIG_BIR_III_4	347	351	PF00653	0.641
LIG_BRCT_BRCA1_1	102	106	PF00533	0.618
LIG_Clathr_ClatBox_1	301	305	PF01394	0.597
LIG_CSL_BTD_1	152	155	PF09270	0.625
LIG_FAT_LD_1	60	68	PF03623	0.599
LIG_FHA_1	108	114	PF00498	0.573
LIG_FHA_1	205	211	PF00498	0.544
LIG_FHA_1	21	27	PF00498	0.633
LIG_FHA_1	231	237	PF00498	0.479
LIG_FHA_1	305	311	PF00498	0.521
LIG_FHA_1	480	486	PF00498	0.513
LIG_FHA_1	488	494	PF00498	0.428
LIG_FHA_1	545	551	PF00498	0.522
LIG_FHA_1	597	603	PF00498	0.639
LIG_FHA_1	667	673	PF00498	0.576
LIG_FHA_1	73	79	PF00498	0.779
LIG_FHA_2	423	429	PF00498	0.497
LIG_FHA_2	511	517	PF00498	0.719
LIG_FHA_2	53	59	PF00498	0.554
LIG_FHA_2	599	605	PF00498	0.621
LIG_FHA_2	659	665	PF00498	0.440
LIG_FHA_2	93	99	PF00498	0.632
LIG_GBD_Chelix_1	341	349	PF00786	0.610
LIG_LIR_Apic_2	428	434	PF02991	0.356
LIG_LIR_Apic_2	516	521	PF02991	0.670
LIG_LIR_Gen_1	10	15	PF02991	0.576
LIG_LIR_Gen_1	20	29	PF02991	0.416
LIG_LIR_Gen_1	272	282	PF02991	0.374
LIG_LIR_Gen_1	411	422	PF02991	0.608
LIG_LIR_LC3C_4	533	537	PF02991	0.581
LIG_LIR_Nem_3	10	14	PF02991	0.661
LIG_LIR_Nem_3	20	25	PF02991	0.697
LIG_LIR_Nem_3	411	417	PF02991	0.577
LIG_LIR_Nem_3	490	495	PF02991	0.515
LIG_LIR_Nem_3	538	543	PF02991	0.443
LIG_NRBOX	59	65	PF00104	0.610
LIG_PCNA_yPIPBox_3	580	590	PF02747	0.579
LIG_PTB_Apo_2	173	180	PF02174	0.620
LIG_PTB_Apo_2	494	501	PF02174	0.519
LIG_PTB_Phospho_1	173	179	PF10480	0.623
LIG_SH2_CRK	358	362	PF00017	0.446
LIG_SH2_NCK_1	358	362	PF00017	0.470
LIG_SH2_PTP2	414	417	PF00017	0.341
LIG_SH2_SRC	674	677	PF00017	0.609
LIG_SH2_STAT3	586	589	PF00017	0.624
LIG_SH2_STAT3	65	68	PF00017	0.538
LIG_SH2_STAT5	332	335	PF00017	0.600
LIG_SH2_STAT5	358	361	PF00017	0.533
LIG_SH2_STAT5	414	417	PF00017	0.567
LIG_SH2_STAT5	586	589	PF00017	0.597
LIG_SH2_STAT5	674	677	PF00017	0.547
LIG_SH3_3	117	123	PF00018	0.587
LIG_SH3_3	305	311	PF00018	0.534
LIG_SH3_3	334	340	PF00018	0.576
LIG_SH3_3	431	437	PF00018	0.613
LIG_SH3_3	536	542	PF00018	0.460
LIG_SH3_3	651	657	PF00018	0.498
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.563
LIG_SUMO_SIM_par_1	549	554	PF11976	0.383
LIG_TYR_ITIM	672	677	PF00017	0.514
LIG_UBA3_1	63	70	PF00899	0.602
LIG_WRC_WIRS_1	8	13	PF05994	0.438
LIG_WRPW_2	540	543	PF00400	0.411
MOD_CDC14_SPxK_1	466	469	PF00782	0.530
MOD_CDK_SPK_2	517	522	PF00069	0.547
MOD_CDK_SPxK_1	151	157	PF00069	0.649
MOD_CDK_SPxK_1	463	469	PF00069	0.488
MOD_CDK_SPxxK_3	396	403	PF00069	0.658
MOD_CDK_SPxxK_3	517	524	PF00069	0.533
MOD_CK1_1	104	110	PF00069	0.632
MOD_CK1_1	139	145	PF00069	0.610
MOD_CK1_1	160	166	PF00069	0.625
MOD_CK1_1	215	221	PF00069	0.609
MOD_CK1_1	265	271	PF00069	0.574
MOD_CK1_1	510	516	PF00069	0.624
MOD_CK1_1	520	526	PF00069	0.535
MOD_CK1_1	66	72	PF00069	0.687
MOD_CK1_1	76	82	PF00069	0.657
MOD_CK2_1	436	442	PF00069	0.712
MOD_CK2_1	598	604	PF00069	0.535
MOD_CK2_1	66	72	PF00069	0.591
MOD_CK2_1	92	98	PF00069	0.441
MOD_GlcNHglycan	110	113	PF01048	0.571
MOD_GlcNHglycan	214	217	PF01048	0.562
MOD_GlcNHglycan	253	256	PF01048	0.727
MOD_GlcNHglycan	258	261	PF01048	0.766
MOD_GlcNHglycan	266	270	PF01048	0.546
MOD_GlcNHglycan	314	317	PF01048	0.660
MOD_GlcNHglycan	350	353	PF01048	0.436
MOD_GlcNHglycan	385	388	PF01048	0.658
MOD_GlcNHglycan	449	452	PF01048	0.484
MOD_GlcNHglycan	563	566	PF01048	0.507
MOD_GlcNHglycan	621	624	PF01048	0.543
MOD_GlcNHglycan	666	669	PF01048	0.658
MOD_GSK3_1	100	107	PF00069	0.641
MOD_GSK3_1	108	115	PF00069	0.403
MOD_GSK3_1	135	142	PF00069	0.601
MOD_GSK3_1	20	27	PF00069	0.666
MOD_GSK3_1	247	254	PF00069	0.679
MOD_GSK3_1	258	265	PF00069	0.580
MOD_GSK3_1	383	390	PF00069	0.712
MOD_GSK3_1	45	52	PF00069	0.731
MOD_GSK3_1	475	482	PF00069	0.626
MOD_GSK3_1	483	490	PF00069	0.523
MOD_GSK3_1	505	512	PF00069	0.627
MOD_GSK3_1	72	79	PF00069	0.656
MOD_N-GLC_1	108	113	PF02516	0.672
MOD_N-GLC_1	479	484	PF02516	0.639
MOD_N-GLC_1	49	54	PF02516	0.634
MOD_N-GLC_1	496	501	PF02516	0.418
MOD_NEK2_1	105	110	PF00069	0.684
MOD_NEK2_1	205	210	PF00069	0.507
MOD_NEK2_1	247	252	PF00069	0.516
MOD_NEK2_1	312	317	PF00069	0.555
MOD_NEK2_1	378	383	PF00069	0.587
MOD_NEK2_1	496	501	PF00069	0.519
MOD_NEK2_1	597	602	PF00069	0.582
MOD_NEK2_1	63	68	PF00069	0.607
MOD_PIKK_1	436	442	PF00454	0.709
MOD_PKA_2	100	106	PF00069	0.754
MOD_PKA_2	113	119	PF00069	0.472
MOD_PKA_2	205	211	PF00069	0.474
MOD_PKA_2	247	253	PF00069	0.617
MOD_PKA_2	27	33	PF00069	0.570
MOD_PKA_2	356	362	PF00069	0.436
MOD_PKA_2	510	516	PF00069	0.676
MOD_PKA_2	561	567	PF00069	0.651
MOD_PKA_2	658	664	PF00069	0.604
MOD_Plk_1	108	114	PF00069	0.597
MOD_Plk_1	188	194	PF00069	0.652
MOD_Plk_1	304	310	PF00069	0.533
MOD_Plk_1	479	485	PF00069	0.601
MOD_Plk_1	49	55	PF00069	0.457
MOD_Plk_1	496	502	PF00069	0.446
MOD_Plk_1	597	603	PF00069	0.561
MOD_Plk_1	640	646	PF00069	0.602
MOD_Plk_2-3	598	604	PF00069	0.663
MOD_Plk_4	101	107	PF00069	0.600
MOD_Plk_4	182	188	PF00069	0.470
MOD_Plk_4	205	211	PF00069	0.476
MOD_Plk_4	297	303	PF00069	0.580
MOD_Plk_4	488	494	PF00069	0.493
MOD_Plk_4	582	588	PF00069	0.420
MOD_Plk_4	598	604	PF00069	0.460
MOD_Plk_4	78	84	PF00069	0.591
MOD_ProDKin_1	151	157	PF00069	0.622
MOD_ProDKin_1	336	342	PF00069	0.602
MOD_ProDKin_1	396	402	PF00069	0.754
MOD_ProDKin_1	430	436	PF00069	0.605
MOD_ProDKin_1	45	51	PF00069	0.510
MOD_ProDKin_1	463	469	PF00069	0.435
MOD_ProDKin_1	517	523	PF00069	0.528
MOD_ProDKin_1	92	98	PF00069	0.609
MOD_SUMO_for_1	35	38	PF00179	0.635
MOD_SUMO_rev_2	442	450	PF00179	0.712
MOD_SUMO_rev_2	606	616	PF00179	0.721
TRG_DiLeu_BaEn_1	612	617	PF01217	0.467
TRG_DiLeu_BaEn_4	604	610	PF01217	0.481
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.626
TRG_DiLeu_BaLyEn_6	668	673	PF01217	0.579
TRG_ENDOCYTIC_2	179	182	PF00928	0.575
TRG_ENDOCYTIC_2	358	361	PF00928	0.444
TRG_ENDOCYTIC_2	414	417	PF00928	0.531
TRG_ENDOCYTIC_2	674	677	PF00928	0.497
TRG_NES_CRM1_1	231	242	PF08389	0.346
TRG_NES_CRM1_1	24	38	PF08389	0.596
TRG_NES_CRM1_1	404	418	PF08389	0.636
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.694
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	456	461	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCZ9	Leptomonas seymouri	56%	97%
A0A0S4JE75	Bodo saltans	24%	84%
A0A1X0P6Q4	Trypanosomatidae	33%	97%
A0A3Q8IJM4	Leishmania donovani	77%	97%
A0A3R7NYR2	Trypanosoma rangeli	34%	100%
A4HXQ4	Leishmania infantum	77%	97%
D0A034	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ARG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	97%
Q4QE14	Leishmania major	73%	100%
V5DMZ5	Trypanosoma cruzi	33%	100%