LeishMANIAdb
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KTSC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
KTSC domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H9D0_LEIBR
TriTrypDb:
LbrM.18.0280 , LBRM2903_180007800 *
Length:
88

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0020023 kinetoplast 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H9D0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9D0

PDB structure(s): 7aih_BE , 7am2_BE , 7ane_BE

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 19 21 PF00675 0.456
CLV_PCSK_KEX2_1 19 21 PF00082 0.456
DEG_Nend_Nbox_1 1 3 PF02207 0.525
DOC_MAPK_MEF2A_6 65 74 PF00069 0.436
DOC_PP1_RVXF_1 17 24 PF00149 0.454
DOC_PP4_FxxP_1 43 46 PF00568 0.517
DOC_WW_Pin1_4 77 82 PF00397 0.418
LIG_14-3-3_CanoR_1 19 24 PF00244 0.442
LIG_LIR_Apic_2 41 46 PF02991 0.502
LIG_REV1ctd_RIR_1 7 16 PF16727 0.473
LIG_SH2_STAT5 56 59 PF00017 0.499
LIG_SH2_STAT5 73 76 PF00017 0.447
MOD_CK1_1 3 9 PF00069 0.482
MOD_CK1_1 50 56 PF00069 0.559
MOD_CK2_1 82 88 PF00069 0.465
MOD_LATS_1 17 23 PF00433 0.476
MOD_N-GLC_1 77 82 PF02516 0.418
MOD_NEK2_1 38 43 PF00069 0.460
MOD_PKA_1 19 25 PF00069 0.453
MOD_PKA_2 19 25 PF00069 0.453
MOD_ProDKin_1 77 83 PF00069 0.414
TRG_ER_diArg_1 19 21 PF00400 0.456

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHE6 Leptomonas seymouri 92% 68%
A0A1X0P6R5 Trypanosomatidae 79% 79%
A0A3Q8ICZ2 Leishmania donovani 94% 75%
A0A3S5IS44 Trypanosoma rangeli 84% 80%
A4HXQ2 Leishmania infantum 94% 75%
B6DTE3 Bodo saltans 73% 92%
D0A030 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 86% 78%
E9ARG3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 75%
Q4QE16 Leishmania major 94% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS