Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9C8_LEIBR

TriTrypDb:

LbrM.18.0260 , LBRM2903_180007600

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H9C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9C8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.376
CLV_C14_Caspase3-7	162	166	PF00656	0.400
CLV_C14_Caspase3-7	245	249	PF00656	0.389
CLV_C14_Caspase3-7	265	269	PF00656	0.396
CLV_NRD_NRD_1	171	173	PF00675	0.573
CLV_NRD_NRD_1	184	186	PF00675	0.694
CLV_NRD_NRD_1	241	243	PF00675	0.670
CLV_NRD_NRD_1	306	308	PF00675	0.739
CLV_NRD_NRD_1	313	315	PF00675	0.659
CLV_NRD_NRD_1	366	368	PF00675	0.613
CLV_PCSK_KEX2_1	171	173	PF00082	0.573
CLV_PCSK_KEX2_1	184	186	PF00082	0.694
CLV_PCSK_KEX2_1	241	243	PF00082	0.632
CLV_PCSK_KEX2_1	305	307	PF00082	0.688
CLV_PCSK_KEX2_1	313	315	PF00082	0.642
CLV_PCSK_KEX2_1	366	368	PF00082	0.675
CLV_PCSK_SKI1_1	171	175	PF00082	0.639
CLV_PCSK_SKI1_1	184	188	PF00082	0.598
CLV_PCSK_SKI1_1	196	200	PF00082	0.582
CLV_PCSK_SKI1_1	281	285	PF00082	0.592
CLV_PCSK_SKI1_1	306	310	PF00082	0.601
CLV_PCSK_SKI1_1	53	57	PF00082	0.578
DEG_APCC_DBOX_1	305	313	PF00400	0.389
DEG_MDM2_SWIB_1	28	36	PF02201	0.227
DEG_Nend_Nbox_1	1	3	PF02207	0.562
DOC_CDC14_PxL_1	200	208	PF14671	0.395
DOC_MAPK_gen_1	50	58	PF00069	0.380
DOC_MAPK_MEF2A_6	228	235	PF00069	0.482
DOC_PP2B_LxvP_1	174	177	PF13499	0.435
DOC_PP4_FxxP_1	61	64	PF00568	0.378
DOC_USP7_MATH_1	110	114	PF00917	0.340
DOC_USP7_MATH_1	51	55	PF00917	0.453
LIG_14-3-3_CanoR_1	132	139	PF00244	0.397
LIG_14-3-3_CanoR_1	14	18	PF00244	0.411
LIG_14-3-3_CanoR_1	261	270	PF00244	0.385
LIG_Actin_WH2_1	196	212	PF00022	0.391
LIG_Actin_WH2_2	68	83	PF00022	0.439
LIG_BIR_III_4	165	169	PF00653	0.396
LIG_BIR_III_4	221	225	PF00653	0.402
LIG_CaM_NSCaTE_8	243	250	PF13499	0.386
LIG_FHA_1	138	144	PF00498	0.302
LIG_FHA_1	14	20	PF00498	0.469
LIG_FHA_1	215	221	PF00498	0.403
LIG_FHA_1	363	369	PF00498	0.572
LIG_FHA_2	142	148	PF00498	0.303
LIG_FHA_2	160	166	PF00498	0.456
LIG_FHA_2	243	249	PF00498	0.385
LIG_FHA_2	294	300	PF00498	0.419
LIG_LIR_Apic_2	341	346	PF02991	0.555
LIG_LIR_Apic_2	59	64	PF02991	0.378
LIG_LIR_Gen_1	123	131	PF02991	0.395
LIG_LIR_Gen_1	152	160	PF02991	0.447
LIG_LIR_Gen_1	229	239	PF02991	0.473
LIG_LIR_Gen_1	268	274	PF02991	0.407
LIG_LIR_Nem_3	112	118	PF02991	0.406
LIG_LIR_Nem_3	123	127	PF02991	0.343
LIG_LIR_Nem_3	152	158	PF02991	0.437
LIG_LIR_Nem_3	21	26	PF02991	0.349
LIG_LIR_Nem_3	229	235	PF02991	0.478
LIG_MAD2	196	204	PF02301	0.490
LIG_MYND_3	203	207	PF01753	0.393
LIG_NRBOX	194	200	PF00104	0.380
LIG_PCNA_yPIPBox_3	132	143	PF02747	0.308
LIG_Pex14_1	115	119	PF04695	0.378
LIG_Pex14_2	28	32	PF04695	0.227
LIG_SH2_CRK	343	347	PF00017	0.438
LIG_SH2_PTP2	26	29	PF00017	0.369
LIG_SH2_PTP2	331	334	PF00017	0.375
LIG_SH2_STAT5	10	13	PF00017	0.634
LIG_SH2_STAT5	118	121	PF00017	0.432
LIG_SH2_STAT5	26	29	PF00017	0.220
LIG_SH2_STAT5	331	334	PF00017	0.513
LIG_SH2_STAT5	347	350	PF00017	0.337
LIG_SH2_STAT5	397	400	PF00017	0.395
LIG_SH3_3	124	130	PF00018	0.290
LIG_SH3_3	45	51	PF00018	0.384
LIG_SUMO_SIM_anti_2	16	21	PF11976	0.227
LIG_SUMO_SIM_anti_2	387	394	PF11976	0.442
LIG_SUMO_SIM_anti_2	76	81	PF11976	0.394
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.330
LIG_SUMO_SIM_par_1	107	113	PF11976	0.472
LIG_SUMO_SIM_par_1	15	21	PF11976	0.227
LIG_SUMO_SIM_par_1	172	179	PF11976	0.429
LIG_SUMO_SIM_par_1	196	202	PF11976	0.385
LIG_SUMO_SIM_par_1	54	59	PF11976	0.374
LIG_TRAF2_1	269	272	PF00917	0.466
LIG_TRAF2_1	371	374	PF00917	0.403
LIG_TYR_ITIM	24	29	PF00017	0.292
LIG_UBA3_1	308	316	PF00899	0.391
MOD_CK1_1	262	268	PF00069	0.489
MOD_CK1_1	352	358	PF00069	0.424
MOD_CK2_1	141	147	PF00069	0.297
MOD_CK2_1	164	170	PF00069	0.392
MOD_CK2_1	368	374	PF00069	0.445
MOD_CK2_1	97	103	PF00069	0.523
MOD_GlcNHglycan	127	130	PF01048	0.592
MOD_GlcNHglycan	2	5	PF01048	0.366
MOD_GlcNHglycan	221	225	PF01048	0.632
MOD_GlcNHglycan	261	264	PF01048	0.704
MOD_GlcNHglycan	290	293	PF01048	0.717
MOD_GlcNHglycan	57	61	PF01048	0.664
MOD_GlcNHglycan	66	69	PF01048	0.641
MOD_GSK3_1	137	144	PF00069	0.368
MOD_GSK3_1	145	152	PF00069	0.464
MOD_GSK3_1	175	182	PF00069	0.429
MOD_GSK3_1	233	240	PF00069	0.553
MOD_GSK3_1	259	266	PF00069	0.413
MOD_GSK3_1	349	356	PF00069	0.436
MOD_GSK3_1	62	69	PF00069	0.541
MOD_N-GLC_1	237	242	PF02516	0.626
MOD_NEK2_1	109	114	PF00069	0.302
MOD_NEK2_1	199	204	PF00069	0.392
MOD_NEK2_1	273	278	PF00069	0.450
MOD_NEK2_1	339	344	PF00069	0.461
MOD_NEK2_1	56	61	PF00069	0.489
MOD_NEK2_1	66	71	PF00069	0.447
MOD_NEK2_1	80	85	PF00069	0.342
MOD_PIKK_1	97	103	PF00454	0.326
MOD_PK_1	145	151	PF00069	0.316
MOD_PKA_1	241	247	PF00069	0.468
MOD_PKA_2	13	19	PF00069	0.469
MOD_PKA_2	131	137	PF00069	0.405
MOD_PKA_2	209	215	PF00069	0.407
MOD_PKA_2	241	247	PF00069	0.414
MOD_PKA_2	80	86	PF00069	0.404
MOD_Plk_1	122	128	PF00069	0.359
MOD_Plk_1	56	62	PF00069	0.379
MOD_Plk_2-3	369	375	PF00069	0.392
MOD_Plk_4	145	151	PF00069	0.417
MOD_Plk_4	66	72	PF00069	0.462
TRG_DiLeu_BaEn_1	170	175	PF01217	0.340
TRG_DiLeu_BaEn_1	373	378	PF01217	0.477
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.351
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.470
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.358
TRG_ENDOCYTIC_2	118	121	PF00928	0.432
TRG_ENDOCYTIC_2	26	29	PF00928	0.369
TRG_ENDOCYTIC_2	331	334	PF00928	0.382
TRG_ENDOCYTIC_2	347	350	PF00928	0.421
TRG_ER_diArg_1	171	173	PF00400	0.348
TRG_ER_diArg_1	241	243	PF00400	0.399
TRG_ER_diArg_1	304	307	PF00400	0.489
TRG_ER_diArg_1	312	314	PF00400	0.431
TRG_ER_diArg_1	366	368	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.702
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.785
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P351	Leptomonas seymouri	28%	100%
A0A3S7WUS7	Leishmania donovani	64%	100%
A4HXQ0	Leishmania infantum	65%	100%
E9ARG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QE18	Leishmania major	62%	99%