Aha1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Activator of Hsp90 ATPase, N-terminal/Activator of Hsp90 ATPase homolog 1-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9C6_LEIBR

TriTrypDb:

LbrM.18.0230 , LBRM2903_180007300

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9C6

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0032781	positive regulation of ATP-dependent activity	4	1
GO:0043462	regulation of ATP-dependent activity	3	1
GO:0044093	positive regulation of molecular function	3	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1

Molecular functions
Term	Name	Level	Count
GO:0001671	ATPase activator activity	3	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0031072	heat shock protein binding	3	12
GO:0051087	protein-folding chaperone binding	3	12
GO:0051879	Hsp90 protein binding	4	12
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.592
CLV_NRD_NRD_1	78	80	PF00675	0.302
CLV_PCSK_SKI1_1	171	175	PF00082	0.544
CLV_PCSK_SKI1_1	203	207	PF00082	0.562
CLV_PCSK_SKI1_1	341	345	PF00082	0.302
CLV_PCSK_SKI1_1	41	45	PF00082	0.328
DEG_SCF_FBW7_1	205	210	PF00400	0.571
DOC_PP1_RVXF_1	339	345	PF00149	0.606
DOC_PP2B_LxvP_1	179	182	PF13499	0.600
DOC_USP7_MATH_1	147	151	PF00917	0.570
DOC_USP7_MATH_1	188	192	PF00917	0.767
DOC_USP7_MATH_1	207	211	PF00917	0.635
DOC_WW_Pin1_4	203	208	PF00397	0.663
DOC_WW_Pin1_4	247	252	PF00397	0.588
LIG_14-3-3_CanoR_1	149	153	PF00244	0.588
LIG_14-3-3_CanoR_1	243	247	PF00244	0.501
LIG_14-3-3_CanoR_1	249	255	PF00244	0.525
LIG_14-3-3_CanoR_1	287	292	PF00244	0.422
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_deltaCOP1_diTrp_1	330	337	PF00928	0.502
LIG_EVH1_1	179	183	PF00568	0.646
LIG_FHA_2	127	133	PF00498	0.517
LIG_FHA_2	156	162	PF00498	0.538
LIG_FHA_2	309	315	PF00498	0.532
LIG_FHA_2	55	61	PF00498	0.489
LIG_LIR_Gen_1	158	167	PF02991	0.500
LIG_LIR_Gen_1	233	241	PF02991	0.496
LIG_LIR_Gen_1	270	281	PF02991	0.512
LIG_LIR_Gen_1	58	67	PF02991	0.591
LIG_LIR_Nem_3	158	163	PF02991	0.508
LIG_LIR_Nem_3	270	276	PF02991	0.512
LIG_LIR_Nem_3	58	64	PF02991	0.591
LIG_PDZ_Class_3	346	351	PF00595	0.303
LIG_Pex14_1	332	336	PF04695	0.502
LIG_Pex14_2	160	164	PF04695	0.502
LIG_PROFILIN_1	180	186	PF00235	0.487
LIG_SH2_PTP2	273	276	PF00017	0.563
LIG_SH2_SRC	124	127	PF00017	0.563
LIG_SH2_SRC	273	276	PF00017	0.563
LIG_SH2_STAP1	124	128	PF00017	0.513
LIG_SH2_STAP1	346	350	PF00017	0.424
LIG_SH2_STAT5	247	250	PF00017	0.502
LIG_SH2_STAT5	273	276	PF00017	0.541
LIG_SH2_STAT5	61	64	PF00017	0.579
LIG_SH2_STAT5	86	89	PF00017	0.502
LIG_SH3_3	177	183	PF00018	0.627
LIG_TRAF2_1	129	132	PF00917	0.523
LIG_TRAF2_1	327	330	PF00917	0.563
LIG_TYR_ITIM	59	64	PF00017	0.588
LIG_WRC_WIRS_1	156	161	PF05994	0.538
LIG_WRC_WIRS_1	261	266	PF05994	0.427
MOD_CDK_SPxK_1	203	209	PF00069	0.567
MOD_CK1_1	14	20	PF00069	0.706
MOD_CK1_1	189	195	PF00069	0.765
MOD_CK1_1	208	214	PF00069	0.584
MOD_CK1_1	242	248	PF00069	0.523
MOD_CK1_1	250	256	PF00069	0.500
MOD_CK1_1	33	39	PF00069	0.588
MOD_CK1_1	68	74	PF00069	0.507
MOD_CK2_1	126	132	PF00069	0.445
MOD_CK2_1	211	217	PF00069	0.763
MOD_CK2_1	308	314	PF00069	0.518
MOD_CK2_1	324	330	PF00069	0.513
MOD_CK2_1	54	60	PF00069	0.520
MOD_Cter_Amidation	200	203	PF01082	0.669
MOD_GlcNHglycan	134	137	PF01048	0.310
MOD_GlcNHglycan	174	177	PF01048	0.700
MOD_GlcNHglycan	186	189	PF01048	0.701
MOD_GlcNHglycan	211	214	PF01048	0.623
MOD_GlcNHglycan	269	272	PF01048	0.350
MOD_GlcNHglycan	317	320	PF01048	0.376
MOD_GlcNHglycan	69	73	PF01048	0.302
MOD_GlcNHglycan	99	102	PF01048	0.255
MOD_GSK3_1	184	191	PF00069	0.740
MOD_GSK3_1	201	208	PF00069	0.485
MOD_GSK3_1	309	316	PF00069	0.603
MOD_GSK3_1	68	75	PF00069	0.506
MOD_LATS_1	37	43	PF00433	0.599
MOD_N-GLC_1	132	137	PF02516	0.381
MOD_N-GLC_1	217	222	PF02516	0.573
MOD_NEK2_1	139	144	PF00069	0.466
MOD_NEK2_1	186	191	PF00069	0.543
MOD_NEK2_1	313	318	PF00069	0.591
MOD_NEK2_1	89	94	PF00069	0.516
MOD_NEK2_2	148	153	PF00069	0.588
MOD_NEK2_2	155	160	PF00069	0.588
MOD_PIKK_1	30	36	PF00454	0.588
MOD_PIKK_1	313	319	PF00454	0.607
MOD_PK_1	39	45	PF00069	0.607
MOD_PKA_2	148	154	PF00069	0.585
MOD_PKA_2	242	248	PF00069	0.433
MOD_PKA_2	286	292	PF00069	0.523
MOD_Plk_1	216	222	PF00069	0.564
MOD_Plk_1	72	78	PF00069	0.494
MOD_Plk_4	139	145	PF00069	0.588
MOD_Plk_4	155	161	PF00069	0.588
MOD_Plk_4	242	248	PF00069	0.519
MOD_Plk_4	277	283	PF00069	0.554
MOD_Plk_4	295	301	PF00069	0.405
MOD_Plk_4	39	45	PF00069	0.597
MOD_ProDKin_1	203	209	PF00069	0.667
MOD_ProDKin_1	247	253	PF00069	0.588
MOD_SUMO_for_1	120	123	PF00179	0.427
MOD_SUMO_for_1	304	307	PF00179	0.529
MOD_SUMO_for_1	62	65	PF00179	0.588
MOD_SUMO_rev_2	250	258	PF00179	0.588
TRG_ENDOCYTIC_2	235	238	PF00928	0.577
TRG_ENDOCYTIC_2	273	276	PF00928	0.563
TRG_ENDOCYTIC_2	61	64	PF00928	0.588
TRG_ENDOCYTIC_2	86	89	PF00928	0.502
TRG_NES_CRM1_1	54	66	PF08389	0.567
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A4	Leptomonas seymouri	71%	99%
A0A0S4JAT2	Bodo saltans	46%	100%
A0A1X0P6W4	Trypanosomatidae	56%	100%
A0A3R7MY48	Trypanosoma rangeli	51%	100%
A0A3S7WUS5	Leishmania donovani	84%	100%
A4HXP7	Leishmania infantum	84%	100%
A6QQC0	Bos taurus	27%	100%
D0A023	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ARF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O95433	Homo sapiens	31%	100%
Q12449	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4QE21	Leishmania major	84%	100%
Q8BK64	Mus musculus	30%	100%
Q8N9S3	Mus musculus	29%	100%
Q9P782	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
V5B6E4	Trypanosoma cruzi	55%	100%