UDP-galactopyranose mutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-galactopyranose mutase

Species:

Leishmania braziliensis

UniProt:

A4H9C5_LEIBR

TriTrypDb:

LbrM.18.0220 , LBRM2903_180007200

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9C5

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006778	porphyrin-containing compound metabolic process	5	1
GO:0006779	porphyrin-containing compound biosynthetic process	6	1
GO:0006783	heme biosynthetic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0033013	tetrapyrrole metabolic process	4	1
GO:0033014	tetrapyrrole biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042168	heme metabolic process	3	1
GO:0042440	pigment metabolic process	2	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046148	pigment biosynthetic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008767	UDP-galactopyranose mutase activity	4	7
GO:0016491	oxidoreductase activity	2	11
GO:0016853	isomerase activity	2	7
GO:0016866	intramolecular transferase activity	3	7
GO:0004729	oxygen-dependent protoporphyrinogen oxidase activity	5	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	1
GO:0070818	protoporphyrinogen oxidase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.227
CLV_C14_Caspase3-7	378	382	PF00656	0.282
CLV_PCSK_KEX2_1	5	7	PF00082	0.288
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.288
CLV_PCSK_SKI1_1	236	240	PF00082	0.360
CLV_PCSK_SKI1_1	245	249	PF00082	0.364
CLV_PCSK_SKI1_1	384	388	PF00082	0.487
DEG_APCC_KENBOX_2	186	190	PF00400	0.266
DEG_SPOP_SBC_1	302	306	PF00917	0.414
DOC_ANK_TNKS_1	142	149	PF00023	0.378
DOC_ANK_TNKS_1	5	12	PF00023	0.269
DOC_CKS1_1	470	475	PF01111	0.352
DOC_MAPK_FxFP_2	205	208	PF00069	0.335
DOC_MAPK_gen_1	185	192	PF00069	0.447
DOC_MAPK_gen_1	404	411	PF00069	0.496
DOC_MAPK_MEF2A_6	160	168	PF00069	0.408
DOC_PP1_RVXF_1	25	32	PF00149	0.227
DOC_PP2B_LxvP_1	289	292	PF13499	0.450
DOC_PP4_FxxP_1	153	156	PF00568	0.335
DOC_PP4_FxxP_1	205	208	PF00568	0.335
DOC_USP7_MATH_1	284	288	PF00917	0.545
DOC_USP7_MATH_1	99	103	PF00917	0.447
DOC_WW_Pin1_4	469	474	PF00397	0.337
DOC_WW_Pin1_4	487	492	PF00397	0.363
LIG_14-3-3_CanoR_1	126	134	PF00244	0.404
LIG_14-3-3_CanoR_1	177	182	PF00244	0.246
LIG_14-3-3_CanoR_1	384	389	PF00244	0.515
LIG_14-3-3_CanoR_1	484	488	PF00244	0.551
LIG_Actin_WH2_2	368	386	PF00022	0.539
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BRCT_BRCA1_1	141	145	PF00533	0.438
LIG_CSL_BTD_1	94	97	PF09270	0.408
LIG_deltaCOP1_diTrp_1	195	205	PF00928	0.335
LIG_deltaCOP1_diTrp_1	86	95	PF00928	0.359
LIG_FHA_1	211	217	PF00498	0.354
LIG_FHA_1	242	248	PF00498	0.447
LIG_FHA_1	261	267	PF00498	0.447
LIG_FHA_1	304	310	PF00498	0.359
LIG_FHA_1	383	389	PF00498	0.546
LIG_FHA_1	426	432	PF00498	0.405
LIG_FHA_1	463	469	PF00498	0.334
LIG_FHA_1	484	490	PF00498	0.520
LIG_FHA_2	134	140	PF00498	0.439
LIG_FHA_2	273	279	PF00498	0.403
LIG_IRF3_LxIS_1	72	78	PF10401	0.480
LIG_LIR_Apic_2	151	156	PF02991	0.326
LIG_LIR_Apic_2	204	208	PF02991	0.335
LIG_LIR_Gen_1	256	265	PF02991	0.341
LIG_LIR_Gen_1	323	334	PF02991	0.385
LIG_LIR_Gen_1	352	361	PF02991	0.423
LIG_LIR_Gen_1	397	407	PF02991	0.517
LIG_LIR_Gen_1	64	73	PF02991	0.335
LIG_LIR_Gen_1	78	86	PF02991	0.335
LIG_LIR_Nem_3	136	140	PF02991	0.227
LIG_LIR_Nem_3	218	224	PF02991	0.311
LIG_LIR_Nem_3	256	260	PF02991	0.341
LIG_LIR_Nem_3	323	329	PF02991	0.369
LIG_LIR_Nem_3	340	345	PF02991	0.370
LIG_LIR_Nem_3	427	432	PF02991	0.502
LIG_LIR_Nem_3	64	69	PF02991	0.335
LIG_LIR_Nem_3	78	83	PF02991	0.335
LIG_MAD2	6	14	PF02301	0.390
LIG_SH2_CRK	257	261	PF00017	0.355
LIG_SH2_CRK	367	371	PF00017	0.428
LIG_SH2_NCK_1	442	446	PF00017	0.463
LIG_SH2_SRC	345	348	PF00017	0.283
LIG_SH2_STAP1	217	221	PF00017	0.349
LIG_SH2_STAP1	257	261	PF00017	0.335
LIG_SH2_STAP1	34	38	PF00017	0.349
LIG_SH2_STAT3	98	101	PF00017	0.335
LIG_SH2_STAT5	140	143	PF00017	0.426
LIG_SH2_STAT5	328	331	PF00017	0.367
LIG_SH2_STAT5	68	71	PF00017	0.335
LIG_SH3_3	467	473	PF00018	0.448
LIG_SH3_3	91	97	PF00018	0.319
LIG_SUMO_SIM_par_1	164	170	PF11976	0.330
LIG_SUMO_SIM_par_1	356	362	PF11976	0.374
LIG_SUMO_SIM_par_1	485	490	PF11976	0.381
LIG_TRAF2_1	129	132	PF00917	0.429
LIG_TYR_ITIM	255	260	PF00017	0.335
LIG_UBA3_1	23	27	PF00899	0.441
LIG_UBA3_1	308	314	PF00899	0.518
MOD_CDK_SPxK_1	469	475	PF00069	0.343
MOD_CK1_1	256	262	PF00069	0.227
MOD_CK2_1	133	139	PF00069	0.346
MOD_CK2_1	272	278	PF00069	0.378
MOD_GlcNHglycan	1	4	PF01048	0.653
MOD_GlcNHglycan	169	172	PF01048	0.227
MOD_GlcNHglycan	284	287	PF01048	0.577
MOD_GlcNHglycan	318	321	PF01048	0.524
MOD_GlcNHglycan	35	39	PF01048	0.289
MOD_GSK3_1	241	248	PF00069	0.471
MOD_GSK3_1	256	263	PF00069	0.384
MOD_GSK3_1	316	323	PF00069	0.430
MOD_GSK3_1	462	469	PF00069	0.477
MOD_GSK3_1	483	490	PF00069	0.563
MOD_GSK3_1	75	82	PF00069	0.480
MOD_N-GLC_1	201	206	PF02516	0.344
MOD_NEK2_1	260	265	PF00069	0.348
MOD_NEK2_1	301	306	PF00069	0.370
MOD_NEK2_1	359	364	PF00069	0.521
MOD_NEK2_1	425	430	PF00069	0.369
MOD_NEK2_1	43	48	PF00069	0.351
MOD_NEK2_2	201	206	PF00069	0.335
MOD_NEK2_2	337	342	PF00069	0.357
MOD_PIKK_1	359	365	PF00454	0.492
MOD_PK_1	177	183	PF00069	0.349
MOD_PKA_2	337	343	PF00069	0.359
MOD_PKA_2	425	431	PF00069	0.360
MOD_PKA_2	483	489	PF00069	0.564
MOD_PKA_2	84	90	PF00069	0.335
MOD_Plk_1	201	207	PF00069	0.335
MOD_Plk_1	34	40	PF00069	0.227
MOD_Plk_1	447	453	PF00069	0.367
MOD_Plk_1	466	472	PF00069	0.440
MOD_Plk_2-3	253	259	PF00069	0.378
MOD_Plk_4	256	262	PF00069	0.227
MOD_Plk_4	284	290	PF00069	0.455
MOD_Plk_4	337	343	PF00069	0.359
MOD_Plk_4	371	377	PF00069	0.432
MOD_Plk_4	384	390	PF00069	0.384
MOD_Plk_4	447	453	PF00069	0.366
MOD_Plk_4	483	489	PF00069	0.491
MOD_Plk_4	84	90	PF00069	0.335
MOD_ProDKin_1	469	475	PF00069	0.343
TRG_ENDOCYTIC_2	217	220	PF00928	0.355
TRG_ENDOCYTIC_2	257	260	PF00928	0.335
TRG_ENDOCYTIC_2	367	370	PF00928	0.414
TRG_ENDOCYTIC_2	66	69	PF00928	0.335
TRG_ER_diArg_1	292	295	PF00400	0.549
TRG_ER_diArg_1	434	437	PF00400	0.376
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0X8	Leptomonas seymouri	75%	100%
A0A0S4J0D0	Bodo saltans	53%	100%
A0A1X0P6P6	Trypanosomatidae	56%	100%
A0A3S5H724	Leishmania donovani	87%	100%
A0A422NWN4	Trypanosoma rangeli	59%	100%
A4HXP6	Leishmania infantum	87%	100%
E9ARF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q5EEK0	Leishmania major	86%	100%
V5BLY6	Trypanosoma cruzi	57%	100%