RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4H9C4_LEIBR

TriTrypDb:

LbrM.18.0210 , LBRM2903_180007100

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H9C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9C4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.479
CLV_C14_Caspase3-7	290	294	PF00656	0.584
CLV_NRD_NRD_1	162	164	PF00675	0.258
CLV_PCSK_KEX2_1	162	164	PF00082	0.275
CLV_PCSK_SKI1_1	118	122	PF00082	0.377
CLV_PCSK_SKI1_1	163	167	PF00082	0.275
CLV_PCSK_SKI1_1	254	258	PF00082	0.440
CLV_PCSK_SKI1_1	41	45	PF00082	0.312
CLV_PCSK_SKI1_1	57	61	PF00082	0.312
CLV_Separin_Metazoa	135	139	PF03568	0.392
DEG_SCF_FBW7_1	262	267	PF00400	0.582
DEG_SCF_FBW7_1	314	320	PF00400	0.446
DOC_CKS1_1	314	319	PF01111	0.481
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.464
DOC_MAPK_gen_1	113	121	PF00069	0.406
DOC_MAPK_gen_1	162	169	PF00069	0.475
DOC_MAPK_MEF2A_6	23	30	PF00069	0.316
DOC_MAPK_MEF2A_6	304	311	PF00069	0.577
DOC_PP1_RVXF_1	160	167	PF00149	0.470
DOC_PP1_RVXF_1	39	45	PF00149	0.454
DOC_PP4_FxxP_1	43	46	PF00568	0.468
DOC_USP7_MATH_1	19	23	PF00917	0.502
DOC_USP7_MATH_1	206	210	PF00917	0.754
DOC_USP7_MATH_1	264	268	PF00917	0.589
DOC_USP7_MATH_1	287	291	PF00917	0.620
DOC_USP7_UBL2_3	89	93	PF12436	0.396
DOC_WW_Pin1_4	104	109	PF00397	0.517
DOC_WW_Pin1_4	156	161	PF00397	0.378
DOC_WW_Pin1_4	258	263	PF00397	0.569
DOC_WW_Pin1_4	278	283	PF00397	0.725
DOC_WW_Pin1_4	303	308	PF00397	0.652
DOC_WW_Pin1_4	313	318	PF00397	0.536
LIG_14-3-3_CanoR_1	228	234	PF00244	0.467
LIG_14-3-3_CterR_2	338	342	PF00244	0.605
LIG_APCC_ABBA_1	166	171	PF00400	0.468
LIG_APCC_ABBA_1	40	45	PF00400	0.466
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_BRCT_BRCA1_1	63	67	PF00533	0.472
LIG_FHA_1	314	320	PF00498	0.671
LIG_FHA_1	77	83	PF00498	0.498
LIG_FHA_2	127	133	PF00498	0.445
LIG_FHA_2	140	146	PF00498	0.435
LIG_FHA_2	16	22	PF00498	0.503
LIG_FHA_2	32	38	PF00498	0.374
LIG_IBAR_NPY_1	328	330	PF08397	0.630
LIG_LIR_Gen_1	245	256	PF02991	0.533
LIG_LIR_Nem_3	245	251	PF02991	0.558
LIG_LIR_Nem_3	277	283	PF02991	0.512
LIG_LIR_Nem_3	37	43	PF02991	0.503
LIG_LIR_Nem_3	45	50	PF02991	0.502
LIG_LIR_Nem_3	64	70	PF02991	0.426
LIG_Pex14_2	40	44	PF04695	0.482
LIG_REV1ctd_RIR_1	231	240	PF16727	0.443
LIG_SH2_CRK	140	144	PF00017	0.512
LIG_SH2_STAP1	330	334	PF00017	0.699
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.472
LIG_TRAF2_1	109	112	PF00917	0.657
LIG_UBA3_1	196	205	PF00899	0.453
MOD_CDC14_SPxK_1	159	162	PF00782	0.378
MOD_CDK_SPK_2	318	323	PF00069	0.444
MOD_CDK_SPxK_1	156	162	PF00069	0.378
MOD_CDK_SPxxK_3	156	163	PF00069	0.378
MOD_CDK_SPxxK_3	303	310	PF00069	0.578
MOD_CK1_1	147	153	PF00069	0.468
MOD_CK1_1	15	21	PF00069	0.559
MOD_CK1_1	211	217	PF00069	0.638
MOD_CK1_1	224	230	PF00069	0.629
MOD_CK2_1	126	132	PF00069	0.476
MOD_CK2_1	139	145	PF00069	0.451
MOD_Cter_Amidation	86	89	PF01082	0.230
MOD_GlcNHglycan	208	211	PF01048	0.542
MOD_GlcNHglycan	272	275	PF01048	0.520
MOD_GSK3_1	15	22	PF00069	0.559
MOD_GSK3_1	152	159	PF00069	0.424
MOD_GSK3_1	208	215	PF00069	0.692
MOD_GSK3_1	224	231	PF00069	0.529
MOD_GSK3_1	254	261	PF00069	0.657
MOD_GSK3_1	264	271	PF00069	0.627
MOD_GSK3_1	309	316	PF00069	0.557
MOD_GSK3_1	330	337	PF00069	0.439
MOD_N-GLC_1	212	217	PF02516	0.677
MOD_N-GLC_1	221	226	PF02516	0.540
MOD_N-GLC_2	184	186	PF02516	0.312
MOD_NEK2_1	270	275	PF00069	0.596
MOD_NEK2_1	309	314	PF00069	0.536
MOD_NEK2_1	334	339	PF00069	0.517
MOD_NEK2_2	139	144	PF00069	0.500
MOD_NEK2_2	187	192	PF00069	0.281
MOD_NEK2_2	264	269	PF00069	0.589
MOD_OFUCOSY	186	191	PF10250	0.405
MOD_PKA_2	12	18	PF00069	0.621
MOD_PKA_2	309	315	PF00069	0.700
MOD_Plk_1	144	150	PF00069	0.472
MOD_Plk_1	31	37	PF00069	0.450
MOD_Plk_4	229	235	PF00069	0.464
MOD_Plk_4	330	336	PF00069	0.688
MOD_Plk_4	50	56	PF00069	0.512
MOD_ProDKin_1	104	110	PF00069	0.515
MOD_ProDKin_1	156	162	PF00069	0.378
MOD_ProDKin_1	258	264	PF00069	0.568
MOD_ProDKin_1	278	284	PF00069	0.725
MOD_ProDKin_1	303	309	PF00069	0.652
MOD_ProDKin_1	313	319	PF00069	0.536
MOD_SUMO_rev_2	15	24	PF00179	0.507
MOD_SUMO_rev_2	201	206	PF00179	0.524
MOD_SUMO_rev_2	84	90	PF00179	0.468
TRG_DiLeu_BaEn_1	132	137	PF01217	0.468
TRG_ENDOCYTIC_2	140	143	PF00928	0.512
TRG_ER_diArg_1	11	14	PF00400	0.563
TRG_ER_diArg_1	113	116	PF00400	0.351
TRG_ER_diArg_1	162	164	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUA1	Leptomonas seymouri	50%	97%
A0A3Q8IAV4	Leishmania donovani	82%	100%
A0A3R7KE41	Trypanosoma rangeli	37%	72%
A4HXP5	Leishmania infantum	82%	100%
E9ARF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	99%
E9ARF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QE23	Leishmania major	83%	100%
Q9FPJ8	Arabidopsis thaliana	24%	88%
Q9JII5	Mus musculus	24%	84%