RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4H9C3_LEIBR

TriTrypDb:

LbrM.18.0200 , LBRM2903_180007000

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H9C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9C3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.399
CLV_NRD_NRD_1	157	159	PF00675	0.225
CLV_NRD_NRD_1	2	4	PF00675	0.475
CLV_PCSK_FUR_1	247	251	PF00082	0.508
CLV_PCSK_KEX2_1	156	158	PF00082	0.296
CLV_PCSK_KEX2_1	249	251	PF00082	0.504
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.504
CLV_PCSK_SKI1_1	113	117	PF00082	0.388
CLV_PCSK_SKI1_1	139	143	PF00082	0.332
CLV_PCSK_SKI1_1	158	162	PF00082	0.285
CLV_PCSK_SKI1_1	230	234	PF00082	0.682
CLV_PCSK_SKI1_1	3	7	PF00082	0.473
CLV_PCSK_SKI1_1	36	40	PF00082	0.362
DEG_SCF_FBW7_1	308	314	PF00400	0.430
DEG_SCF_FBW7_2	232	237	PF00400	0.522
DEG_SCF_TRCP1_1	328	334	PF00400	0.582
DOC_CKS1_1	203	208	PF01111	0.506
DOC_CKS1_1	265	270	PF01111	0.592
DOC_CKS1_1	308	313	PF01111	0.492
DOC_MAPK_gen_1	108	116	PF00069	0.434
DOC_MAPK_gen_1	156	164	PF00069	0.496
DOC_MAPK_gen_1	202	211	PF00069	0.476
DOC_MAPK_gen_1	75	85	PF00069	0.585
DOC_MAPK_MEF2A_6	156	164	PF00069	0.497
DOC_MAPK_MEF2A_6	235	244	PF00069	0.527
DOC_MAPK_MEF2A_6	327	335	PF00069	0.526
DOC_PP1_RVXF_1	155	162	PF00149	0.493
DOC_USP7_MATH_1	274	278	PF00917	0.748
DOC_USP7_MATH_1	326	330	PF00917	0.581
DOC_USP7_MATH_1	341	345	PF00917	0.593
DOC_WW_Pin1_4	12	17	PF00397	0.478
DOC_WW_Pin1_4	202	207	PF00397	0.579
DOC_WW_Pin1_4	223	228	PF00397	0.573
DOC_WW_Pin1_4	230	235	PF00397	0.571
DOC_WW_Pin1_4	264	269	PF00397	0.612
DOC_WW_Pin1_4	307	312	PF00397	0.542
DOC_WW_Pin1_4	99	104	PF00397	0.459
LIG_14-3-3_CanoR_1	222	227	PF00244	0.550
LIG_14-3-3_CanoR_1	36	45	PF00244	0.467
LIG_Actin_WH2_2	23	38	PF00022	0.497
LIG_APCC_ABBA_1	141	146	PF00400	0.493
LIG_APCC_ABBAyCdc20_2	140	146	PF00400	0.497
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BIR_III_4	79	83	PF00653	0.497
LIG_BRCT_BRCA1_1	10	14	PF00533	0.534
LIG_FHA_1	198	204	PF00498	0.597
LIG_FHA_1	259	265	PF00498	0.624
LIG_FHA_1	283	289	PF00498	0.652
LIG_FHA_1	330	336	PF00498	0.582
LIG_FHA_1	60	66	PF00498	0.493
LIG_FHA_1	87	93	PF00498	0.586
LIG_FHA_2	122	128	PF00498	0.417
LIG_FHA_2	161	167	PF00498	0.581
LIG_FHA_2	312	318	PF00498	0.448
LIG_LIR_Nem_3	134	138	PF02991	0.523
LIG_LIR_Nem_3	19	25	PF02991	0.354
LIG_LIR_Nem_3	214	220	PF02991	0.500
LIG_LIR_Nem_3	313	318	PF02991	0.573
LIG_LIR_Nem_3	40	45	PF02991	0.502
LIG_LIR_Nem_3	62	67	PF02991	0.485
LIG_SH2_CRK	135	139	PF00017	0.562
LIG_SH2_GRB2like	199	202	PF00017	0.443
LIG_SH2_STAP1	199	203	PF00017	0.523
LIG_SH2_STAP1	228	232	PF00017	0.530
LIG_SH2_STAT3	55	58	PF00017	0.497
LIG_SH2_STAT5	199	202	PF00017	0.601
LIG_SH2_STAT5	25	28	PF00017	0.517
LIG_SH2_STAT5	256	259	PF00017	0.514
LIG_SH3_3	200	206	PF00018	0.468
LIG_SH3_3	305	311	PF00018	0.530
LIG_SUMO_SIM_anti_2	124	134	PF11976	0.399
LIG_SUMO_SIM_par_1	119	127	PF11976	0.493
LIG_TRAF2_1	104	107	PF00917	0.506
LIG_WRC_WIRS_1	161	166	PF05994	0.497
MOD_CDK_SPK_2	230	235	PF00069	0.528
MOD_CDK_SPK_2	264	269	PF00069	0.581
MOD_CDK_SPxxK_3	223	230	PF00069	0.511
MOD_CK1_1	134	140	PF00069	0.399
MOD_CK1_1	223	229	PF00069	0.598
MOD_CK1_1	236	242	PF00069	0.582
MOD_CK1_1	270	276	PF00069	0.631
MOD_CK1_1	329	335	PF00069	0.660
MOD_CK1_1	56	62	PF00069	0.492
MOD_CK2_1	160	166	PF00069	0.497
MOD_DYRK1A_RPxSP_1	202	206	PF00069	0.476
MOD_GlcNHglycan	272	275	PF01048	0.524
MOD_GlcNHglycan	328	331	PF01048	0.587
MOD_GlcNHglycan	339	342	PF01048	0.589
MOD_GlcNHglycan	39	42	PF01048	0.338
MOD_GlcNHglycan	55	58	PF01048	0.301
MOD_GSK3_1	193	200	PF00069	0.484
MOD_GSK3_1	222	229	PF00069	0.591
MOD_GSK3_1	270	277	PF00069	0.615
MOD_GSK3_1	307	314	PF00069	0.623
MOD_GSK3_1	337	344	PF00069	0.538
MOD_GSK3_1	8	15	PF00069	0.563
MOD_N-GLC_1	144	149	PF02516	0.297
MOD_N-GLC_1	292	297	PF02516	0.451
MOD_N-GLC_1	43	48	PF02516	0.311
MOD_N-GLC_2	179	181	PF02516	0.297
MOD_NEK2_1	131	136	PF00069	0.484
MOD_NEK2_1	294	299	PF00069	0.624
MOD_NEK2_1	86	91	PF00069	0.497
MOD_NEK2_2	320	325	PF00069	0.426
MOD_PIKK_1	294	300	PF00454	0.549
MOD_PIKK_1	341	347	PF00454	0.522
MOD_PK_1	88	94	PF00069	0.556
MOD_PKA_1	139	145	PF00069	0.497
MOD_PKA_2	326	332	PF00069	0.611
MOD_PKA_2	337	343	PF00069	0.618
MOD_Plk_1	236	242	PF00069	0.563
MOD_Plk_4	45	51	PF00069	0.497
MOD_ProDKin_1	12	18	PF00069	0.472
MOD_ProDKin_1	202	208	PF00069	0.578
MOD_ProDKin_1	223	229	PF00069	0.573
MOD_ProDKin_1	230	236	PF00069	0.568
MOD_ProDKin_1	264	270	PF00069	0.611
MOD_ProDKin_1	307	313	PF00069	0.543
MOD_ProDKin_1	99	105	PF00069	0.457
MOD_SUMO_for_1	248	251	PF00179	0.504
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.497
TRG_ENDOCYTIC_2	135	138	PF00928	0.571
TRG_ER_diArg_1	108	111	PF00400	0.360
TRG_ER_diArg_1	156	158	PF00400	0.496
TRG_ER_diArg_1	335	338	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II02	Leishmania donovani	26%	69%
A0A3S7WUT6	Leishmania donovani	69%	100%
A4HXP4	Leishmania infantum	69%	100%
A4I5P8	Leishmania infantum	25%	69%
E9ARF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QE24	Leishmania major	68%	100%
Q9C652	Arabidopsis thaliana	25%	96%
Q9SAB3	Arabidopsis thaliana	23%	86%
V5BLA5	Trypanosoma cruzi	25%	89%