RNA recognition motif family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4H9C2_LEIBR

TriTrypDb:

LbrM.18.0190 , LBRM2903_180006900

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H9C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9C2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.398
CLV_NRD_NRD_1	164	166	PF00675	0.298
CLV_PCSK_KEX2_1	163	165	PF00082	0.323
CLV_PCSK_KEX2_1	210	212	PF00082	0.625
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.580
CLV_PCSK_SKI1_1	120	124	PF00082	0.479
CLV_PCSK_SKI1_1	146	150	PF00082	0.330
CLV_PCSK_SKI1_1	165	169	PF00082	0.419
CLV_PCSK_SKI1_1	43	47	PF00082	0.362
DEG_Nend_UBRbox_3	1	3	PF02207	0.591
DEG_SCF_FBW7_1	279	286	PF00400	0.633
DEG_SPOP_SBC_1	321	325	PF00917	0.620
DOC_CDC14_PxL_1	265	273	PF14671	0.592
DOC_CKS1_1	20	25	PF01111	0.534
DOC_MAPK_DCC_7	240	248	PF00069	0.488
DOC_MAPK_gen_1	115	123	PF00069	0.467
DOC_MAPK_gen_1	163	171	PF00069	0.527
DOC_MAPK_gen_1	82	92	PF00069	0.502
DOC_MAPK_MEF2A_6	163	171	PF00069	0.527
DOC_PP1_RVXF_1	162	169	PF00149	0.523
DOC_PP2B_LxvP_1	246	249	PF13499	0.478
DOC_PP4_FxxP_1	20	23	PF00568	0.565
DOC_USP7_MATH_1	206	210	PF00917	0.585
DOC_USP7_MATH_1	233	237	PF00917	0.657
DOC_USP7_MATH_1	283	287	PF00917	0.708
DOC_USP7_MATH_1	321	325	PF00917	0.715
DOC_WW_Pin1_4	106	111	PF00397	0.550
DOC_WW_Pin1_4	19	24	PF00397	0.423
DOC_WW_Pin1_4	227	232	PF00397	0.689
DOC_WW_Pin1_4	279	284	PF00397	0.667
LIG_14-3-3_CanoR_1	301	307	PF00244	0.524
LIG_14-3-3_CanoR_1	322	331	PF00244	0.616
LIG_14-3-3_CanoR_1	43	52	PF00244	0.409
LIG_Actin_WH2_2	30	45	PF00022	0.527
LIG_APCC_ABBA_1	148	153	PF00400	0.484
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.527
LIG_BIR_III_4	86	90	PF00653	0.502
LIG_BRCT_BRCA1_1	329	333	PF00533	0.638
LIG_FHA_1	67	73	PF00498	0.488
LIG_FHA_1	94	100	PF00498	0.580
LIG_FHA_2	129	135	PF00498	0.540
LIG_FHA_2	168	174	PF00498	0.527
LIG_FHA_2	256	262	PF00498	0.479
LIG_IBAR_NPY_1	336	338	PF08397	0.562
LIG_LIR_Gen_1	300	311	PF02991	0.490
LIG_LIR_Nem_3	141	145	PF02991	0.528
LIG_LIR_Nem_3	26	32	PF02991	0.409
LIG_LIR_Nem_3	300	306	PF02991	0.495
LIG_LIR_Nem_3	47	52	PF02991	0.556
LIG_LIR_Nem_3	69	74	PF02991	0.519
LIG_PDZ_Class_2	342	347	PF00595	0.492
LIG_SH2_CRK	142	146	PF00017	0.562
LIG_SH2_CRK	303	307	PF00017	0.495
LIG_SH2_CRK	338	342	PF00017	0.543
LIG_SH2_NCK_1	303	307	PF00017	0.495
LIG_SH2_STAP1	329	333	PF00017	0.681
LIG_SH2_STAT3	62	65	PF00017	0.502
LIG_SH2_STAT5	21	24	PF00017	0.524
LIG_SH2_STAT5	32	35	PF00017	0.527
LIG_SH3_3	239	245	PF00018	0.702
LIG_SUMO_SIM_anti_2	131	141	PF11976	0.536
LIG_SUMO_SIM_par_1	126	134	PF11976	0.512
LIG_SUMO_SIM_par_1	244	250	PF11976	0.474
LIG_SUMO_SIM_par_1	5	11	PF11976	0.455
LIG_TRAF2_1	111	114	PF00917	0.670
LIG_WRC_WIRS_1	168	173	PF05994	0.527
LIG_WRC_WIRS_1	260	265	PF05994	0.675
MOD_CDK_SPK_2	227	232	PF00069	0.510
MOD_CDK_SPxK_1	279	285	PF00069	0.634
MOD_CK1_1	141	147	PF00069	0.512
MOD_CK1_1	216	222	PF00069	0.689
MOD_CK1_1	235	241	PF00069	0.687
MOD_CK1_1	259	265	PF00069	0.573
MOD_CK1_1	275	281	PF00069	0.666
MOD_CK1_1	316	322	PF00069	0.546
MOD_CK1_1	63	69	PF00069	0.506
MOD_CK2_1	167	173	PF00069	0.527
MOD_CK2_1	255	261	PF00069	0.540
MOD_CK2_1	270	276	PF00069	0.733
MOD_GlcNHglycan	10	13	PF01048	0.457
MOD_GlcNHglycan	218	221	PF01048	0.735
MOD_GlcNHglycan	46	49	PF01048	0.419
MOD_GlcNHglycan	62	65	PF01048	0.247
MOD_GSK3_1	19	26	PF00069	0.559
MOD_GSK3_1	221	228	PF00069	0.669
MOD_GSK3_1	232	239	PF00069	0.608
MOD_GSK3_1	255	262	PF00069	0.586
MOD_GSK3_1	271	278	PF00069	0.710
MOD_GSK3_1	279	286	PF00069	0.673
MOD_GSK3_1	297	304	PF00069	0.480
MOD_GSK3_1	312	319	PF00069	0.616
MOD_LATS_1	299	305	PF00433	0.493
MOD_N-GLC_1	151	156	PF02516	0.327
MOD_N-GLC_1	316	321	PF02516	0.723
MOD_N-GLC_1	50	55	PF02516	0.224
MOD_N-GLC_2	186	188	PF02516	0.362
MOD_NEK2_1	138	143	PF00069	0.417
MOD_NEK2_1	226	231	PF00069	0.665
MOD_NEK2_1	263	268	PF00069	0.520
MOD_NEK2_1	327	332	PF00069	0.481
MOD_NEK2_1	93	98	PF00069	0.552
MOD_PIKK_1	13	19	PF00454	0.660
MOD_PIKK_1	263	269	PF00454	0.662
MOD_PIKK_1	287	293	PF00454	0.632
MOD_PK_1	213	219	PF00069	0.601
MOD_PK_1	95	101	PF00069	0.548
MOD_PKA_1	146	152	PF00069	0.527
MOD_PKA_2	236	242	PF00069	0.695
MOD_PKA_2	321	327	PF00069	0.691
MOD_PKB_1	211	219	PF00069	0.527
MOD_Plk_1	275	281	PF00069	0.743
MOD_Plk_1	316	322	PF00069	0.738
MOD_Plk_4	336	342	PF00069	0.680
MOD_Plk_4	52	58	PF00069	0.562
MOD_ProDKin_1	106	112	PF00069	0.550
MOD_ProDKin_1	19	25	PF00069	0.415
MOD_ProDKin_1	227	233	PF00069	0.688
MOD_ProDKin_1	279	285	PF00069	0.670
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.502
TRG_ENDOCYTIC_2	142	145	PF00928	0.562
TRG_ENDOCYTIC_2	303	306	PF00928	0.496
TRG_ENDOCYTIC_2	338	341	PF00928	0.535
TRG_ER_diArg_1	115	118	PF00400	0.620
TRG_ER_diArg_1	163	165	PF00400	0.563
TRG_ER_diArg_1	211	214	PF00400	0.635
TRG_NLS_MonoExtC_3	209	215	PF00514	0.462
TRG_NLS_MonoExtN_4	208	214	PF00514	0.619
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P516	Leptomonas seymouri	61%	93%
A0A3Q8IAV4	Leishmania donovani	47%	100%
A0A3Q8IAX1	Leishmania donovani	79%	100%
A4HXP3	Leishmania infantum	79%	100%
A4HXP5	Leishmania infantum	47%	100%
E9ARF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QE25	Leishmania major	78%	100%
V5B1R5	Trypanosoma cruzi	40%	84%