Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania braziliensis

UniProt:

A4H9C1_LEIBR

TriTrypDb:

LbrM.18.0180 , LBRM2903_180006700 , LBRM2903_180006800

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H9C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9C1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0009056	catabolic process	2	1
GO:0016042	lipid catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016298	lipase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0005488	binding	1	1
GO:0008901	ferredoxin hydrogenase activity	5	1
GO:0016151	nickel cation binding	6	1
GO:0016491	oxidoreductase activity	2	1
GO:0016695	oxidoreductase activity, acting on hydrogen as donor	3	1
GO:0016699	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor	4	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	554	558	PF00656	0.370
CLV_NRD_NRD_1	182	184	PF00675	0.327
CLV_NRD_NRD_1	562	564	PF00675	0.632
CLV_NRD_NRD_1	614	616	PF00675	0.459
CLV_NRD_NRD_1	93	95	PF00675	0.328
CLV_PCSK_KEX2_1	182	184	PF00082	0.269
CLV_PCSK_KEX2_1	562	564	PF00082	0.632
CLV_PCSK_KEX2_1	614	616	PF00082	0.559
CLV_PCSK_KEX2_1	93	95	PF00082	0.292
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.292
CLV_PCSK_SKI1_1	137	141	PF00082	0.474
CLV_PCSK_SKI1_1	237	241	PF00082	0.338
CLV_PCSK_SKI1_1	353	357	PF00082	0.302
CLV_PCSK_SKI1_1	443	447	PF00082	0.276
DEG_APCC_DBOX_1	236	244	PF00400	0.580
DEG_APCC_DBOX_1	470	478	PF00400	0.274
DEG_SPOP_SBC_1	691	695	PF00917	0.486
DOC_CDC14_PxL_1	505	513	PF14671	0.335
DOC_CYCLIN_RxL_1	234	241	PF00134	0.545
DOC_CYCLIN_yClb5_NLxxxL_5	294	303	PF00134	0.412
DOC_MAPK_gen_1	562	570	PF00069	0.241
DOC_MAPK_gen_1	614	622	PF00069	0.323
DOC_MAPK_gen_1	93	101	PF00069	0.482
DOC_MAPK_HePTP_8	91	103	PF00069	0.504
DOC_MAPK_MEF2A_6	141	150	PF00069	0.334
DOC_MAPK_MEF2A_6	365	374	PF00069	0.518
DOC_MAPK_MEF2A_6	615	624	PF00069	0.364
DOC_MAPK_MEF2A_6	93	101	PF00069	0.499
DOC_MAPK_RevD_3	80	95	PF00069	0.305
DOC_PP1_RVXF_1	532	539	PF00149	0.217
DOC_PP4_MxPP_1	676	679	PF00568	0.292
DOC_SPAK_OSR1_1	183	187	PF12202	0.564
DOC_SPAK_OSR1_1	283	287	PF12202	0.564
DOC_SPAK_OSR1_1	667	671	PF12202	0.364
DOC_USP7_MATH_1	169	173	PF00917	0.480
DOC_USP7_MATH_1	54	58	PF00917	0.221
DOC_USP7_MATH_1	80	84	PF00917	0.223
DOC_WW_Pin1_4	265	270	PF00397	0.601
DOC_WW_Pin1_4	396	401	PF00397	0.487
DOC_WW_Pin1_4	577	582	PF00397	0.437
DOC_WW_Pin1_4	634	639	PF00397	0.342
DOC_WW_Pin1_4	674	679	PF00397	0.406
LIG_14-3-3_CanoR_1	171	180	PF00244	0.544
LIG_14-3-3_CanoR_1	242	247	PF00244	0.548
LIG_14-3-3_CanoR_1	256	265	PF00244	0.528
LIG_14-3-3_CanoR_1	365	372	PF00244	0.512
LIG_14-3-3_CanoR_1	39	48	PF00244	0.462
LIG_14-3-3_CanoR_1	543	551	PF00244	0.344
LIG_14-3-3_CanoR_1	562	570	PF00244	0.404
LIG_Actin_WH2_2	383	399	PF00022	0.554
LIG_Actin_WH2_2	529	545	PF00022	0.385
LIG_AP2alpha_1	645	649	PF02296	0.313
LIG_APCC_ABBA_1	99	104	PF00400	0.312
LIG_BRCT_BRCA1_1	14	18	PF00533	0.481
LIG_BRCT_BRCA1_1	281	285	PF00533	0.564
LIG_BRCT_BRCA1_1	435	439	PF00533	0.362
LIG_BRCT_BRCA1_1	566	570	PF00533	0.288
LIG_Clathr_ClatBox_1	100	104	PF01394	0.312
LIG_FHA_1	103	109	PF00498	0.375
LIG_FHA_1	134	140	PF00498	0.275
LIG_FHA_1	224	230	PF00498	0.496
LIG_FHA_1	330	336	PF00498	0.389
LIG_FHA_1	364	370	PF00498	0.405
LIG_FHA_1	391	397	PF00498	0.477
LIG_FHA_1	542	548	PF00498	0.391
LIG_FHA_1	583	589	PF00498	0.377
LIG_FHA_1	605	611	PF00498	0.457
LIG_FHA_1	696	702	PF00498	0.542
LIG_FHA_1	77	83	PF00498	0.219
LIG_FHA_2	346	352	PF00498	0.523
LIG_FHA_2	393	399	PF00498	0.482
LIG_FHA_2	692	698	PF00498	0.469
LIG_GBD_Chelix_1	455	463	PF00786	0.336
LIG_KLC1_Yacidic_2	666	671	PF13176	0.392
LIG_LIR_Apic_2	577	582	PF02991	0.302
LIG_LIR_Apic_2	605	611	PF02991	0.465
LIG_LIR_Gen_1	109	117	PF02991	0.265
LIG_LIR_Gen_1	173	184	PF02991	0.452
LIG_LIR_Gen_1	198	209	PF02991	0.558
LIG_LIR_Gen_1	295	304	PF02991	0.568
LIG_LIR_Gen_1	385	394	PF02991	0.525
LIG_LIR_Gen_1	515	524	PF02991	0.345
LIG_LIR_Gen_1	627	636	PF02991	0.248
LIG_LIR_Nem_3	109	113	PF02991	0.237
LIG_LIR_Nem_3	173	179	PF02991	0.449
LIG_LIR_Nem_3	198	204	PF02991	0.543
LIG_LIR_Nem_3	288	292	PF02991	0.511
LIG_LIR_Nem_3	295	299	PF02991	0.564
LIG_LIR_Nem_3	385	390	PF02991	0.525
LIG_LIR_Nem_3	465	470	PF02991	0.256
LIG_LIR_Nem_3	515	519	PF02991	0.333
LIG_LIR_Nem_3	521	527	PF02991	0.299
LIG_LIR_Nem_3	618	624	PF02991	0.329
LIG_LIR_Nem_3	627	631	PF02991	0.337
LIG_LIR_Nem_3	647	652	PF02991	0.161
LIG_MLH1_MIPbox_1	281	285	PF16413	0.564
LIG_MYND_1	265	269	PF01753	0.452
LIG_NRBOX	430	436	PF00104	0.524
LIG_PDZ_Class_1	703	708	PF00595	0.468
LIG_Pex14_1	180	184	PF04695	0.600
LIG_Pex14_2	158	162	PF04695	0.276
LIG_Pex14_2	208	212	PF04695	0.619
LIG_Pex14_2	551	555	PF04695	0.230
LIG_Pex14_2	645	649	PF04695	0.270
LIG_Pex14_2	7	11	PF04695	0.525
LIG_PTB_Apo_2	573	580	PF02174	0.284
LIG_PTB_Phospho_1	573	579	PF10480	0.280
LIG_REV1ctd_RIR_1	647	655	PF16727	0.205
LIG_SH2_CRK	215	219	PF00017	0.523
LIG_SH2_CRK	289	293	PF00017	0.447
LIG_SH2_CRK	467	471	PF00017	0.264
LIG_SH2_CRK	479	483	PF00017	0.242
LIG_SH2_CRK	505	509	PF00017	0.335
LIG_SH2_CRK	579	583	PF00017	0.458
LIG_SH2_NCK_1	215	219	PF00017	0.523
LIG_SH2_NCK_1	479	483	PF00017	0.249
LIG_SH2_NCK_1	505	509	PF00017	0.335
LIG_SH2_PTP2	597	600	PF00017	0.364
LIG_SH2_PTP2	621	624	PF00017	0.372
LIG_SH2_SRC	215	218	PF00017	0.581
LIG_SH2_SRC	409	412	PF00017	0.474
LIG_SH2_SRC	479	482	PF00017	0.274
LIG_SH2_SRC	621	624	PF00017	0.347
LIG_SH2_STAP1	176	180	PF00017	0.513
LIG_SH2_STAP1	201	205	PF00017	0.517
LIG_SH2_STAP1	281	285	PF00017	0.460
LIG_SH2_STAT3	130	133	PF00017	0.222
LIG_SH2_STAT5	102	105	PF00017	0.290
LIG_SH2_STAT5	130	133	PF00017	0.388
LIG_SH2_STAT5	154	157	PF00017	0.387
LIG_SH2_STAT5	360	363	PF00017	0.507
LIG_SH2_STAT5	420	423	PF00017	0.494
LIG_SH2_STAT5	47	50	PF00017	0.353
LIG_SH2_STAT5	597	600	PF00017	0.311
LIG_SH2_STAT5	621	624	PF00017	0.360
LIG_SH2_STAT5	669	672	PF00017	0.376
LIG_SH3_3	351	357	PF00018	0.532
LIG_SH3_3	617	623	PF00018	0.297
LIG_SUMO_SIM_anti_2	366	373	PF11976	0.558
LIG_SUMO_SIM_par_1	390	395	PF11976	0.481
LIG_SUMO_SIM_par_1	599	605	PF11976	0.378
LIG_TYR_ITIM	595	600	PF00017	0.365
LIG_WRC_WIRS_1	516	521	PF05994	0.382
LIG_WW_3	580	584	PF00397	0.313
MOD_CDC14_SPxK_1	580	583	PF00782	0.314
MOD_CDK_SPK_2	582	587	PF00069	0.286
MOD_CDK_SPxK_1	577	583	PF00069	0.305
MOD_CDK_SPxxK_3	265	272	PF00069	0.618
MOD_CK1_1	564	570	PF00069	0.347
MOD_CK1_1	674	680	PF00069	0.440
MOD_CK1_1	684	690	PF00069	0.428
MOD_CK2_1	192	198	PF00069	0.520
MOD_CK2_1	515	521	PF00069	0.372
MOD_CK2_1	691	697	PF00069	0.502
MOD_GlcNHglycan	163	167	PF01048	0.365
MOD_GlcNHglycan	21	24	PF01048	0.279
MOD_GlcNHglycan	31	34	PF01048	0.326
MOD_GlcNHglycan	435	438	PF01048	0.256
MOD_GlcNHglycan	459	462	PF01048	0.422
MOD_GlcNHglycan	563	566	PF01048	0.612
MOD_GlcNHglycan	689	692	PF01048	0.686
MOD_GlcNHglycan	71	74	PF01048	0.322
MOD_GSK3_1	102	109	PF00069	0.252
MOD_GSK3_1	125	132	PF00069	0.360
MOD_GSK3_1	238	245	PF00069	0.568
MOD_GSK3_1	35	42	PF00069	0.205
MOD_GSK3_1	392	399	PF00069	0.546
MOD_GSK3_1	54	61	PF00069	0.163
MOD_GSK3_1	547	554	PF00069	0.335
MOD_GSK3_1	570	577	PF00069	0.398
MOD_GSK3_1	687	694	PF00069	0.477
MOD_GSK3_1	76	83	PF00069	0.294
MOD_LATS_1	254	260	PF00433	0.637
MOD_N-GLC_1	191	196	PF02516	0.308
MOD_N-GLC_1	40	45	PF02516	0.550
MOD_N-GLC_1	589	594	PF02516	0.602
MOD_NEK2_1	18	23	PF00069	0.295
MOD_NEK2_1	191	196	PF00069	0.591
MOD_NEK2_1	285	290	PF00069	0.410
MOD_NEK2_1	29	34	PF00069	0.301
MOD_NEK2_1	345	350	PF00069	0.449
MOD_NEK2_1	35	40	PF00069	0.301
MOD_NEK2_1	447	452	PF00069	0.246
MOD_NEK2_1	457	462	PF00069	0.293
MOD_NEK2_1	570	575	PF00069	0.412
MOD_NEK2_1	76	81	PF00069	0.326
MOD_NEK2_1	89	94	PF00069	0.460
MOD_PIKK_1	125	131	PF00454	0.220
MOD_PIKK_1	256	262	PF00454	0.570
MOD_PKA_2	170	176	PF00069	0.498
MOD_PKA_2	255	261	PF00069	0.537
MOD_PKA_2	364	370	PF00069	0.509
MOD_PKA_2	374	380	PF00069	0.418
MOD_PKA_2	542	548	PF00069	0.370
MOD_PKA_2	561	567	PF00069	0.419
MOD_PKA_2	570	576	PF00069	0.350
MOD_Plk_1	329	335	PF00069	0.383
MOD_Plk_1	589	595	PF00069	0.376
MOD_Plk_4	223	229	PF00069	0.389
MOD_Plk_4	551	557	PF00069	0.246
MOD_Plk_4	564	570	PF00069	0.236
MOD_Plk_4	574	580	PF00069	0.405
MOD_Plk_4	636	642	PF00069	0.229
MOD_ProDKin_1	265	271	PF00069	0.598
MOD_ProDKin_1	396	402	PF00069	0.487
MOD_ProDKin_1	577	583	PF00069	0.440
MOD_ProDKin_1	634	640	PF00069	0.340
MOD_ProDKin_1	674	680	PF00069	0.407
TRG_DiLeu_BaEn_1	342	347	PF01217	0.590
TRG_DiLeu_BaEn_3	629	635	PF01217	0.220
TRG_DiLeu_BaEn_4	342	348	PF01217	0.447
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.529
TRG_ENDOCYTIC_2	121	124	PF00928	0.305
TRG_ENDOCYTIC_2	154	157	PF00928	0.387
TRG_ENDOCYTIC_2	176	179	PF00928	0.423
TRG_ENDOCYTIC_2	201	204	PF00928	0.565
TRG_ENDOCYTIC_2	215	218	PF00928	0.457
TRG_ENDOCYTIC_2	281	284	PF00928	0.476
TRG_ENDOCYTIC_2	289	292	PF00928	0.472
TRG_ENDOCYTIC_2	419	422	PF00928	0.554
TRG_ENDOCYTIC_2	467	470	PF00928	0.256
TRG_ENDOCYTIC_2	505	508	PF00928	0.335
TRG_ENDOCYTIC_2	597	600	PF00928	0.339
TRG_ENDOCYTIC_2	621	624	PF00928	0.347
TRG_ER_diArg_1	181	183	PF00400	0.492
TRG_ER_diArg_1	470	473	PF00400	0.275
TRG_ER_diArg_1	614	616	PF00400	0.259
TRG_NES_CRM1_1	147	163	PF08389	0.448
TRG_NES_CRM1_1	368	382	PF08389	0.456
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR2	Leptomonas seymouri	59%	100%
A0A0S4JEE8	Bodo saltans	35%	90%
A0A1X0P6P4	Trypanosomatidae	41%	100%
A0A3R7KUA8	Trypanosoma rangeli	40%	100%
A0A3S7WUY2	Leishmania donovani	74%	100%
A4HXP2	Leishmania infantum	74%	100%
D0A020	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ARF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
P0C1S9	Rattus norvegicus	27%	100%
Q4QE26	Leishmania major	74%	100%
Q5YLM1	Rattus norvegicus	28%	68%
Q6WQJ1	Mus musculus	28%	68%
Q8NCG7	Homo sapiens	28%	100%
Q91WC9	Mus musculus	28%	100%
Q9Y4D2	Homo sapiens	27%	68%
V5APZ1	Trypanosoma cruzi	39%	100%