Protein-serine/threonine phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase type 5, putative

Species:

Leishmania braziliensis

UniProt:

A4H9C0_LEIBR

TriTrypDb:

LbrM.18.0170 , LBRM2903_180006600

Length:

469

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H9C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9C0

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016311	dephosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0004722	protein serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0017018	myosin phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.523
CLV_C14_Caspase3-7	202	206	PF00656	0.523
CLV_NRD_NRD_1	108	110	PF00675	0.335
CLV_NRD_NRD_1	173	175	PF00675	0.363
CLV_NRD_NRD_1	75	77	PF00675	0.352
CLV_PCSK_KEX2_1	119	121	PF00082	0.296
CLV_PCSK_KEX2_1	371	373	PF00082	0.310
CLV_PCSK_KEX2_1	457	459	PF00082	0.454
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.389
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.296
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.454
CLV_PCSK_PC7_1	367	373	PF00082	0.296
CLV_PCSK_SKI1_1	116	120	PF00082	0.414
CLV_PCSK_SKI1_1	137	141	PF00082	0.230
CLV_PCSK_SKI1_1	190	194	PF00082	0.334
CLV_PCSK_SKI1_1	237	241	PF00082	0.296
CLV_PCSK_SKI1_1	414	418	PF00082	0.343
CLV_PCSK_SKI1_1	431	435	PF00082	0.298
DEG_Nend_UBRbox_2	1	3	PF02207	0.615
DOC_CYCLIN_RxL_1	234	243	PF00134	0.300
DOC_MAPK_gen_1	174	184	PF00069	0.352
DOC_MAPK_gen_1	6	15	PF00069	0.493
DOC_MAPK_gen_1	76	84	PF00069	0.392
DOC_MAPK_HePTP_8	40	52	PF00069	0.425
DOC_MAPK_MEF2A_6	178	186	PF00069	0.292
DOC_MAPK_MEF2A_6	389	397	PF00069	0.328
DOC_MAPK_MEF2A_6	43	52	PF00069	0.428
DOC_PP1_RVXF_1	117	124	PF00149	0.330
DOC_PP2B_LxvP_1	50	53	PF13499	0.413
DOC_PP4_FxxP_1	419	422	PF00568	0.325
DOC_USP7_MATH_1	126	130	PF00917	0.405
DOC_USP7_MATH_1	23	27	PF00917	0.481
DOC_WW_Pin1_4	230	235	PF00397	0.378
DOC_WW_Pin1_4	33	38	PF00397	0.368
DOC_WW_Pin1_4	365	370	PF00397	0.355
LIG_14-3-3_CanoR_1	247	253	PF00244	0.296
LIG_14-3-3_CanoR_1	292	302	PF00244	0.411
LIG_14-3-3_CanoR_1	76	84	PF00244	0.369
LIG_APCC_ABBA_1	300	305	PF00400	0.296
LIG_BRCT_BRCA1_1	296	300	PF00533	0.321
LIG_BRCT_BRCA1_1	303	307	PF00533	0.308
LIG_FHA_1	136	142	PF00498	0.337
LIG_FHA_1	310	316	PF00498	0.330
LIG_FHA_1	34	40	PF00498	0.398
LIG_FHA_1	392	398	PF00498	0.206
LIG_FHA_2	200	206	PF00498	0.445
LIG_FHA_2	332	338	PF00498	0.316
LIG_GBD_Chelix_1	181	189	PF00786	0.330
LIG_LIR_Apic_2	147	151	PF02991	0.307
LIG_LIR_Apic_2	355	361	PF02991	0.296
LIG_LIR_Apic_2	417	422	PF02991	0.323
LIG_LIR_Gen_1	180	191	PF02991	0.311
LIG_LIR_Gen_1	297	307	PF02991	0.326
LIG_LIR_Gen_1	447	455	PF02991	0.414
LIG_LIR_Gen_1	93	102	PF02991	0.508
LIG_LIR_LC3C_4	394	397	PF02991	0.206
LIG_LIR_Nem_3	180	186	PF02991	0.311
LIG_LIR_Nem_3	194	198	PF02991	0.311
LIG_LIR_Nem_3	297	303	PF02991	0.321
LIG_LIR_Nem_3	304	310	PF02991	0.347
LIG_LIR_Nem_3	447	452	PF02991	0.411
LIG_LIR_Nem_3	93	97	PF02991	0.356
LIG_Pex14_2	240	244	PF04695	0.296
LIG_Pex14_2	303	307	PF04695	0.296
LIG_PTB_Apo_2	238	245	PF02174	0.296
LIG_PTB_Apo_2	39	46	PF02174	0.382
LIG_RPA_C_Fungi	38	50	PF08784	0.390
LIG_SH2_CRK	148	152	PF00017	0.311
LIG_SH2_CRK	220	224	PF00017	0.296
LIG_SH2_CRK	261	265	PF00017	0.311
LIG_SH2_STAP1	27	31	PF00017	0.353
LIG_SH2_STAP1	295	299	PF00017	0.330
LIG_SH2_STAT3	424	427	PF00017	0.374
LIG_SH2_STAT5	14	17	PF00017	0.514
LIG_SH2_STAT5	238	241	PF00017	0.296
LIG_SH2_STAT5	424	427	PF00017	0.371
LIG_SH2_STAT5	446	449	PF00017	0.540
LIG_SH2_STAT5	47	50	PF00017	0.421
LIG_SH3_3	198	204	PF00018	0.443
LIG_SH3_3	371	377	PF00018	0.330
LIG_SH3_3	449	455	PF00018	0.418
LIG_SUMO_SIM_par_1	393	399	PF11976	0.206
LIG_TRAF2_1	165	168	PF00917	0.439
LIG_UBA3_1	185	193	PF00899	0.301
LIG_UBA3_1	222	227	PF00899	0.330
LIG_WRC_WIRS_1	446	451	PF05994	0.423
MOD_CDK_SPxK_1	365	371	PF00069	0.355
MOD_CDK_SPxxK_3	230	237	PF00069	0.355
MOD_CDK_SPxxK_3	365	372	PF00069	0.355
MOD_Cter_Amidation	455	458	PF01082	0.451
MOD_GlcNHglycan	148	151	PF01048	0.212
MOD_GlcNHglycan	349	352	PF01048	0.313
MOD_GlcNHglycan	419	422	PF01048	0.325
MOD_GlcNHglycan	78	81	PF01048	0.382
MOD_LATS_1	74	80	PF00433	0.241
MOD_N-GLC_1	154	159	PF02516	0.389
MOD_N-GLC_1	199	204	PF02516	0.284
MOD_N-GLC_1	391	396	PF02516	0.206
MOD_N-GLC_2	423	425	PF02516	0.339
MOD_NEK2_1	191	196	PF00069	0.321
MOD_NEK2_1	353	358	PF00069	0.303
MOD_PKA_1	76	82	PF00069	0.346
MOD_PKA_2	246	252	PF00069	0.296
MOD_PKA_2	435	441	PF00069	0.386
MOD_Plk_1	154	160	PF00069	0.371
MOD_Plk_1	199	205	PF00069	0.394
MOD_Plk_1	207	213	PF00069	0.313
MOD_Plk_1	331	337	PF00069	0.355
MOD_Plk_1	391	397	PF00069	0.206
MOD_Plk_2-3	331	337	PF00069	0.330
MOD_Plk_4	254	260	PF00069	0.296
MOD_Plk_4	35	41	PF00069	0.450
MOD_Plk_4	353	359	PF00069	0.333
MOD_Plk_4	383	389	PF00069	0.305
MOD_Plk_4	391	397	PF00069	0.305
MOD_ProDKin_1	230	236	PF00069	0.378
MOD_ProDKin_1	33	39	PF00069	0.360
MOD_ProDKin_1	365	371	PF00069	0.355
MOD_SUMO_for_1	402	405	PF00179	0.336
MOD_SUMO_for_1	48	51	PF00179	0.358
MOD_SUMO_for_1	7	10	PF00179	0.478
MOD_SUMO_rev_2	112	121	PF00179	0.430
MOD_SUMO_rev_2	168	176	PF00179	0.439
TRG_ENDOCYTIC_2	195	198	PF00928	0.382
TRG_ENDOCYTIC_2	220	223	PF00928	0.298
TRG_ENDOCYTIC_2	261	264	PF00928	0.311
TRG_ENDOCYTIC_2	446	449	PF00928	0.540
TRG_ENDOCYTIC_2	47	50	PF00928	0.481
TRG_ER_diArg_1	120	123	PF00400	0.301
TRG_NLS_Bipartite_1	109	123	PF00514	0.206
TRG_NLS_MonoExtC_3	118	124	PF00514	0.439
TRG_NLS_MonoExtN_4	116	123	PF00514	0.389
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSR2	Leptomonas seymouri	36%	100%
A0A0N1ILH2	Leptomonas seymouri	30%	100%
A0A0N1PBN9	Leptomonas seymouri	84%	100%
A0A0S4JDD1	Bodo saltans	36%	100%
A0A0S4JEU6	Bodo saltans	67%	99%
A0A0S4JKZ6	Bodo saltans	36%	95%
A0A1X0NJI7	Trypanosomatidae	32%	84%
A0A1X0P6Y9	Trypanosomatidae	76%	99%
A0A1X0P7Q5	Trypanosomatidae	36%	100%
A0A1X0P9R6	Trypanosomatidae	30%	100%
A0A3R7MM48	Trypanosoma rangeli	32%	100%
A0A3S5H6T9	Leishmania donovani	36%	100%
A0A3S5H7Q6	Leishmania donovani	42%	100%
A0A3S7WUR2	Leishmania donovani	93%	100%
A0A3S7WZ39	Leishmania donovani	44%	100%
A0A3S7XAY3	Leishmania donovani	31%	100%
A0A422N1U7	Trypanosoma rangeli	29%	78%
A0A422N9D5	Trypanosoma rangeli	36%	100%
A0A422NWG6	Trypanosoma rangeli	75%	99%
A4H7Z3	Leishmania braziliensis	36%	100%
A4HJQ1	Leishmania braziliensis	41%	100%
A4HP65	Leishmania braziliensis	30%	100%
A4HWC1	Leishmania infantum	36%	100%
A4HXP1	Leishmania infantum	92%	100%
A4I1H6	Leishmania infantum	44%	100%
A4I768	Leishmania infantum	42%	100%
A4IDH0	Leishmania infantum	31%	100%
C9ZM48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZX13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A019	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	99%
D0A358	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A366	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	74%
E9AQ21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9ARF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9ASX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AXL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B262	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
G5EBX9	Caenorhabditis elegans	36%	66%
O14829	Homo sapiens	32%	72%
O35655	Mus musculus	35%	72%
O43049	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	99%
O74789	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P14747	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	78%
P20654	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	100%
P23287	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	85%
P33329	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	66%
P40421	Drosophila melanogaster	37%	71%
P53041	Homo sapiens	50%	94%
P53042	Rattus norvegicus	49%	94%
P53043	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	91%
P62136	Homo sapiens	35%	100%
P62137	Mus musculus	35%	100%
P62138	Rattus norvegicus	35%	100%
P62139	Oryctolagus cuniculus	35%	100%
Q05681	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	34%	84%
Q28IV3	Xenopus tropicalis	26%	71%
Q3SWT6	Rattus norvegicus	35%	73%
Q3T0E7	Bos taurus	35%	100%
Q4Q1M5	Leishmania major	31%	100%
Q4Q5Z8	Leishmania major	42%	100%
Q4Q9W1	Leishmania major	44%	100%
Q4QE27	Leishmania major	92%	100%
Q4QFG0	Leishmania major	35%	100%
Q60676	Mus musculus	49%	94%
Q84K11	Solanum lycopersicum	58%	84%
Q84XU2	Arabidopsis thaliana	47%	87%
Q8WMS6	Canis lupus familiaris	35%	100%
Q9FN02	Arabidopsis thaliana	33%	100%
Q9NES8	Caenorhabditis elegans	52%	95%
Q9XW79	Caenorhabditis elegans	37%	100%
V5BBR3	Trypanosoma cruzi	35%	100%
V5BBS3	Trypanosoma cruzi	30%	78%
V5D5S2	Trypanosoma cruzi	76%	99%