CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania braziliensis

UniProt:

A4H9B9_LEIBR

TriTrypDb:

LbrM.18.0160 , LBRM2903_180006500

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 9
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20
GO:0005886	plasma membrane	3	5
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4H9B9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9B9

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	20
GO:0042592	homeostatic process	3	20
GO:0048878	chemical homeostasis	4	20
GO:0050801	monoatomic ion homeostasis	5	20
GO:0055065	obsolete metal ion homeostasis	7	20
GO:0055080	monoatomic cation homeostasis	6	20
GO:0065007	biological regulation	1	20
GO:0065008	regulation of biological quality	2	20
GO:0072507	obsolete divalent inorganic cation homeostasis	7	20
GO:0098771	inorganic ion homeostasis	6	20

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.247
CLV_NRD_NRD_1	244	246	PF00675	0.446
CLV_NRD_NRD_1	278	280	PF00675	0.525
CLV_NRD_NRD_1	357	359	PF00675	0.463
CLV_NRD_NRD_1	38	40	PF00675	0.686
CLV_NRD_NRD_1	59	61	PF00675	0.566
CLV_PCSK_KEX2_1	2	4	PF00082	0.673
CLV_PCSK_KEX2_1	357	359	PF00082	0.463
CLV_PCSK_KEX2_1	58	60	PF00082	0.583
CLV_PCSK_KEX2_1	743	745	PF00082	0.777
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.562
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.609
CLV_PCSK_PC1ET2_1	743	745	PF00082	0.601
CLV_PCSK_SKI1_1	373	377	PF00082	0.564
CLV_PCSK_SKI1_1	40	44	PF00082	0.520
CLV_PCSK_SKI1_1	529	533	PF00082	0.498
CLV_PCSK_SKI1_1	615	619	PF00082	0.510
CLV_PCSK_SKI1_1	672	676	PF00082	0.592
DEG_APCC_DBOX_1	46	54	PF00400	0.315
DEG_Nend_UBRbox_1	1	4	PF02207	0.444
DOC_CKS1_1	284	289	PF01111	0.287
DOC_CKS1_1	299	304	PF01111	0.266
DOC_CKS1_1	480	485	PF01111	0.358
DOC_CKS1_1	648	653	PF01111	0.302
DOC_CYCLIN_RxL_1	526	535	PF00134	0.267
DOC_CYCLIN_RxL_1	666	676	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.285
DOC_CYCLIN_yCln2_LP_2	648	654	PF00134	0.407
DOC_MAPK_DCC_7	478	488	PF00069	0.338
DOC_MAPK_gen_1	12	20	PF00069	0.554
DOC_MAPK_gen_1	241	249	PF00069	0.340
DOC_MAPK_gen_1	261	271	PF00069	0.231
DOC_MAPK_gen_1	310	318	PF00069	0.354
DOC_MAPK_gen_1	39	45	PF00069	0.315
DOC_MAPK_gen_1	56	65	PF00069	0.255
DOC_MAPK_gen_1	609	619	PF00069	0.370
DOC_MAPK_gen_1	686	694	PF00069	0.485
DOC_MAPK_MEF2A_6	12	20	PF00069	0.539
DOC_MAPK_MEF2A_6	264	271	PF00069	0.370
DOC_MAPK_MEF2A_6	612	620	PF00069	0.380
DOC_MAPK_NFAT4_5	264	272	PF00069	0.300
DOC_PP1_RVXF_1	483	489	PF00149	0.423
DOC_PP2B_LxvP_1	474	477	PF13499	0.419
DOC_PP2B_LxvP_1	652	655	PF13499	0.313
DOC_PP4_FxxP_1	492	495	PF00568	0.473
DOC_PP4_FxxP_1	6	9	PF00568	0.413
DOC_SPAK_OSR1_1	60	64	PF12202	0.243
DOC_USP7_MATH_1	202	206	PF00917	0.313
DOC_USP7_MATH_1	317	321	PF00917	0.389
DOC_USP7_MATH_1	412	416	PF00917	0.446
DOC_USP7_MATH_1	495	499	PF00917	0.383
DOC_USP7_MATH_1	581	585	PF00917	0.404
DOC_USP7_MATH_1	705	709	PF00917	0.446
DOC_USP7_UBL2_3	105	109	PF12436	0.485
DOC_USP7_UBL2_3	119	123	PF12436	0.520
DOC_USP7_UBL2_3	242	246	PF12436	0.345
DOC_WW_Pin1_4	283	288	PF00397	0.320
DOC_WW_Pin1_4	298	303	PF00397	0.309
DOC_WW_Pin1_4	341	346	PF00397	0.434
DOC_WW_Pin1_4	479	484	PF00397	0.477
DOC_WW_Pin1_4	51	56	PF00397	0.362
DOC_WW_Pin1_4	541	546	PF00397	0.424
DOC_WW_Pin1_4	560	565	PF00397	0.425
DOC_WW_Pin1_4	647	652	PF00397	0.408
LIG_14-3-3_CanoR_1	15	21	PF00244	0.534
LIG_14-3-3_CanoR_1	261	271	PF00244	0.472
LIG_14-3-3_CanoR_1	295	302	PF00244	0.409
LIG_14-3-3_CanoR_1	416	426	PF00244	0.366
LIG_14-3-3_CanoR_1	515	523	PF00244	0.273
LIG_14-3-3_CanoR_1	609	619	PF00244	0.331
LIG_Actin_WH2_2	184	201	PF00022	0.304
LIG_AP2alpha_1	143	147	PF02296	0.334
LIG_APCC_ABBA_1	180	185	PF00400	0.294
LIG_APCC_ABBA_1	248	253	PF00400	0.253
LIG_APCC_ABBA_1	372	377	PF00400	0.366
LIG_BIR_III_4	41	45	PF00653	0.310
LIG_BRCT_BRCA1_1	143	147	PF00533	0.257
LIG_BRCT_BRCA1_1	414	418	PF00533	0.359
LIG_BRCT_BRCA1_1	583	587	PF00533	0.531
LIG_BRCT_BRCA1_1	629	633	PF00533	0.373
LIG_BRCT_BRCA1_1	77	81	PF00533	0.263
LIG_BRCT_BRCA1_2	583	589	PF00533	0.408
LIG_CSK_EPIYA_1	456	460	PF00017	0.331
LIG_EH1_1	172	180	PF00400	0.245
LIG_FHA_1	125	131	PF00498	0.294
LIG_FHA_1	158	164	PF00498	0.317
LIG_FHA_1	175	181	PF00498	0.254
LIG_FHA_1	213	219	PF00498	0.416
LIG_FHA_1	233	239	PF00498	0.190
LIG_FHA_1	295	301	PF00498	0.298
LIG_FHA_1	459	465	PF00498	0.355
LIG_FHA_1	471	477	PF00498	0.481
LIG_FHA_1	494	500	PF00498	0.415
LIG_FHA_1	549	555	PF00498	0.487
LIG_FHA_1	561	567	PF00498	0.535
LIG_FHA_1	572	578	PF00498	0.533
LIG_FHA_1	591	597	PF00498	0.296
LIG_FHA_1	647	653	PF00498	0.359
LIG_FHA_1	726	732	PF00498	0.456
LIG_FHA_1	83	89	PF00498	0.274
LIG_FHA_1	91	97	PF00498	0.428
LIG_FHA_2	284	290	PF00498	0.356
LIG_FHA_2	337	343	PF00498	0.463
LIG_FHA_2	428	434	PF00498	0.290
LIG_GBD_Chelix_1	174	182	PF00786	0.289
LIG_Integrin_isoDGR_2	467	469	PF01839	0.538
LIG_IRF3_LxIS_1	125	131	PF10401	0.334
LIG_LIR_Apic_2	490	495	PF02991	0.437
LIG_LIR_Gen_1	142	150	PF02991	0.316
LIG_LIR_Gen_1	205	214	PF02991	0.441
LIG_LIR_Gen_1	301	308	PF02991	0.447
LIG_LIR_Gen_1	448	458	PF02991	0.530
LIG_LIR_Gen_1	639	648	PF02991	0.303
LIG_LIR_Gen_1	656	665	PF02991	0.272
LIG_LIR_LC3C_4	326	331	PF02991	0.388
LIG_LIR_Nem_3	142	146	PF02991	0.303
LIG_LIR_Nem_3	168	174	PF02991	0.246
LIG_LIR_Nem_3	19	23	PF02991	0.487
LIG_LIR_Nem_3	205	210	PF02991	0.417
LIG_LIR_Nem_3	441	447	PF02991	0.345
LIG_LIR_Nem_3	448	453	PF02991	0.405
LIG_LIR_Nem_3	456	462	PF02991	0.398
LIG_LIR_Nem_3	639	643	PF02991	0.313
LIG_LIR_Nem_3	656	660	PF02991	0.262
LIG_LIR_Nem_3	676	681	PF02991	0.393
LIG_LIR_Nem_3	78	84	PF02991	0.319
LIG_MLH1_MIPbox_1	583	587	PF16413	0.408
LIG_NRBOX	266	272	PF00104	0.357
LIG_NRBOX	64	70	PF00104	0.333
LIG_Pex14_1	507	511	PF04695	0.305
LIG_Pex14_1	523	527	PF04695	0.313
LIG_Pex14_2	143	147	PF04695	0.340
LIG_Pex14_2	488	492	PF04695	0.338
LIG_Pex14_2	653	657	PF04695	0.306
LIG_Pex3_1	65	76	PF04882	0.172
LIG_REV1ctd_RIR_1	584	593	PF16727	0.381
LIG_SH2_CRK	668	672	PF00017	0.310
LIG_SH2_CRK	681	685	PF00017	0.281
LIG_SH2_CRK	74	78	PF00017	0.348
LIG_SH2_GRB2like	512	515	PF00017	0.278
LIG_SH2_NCK_1	450	454	PF00017	0.510
LIG_SH2_NCK_1	459	463	PF00017	0.480
LIG_SH2_PTP2	527	530	PF00017	0.364
LIG_SH2_PTP2	62	65	PF00017	0.353
LIG_SH2_STAP1	110	114	PF00017	0.478
LIG_SH2_STAP1	196	200	PF00017	0.428
LIG_SH2_STAT3	521	524	PF00017	0.401
LIG_SH2_STAT3	679	682	PF00017	0.233
LIG_SH2_STAT5	26	29	PF00017	0.427
LIG_SH2_STAT5	293	296	PF00017	0.308
LIG_SH2_STAT5	491	494	PF00017	0.297
LIG_SH2_STAT5	512	515	PF00017	0.302
LIG_SH2_STAT5	527	530	PF00017	0.286
LIG_SH2_STAT5	62	65	PF00017	0.308
LIG_SH2_STAT5	642	645	PF00017	0.387
LIG_SH3_2	480	485	PF14604	0.433
LIG_SH3_3	459	465	PF00018	0.487
LIG_SH3_3	474	480	PF00018	0.405
LIG_SH3_3	561	567	PF00018	0.546
LIG_SH3_3	691	697	PF00018	0.550
LIG_SH3_4	105	112	PF00018	0.372
LIG_Sin3_3	657	664	PF02671	0.216
LIG_SUMO_SIM_anti_2	176	183	PF11976	0.327
LIG_SUMO_SIM_anti_2	326	333	PF11976	0.314
LIG_SUMO_SIM_anti_2	613	620	PF11976	0.429
LIG_SUMO_SIM_anti_2	95	102	PF11976	0.421
LIG_SUMO_SIM_par_1	126	131	PF11976	0.299
LIG_SUMO_SIM_par_1	136	142	PF11976	0.334
LIG_SUMO_SIM_par_1	215	221	PF11976	0.289
LIG_SUMO_SIM_par_1	326	333	PF11976	0.290
LIG_TRAF2_2	560	565	PF00917	0.434
LIG_UBA3_1	114	119	PF00899	0.538
LIG_UBA3_1	284	290	PF00899	0.394
LIG_WRC_WIRS_1	637	642	PF05994	0.386
LIG_WW_3	482	486	PF00397	0.455
MOD_CDK_SPK_2	51	56	PF00069	0.387
MOD_CDK_SPxK_1	479	485	PF00069	0.494
MOD_CDK_SPxxK_3	283	290	PF00069	0.398
MOD_CDK_SPxxK_3	51	58	PF00069	0.384
MOD_CK1_1	194	200	PF00069	0.457
MOD_CK1_1	232	238	PF00069	0.340
MOD_CK1_1	311	317	PF00069	0.318
MOD_CK1_1	344	350	PF00069	0.427
MOD_CK1_1	367	373	PF00069	0.312
MOD_CK1_1	417	423	PF00069	0.462
MOD_CK1_1	490	496	PF00069	0.439
MOD_CK1_1	546	552	PF00069	0.523
MOD_CK1_1	568	574	PF00069	0.497
MOD_CK1_1	600	606	PF00069	0.401
MOD_CK1_1	698	704	PF00069	0.425
MOD_CK2_1	283	289	PF00069	0.395
MOD_CK2_1	336	342	PF00069	0.424
MOD_CK2_1	579	585	PF00069	0.438
MOD_GlcNHglycan	101	104	PF01048	0.228
MOD_GlcNHglycan	164	168	PF01048	0.473
MOD_GlcNHglycan	31	34	PF01048	0.559
MOD_GlcNHglycan	310	313	PF01048	0.544
MOD_GlcNHglycan	319	322	PF01048	0.537
MOD_GlcNHglycan	411	415	PF01048	0.650
MOD_GlcNHglycan	574	577	PF01048	0.604
MOD_GlcNHglycan	656	660	PF01048	0.576
MOD_GlcNHglycan	77	80	PF01048	0.292
MOD_GSK3_1	124	131	PF00069	0.315
MOD_GSK3_1	187	194	PF00069	0.495
MOD_GSK3_1	212	219	PF00069	0.416
MOD_GSK3_1	294	301	PF00069	0.356
MOD_GSK3_1	333	340	PF00069	0.342
MOD_GSK3_1	363	370	PF00069	0.280
MOD_GSK3_1	399	406	PF00069	0.454
MOD_GSK3_1	410	417	PF00069	0.415
MOD_GSK3_1	495	502	PF00069	0.417
MOD_GSK3_1	515	522	PF00069	0.307
MOD_GSK3_1	539	546	PF00069	0.384
MOD_GSK3_1	565	572	PF00069	0.461
MOD_GSK3_1	632	639	PF00069	0.353
MOD_GSK3_1	695	702	PF00069	0.491
MOD_GSK3_1	711	718	PF00069	0.519
MOD_GSK3_1	738	745	PF00069	0.518
MOD_N-GLC_1	337	342	PF02516	0.632
MOD_N-GLC_1	513	518	PF02516	0.592
MOD_N-GLC_2	691	693	PF02516	0.540
MOD_NEK2_1	128	133	PF00069	0.296
MOD_NEK2_1	16	21	PF00069	0.500
MOD_NEK2_1	173	178	PF00069	0.277
MOD_NEK2_1	212	217	PF00069	0.451
MOD_NEK2_1	218	223	PF00069	0.450
MOD_NEK2_1	308	313	PF00069	0.344
MOD_NEK2_1	31	36	PF00069	0.584
MOD_NEK2_1	361	366	PF00069	0.258
MOD_NEK2_1	418	423	PF00069	0.516
MOD_NEK2_1	501	506	PF00069	0.356
MOD_NEK2_1	513	518	PF00069	0.334
MOD_NEK2_1	569	574	PF00069	0.475
MOD_NEK2_1	699	704	PF00069	0.503
MOD_NEK2_2	202	207	PF00069	0.416
MOD_PIKK_1	501	507	PF00454	0.356
MOD_PIKK_1	543	549	PF00454	0.534
MOD_PIKK_1	569	575	PF00454	0.582
MOD_PIKK_1	590	596	PF00454	0.403
MOD_PK_1	49	55	PF00069	0.306
MOD_PK_1	666	672	PF00069	0.366
MOD_PKA_2	155	161	PF00069	0.340
MOD_PKA_2	294	300	PF00069	0.396
MOD_PKA_2	687	693	PF00069	0.455
MOD_PKA_2	703	709	PF00069	0.516
MOD_Plk_1	337	343	PF00069	0.519
MOD_Plk_1	377	383	PF00069	0.346
MOD_Plk_1	513	519	PF00069	0.389
MOD_Plk_1	600	606	PF00069	0.415
MOD_Plk_1	655	661	PF00069	0.293
MOD_Plk_4	110	116	PF00069	0.472
MOD_Plk_4	124	130	PF00069	0.265
MOD_Plk_4	174	180	PF00069	0.315
MOD_Plk_4	202	208	PF00069	0.351
MOD_Plk_4	289	295	PF00069	0.273
MOD_Plk_4	324	330	PF00069	0.389
MOD_Plk_4	367	373	PF00069	0.312
MOD_Plk_4	403	409	PF00069	0.432
MOD_Plk_4	487	493	PF00069	0.327
MOD_Plk_4	495	501	PF00069	0.333
MOD_Plk_4	553	559	PF00069	0.560
MOD_Plk_4	565	571	PF00069	0.410
MOD_Plk_4	719	725	PF00069	0.569
MOD_ProDKin_1	283	289	PF00069	0.326
MOD_ProDKin_1	298	304	PF00069	0.307
MOD_ProDKin_1	341	347	PF00069	0.425
MOD_ProDKin_1	479	485	PF00069	0.477
MOD_ProDKin_1	51	57	PF00069	0.358
MOD_ProDKin_1	541	547	PF00069	0.427
MOD_ProDKin_1	560	566	PF00069	0.425
MOD_ProDKin_1	647	653	PF00069	0.405
MOD_SUMO_for_1	263	266	PF00179	0.420
MOD_SUMO_rev_2	101	111	PF00179	0.437
MOD_SUMO_rev_2	234	244	PF00179	0.311
MOD_SUMO_rev_2	275	281	PF00179	0.286
MOD_SUMO_rev_2	533	538	PF00179	0.429
TRG_DiLeu_BaEn_1	243	248	PF01217	0.260
TRG_DiLeu_BaEn_1	266	271	PF01217	0.287
TRG_DiLeu_BaEn_1	719	724	PF01217	0.514
TRG_DiLeu_BaEn_4	233	239	PF01217	0.340
TRG_DiLeu_BaEn_4	533	539	PF01217	0.237
TRG_DiLeu_BaLyEn_6	612	617	PF01217	0.412
TRG_ENDOCYTIC_2	450	453	PF00928	0.498
TRG_ENDOCYTIC_2	459	462	PF00928	0.430
TRG_ENDOCYTIC_2	489	492	PF00928	0.405
TRG_ENDOCYTIC_2	527	530	PF00928	0.294
TRG_ENDOCYTIC_2	62	65	PF00928	0.319
TRG_ENDOCYTIC_2	681	684	PF00928	0.283
TRG_ENDOCYTIC_2	74	77	PF00928	0.352
TRG_ER_diArg_1	153	156	PF00400	0.340
TRG_ER_diArg_1	3	6	PF00400	0.598
TRG_ER_diArg_1	313	316	PF00400	0.342
TRG_ER_diArg_1	357	359	PF00400	0.358
TRG_ER_diArg_1	59	61	PF00400	0.262
TRG_NLS_MonoExtN_4	55	62	PF00514	0.268
TRG_Pf-PMV_PEXEL_1	529	533	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK76	Leptomonas seymouri	64%	99%
A0A0S4JDJ1	Bodo saltans	36%	79%
A0A0S4JGZ5	Bodo saltans	32%	90%
A0A1X0P6Q5	Trypanosomatidae	43%	100%
A0A1X0P7K4	Trypanosomatidae	26%	100%
A0A3S7WUR9	Leishmania donovani	79%	100%
A0A3S7WUS2	Leishmania donovani	31%	100%
A0A422NWG4	Trypanosoma rangeli	40%	100%
A4H9B8	Leishmania braziliensis	31%	99%
A4HXN9	Leishmania infantum	31%	100%
A4HXP0	Leishmania infantum	79%	100%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ARF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ARF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QE28	Leishmania major	78%	100%
Q4QE29	Leishmania major	32%	100%
V5B9W6	Trypanosoma cruzi	41%	100%
V5BEH2	Trypanosoma cruzi	30%	100%