CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania braziliensis

UniProt:

A4H9B8_LEIBR

TriTrypDb:

LbrM.18.0150 , LBRM2903_180006400

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 10
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	7
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4H9B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9B8

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	22
GO:0042592	homeostatic process	3	22
GO:0048878	chemical homeostasis	4	22
GO:0050801	monoatomic ion homeostasis	5	22
GO:0055065	obsolete metal ion homeostasis	7	22
GO:0055080	monoatomic cation homeostasis	6	22
GO:0065007	biological regulation	1	22
GO:0065008	regulation of biological quality	2	22
GO:0072507	obsolete divalent inorganic cation homeostasis	7	22
GO:0098771	inorganic ion homeostasis	6	22

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	480	484	PF00656	0.357
CLV_C14_Caspase3-7	486	490	PF00656	0.368
CLV_NRD_NRD_1	143	145	PF00675	0.458
CLV_NRD_NRD_1	208	210	PF00675	0.471
CLV_NRD_NRD_1	32	34	PF00675	0.255
CLV_NRD_NRD_1	586	588	PF00675	0.506
CLV_NRD_NRD_1	623	625	PF00675	0.733
CLV_NRD_NRD_1	627	629	PF00675	0.685
CLV_PCSK_KEX2_1	208	210	PF00082	0.506
CLV_PCSK_KEX2_1	336	338	PF00082	0.735
CLV_PCSK_KEX2_1	636	638	PF00082	0.667
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.750
CLV_PCSK_PC1ET2_1	636	638	PF00082	0.685
CLV_PCSK_PC7_1	632	638	PF00082	0.716
CLV_PCSK_SKI1_1	145	149	PF00082	0.350
CLV_PCSK_SKI1_1	170	174	PF00082	0.598
CLV_PCSK_SKI1_1	260	264	PF00082	0.536
CLV_PCSK_SKI1_1	33	37	PF00082	0.332
CLV_PCSK_SKI1_1	464	468	PF00082	0.495
DEG_APCC_DBOX_1	143	151	PF00400	0.237
DEG_APCC_DBOX_1	169	177	PF00400	0.391
DEG_Nend_Nbox_1	1	3	PF02207	0.398
DEG_SPOP_SBC_1	427	431	PF00917	0.282
DOC_ANK_TNKS_1	224	231	PF00023	0.190
DOC_CDC14_PxL_1	555	563	PF14671	0.298
DOC_CYCLIN_RxL_1	121	131	PF00134	0.338
DOC_MAPK_gen_1	225	234	PF00069	0.355
DOC_MAPK_JIP1_4	124	130	PF00069	0.278
DOC_MAPK_MEF2A_6	107	116	PF00069	0.308
DOC_MAPK_MEF2A_6	33	40	PF00069	0.424
DOC_PP1_RVXF_1	417	423	PF00149	0.417
DOC_PP4_FxxP_1	287	290	PF00568	0.250
DOC_USP7_MATH_1	310	314	PF00917	0.390
DOC_USP7_MATH_1	363	367	PF00917	0.344
DOC_USP7_MATH_1	566	570	PF00917	0.349
DOC_USP7_MATH_1	623	627	PF00917	0.539
DOC_USP7_UBL2_3	145	149	PF12436	0.338
DOC_USP7_UBL2_3	157	161	PF12436	0.402
DOC_USP7_UBL2_3	326	330	PF12436	0.543
DOC_USP7_UBL2_3	625	629	PF12436	0.466
DOC_WW_Pin1_4	185	190	PF00397	0.259
DOC_WW_Pin1_4	299	304	PF00397	0.580
DOC_WW_Pin1_4	490	495	PF00397	0.525
DOC_WW_Pin1_4	601	606	PF00397	0.540
LIG_14-3-3_CanoR_1	170	176	PF00244	0.401
LIG_14-3-3_CanoR_1	538	546	PF00244	0.306
LIG_14-3-3_CanoR_1	576	584	PF00244	0.354
LIG_14-3-3_CanoR_1	595	605	PF00244	0.469
LIG_14-3-3_CanoR_1	624	628	PF00244	0.477
LIG_APCC_ABBA_1	151	156	PF00400	0.249
LIG_APCC_ABBA_1	218	223	PF00400	0.253
LIG_APCC_ABBA_1	83	88	PF00400	0.297
LIG_APCC_ABBAyCdc20_2	217	223	PF00400	0.253
LIG_BRCT_BRCA1_1	518	522	PF00533	0.276
LIG_Clathr_ClatBox_1	285	289	PF01394	0.284
LIG_Clathr_ClatBox_1	371	375	PF01394	0.266
LIG_Clathr_ClatBox_1	9	13	PF01394	0.517
LIG_FHA_1	12	18	PF00498	0.413
LIG_FHA_1	281	287	PF00498	0.338
LIG_FHA_1	341	347	PF00498	0.418
LIG_FHA_1	394	400	PF00498	0.401
LIG_FHA_1	4	10	PF00498	0.435
LIG_FHA_1	455	461	PF00498	0.296
LIG_FHA_1	46	52	PF00498	0.297
LIG_FHA_1	521	527	PF00498	0.229
LIG_FHA_1	54	60	PF00498	0.313
LIG_FHA_1	563	569	PF00498	0.301
LIG_FHA_1	602	608	PF00498	0.390
LIG_FHA_1	610	616	PF00498	0.402
LIG_FHA_1	78	84	PF00498	0.262
LIG_FHA_2	186	192	PF00498	0.271
LIG_FHA_2	198	204	PF00498	0.313
LIG_FHA_2	248	254	PF00498	0.282
LIG_FHA_2	371	377	PF00498	0.294
LIG_FHA_2	576	582	PF00498	0.343
LIG_FHA_2	604	610	PF00498	0.399
LIG_GBD_Chelix_1	46	54	PF00786	0.293
LIG_GBD_Chelix_1	73	81	PF00786	0.301
LIG_IRF3_LxIS_1	109	115	PF10401	0.159
LIG_KLC1_Yacidic_2	13	18	PF13176	0.530
LIG_LIR_Gen_1	13	23	PF02991	0.512
LIG_LIR_Gen_1	449	460	PF02991	0.333
LIG_LIR_Gen_1	519	530	PF02991	0.236
LIG_LIR_Gen_1	545	554	PF02991	0.304
LIG_LIR_Gen_1	563	568	PF02991	0.178
LIG_LIR_LC3C_4	261	265	PF02991	0.375
LIG_LIR_Nem_3	13	19	PF02991	0.494
LIG_LIR_Nem_3	366	371	PF02991	0.404
LIG_LIR_Nem_3	449	455	PF02991	0.310
LIG_LIR_Nem_3	519	525	PF02991	0.247
LIG_LIR_Nem_3	545	549	PF02991	0.308
LIG_LIR_Nem_3	563	567	PF02991	0.181
LIG_MAD2	510	518	PF02301	0.396
LIG_NRBOX	45	51	PF00104	0.308
LIG_Pex14_1	442	446	PF04695	0.300
LIG_PTAP_UEV_1	341	346	PF05743	0.358
LIG_SH2_CRK	2	6	PF00017	0.546
LIG_SH2_CRK	564	568	PF00017	0.308
LIG_SH2_SRC	16	19	PF00017	0.530
LIG_SH2_SRC	221	224	PF00017	0.197
LIG_SH2_STAP1	31	35	PF00017	0.456
LIG_SH2_STAP1	564	568	PF00017	0.315
LIG_SH2_STAT5	16	19	PF00017	0.548
LIG_SH2_STAT5	2	5	PF00017	0.506
LIG_SH2_STAT5	233	236	PF00017	0.240
LIG_SH2_STAT5	242	245	PF00017	0.404
LIG_SH2_STAT5	276	279	PF00017	0.361
LIG_SH2_STAT5	447	450	PF00017	0.300
LIG_SH2_STAT5	452	455	PF00017	0.298
LIG_SH2_STAT5	564	567	PF00017	0.279
LIG_SH3_3	115	121	PF00018	0.306
LIG_SH3_3	339	345	PF00018	0.450
LIG_SH3_3	406	412	PF00018	0.453
LIG_SH3_3	556	562	PF00018	0.361
LIG_SH3_3	612	618	PF00018	0.534
LIG_SUMO_SIM_anti_2	261	266	PF11976	0.239
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.334
LIG_SUMO_SIM_par_1	171	177	PF11976	0.409
LIG_SUMO_SIM_par_1	191	197	PF11976	0.234
LIG_SUMO_SIM_par_1	370	376	PF11976	0.269
LIG_SUMO_SIM_par_1	522	527	PF11976	0.260
LIG_SUMO_SIM_par_1	55	61	PF11976	0.323
LIG_SUMO_SIM_par_1	581	586	PF11976	0.299
LIG_TRAF2_1	23	26	PF00917	0.530
LIG_TRFH_1	117	121	PF08558	0.308
LIG_TYR_ITSM	12	19	PF00017	0.530
LIG_UBA3_1	116	124	PF00899	0.308
LIG_UBA3_1	150	157	PF00899	0.330
LIG_WRC_WIRS_1	543	548	PF05994	0.373
MOD_CDK_SPK_2	299	304	PF00069	0.557
MOD_CK1_1	159	165	PF00069	0.425
MOD_CK1_1	247	253	PF00069	0.397
MOD_CK1_1	27	33	PF00069	0.409
MOD_CK1_1	313	319	PF00069	0.541
MOD_CK1_1	340	346	PF00069	0.519
MOD_CK1_1	393	399	PF00069	0.335
MOD_CK1_1	428	434	PF00069	0.480
MOD_CK1_1	488	494	PF00069	0.550
MOD_CK1_1	520	526	PF00069	0.393
MOD_CK1_1	569	575	PF00069	0.312
MOD_CK1_1	93	99	PF00069	0.452
MOD_CK2_1	185	191	PF00069	0.307
MOD_CK2_1	201	207	PF00069	0.307
MOD_CK2_1	397	403	PF00069	0.528
MOD_CK2_1	405	411	PF00069	0.518
MOD_CK2_1	426	432	PF00069	0.462
MOD_CK2_1	603	609	PF00069	0.386
MOD_GlcNHglycan	158	161	PF01048	0.529
MOD_GlcNHglycan	332	335	PF01048	0.787
MOD_GlcNHglycan	364	368	PF01048	0.560
MOD_GlcNHglycan	389	395	PF01048	0.508
MOD_GlcNHglycan	519	522	PF01048	0.499
MOD_GlcNHglycan	526	529	PF01048	0.474
MOD_GSK3_1	197	204	PF00069	0.302
MOD_GSK3_1	326	333	PF00069	0.484
MOD_GSK3_1	393	400	PF00069	0.464
MOD_GSK3_1	421	428	PF00069	0.440
MOD_GSK3_1	454	461	PF00069	0.307
MOD_GSK3_1	485	492	PF00069	0.443
MOD_GSK3_1	516	523	PF00069	0.256
MOD_GSK3_1	53	60	PF00069	0.320
MOD_GSK3_1	538	545	PF00069	0.346
MOD_GSK3_1	562	569	PF00069	0.305
MOD_GSK3_1	609	616	PF00069	0.475
MOD_LATS_1	335	341	PF00433	0.488
MOD_LATS_1	536	542	PF00433	0.245
MOD_N-GLC_1	304	309	PF02516	0.738
MOD_N-GLC_1	458	463	PF02516	0.582
MOD_N-GLC_2	433	435	PF02516	0.474
MOD_NEK2_1	112	117	PF00069	0.422
MOD_NEK2_1	171	176	PF00069	0.406
MOD_NEK2_1	196	201	PF00069	0.320
MOD_NEK2_1	405	410	PF00069	0.510
MOD_NEK2_1	45	50	PF00069	0.297
MOD_NEK2_1	524	529	PF00069	0.269
MOD_NEK2_1	57	62	PF00069	0.316
MOD_NEK2_1	575	580	PF00069	0.308
MOD_NEK2_2	11	16	PF00069	0.530
MOD_NEK2_2	623	628	PF00069	0.365
MOD_PIKK_1	280	286	PF00454	0.296
MOD_PIKK_1	304	310	PF00454	0.563
MOD_PIKK_1	575	581	PF00454	0.320
MOD_PIKK_1	58	64	PF00454	0.308
MOD_PKA_2	569	575	PF00069	0.305
MOD_PKA_2	623	629	PF00069	0.467
MOD_Plk_1	247	253	PF00069	0.377
MOD_Plk_1	27	33	PF00069	0.422
MOD_Plk_1	458	464	PF00069	0.379
MOD_Plk_1	562	568	PF00069	0.286
MOD_Plk_4	11	17	PF00069	0.435
MOD_Plk_4	171	177	PF00069	0.356
MOD_Plk_4	238	244	PF00069	0.466
MOD_Plk_4	266	272	PF00069	0.327
MOD_Plk_4	405	411	PF00069	0.496
MOD_Plk_4	45	51	PF00069	0.267
MOD_Plk_4	53	59	PF00069	0.296
MOD_Plk_4	610	616	PF00069	0.512
MOD_Plk_4	77	83	PF00069	0.316
MOD_ProDKin_1	185	191	PF00069	0.259
MOD_ProDKin_1	299	305	PF00069	0.580
MOD_ProDKin_1	490	496	PF00069	0.524
MOD_ProDKin_1	601	607	PF00069	0.540
MOD_SUMO_rev_2	137	147	PF00179	0.299
MOD_SUMO_rev_2	389	399	PF00179	0.384
MOD_SUMO_rev_2	581	589	PF00179	0.413
MOD_SUMO_rev_2	633	638	PF00179	0.524
TRG_DiLeu_BaEn_1	146	151	PF01217	0.249
TRG_DiLeu_BaEn_2	363	369	PF01217	0.323
TRG_DiLeu_BaEn_2	71	77	PF01217	0.274
TRG_ENDOCYTIC_2	16	19	PF00928	0.548
TRG_ENDOCYTIC_2	2	5	PF00928	0.531
TRG_ENDOCYTIC_2	452	455	PF00928	0.286
TRG_ENDOCYTIC_2	564	567	PF00928	0.285
TRG_ER_diArg_1	208	210	PF00400	0.265
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	587	591	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5K6	Leptomonas seymouri	60%	87%
A0A0N1IK76	Leptomonas seymouri	32%	85%
A0A0S4JDJ1	Bodo saltans	30%	68%
A0A1X0P6Q5	Trypanosomatidae	33%	86%
A0A1X0P7K4	Trypanosomatidae	37%	92%
A0A3R7M693	Trypanosoma rangeli	37%	96%
A0A3S7WUR9	Leishmania donovani	32%	86%
A0A3S7WUS2	Leishmania donovani	76%	91%
A0A422NWG4	Trypanosoma rangeli	32%	87%
A4H9B9	Leishmania braziliensis	31%	86%
A4HIN7	Leishmania braziliensis	25%	100%
A4HXN9	Leishmania infantum	76%	91%
A4HXP0	Leishmania infantum	31%	86%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	87%
E9ARF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	91%
E9ARF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	86%
Q4QE28	Leishmania major	31%	100%
Q4QE29	Leishmania major	75%	100%
Q9GYL2	Caenorhabditis elegans	24%	84%
V5B9W6	Trypanosoma cruzi	31%	87%
V5BEH2	Trypanosoma cruzi	37%	94%